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The map label for this gene is ctpA-1 [H]

Identifier: 21673997

GI number: 21673997

Start: 1101105

End: 1102721

Strand: Reverse

Name: ctpA-1 [H]

Synonym: CT1171

Alternate gene names: 21673997

Gene position: 1102721-1101105 (Counterclockwise)

Preceding gene: 21673998

Following gene: 21673996

Centisome position: 51.17

GC content: 54.17

Gene sequence:

>1617_bases
ATGTCTCGTATTTTCACTGTTATTATCATGTTGCTCATCGGAGGATTCGGTTATTTTATCGGATGGCGGATGAACAGTGG
GACTGGGGGAAAAATGGTCGATACCTACAATTTGATCAGGTCGTATTATGTCGATCCTGTCAATGCCGACAGCCTTCAAA
GCGCGGGTGTTCGCGGCATGTTGCAGTCGCTCGATCCCCACTCCATCTATCTCGAACCCGAAAAAGCCGCGATCACCCAG
TCCAACTTCAATGGCAATTTCGAGGGGATTGGTGTCGAGTTCGATGTCGTACGCGATACGCTTTTGGTGGTGACACCCCT
CGCTGGGGGGCCAAGCGAGTCTGCTGGCATCATGCCCGGAGATCGGATCATTGGGATCGACTCGAAGAATGTTATCGGCA
TCAAGCCTTCGGCTGTTCTTGGCAAGCTCAGGGGCGAGCGGGGCACAAGAGTCAGGCTGAGAATTTATCGGCCCCTGACC
CGCCGGACGATTGATTTTCTGGTGACGCGCGGAAAGATTTCGACATCGAGCATCGACGCAGCTTTTCTCGACGATGCGCG
TACCGGCTACATCCGCATCAGCCAGTTCGTAGAGACCACGGGAAGCGAGTTTCACAATGCCGTGCAAAAGCTGCGCGACA
AGGGGATGCGGAAGCTCATTATCGATGTGCGGGGCAATCCCGGCGGCTACCTCGATCAGGCCGTGGCTGTGGCGGATGAA
CTGCTTCCTGCGGGAAAGCTCATTGTTTATACCAAAAGCCGGCACGGTGGTGACGATCAGATGAAGTACTTATCGACCTC
CGGCGGGATTTTCGAGAAGGGAGAAGTCTGCCTTCTGGTTGACCGCGGTAGTGCTTCGGCGGCGGAAATCCTTGCCGGTG
CGCTTCAGGATAACCGGCGCGCATTGCTCATCGGTGAGCTGACATTCGGCAAGGGGCTTGTTCAGCGTCAGTTCAAACTG
CCCGACGATTCGGTTGTCAGGCTTACCGTTTCGAGATATTTCACTCCGTCGGGCCGTCAGATTCAGCGGGAGTATGATGA
CGGTCTTCAGGGGCGTGAGCGCTATTACAAGGAGATGTTTACCCGGAATCTGCCAGGTGGTTTTATAAAAAAGTACGGTG
ACCTCATGTACCGGGAGGGGCAGAACATTTCGGTCTACAGTACCGGAAGTTTGCTGAAAAACACCGCTGCGGACAGCCTC
CGTGCTGTGCTTGCCAAGGCCGGTGGCATCATGCCCGATTACTGGGTTTTCGGCAAGCCGTACTCCAATCTGTACCAGGA
GCTCTACGCCAAGGGTGTCATTGAGGATATCGCGCTGAAACTGATCGACGATCCTTCCGATCCTGTCCAGAAATACCGGA
GTTCGGCGACTTCGTATCTTGATGGATACCATGTACCAGTGAACCTCGAAGCGCTTGTCAGAAAAGAGTGCGCGGAGGCA
AAGGTGCAATTCAACCAAGCCGAGTTTGACCGTGACCGGGCCGATATAGCTCTAGCGCTCAAGGCCAGGGTTGCCAGGCA
TCTGTTCGGAACTGAAGAACAGATCAGGGTGTTAGTCAGTGAAGGTGATCCTGTCATGAAGGTTGCGCGGCATTTCATCG
AAAAGAGCGCTTCATGA

Upstream 100 bases:

>100_bases
CCGCTATCTCGCTATCGGTCTGTTTGAGTTTTTTTGCATGACTTGCGCTGTATTGAGCTACAGTTGCCACCTGTCTAACG
GTTAATCTGAATCGATCGCT

Downstream 100 bases:

>100_bases
GTCAATAGGAAAAAGCTGTTTTTCAGGCAGTACGGAGGCCTTTAACCAATTTTTCATACAATCCGGTTTACTATGTCACT
ACTTGAAAAAATCAACAGTA

Product: carboxyl-terminal protease

Products: NA

Alternate protein names: C-terminal processing protease [H]

Number of amino acids: Translated: 538; Mature: 537

Protein sequence:

>538_residues
MSRIFTVIIMLLIGGFGYFIGWRMNSGTGGKMVDTYNLIRSYYVDPVNADSLQSAGVRGMLQSLDPHSIYLEPEKAAITQ
SNFNGNFEGIGVEFDVVRDTLLVVTPLAGGPSESAGIMPGDRIIGIDSKNVIGIKPSAVLGKLRGERGTRVRLRIYRPLT
RRTIDFLVTRGKISTSSIDAAFLDDARTGYIRISQFVETTGSEFHNAVQKLRDKGMRKLIIDVRGNPGGYLDQAVAVADE
LLPAGKLIVYTKSRHGGDDQMKYLSTSGGIFEKGEVCLLVDRGSASAAEILAGALQDNRRALLIGELTFGKGLVQRQFKL
PDDSVVRLTVSRYFTPSGRQIQREYDDGLQGRERYYKEMFTRNLPGGFIKKYGDLMYREGQNISVYSTGSLLKNTAADSL
RAVLAKAGGIMPDYWVFGKPYSNLYQELYAKGVIEDIALKLIDDPSDPVQKYRSSATSYLDGYHVPVNLEALVRKECAEA
KVQFNQAEFDRDRADIALALKARVARHLFGTEEQIRVLVSEGDPVMKVARHFIEKSAS

Sequences:

>Translated_538_residues
MSRIFTVIIMLLIGGFGYFIGWRMNSGTGGKMVDTYNLIRSYYVDPVNADSLQSAGVRGMLQSLDPHSIYLEPEKAAITQ
SNFNGNFEGIGVEFDVVRDTLLVVTPLAGGPSESAGIMPGDRIIGIDSKNVIGIKPSAVLGKLRGERGTRVRLRIYRPLT
RRTIDFLVTRGKISTSSIDAAFLDDARTGYIRISQFVETTGSEFHNAVQKLRDKGMRKLIIDVRGNPGGYLDQAVAVADE
LLPAGKLIVYTKSRHGGDDQMKYLSTSGGIFEKGEVCLLVDRGSASAAEILAGALQDNRRALLIGELTFGKGLVQRQFKL
PDDSVVRLTVSRYFTPSGRQIQREYDDGLQGRERYYKEMFTRNLPGGFIKKYGDLMYREGQNISVYSTGSLLKNTAADSL
RAVLAKAGGIMPDYWVFGKPYSNLYQELYAKGVIEDIALKLIDDPSDPVQKYRSSATSYLDGYHVPVNLEALVRKECAEA
KVQFNQAEFDRDRADIALALKARVARHLFGTEEQIRVLVSEGDPVMKVARHFIEKSAS
>Mature_537_residues
SRIFTVIIMLLIGGFGYFIGWRMNSGTGGKMVDTYNLIRSYYVDPVNADSLQSAGVRGMLQSLDPHSIYLEPEKAAITQS
NFNGNFEGIGVEFDVVRDTLLVVTPLAGGPSESAGIMPGDRIIGIDSKNVIGIKPSAVLGKLRGERGTRVRLRIYRPLTR
RTIDFLVTRGKISTSSIDAAFLDDARTGYIRISQFVETTGSEFHNAVQKLRDKGMRKLIIDVRGNPGGYLDQAVAVADEL
LPAGKLIVYTKSRHGGDDQMKYLSTSGGIFEKGEVCLLVDRGSASAAEILAGALQDNRRALLIGELTFGKGLVQRQFKLP
DDSVVRLTVSRYFTPSGRQIQREYDDGLQGRERYYKEMFTRNLPGGFIKKYGDLMYREGQNISVYSTGSLLKNTAADSLR
AVLAKAGGIMPDYWVFGKPYSNLYQELYAKGVIEDIALKLIDDPSDPVQKYRSSATSYLDGYHVPVNLEALVRKECAEAK
VQFNQAEFDRDRADIALALKARVARHLFGTEEQIRVLVSEGDPVMKVARHFIEKSAS

Specific function: Involved in the signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro-sigma-K during sporulation. The signaling serine protease CtpB triggers pro-sigma-K processing by cleaving the regulatory protein

COG id: COG0793

COG function: function code M; Periplasmic protease

Gene ontology:

Cell location: Forespore intermembrane space. Note=Is expressed in both the mother cell and forespore compartments but that synthesis in the forespore is both necessary and sufficient for the proper timing of pro-sigma-K processing [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Escherichia coli, GI1788134, Length=321, Percent_Identity=29.2834890965732, Blast_Score=131, Evalue=9e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR005151
- InterPro:   IPR004447
- InterPro:   IPR002477 [H]

Pfam domain/function: PF00595 PDZ; PF03572 Peptidase_S41; PF01471 PG_binding_1 [H]

EC number: =3.4.21.102 [H]

Molecular weight: Translated: 59509; Mature: 59378

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIFTVIIMLLIGGFGYFIGWRMNSGTGGKMVDTYNLIRSYYVDPVNADSLQSAGVRGM
CHHHHHHHHHHHHCCHHHEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LQSLDPHSIYLEPEKAAITQSNFNGNFEGIGVEFDVVRDTLLVVTPLAGGPSESAGIMPG
HHCCCCCEEEECCCHHEEEECCCCCCEEEECEEHHHHHCEEEEEEECCCCCCCCCCCCCC
DRIIGIDSKNVIGIKPSAVLGKLRGERGTRVRLRIYRPLTRRTIDFLVTRGKISTSSIDA
CEEEECCCCCEEECCHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHEECCCCCCCCCCH
AFLDDARTGYIRISQFVETTGSEFHNAVQKLRDKGMRKLIIDVRGNPGGYLDQAVAVADE
HHHCCCCCCCEEHHHHHHHCCHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHH
LLPAGKLIVYTKSRHGGDDQMKYLSTSGGIFEKGEVCLLVDRGSASAAEILAGALQDNRR
HCCCCEEEEEECCCCCCCHHHHEEECCCCCEECCCEEEEEECCCCHHHHHHHHHHCCCCE
ALLIGELTFGKGLVQRQFKLPDDSVVRLTVSRYFTPSGRQIQREYDDGLQGRERYYKEMF
EEEEEEECCCCHHHHHHCCCCCCCEEEEEEEHEECCCCHHHHHHHHCCCCHHHHHHHHHH
TRNLPGGFIKKYGDLMYREGQNISVYSTGSLLKNTAADSLRAVLAKAGGIMPDYWVFGKP
HCCCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCC
YSNLYQELYAKGVIEDIALKLIDDPSDPVQKYRSSATSYLDGYHVPVNLEALVRKECAEA
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
KVQFNQAEFDRDRADIALALKARVARHLFGTEEQIRVLVSEGDPVMKVARHFIEKSAS
HHCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SRIFTVIIMLLIGGFGYFIGWRMNSGTGGKMVDTYNLIRSYYVDPVNADSLQSAGVRGM
HHHHHHHHHHHHCCHHHEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LQSLDPHSIYLEPEKAAITQSNFNGNFEGIGVEFDVVRDTLLVVTPLAGGPSESAGIMPG
HHCCCCCEEEECCCHHEEEECCCCCCEEEECEEHHHHHCEEEEEEECCCCCCCCCCCCCC
DRIIGIDSKNVIGIKPSAVLGKLRGERGTRVRLRIYRPLTRRTIDFLVTRGKISTSSIDA
CEEEECCCCCEEECCHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHEECCCCCCCCCCH
AFLDDARTGYIRISQFVETTGSEFHNAVQKLRDKGMRKLIIDVRGNPGGYLDQAVAVADE
HHHCCCCCCCEEHHHHHHHCCHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHH
LLPAGKLIVYTKSRHGGDDQMKYLSTSGGIFEKGEVCLLVDRGSASAAEILAGALQDNRR
HCCCCEEEEEECCCCCCCHHHHEEECCCCCEECCCEEEEEECCCCHHHHHHHHHHCCCCE
ALLIGELTFGKGLVQRQFKLPDDSVVRLTVSRYFTPSGRQIQREYDDGLQGRERYYKEMF
EEEEEEECCCCHHHHHHCCCCCCCEEEEEEEHEECCCCHHHHHHHHCCCCHHHHHHHHHH
TRNLPGGFIKKYGDLMYREGQNISVYSTGSLLKNTAADSLRAVLAKAGGIMPDYWVFGKP
HCCCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCC
YSNLYQELYAKGVIEDIALKLIDDPSDPVQKYRSSATSYLDGYHVPVNLEALVRKECAEA
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
KVQFNQAEFDRDRADIALALKARVARHLFGTEEQIRVLVSEGDPVMKVARHFIEKSAS
HHCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9570401; 9384377 [H]