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The map label for this gene is dmpD [H]

Identifier: 21673775

GI number: 21673775

Start: 894972

End: 895859

Strand: Direct

Name: dmpD [H]

Synonym: CT0947

Alternate gene names: 21673775

Gene position: 894972-895859 (Clockwise)

Preceding gene: 21673774

Following gene: 21673776

Centisome position: 41.53

GC content: 62.05

Gene sequence:

>888_bases
ATGGACTCTTTTCTCGACATACAGCGGAAGAAAGCCGATGCTGACAGTAAGTTCATCGACTGCAACGGCTTCCGGGTGCA
CTACAAGCGCTACGGCAGCGGCAAGCCGCCTTTCATCGTGCTGCTGCACGGCAGCTTTCTGAGCATCCGCTCGTGGCGCG
ATGTGGCGGTTCCGCTCGCCGAGAACGCGACCGTGCTGGCGTTCGACCGCCCGGCCTTCGGGCTGACTTCGCGCCCCGTG
CCGTCGCGATCCAACGCGGCGCGGTACAGCCCCGAGGCGCAGAGTGACCTCGTCGTGGCGCTGATGGACAAGCTCGGCAT
GGATCGCGCCGTCATTGTTGGCAACTCGACCGGCGGCACGCTGGCGCTGCTGACAGCGTTGCGCCACCCGAGGCGCGTGC
AGGGCCTCGTGCTCGTGGGTGCGATGATCTACAGCGGCTACGCCAACAGTGAGGTGCCCGCCGTGATGAAGCCCTTCATG
AAGGCGATGTCGCCGGTATTTTCGCGGCTGATGAAGGTGATTATTACCAAACTTTACGACAAGAACATTCGGGGATTCTG
GCACGTCAAGTCGCGCCTTTCGGACGAGACGCTTGCCGCTTTCAGAAATGATTTTATGGTCGGCGACTGGTCGCGCGGCT
TCTGGGAGCTGTTTCTCGAAACGCACCGCCTCTATTTTAACCGGCGCGTCTCTTCGGCCTGGGCGCCGTCGCTCGTCGTG
ACCGGCGAGCACGACCTGACGGTTAAGACCGAAGAGAGTTTCCGGCTGGCGCGTGAGCTGCCGAGGGCGGAGCTGCTCGT
GATTCCCGATTGCGCTCATCTGCCGCAGGAGGAGCAGCCCGCCGCGTTCGTTGCCGGGGTTAAGAAATTTGTCGAAAAGC
TCGTCTGA

Upstream 100 bases:

>100_bases
GCGGCGATGGCTATGCAGGTGATCGAGGCGTCGGTGAAAATCTACAACGAAATGGCTACCTTCAGTTCGGCGGGAGTTTC
CGGCAAAAACGACTGATAAC

Downstream 100 bases:

>100_bases
GATGCTGAGCGGACTCGTGACAGCGCTCCGGACGCTGACAGCGCTGCCGGTGCCGGGGCGTGACGCCGAGCGGTTCAGCT
CGTCGCTCTACTGGTTTCCG

Product: alpha/beta fold family hydrolase

Products: 2-oxopent-4-enoate; succinate [C]

Alternate protein names: HMSH [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MDSFLDIQRKKADADSKFIDCNGFRVHYKRYGSGKPPFIVLLHGSFLSIRSWRDVAVPLAENATVLAFDRPAFGLTSRPV
PSRSNAARYSPEAQSDLVVALMDKLGMDRAVIVGNSTGGTLALLTALRHPRRVQGLVLVGAMIYSGYANSEVPAVMKPFM
KAMSPVFSRLMKVIITKLYDKNIRGFWHVKSRLSDETLAAFRNDFMVGDWSRGFWELFLETHRLYFNRRVSSAWAPSLVV
TGEHDLTVKTEESFRLARELPRAELLVIPDCAHLPQEEQPAAFVAGVKKFVEKLV

Sequences:

>Translated_295_residues
MDSFLDIQRKKADADSKFIDCNGFRVHYKRYGSGKPPFIVLLHGSFLSIRSWRDVAVPLAENATVLAFDRPAFGLTSRPV
PSRSNAARYSPEAQSDLVVALMDKLGMDRAVIVGNSTGGTLALLTALRHPRRVQGLVLVGAMIYSGYANSEVPAVMKPFM
KAMSPVFSRLMKVIITKLYDKNIRGFWHVKSRLSDETLAAFRNDFMVGDWSRGFWELFLETHRLYFNRRVSSAWAPSLVV
TGEHDLTVKTEESFRLARELPRAELLVIPDCAHLPQEEQPAAFVAGVKKFVEKLV
>Mature_295_residues
MDSFLDIQRKKADADSKFIDCNGFRVHYKRYGSGKPPFIVLLHGSFLSIRSWRDVAVPLAENATVLAFDRPAFGLTSRPV
PSRSNAARYSPEAQSDLVVALMDKLGMDRAVIVGNSTGGTLALLTALRHPRRVQGLVLVGAMIYSGYANSEVPAVMKPFM
KAMSPVFSRLMKVIITKLYDKNIRGFWHVKSRLSDETLAAFRNDFMVGDWSRGFWELFLETHRLYFNRRVSSAWAPSLVV
TGEHDLTVKTEESFRLARELPRAELLVIPDCAHLPQEEQPAAFVAGVKKFVEKLV

Specific function: Conversion of 2-hydroxymuconic acid semialdehyde to 2- hydroxypent-2,4-dienoate [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dmpD/todF/xylF esterase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: 3.7.1.- [C]

Molecular weight: Translated: 33134; Mature: 33134

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSFLDIQRKKADADSKFIDCNGFRVHYKRYGSGKPPFIVLLHGSFLSIRSWRDVAVPLA
CCCHHHHHHHHCCCCCCEEECCCEEEEEEECCCCCCCEEEEECCCEEEECCCCCEEEEEC
ENATVLAFDRPAFGLTSRPVPSRSNAARYSPEAQSDLVVALMDKLGMDRAVIVGNSTGGT
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCH
LALLTALRHPRRVQGLVLVGAMIYSGYANSEVPAVMKPFMKAMSPVFSRLMKVIITKLYD
HHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
KNIRGFWHVKSRLSDETLAAFRNDFMVGDWSRGFWELFLETHRLYFNRRVSSAWAPSLVV
CCCCEEEHHHHHCCHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
TGEHDLTVKTEESFRLARELPRAELLVIPDCAHLPQEEQPAAFVAGVKKFVEKLV
ECCCCEEEECHHHHHHHHHCCCCEEEECCCHHCCCCCCCCHHHHHHHHHHHHHHC
>Mature Secondary Structure
MDSFLDIQRKKADADSKFIDCNGFRVHYKRYGSGKPPFIVLLHGSFLSIRSWRDVAVPLA
CCCHHHHHHHHCCCCCCEEECCCEEEEEEECCCCCCCEEEEECCCEEEECCCCCEEEEEC
ENATVLAFDRPAFGLTSRPVPSRSNAARYSPEAQSDLVVALMDKLGMDRAVIVGNSTGGT
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCH
LALLTALRHPRRVQGLVLVGAMIYSGYANSEVPAVMKPFMKAMSPVFSRLMKVIITKLYD
HHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
KNIRGFWHVKSRLSDETLAAFRNDFMVGDWSRGFWELFLETHRLYFNRRVSSAWAPSLVV
CCCCEEEHHHHHCCHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
TGEHDLTVKTEESFRLARELPRAELLVIPDCAHLPQEEQPAAFVAGVKKFVEKLV
ECCCCEEEECHHHHHHHHHCCCCEEEECCCHHCCCCCCCCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-hydroxy-6-ketononadienedicarboxylate; H2O [C]

Specific reaction: 2-hydroxy-6-ketononadienedicarboxylate + H2O = 2-oxopent-4-enoate + succinate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2194577 [H]