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The map label for this gene is pepD [H]

Identifier: 21673884

GI number: 21673884

Start: 994670

End: 996130

Strand: Direct

Name: pepD [H]

Synonym: CT1058

Alternate gene names: 21673884

Gene position: 994670-996130 (Clockwise)

Preceding gene: 21673883

Following gene: 21673885

Centisome position: 46.16

GC content: 62.15

Gene sequence:

>1461_bases
ATGAGCAACATTTTTCTCTCGCTTGAGCCGAAAATACTTTGGAGCCACTTTTACCGCCTGACACAAATTCCGCGGCCTTC
GGGGCATGAGGAGGCAGTTCGGACCTATGTCGCTGACGTGGCGAAACGTTGCGGGTTGGAATGGCTCGTCGATGAGGCAG
GTAACATCATTGTGCGCAAACCGGCGTCGGCGGGGATGGAGCGTCGGCGGGGCGTTATCCTGCAGGCGCATCTCGACATG
GTGCCGCAGAAGAACGCAGGGACAGCGCACGACTTCACGAAGGATCCGATCGACGCCGTGATCGATGGTGAATGGGTGCA
TGCGCGCGGCACCACGCTGGGGGCGGACAATGGCATCGGTGTGGCGGCGGCGCTGGCTGTGCTTGAATCGGACGACTTGC
GCCACGGACCGCTCGAAGCGCTTTTCACGGTGAACGAGGAGGCTGGCATGACCGGAGCGCTGGGGCTGAAACCGGGAGTG
CTCAGGGGCGACATTCTGCTGAACCTCGACTCCGAGGATGAAGGCGAACTCTTCATTGGCTGCGCGGGCGGACTCGACGG
TACGATGCGCTTCGACTATTCCTGCGAGCCGCTGCCTCCCGGTTACTCCGGCATCGAAATCCGGGTCTCCGGTTTGCGCG
GCGGGCATAGCGGCATGGACATCGATCTTGGCCGGGGCAACGCCAACAAGATCATGAACAGGCTGTTGCAGATGGGTCGG
GAGCACCACGGGCTGCTGCTTGCATCCATCGACGGCGGAAGCCTGCGCAACGCCATTCCGCGCGAATCGGTGGCACTGGT
TGCCGTACCGTCCGCGCAAAAAGTAGCGTTTCTCGACGAGCTTCATTCGCTCGCCTCGGCCATCGGTCTCGAGCTGAACG
GGGTTGATCCGGAGCTGCGGGTCGAGGCTGCGGATGCCGCGCTTCCTGTAGGAATGATCGACGATACCGTGGCGCAACGC
CTCTTCGATGCGGTGGCAGCCTGCCCGAACGGCGTGCATCGCATGAGCGAAGCGATGGCGGGTCTGGTCGAAACCTCGAA
CAATCTTGCCCGCGTCCATTCGGACGGACGCGCAGTGAGCGTCGAGTGCCTGCTCCGGAGCGCCTCGGTGGAGGGGATGC
GCGAACTTGCCGACGCGGTCGCGGGCATCGCCGAACGTGCCGGAACGGTAGCCGCGTTCGAGAACGGCTATCCCGGATGG
AAGCCAAATCCCGCTTCGCCGATCCTGAAATGCATGGTCAAAGTCTATCGCGACCGCTTCGGCAAAACGCCGGAGATCCG
CGCGGTGCATGCCGGTCTGGAGTGTGGCATCATCGGCGCAAACAATCCGCAGCTTGACATGATTTCGTTCGGCCCGACCA
TCCGCCATCCGCATTCGCCGGACGAAAAGGTTGAGTGCTCGTCGGTACTGAAATTCTGGGAATTGCTTGTGGCAACGCTG
GAGGAGGTGCCAGAGCCGTGA

Upstream 100 bases:

>100_bases
TGACAAAACAAAAAAACGTCAATACCGAATGCCGGAAAAACGGCGCCTGGTCATCACTGATGAGTTGATATGCAGAAGAA
ACTGAATCGAGCACGCCATT

Downstream 100 bases:

>100_bases
AGACGCCCTACAGCTACAACACCATTTCGGATTTTCTCTTGTCGCAACCGCTGACGGTTGATGTGGAGGTTGACGACGAG
ACTGCCGGGTGTTTTCCGCT

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MSNIFLSLEPKILWSHFYRLTQIPRPSGHEEAVRTYVADVAKRCGLEWLVDEAGNIIVRKPASAGMERRRGVILQAHLDM
VPQKNAGTAHDFTKDPIDAVIDGEWVHARGTTLGADNGIGVAAALAVLESDDLRHGPLEALFTVNEEAGMTGALGLKPGV
LRGDILLNLDSEDEGELFIGCAGGLDGTMRFDYSCEPLPPGYSGIEIRVSGLRGGHSGMDIDLGRGNANKIMNRLLQMGR
EHHGLLLASIDGGSLRNAIPRESVALVAVPSAQKVAFLDELHSLASAIGLELNGVDPELRVEAADAALPVGMIDDTVAQR
LFDAVAACPNGVHRMSEAMAGLVETSNNLARVHSDGRAVSVECLLRSASVEGMRELADAVAGIAERAGTVAAFENGYPGW
KPNPASPILKCMVKVYRDRFGKTPEIRAVHAGLECGIIGANNPQLDMISFGPTIRHPHSPDEKVECSSVLKFWELLVATL
EEVPEP

Sequences:

>Translated_486_residues
MSNIFLSLEPKILWSHFYRLTQIPRPSGHEEAVRTYVADVAKRCGLEWLVDEAGNIIVRKPASAGMERRRGVILQAHLDM
VPQKNAGTAHDFTKDPIDAVIDGEWVHARGTTLGADNGIGVAAALAVLESDDLRHGPLEALFTVNEEAGMTGALGLKPGV
LRGDILLNLDSEDEGELFIGCAGGLDGTMRFDYSCEPLPPGYSGIEIRVSGLRGGHSGMDIDLGRGNANKIMNRLLQMGR
EHHGLLLASIDGGSLRNAIPRESVALVAVPSAQKVAFLDELHSLASAIGLELNGVDPELRVEAADAALPVGMIDDTVAQR
LFDAVAACPNGVHRMSEAMAGLVETSNNLARVHSDGRAVSVECLLRSASVEGMRELADAVAGIAERAGTVAAFENGYPGW
KPNPASPILKCMVKVYRDRFGKTPEIRAVHAGLECGIIGANNPQLDMISFGPTIRHPHSPDEKVECSSVLKFWELLVATL
EEVPEP
>Mature_485_residues
SNIFLSLEPKILWSHFYRLTQIPRPSGHEEAVRTYVADVAKRCGLEWLVDEAGNIIVRKPASAGMERRRGVILQAHLDMV
PQKNAGTAHDFTKDPIDAVIDGEWVHARGTTLGADNGIGVAAALAVLESDDLRHGPLEALFTVNEEAGMTGALGLKPGVL
RGDILLNLDSEDEGELFIGCAGGLDGTMRFDYSCEPLPPGYSGIEIRVSGLRGGHSGMDIDLGRGNANKIMNRLLQMGRE
HHGLLLASIDGGSLRNAIPRESVALVAVPSAQKVAFLDELHSLASAIGLELNGVDPELRVEAADAALPVGMIDDTVAQRL
FDAVAACPNGVHRMSEAMAGLVETSNNLARVHSDGRAVSVECLLRSASVEGMRELADAVAGIAERAGTVAAFENGYPGWK
PNPASPILKCMVKVYRDRFGKTPEIRAVHAGLECGIIGANNPQLDMISFGPTIRHPHSPDEKVECSSVLKFWELLVATLE
EVPEP

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=489, Percent_Identity=45.398773006135, Blast_Score=422, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 51977; Mature: 51846

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNIFLSLEPKILWSHFYRLTQIPRPSGHEEAVRTYVADVAKRCGLEWLVDEAGNIIVRK
CCCEEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEC
PASAGMERRRGVILQAHLDMVPQKNAGTAHDFTKDPIDAVIDGEWVHARGTTLGADNGIG
CHHHCHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHCCCCEEEECCCCCCCCCCCH
VAAALAVLESDDLRHGPLEALFTVNEEAGMTGALGLKPGVLRGDILLNLDSEDEGELFIG
HHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEECEEEEEECCCCCCCEEEE
CAGGLDGTMRFDYSCEPLPPGYSGIEIRVSGLRGGHSGMDIDLGRGNANKIMNRLLQMGR
EECCCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHCC
EHHGLLLASIDGGSLRNAIPRESVALVAVPSAQKVAFLDELHSLASAIGLELNGVDPELR
CCCCEEEEEECCCHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCEECCCCCCEE
VEAADAALPVGMIDDTVAQRLFDAVAACPNGVHRMSEAMAGLVETSNNLARVHSDGRAVS
EEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEE
VECLLRSASVEGMRELADAVAGIAERAGTVAAFENGYPGWKPNPASPILKCMVKVYRDRF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHC
GKTPEIRAVHAGLECGIIGANNPQLDMISFGPTIRHPHSPDEKVECSSVLKFWELLVATL
CCCCCEEEEECCCEEEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EEVPEP
HHCCCC
>Mature Secondary Structure 
SNIFLSLEPKILWSHFYRLTQIPRPSGHEEAVRTYVADVAKRCGLEWLVDEAGNIIVRK
CCEEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEC
PASAGMERRRGVILQAHLDMVPQKNAGTAHDFTKDPIDAVIDGEWVHARGTTLGADNGIG
CHHHCHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHCCCCEEEECCCCCCCCCCCH
VAAALAVLESDDLRHGPLEALFTVNEEAGMTGALGLKPGVLRGDILLNLDSEDEGELFIG
HHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEECEEEEEECCCCCCCEEEE
CAGGLDGTMRFDYSCEPLPPGYSGIEIRVSGLRGGHSGMDIDLGRGNANKIMNRLLQMGR
EECCCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHCC
EHHGLLLASIDGGSLRNAIPRESVALVAVPSAQKVAFLDELHSLASAIGLELNGVDPELR
CCCCEEEEEECCCHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCEECCCCCCEE
VEAADAALPVGMIDDTVAQRLFDAVAACPNGVHRMSEAMAGLVETSNNLARVHSDGRAVS
EEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEE
VECLLRSASVEGMRELADAVAGIAERAGTVAAFENGYPGWKPNPASPILKCMVKVYRDRF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHC
GKTPEIRAVHAGLECGIIGANNPQLDMISFGPTIRHPHSPDEKVECSSVLKFWELLVATL
CCCCCEEEEECCCEEEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EEVPEP
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]