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The map label for this gene is metC [H]

Identifier: 21673531

GI number: 21673531

Start: 686241

End: 687383

Strand: Reverse

Name: metC [H]

Synonym: CT0701

Alternate gene names: 21673531

Gene position: 687383-686241 (Counterclockwise)

Preceding gene: 21673532

Following gene: 21673530

Centisome position: 31.9

GC content: 62.55

Gene sequence:

>1143_bases
ATGCACTTTGAAACCATCGCCATCCATGACGGCAATACGCCGGAGAGCTGCACCGGATCGGTGACGCCGCCGGTTTACCA
GACCTCGACTTTCGCGCGTCCCAGCCTCGACGAGCGGGGTGAATTTTTCTATTCGCGCATCGGCAACCCGACGCGCTCGG
CGCTCGAATCGACCCTCGCGCTGCTTGAAAATGGCAAACATGCAACGACCTTTGCCTCCGGCGTAGCGGCGATGATGGCC
GCTATGCAGGTGCTCAAACCGGGCGATCACGTCGTTTCGAGCCTCGACGTTTATGGCGGCAGCTACCGGATTTTCGAGCA
GCTCATGCGTCCGTGGGGCGTCGAAACCTCCTACGCGGCGAGCGAAGCAACGGAGAGTTATATCGAGTGCATCCGCCCGG
AAACCCGCATGATCTGGATCGAATCGCCCTCGAATCCTCTTTTGCAGATTTGCGACATCCGCGCCCTCGCCGAGATCGCC
AACGAACGTGGCATCGTACTCGCGGTCGATAACACCTTCGCCAGCCCCTACTTCCAGCGCCCGCTCGACCTCGGCGCGCA
CATTGTCGTGCACAGCACCACCAAGTATCTCGGCGGGCACAGCGACGTGATCGGCGGCGCGGTCGTCGCGTCGGACGACA
ACCTCAATCTCACGATCCGCAACTACCAGGGCGCGGCGGGCGCGATTCCCGGCCCGTGGGATTGCTGGCTGATTTCGCGC
GGCATCAAGACGCTGAAAATCCGTATGGAGGAGCACCAGAAAAACGCGCTGCATCTGGCGCGAGCGCTCGAAAAGCACCC
GGCGGTGAGCCGCGTCATCTACCCCGGACTAGAGTCTCACCCGCAGCACGAGCTGGCCAAACGCCAGATGAGCGGCTTCG
GCGGAATGCTGACCATCGCGCTGAAAGGCGGACTTCCGGCAGTCCGCAAAATGATCGAGAGCCTGAAACTCTTCGTCATC
GCCGACAGCCTCGGCGGCGTGGAGTCACTCGTCGCCTCGCCCGCGCGGATGACTCTCGGCCCACTGAGTCAGGCCGAGCG
CGACCGACGCGCCTGCACCGACGACCTCGTGCGGCTCTCGATTGGCCTCGAAAACGCGGAGGATCTCGAAGCGGACCTCC
TGCAAGCCCTTGCAACCATCTAA

Upstream 100 bases:

>100_bases
ACATCATACCATAAATATACCGTAAACGCGGTAGCCCGGAAACCGCGAATTGTGCTTACCTTGTCCGTACATCCGCAAAA
ACGAACGAGCACAACAACCC

Downstream 100 bases:

>100_bases
AATTCAACAACATGGCCACCATCGCAAATATCACGAACACCATCGGACGCACGCCGCTGGTGCGGCTCAACAAGCTCGCC
AAGGGCCTCGACGCCGATAT

Product: trans-sulfuration enzyme family protein

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MHFETIAIHDGNTPESCTGSVTPPVYQTSTFARPSLDERGEFFYSRIGNPTRSALESTLALLENGKHATTFASGVAAMMA
AMQVLKPGDHVVSSLDVYGGSYRIFEQLMRPWGVETSYAASEATESYIECIRPETRMIWIESPSNPLLQICDIRALAEIA
NERGIVLAVDNTFASPYFQRPLDLGAHIVVHSTTKYLGGHSDVIGGAVVASDDNLNLTIRNYQGAAGAIPGPWDCWLISR
GIKTLKIRMEEHQKNALHLARALEKHPAVSRVIYPGLESHPQHELAKRQMSGFGGMLTIALKGGLPAVRKMIESLKLFVI
ADSLGGVESLVASPARMTLGPLSQAERDRRACTDDLVRLSIGLENAEDLEADLLQALATI

Sequences:

>Translated_380_residues
MHFETIAIHDGNTPESCTGSVTPPVYQTSTFARPSLDERGEFFYSRIGNPTRSALESTLALLENGKHATTFASGVAAMMA
AMQVLKPGDHVVSSLDVYGGSYRIFEQLMRPWGVETSYAASEATESYIECIRPETRMIWIESPSNPLLQICDIRALAEIA
NERGIVLAVDNTFASPYFQRPLDLGAHIVVHSTTKYLGGHSDVIGGAVVASDDNLNLTIRNYQGAAGAIPGPWDCWLISR
GIKTLKIRMEEHQKNALHLARALEKHPAVSRVIYPGLESHPQHELAKRQMSGFGGMLTIALKGGLPAVRKMIESLKLFVI
ADSLGGVESLVASPARMTLGPLSQAERDRRACTDDLVRLSIGLENAEDLEADLLQALATI
>Mature_380_residues
MHFETIAIHDGNTPESCTGSVTPPVYQTSTFARPSLDERGEFFYSRIGNPTRSALESTLALLENGKHATTFASGVAAMMA
AMQVLKPGDHVVSSLDVYGGSYRIFEQLMRPWGVETSYAASEATESYIECIRPETRMIWIESPSNPLLQICDIRALAEIA
NERGIVLAVDNTFASPYFQRPLDLGAHIVVHSTTKYLGGHSDVIGGAVVASDDNLNLTIRNYQGAAGAIPGPWDCWLISR
GIKTLKIRMEEHQKNALHLARALEKHPAVSRVIYPGLESHPQHELAKRQMSGFGGMLTIALKGGLPAVRKMIESLKLFVI
ADSLGGVESLVASPARMTLGPLSQAERDRRACTDDLVRLSIGLENAEDLEADLLQALATI

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=378, Percent_Identity=46.8253968253968, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI299473759, Length=378, Percent_Identity=43.1216931216931, Blast_Score=291, Evalue=5e-79,
Organism=Homo sapiens, GI25453487, Length=377, Percent_Identity=40.8488063660477, Blast_Score=264, Evalue=1e-70,
Organism=Escherichia coli, GI1790375, Length=370, Percent_Identity=39.1891891891892, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI1789383, Length=395, Percent_Identity=28.3544303797468, Blast_Score=163, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17538055, Length=380, Percent_Identity=46.0526315789474, Blast_Score=332, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI17560056, Length=380, Percent_Identity=44.4736842105263, Blast_Score=330, Evalue=6e-91,
Organism=Caenorhabditis elegans, GI71980708, Length=376, Percent_Identity=38.031914893617, Blast_Score=245, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6319307, Length=384, Percent_Identity=40.625, Blast_Score=285, Evalue=7e-78,
Organism=Saccharomyces cerevisiae, GI6323333, Length=436, Percent_Identity=33.0275229357798, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6321170, Length=322, Percent_Identity=34.1614906832298, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6321254, Length=407, Percent_Identity=30.4668304668305, Blast_Score=169, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6321904, Length=393, Percent_Identity=31.2977099236641, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6322970, Length=272, Percent_Identity=25, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI19922554, Length=378, Percent_Identity=42.8571428571429, Blast_Score=342, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 41322; Mature: 41322

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFETIAIHDGNTPESCTGSVTPPVYQTSTFARPSLDERGEFFYSRIGNPTRSALESTLA
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHH
LLENGKHATTFASGVAAMMAAMQVLKPGDHVVSSLDVYGGSYRIFEQLMRPWGVETSYAA
HHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHH
SEATESYIECIRPETRMIWIESPSNPLLQICDIRALAEIANERGIVLAVDNTFASPYFQR
HHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHC
PLDLGAHIVVHSTTKYLGGHSDVIGGAVVASDDNLNLTIRNYQGAAGAIPGPWDCWLISR
CCCCCCEEEEECCHHHHCCCCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHC
GIKTLKIRMEEHQKNALHLARALEKHPAVSRVIYPGLESHPQHELAKRQMSGFGGMLTIA
CCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEE
LKGGLPAVRKMIESLKLFVIADSLGGVESLVASPARMTLGPLSQAERDRRACTDDLVRLS
EECCCHHHHHHHHHHEEEEEECCCCCHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHH
IGLENAEDLEADLLQALATI
CCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHFETIAIHDGNTPESCTGSVTPPVYQTSTFARPSLDERGEFFYSRIGNPTRSALESTLA
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHH
LLENGKHATTFASGVAAMMAAMQVLKPGDHVVSSLDVYGGSYRIFEQLMRPWGVETSYAA
HHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHH
SEATESYIECIRPETRMIWIESPSNPLLQICDIRALAEIANERGIVLAVDNTFASPYFQR
HHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHC
PLDLGAHIVVHSTTKYLGGHSDVIGGAVVASDDNLNLTIRNYQGAAGAIPGPWDCWLISR
CCCCCCEEEEECCHHHHCCCCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHC
GIKTLKIRMEEHQKNALHLARALEKHPAVSRVIYPGLESHPQHELAKRQMSGFGGMLTIA
CCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEE
LKGGLPAVRKMIESLKLFVIADSLGGVESLVASPARMTLGPLSQAERDRRACTDDLVRLS
EECCCHHHHHHHHHHEEEEEECCCCCHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHH
IGLENAEDLEADLLQALATI
CCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]