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The map label for this gene is neuA [H]

Identifier: 21673979

GI number: 21673979

Start: 1082995

End: 1083699

Strand: Reverse

Name: neuA [H]

Synonym: CT1153

Alternate gene names: 21673979

Gene position: 1083699-1082995 (Counterclockwise)

Preceding gene: 21673980

Following gene: 21673978

Centisome position: 50.29

GC content: 59.57

Gene sequence:

>705_bases
ATGCGGACGGCAGCCATCATTCCGGCGCGCGGCGGCTCGAAGGGCCTGAAAAACAAGAATATCCACCCCATAGCTGGTCT
TCCGCTGCTGGCATGGAGCGTCTTGCAGGCTTTGGATGCCGAACACGTCGATCAGGTTTTCGTGACTACTGACGACGCGG
CCATCGCTCAGGTGGCACGGCAGTTCGGTGCGGAGGTGATCGATCGCCCGGAGCGCATCAGCGGCGACAAGGCGACCTCG
GAGTCGGCGCTCTTGCACGCGCTCGAAGTGATTGCCGAGCGGTACGGCGCGGAGCCGGAGACGGTCGTGTTCCTGCAAGC
AACCTCGCCCTTACGCAAGCCGGGGGACATCGATCGCGCCATCGAACTGTTTCGGCTCGAAGGGGCCGATTCGCTCATTT
CGGTGACGCGGGCCGACGACCTGACCATATGGGAACAGCGCGGAGGCGACTGGAATAGTGTGAACTTCGACTATCGGAAT
CGCGGAATGCGGCAGGATCGACCGTCGCAGTTCATCGAAAACGGCTCGATCTACCTCTTTACGCCCTCGGTGCTGCGCGA
GTTCGGTAATCGTATTGGCCAGAAGCTTTCGGTGTATCTGATGGAGTTCTGGCAGACCTGGGAGATCGATACCATTGAGG
AGGTCGATCTCGTCGAATTTTACCTGAAGCAGAAAGGCATCGATCGTTCGTTCCTCCGATCCTGA

Upstream 100 bases:

>100_bases
GAATCGCTCGGCAGCTCGAAAAATCGCCGAAGTCTGCCGGGAGGTGATCGAAAAATGATGCGGAACAGACAATAACCAAG
AAACGTACGGAAATCACTGA

Downstream 100 bases:

>100_bases
AATCCGACAAACCCAACAAAATCAAGACAATATGAACTTTTTTCTTTCCACCGACCTGTGTATCGGGGTCAACGAGGCCC
TCTCTGTGCATGAGCATCTT

Product: acylneuraminate cytidylyltransferase

Products: diphosphate; CMP-N-acylneuraminate

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MRTAAIIPARGGSKGLKNKNIHPIAGLPLLAWSVLQALDAEHVDQVFVTTDDAAIAQVARQFGAEVIDRPERISGDKATS
ESALLHALEVIAERYGAEPETVVFLQATSPLRKPGDIDRAIELFRLEGADSLISVTRADDLTIWEQRGGDWNSVNFDYRN
RGMRQDRPSQFIENGSIYLFTPSVLREFGNRIGQKLSVYLMEFWQTWEIDTIEEVDLVEFYLKQKGIDRSFLRS

Sequences:

>Translated_234_residues
MRTAAIIPARGGSKGLKNKNIHPIAGLPLLAWSVLQALDAEHVDQVFVTTDDAAIAQVARQFGAEVIDRPERISGDKATS
ESALLHALEVIAERYGAEPETVVFLQATSPLRKPGDIDRAIELFRLEGADSLISVTRADDLTIWEQRGGDWNSVNFDYRN
RGMRQDRPSQFIENGSIYLFTPSVLREFGNRIGQKLSVYLMEFWQTWEIDTIEEVDLVEFYLKQKGIDRSFLRS
>Mature_234_residues
MRTAAIIPARGGSKGLKNKNIHPIAGLPLLAWSVLQALDAEHVDQVFVTTDDAAIAQVARQFGAEVIDRPERISGDKATS
ESALLHALEVIAERYGAEPETVVFLQATSPLRKPGDIDRAIELFRLEGADSLISVTRADDLTIWEQRGGDWNSVNFDYRN
RGMRQDRPSQFIENGSIYLFTPSVLREFGNRIGQKLSVYLMEFWQTWEIDTIEEVDLVEFYLKQKGIDRSFLRS

Specific function: Required for biosynthesis of LAH modification in the post-translational modification of Campylobacter coli flagellin [H]

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=211, Percent_Identity=38.3886255924171, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: 2.7.7.43

Molecular weight: Translated: 26382; Mature: 26382

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTAAIIPARGGSKGLKNKNIHPIAGLPLLAWSVLQALDAEHVDQVFVTTDDAAIAQVAR
CCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHCEEEEECCHHHHHHHHH
QFGAEVIDRPERISGDKATSESALLHALEVIAERYGAEPETVVFLQATSPLRKPGDIDRA
HHCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHH
IELFRLEGADSLISVTRADDLTIWEQRGGDWNSVNFDYRNRGMRQDRPSQFIENGSIYLF
HHHHHCCCCCHHEEECCCCCCEEECCCCCCCCCCCCHHHHCCCCCCCHHHHHHCCCEEEE
TPSVLREFGNRIGQKLSVYLMEFWQTWEIDTIEEVDLVEFYLKQKGIDRSFLRS
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure
MRTAAIIPARGGSKGLKNKNIHPIAGLPLLAWSVLQALDAEHVDQVFVTTDDAAIAQVAR
CCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHCEEEEECCHHHHHHHHH
QFGAEVIDRPERISGDKATSESALLHALEVIAERYGAEPETVVFLQATSPLRKPGDIDRA
HHCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHH
IELFRLEGADSLISVTRADDLTIWEQRGGDWNSVNFDYRNRGMRQDRPSQFIENGSIYLF
HHHHHCCCCCHHEEECCCCCCEEECCCCCCCCCCCCHHHHCCCCCCCHHHHHHCCCEEEE
TPSVLREFGNRIGQKLSVYLMEFWQTWEIDTIEEVDLVEFYLKQKGIDRSFLRS
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: CTP; N-acylneuraminate

Specific reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8825781 [H]