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The map label for this gene is mtd [H]

Identifier: 21673549

GI number: 21673549

Start: 701432

End: 702322

Strand: Direct

Name: mtd [H]

Synonym: CT0719

Alternate gene names: 21673549

Gene position: 701432-702322 (Clockwise)

Preceding gene: 21673547

Following gene: 21673550

Centisome position: 32.55

GC content: 56.79

Gene sequence:

>891_bases
ATGAAAGTGCTTGAACCGAACCCTGTTGCCGCCTCGTTTCGTGACGCCGTCCGCCGGCAGATTAGCGAGGAGCAGCTTAC
GATCAACATTGTTGGTATTCTCGCCTCAGACGACCCCGCCTCGATCACTTATGCCGACTATACCCGCGCCGGATGCGAAG
ATGTTGGCATTCATTTTGATCTCAGGAAGTGCGAGCCGGAGTCGGTGAGAGCCACCCTCGAAGCGGCTAATCGCGACAGC
GCTGTTCACGGCATTTTCGTCTATTACCCGATCTGGGGCGACAAGCGCGACGCGGAGTTGCGCGACCTGATTTCGCCACA
CAAGGATGTTGAGGGGTTGTCGCCGCACTGGATCAAAAAGCTCTACGCCAACGAGCGTTTCGACGACACGGAACGGAGAT
TCAAGTCGATTTTGCCCTGTACGCCGCTGGCCATTATCAAGCTGCTCGAAGTCACTGAAGCTTACGCACCCTTCGGCTTG
CCGTTTGGCGGCCAGCAGATCACCATTTTCAACCGCTCGGAGGTCGTCGGCAGACCGCTTGCTTACATGCTCTCGAACGA
CGGCGCACGTGTTTACTCTTTCGATATTAACGGCGGTTTTGTCGTCGACGTCAACAGCTCTGACCACGAATCGCGCCCCG
TCACGCGTGAGGAGGCGCTCAGCCAGTCGGATATCGTTATCACTGGCGTGCCGTCGCCGCACTTTGAAAAGGTGAGGGCT
GAGGAGCTGAAGCCGGGCGCGATCTGTCTCAACTTCTCCTATATCCAGAACTTCGAGCCGGAGGCCAAAGAGGCTGCGTC
GCTTTACATTCCGAGGGTCGGCCCCATGACGGTGGCCATGTGTATGAGAAACGCCCTGCAACTCTATCACAACTACCACC
ATGAAGTCTGA

Upstream 100 bases:

>100_bases
TCCGGCAGGAGCATAGCCCGCCATCTCCTTGAATATTCCATTCCCGGCACTTGCGCCCGTCAGGAACCTCGATGAACCGA
ACCGACCCCACCACTGAATC

Downstream 100 bases:

>100_bases
CGGAACGCTCGGGTGGAGCGCAATCTCCACCTATCTCGACAGTCTTGCCAGCGCTGACCCCACTCCCGGCGGCGGCGCGG
CGGCGGCAGTCACGGCGGCA

Product: methylenetetrahydrofolate dehydrogenase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MKVLEPNPVAASFRDAVRRQISEEQLTINIVGILASDDPASITYADYTRAGCEDVGIHFDLRKCEPESVRATLEAANRDS
AVHGIFVYYPIWGDKRDAELRDLISPHKDVEGLSPHWIKKLYANERFDDTERRFKSILPCTPLAIIKLLEVTEAYAPFGL
PFGGQQITIFNRSEVVGRPLAYMLSNDGARVYSFDINGGFVVDVNSSDHESRPVTREEALSQSDIVITGVPSPHFEKVRA
EELKPGAICLNFSYIQNFEPEAKEAASLYIPRVGPMTVAMCMRNALQLYHNYHHEV

Sequences:

>Translated_296_residues
MKVLEPNPVAASFRDAVRRQISEEQLTINIVGILASDDPASITYADYTRAGCEDVGIHFDLRKCEPESVRATLEAANRDS
AVHGIFVYYPIWGDKRDAELRDLISPHKDVEGLSPHWIKKLYANERFDDTERRFKSILPCTPLAIIKLLEVTEAYAPFGL
PFGGQQITIFNRSEVVGRPLAYMLSNDGARVYSFDINGGFVVDVNSSDHESRPVTREEALSQSDIVITGVPSPHFEKVRA
EELKPGAICLNFSYIQNFEPEAKEAASLYIPRVGPMTVAMCMRNALQLYHNYHHEV
>Mature_296_residues
MKVLEPNPVAASFRDAVRRQISEEQLTINIVGILASDDPASITYADYTRAGCEDVGIHFDLRKCEPESVRATLEAANRDS
AVHGIFVYYPIWGDKRDAELRDLISPHKDVEGLSPHWIKKLYANERFDDTERRFKSILPCTPLAIIKLLEVTEAYAPFGL
PFGGQQITIFNRSEVVGRPLAYMLSNDGARVYSFDINGGFVVDVNSSDHESRPVTREEALSQSDIVITGVPSPHFEKVRA
EELKPGAICLNFSYIQNFEPEAKEAASLYIPRVGPMTVAMCMRNALQLYHNYHHEV

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate [H]

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=319, Percent_Identity=26.9592476489028, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1786741, Length=277, Percent_Identity=26.7148014440433, Blast_Score=81, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17568735, Length=236, Percent_Identity=28.8135593220339, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6322933, Length=302, Percent_Identity=41.3907284768212, Blast_Score=225, Evalue=8e-60,
Organism=Saccharomyces cerevisiae, GI6321643, Length=323, Percent_Identity=26.3157894736842, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6319558, Length=317, Percent_Identity=24.6056782334385, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24645718, Length=319, Percent_Identity=24.7648902821317, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17137370, Length=319, Percent_Identity=24.7648902821317, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI62472483, Length=319, Percent_Identity=24.7648902821317, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45551871, Length=319, Percent_Identity=24.7648902821317, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17136816, Length=280, Percent_Identity=23.2142857142857, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17136818, Length=280, Percent_Identity=23.2142857142857, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631 [H]

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C [H]

EC number: =1.5.1.5; =3.5.4.9 [H]

Molecular weight: Translated: 33244; Mature: 33244

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLEPNPVAASFRDAVRRQISEEQLTINIVGILASDDPASITYADYTRAGCEDVGIHFD
CCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCEEEECCCCCCCCCCCCEEEE
LRKCEPESVRATLEAANRDSAVHGIFVYYPIWGDKRDAELRDLISPHKDVEGLSPHWIKK
ECCCCHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCHHHHHHCCCCCCCCCCCHHHHHH
LYANERFDDTERRFKSILPCTPLAIIKLLEVTEAYAPFGLPFGGQQITIFNRSEVVGRPL
HHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECHHHHCCCC
AYMLSNDGARVYSFDINGGFVVDVNSSDHESRPVTREEALSQSDIVITGVPSPHFEKVRA
EEEECCCCCEEEEEECCCCEEEECCCCCCCCCCCCHHHHCCCCCEEEECCCCCHHHHHHH
EELKPGAICLNFSYIQNFEPEAKEAASLYIPRVGPMTVAMCMRNALQLYHNYHHEV
HHCCCCEEEEEEHHHHCCCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKVLEPNPVAASFRDAVRRQISEEQLTINIVGILASDDPASITYADYTRAGCEDVGIHFD
CCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCEEEECCCCCCCCCCCCEEEE
LRKCEPESVRATLEAANRDSAVHGIFVYYPIWGDKRDAELRDLISPHKDVEGLSPHWIKK
ECCCCHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCHHHHHHCCCCCCCCCCCHHHHHH
LYANERFDDTERRFKSILPCTPLAIIKLLEVTEAYAPFGLPFGGQQITIFNRSEVVGRPL
HHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECHHHHCCCC
AYMLSNDGARVYSFDINGGFVVDVNSSDHESRPVTREEALSQSDIVITGVPSPHFEKVRA
EEEECCCCCEEEEEECCCCEEEECCCCCCCCCCCCHHHHCCCCCEEEECCCCCHHHHHHH
EELKPGAICLNFSYIQNFEPEAKEAASLYIPRVGPMTVAMCMRNALQLYHNYHHEV
HHCCCCEEEEEEHHHHCCCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA