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The map label for this gene is ffh [H]

Identifier: 21673993

GI number: 21673993

Start: 1097251

End: 1098600

Strand: Reverse

Name: ffh [H]

Synonym: CT1167

Alternate gene names: 21673993

Gene position: 1098600-1097251 (Counterclockwise)

Preceding gene: 21673995

Following gene: 21673992

Centisome position: 50.98

GC content: 54.67

Gene sequence:

>1350_bases
ATGTTCGACAATCTCAGTGACAAACTTGAGCTGACCTTAAAAAAACTCGCCGGTCAGGCGACGATCAACGAGGTCAACAT
CGGTATCGCGATGCGCGACATCAAGCGTGCCCTCTTGAGCGCCGATGTCAACTACAAGGTTGCCAAAAAGCTGGTCGAGG
ATATTCGCGAGAAGTCCCTCGGCGAATCGGTCATCAAGAGCGTCTCTCCGGCGCAGATGATCGTCAAGATCGTCAACGAT
GAGCTAACCGAAATCATGGGCGGCCAGAACCAGCCGCTGAATCTCCCTCCCAAGAAAATTCCTGCCATCGTGATGGTTGC
CGGTCTCCAGGGTTCCGGCAAAACCACCTTCTGCGCCAAGCTGGCCAAGCGCCTCAAAAAGAACGGCAAGAATCCGATCC
TTGTCGCCGCCGACGTTTACCGTCCGGCAGCGGTCGAGCAGCTCAAGACGCTCGGCGAGCAGATTGATGTGCCTGTATTT
TCCATCGAAGAGCAAGACGCCATGAAGGCTGCGCTTGGTGGTCTTGAAGCTGCCAAAGCCGGGGCGAAAGATGTTGTGAT
CGTTGACACCGCCGGGCGTTTGCAGATCGACGAAGCGATGATGGCCGAGGCTGAAGCGCTCAAAAACCGCCTCAGTCCTG
ACGAGCTTTTATTCGTCGTCGATTCAATGATGGGCCAGGAGGCGGTGAACACCGCCAAGGCGTTCAACGATCGACTTGAT
TTCGATGGCGTTGTGCTCACCAAGCTTGATGGCGATGCACGTGGTGGTGCCGCTCTGTCGATCCGCCAGGTGGTCGAAAA
GCCGATCAAGTTCATGAGCGTCGGCGAGAAGGTCGATGATCTCGACGTGTTCTACCCGGATCGCATGGCCCAGAGGATTC
TCGGCATGGGCGATATCGTCAGCTTTGTCGAAAAGGCCCAGGAGGCGCTCGATCTTGAAAAGACGATGGCGATGCAGTCG
AAGCTCATGAAGAACGAGTTCGACCTTGACGACTTTTTCGATCAGCTCCAGCAGCTCAAAAAAATGGGTTCGATCCAGGG
TCTCATCGAAATGGTACCCGGTCTGAACAAGATGGTGCCGAAGCAGGATCTCGAAAACATCAACTTCAAGCCCATTGAGG
CGATAATCTCCTCGATGACCAAACAGGAGCGCAAGCACCCTGAAATAATCAACGGCAGCCGCCGCAAGCGTATCGCGCTT
GGCAGCGGCACGAGGGTGCAAGAGGTCAATATGCTGCTCAAGCAGTTTGCCGAAATGAAGAAAATGATGCGCTCGGTGAA
TCGCCTGGCCAAGTCAGGCCGCAAGATCACCACGGAGAACCTTGCACTCGACAAGTTTCTGAAACGATAA

Upstream 100 bases:

>100_bases
GAAAATAGTTTGGTGACGGTCGCATCGTTTGGTTTTATTTTACAAGAATATTTTTATATTTAAAGCTATCCATTTTTAGA
ATTTCTGTGACAGGTTCAAT

Downstream 100 bases:

>100_bases
ATGAACAATCTCTCCCATAAATTAAACTTATTACGCATTGGTTAAGATCAGATTGAAAAGAGCCGGAAGGAAAAAGATGC
CGTTCTACCAGATCGTTGCT

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MFDNLSDKLELTLKKLAGQATINEVNIGIAMRDIKRALLSADVNYKVAKKLVEDIREKSLGESVIKSVSPAQMIVKIVND
ELTEIMGGQNQPLNLPPKKIPAIVMVAGLQGSGKTTFCAKLAKRLKKNGKNPILVAADVYRPAAVEQLKTLGEQIDVPVF
SIEEQDAMKAALGGLEAAKAGAKDVVIVDTAGRLQIDEAMMAEAEALKNRLSPDELLFVVDSMMGQEAVNTAKAFNDRLD
FDGVVLTKLDGDARGGAALSIRQVVEKPIKFMSVGEKVDDLDVFYPDRMAQRILGMGDIVSFVEKAQEALDLEKTMAMQS
KLMKNEFDLDDFFDQLQQLKKMGSIQGLIEMVPGLNKMVPKQDLENINFKPIEAIISSMTKQERKHPEIINGSRRKRIAL
GSGTRVQEVNMLLKQFAEMKKMMRSVNRLAKSGRKITTENLALDKFLKR

Sequences:

>Translated_449_residues
MFDNLSDKLELTLKKLAGQATINEVNIGIAMRDIKRALLSADVNYKVAKKLVEDIREKSLGESVIKSVSPAQMIVKIVND
ELTEIMGGQNQPLNLPPKKIPAIVMVAGLQGSGKTTFCAKLAKRLKKNGKNPILVAADVYRPAAVEQLKTLGEQIDVPVF
SIEEQDAMKAALGGLEAAKAGAKDVVIVDTAGRLQIDEAMMAEAEALKNRLSPDELLFVVDSMMGQEAVNTAKAFNDRLD
FDGVVLTKLDGDARGGAALSIRQVVEKPIKFMSVGEKVDDLDVFYPDRMAQRILGMGDIVSFVEKAQEALDLEKTMAMQS
KLMKNEFDLDDFFDQLQQLKKMGSIQGLIEMVPGLNKMVPKQDLENINFKPIEAIISSMTKQERKHPEIINGSRRKRIAL
GSGTRVQEVNMLLKQFAEMKKMMRSVNRLAKSGRKITTENLALDKFLKR
>Mature_449_residues
MFDNLSDKLELTLKKLAGQATINEVNIGIAMRDIKRALLSADVNYKVAKKLVEDIREKSLGESVIKSVSPAQMIVKIVND
ELTEIMGGQNQPLNLPPKKIPAIVMVAGLQGSGKTTFCAKLAKRLKKNGKNPILVAADVYRPAAVEQLKTLGEQIDVPVF
SIEEQDAMKAALGGLEAAKAGAKDVVIVDTAGRLQIDEAMMAEAEALKNRLSPDELLFVVDSMMGQEAVNTAKAFNDRLD
FDGVVLTKLDGDARGGAALSIRQVVEKPIKFMSVGEKVDDLDVFYPDRMAQRILGMGDIVSFVEKAQEALDLEKTMAMQS
KLMKNEFDLDDFFDQLQQLKKMGSIQGLIEMVPGLNKMVPKQDLENINFKPIEAIISSMTKQERKHPEIINGSRRKRIAL
GSGTRVQEVNMLLKQFAEMKKMMRSVNRLAKSGRKITTENLALDKFLKR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=447, Percent_Identity=33.3333333333333, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI226371618, Length=355, Percent_Identity=35.2112676056338, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI89061728, Length=164, Percent_Identity=36.5853658536585, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI23308697, Length=307, Percent_Identity=29.9674267100977, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI295424842, Length=307, Percent_Identity=29.9674267100977, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1788963, Length=427, Percent_Identity=48.9461358313817, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1789874, Length=265, Percent_Identity=33.5849056603774, Blast_Score=149, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=435, Percent_Identity=30.5747126436782, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI193206261, Length=294, Percent_Identity=29.2517006802721, Blast_Score=98, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6325345, Length=416, Percent_Identity=35.5769230769231, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6320498, Length=310, Percent_Identity=23.8709677419355, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17647949, Length=355, Percent_Identity=34.9295774647887, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24641198, Length=312, Percent_Identity=28.2051282051282, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49604; Mature: 49604

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDNLSDKLELTLKKLAGQATINEVNIGIAMRDIKRALLSADVNYKVAKKLVEDIREKSL
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GESVIKSVSPAQMIVKIVNDELTEIMGGQNQPLNLPPKKIPAIVMVAGLQGSGKTTFCAK
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCEEEEEECCCCCCCHHHHHH
LAKRLKKNGKNPILVAADVYRPAAVEQLKTLGEQIDVPVFSIEEQDAMKAALGGLEAAKA
HHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHCCHHHHHC
GAKDVVIVDTAGRLQIDEAMMAEAEALKNRLSPDELLFVVDSMMGQEAVNTAKAFNDRLD
CCCCEEEEECCCCEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FDGVVLTKLDGDARGGAALSIRQVVEKPIKFMSVGEKVDDLDVFYPDRMAQRILGMGDIV
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHH
SFVEKAQEALDLEKTMAMQSKLMKNEFDLDDFFDQLQQLKKMGSIQGLIEMVPGLNKMVP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCC
KQDLENINFKPIEAIISSMTKQERKHPEIINGSRRKRIALGSGTRVQEVNMLLKQFAEMK
HHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHH
KMMRSVNRLAKSGRKITTENLALDKFLKR
HHHHHHHHHHHCCCEECHHHHHHHHHHCC
>Mature Secondary Structure
MFDNLSDKLELTLKKLAGQATINEVNIGIAMRDIKRALLSADVNYKVAKKLVEDIREKSL
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GESVIKSVSPAQMIVKIVNDELTEIMGGQNQPLNLPPKKIPAIVMVAGLQGSGKTTFCAK
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCEEEEEECCCCCCCHHHHHH
LAKRLKKNGKNPILVAADVYRPAAVEQLKTLGEQIDVPVFSIEEQDAMKAALGGLEAAKA
HHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHCCHHHHHC
GAKDVVIVDTAGRLQIDEAMMAEAEALKNRLSPDELLFVVDSMMGQEAVNTAKAFNDRLD
CCCCEEEEECCCCEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FDGVVLTKLDGDARGGAALSIRQVVEKPIKFMSVGEKVDDLDVFYPDRMAQRILGMGDIV
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHH
SFVEKAQEALDLEKTMAMQSKLMKNEFDLDDFFDQLQQLKKMGSIQGLIEMVPGLNKMVP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCC
KQDLENINFKPIEAIISSMTKQERKHPEIINGSRRKRIALGSGTRVQEVNMLLKQFAEMK
HHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHH
KMMRSVNRLAKSGRKITTENLALDKFLKR
HHHHHHHHHHHCCCEECHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]