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The map label for this gene is cysK [H]

Identifier: 21673530

GI number: 21673530

Start: 685297

End: 686229

Strand: Reverse

Name: cysK [H]

Synonym: CT0700

Alternate gene names: 21673530

Gene position: 686229-685297 (Counterclockwise)

Preceding gene: 21673531

Following gene: 21673529

Centisome position: 31.84

GC content: 63.88

Gene sequence:

>933_bases
ATGGCCACCATCGCAAATATCACGAACACCATCGGACGCACGCCGCTGGTGCGGCTCAACAAGCTCGCCAAGGGCCTCGA
CGCCGATATTCTCCTCAAGCTTGAATACTTCAACCCGCTCGGCAGCGTGAAGGATCGCATCGGGCGCGCCATGATCGAAG
CTGCCGAAGCCGAGGGGAAAATCGACGCCCGGACGCTCATCGTCGAGCCGACCAGCGGCAACACCGGCATCGCGCTCGCC
TTCGTCTGCGCCCAGCGCGGCTACCGGCTGCTGCTCACGATGCCCGAAACCATGAGCATCGAGCGCCGCAAACTGCTGCG
CTACCTCGGCGCGGAGCTGGTGCTCACTCCCGGAGCGCAGGGGATGAAAGGGGCGATTGAAGAGGCGGCGCGGATCGTCG
AGGCGGAGAAAAACAGCTTCAACCCCGGCCAGTTCCGCAACCCGGCCAACCCCCTGATTCACCAGGCGACCACCGGCCCC
GAAATCTGGAACGACACCGAAGGGCGCGTTGACATGCTTGTTTCAGGCGTCGGCACGGGCGGCACCATCACCGGCACATC
ACGTTTCATCAAGGCGCTGAAGCCCAACTTCAAAAGCATCGCCGTGGAGCCCAAAGATTCAGCTGTGCTCTCCGGCGGGC
AGCCGGGGCCTCACAAAATCCAGGGCATCGGCGCGGGCTTCGTGCCCGATGTGCTCGACGTCTCGCTGCTCGACGAGGTG
GTGACGGTGAGCAACGACGACGCGATCTCGACCGCGCGGGCACTCGCTTCGCAGGAGGGCATCCTCTGCGGTATCTCCTC
CGGCGCGGCGGTTCACGCAGCCATCGAAGTGGCGAAACGCTCGTCATCCGCAGGCAAAACCATCGTCGCCATCATCCCGA
GCACCGGCGAACGCTACCTCAGCACTGCGCTGTTTGAAGACATCGAAGCGTGA

Upstream 100 bases:

>100_bases
GCACCGACGACCTCGTGCGGCTCTCGATTGGCCTCGAAAACGCGGAGGATCTCGAAGCGGACCTCCTGCAAGCCCTTGCA
ACCATCTAAAATTCAACAAC

Downstream 100 bases:

>100_bases
GAAATCCGCTTTTATCATTCAGGAGGGTTTCAACCCGACGGATATTTGAAAATCTTACATTCACATTGCCCCGGCTTTCA
AGCCGGGGTTCAAAAGAAGA

Product: cysteine synthase

Products: NA

Alternate protein names: OAS sulfhydrylase; OASS; Cysteine synthase A; CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine-specific cysteine synthase; Sulfide-dependent cysteine synthase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MATIANITNTIGRTPLVRLNKLAKGLDADILLKLEYFNPLGSVKDRIGRAMIEAAEAEGKIDARTLIVEPTSGNTGIALA
FVCAQRGYRLLLTMPETMSIERRKLLRYLGAELVLTPGAQGMKGAIEEAARIVEAEKNSFNPGQFRNPANPLIHQATTGP
EIWNDTEGRVDMLVSGVGTGGTITGTSRFIKALKPNFKSIAVEPKDSAVLSGGQPGPHKIQGIGAGFVPDVLDVSLLDEV
VTVSNDDAISTARALASQEGILCGISSGAAVHAAIEVAKRSSSAGKTIVAIIPSTGERYLSTALFEDIEA

Sequences:

>Translated_310_residues
MATIANITNTIGRTPLVRLNKLAKGLDADILLKLEYFNPLGSVKDRIGRAMIEAAEAEGKIDARTLIVEPTSGNTGIALA
FVCAQRGYRLLLTMPETMSIERRKLLRYLGAELVLTPGAQGMKGAIEEAARIVEAEKNSFNPGQFRNPANPLIHQATTGP
EIWNDTEGRVDMLVSGVGTGGTITGTSRFIKALKPNFKSIAVEPKDSAVLSGGQPGPHKIQGIGAGFVPDVLDVSLLDEV
VTVSNDDAISTARALASQEGILCGISSGAAVHAAIEVAKRSSSAGKTIVAIIPSTGERYLSTALFEDIEA
>Mature_309_residues
ATIANITNTIGRTPLVRLNKLAKGLDADILLKLEYFNPLGSVKDRIGRAMIEAAEAEGKIDARTLIVEPTSGNTGIALAF
VCAQRGYRLLLTMPETMSIERRKLLRYLGAELVLTPGAQGMKGAIEEAARIVEAEKNSFNPGQFRNPANPLIHQATTGPE
IWNDTEGRVDMLVSGVGTGGTITGTSRFIKALKPNFKSIAVEPKDSAVLSGGQPGPHKIQGIGAGFVPDVLDVSLLDEVV
TVSNDDAISTARALASQEGILCGISSGAAVHAAIEVAKRSSSAGKTIVAIIPSTGERYLSTALFEDIEA

Specific function: Catalyzes the conversion of O-acetylserine (OAS) to cysteine through the elimination of acetate and addition of hydrogen sulfide [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=311, Percent_Identity=41.4790996784566, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI295821200, Length=311, Percent_Identity=41.4790996784566, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI4557415, Length=311, Percent_Identity=41.4790996784566, Blast_Score=226, Evalue=3e-59,
Organism=Escherichia coli, GI1788754, Length=308, Percent_Identity=59.0909090909091, Blast_Score=317, Evalue=5e-88,
Organism=Escherichia coli, GI2367138, Length=302, Percent_Identity=43.3774834437086, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17535051, Length=299, Percent_Identity=51.8394648829431, Blast_Score=309, Evalue=9e-85,
Organism=Caenorhabditis elegans, GI115535073, Length=304, Percent_Identity=54.9342105263158, Blast_Score=306, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI17562970, Length=301, Percent_Identity=51.1627906976744, Blast_Score=303, Evalue=8e-83,
Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=51.877133105802, Blast_Score=295, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI17561720, Length=298, Percent_Identity=50.6711409395973, Blast_Score=271, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI32566672, Length=215, Percent_Identity=50.2325581395349, Blast_Score=217, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI17534315, Length=319, Percent_Identity=38.2445141065831, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI25147552, Length=315, Percent_Identity=37.7777777777778, Blast_Score=167, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17561716, Length=118, Percent_Identity=50.8474576271186, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71991565, Length=300, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=316, Percent_Identity=37.6582278481013, Blast_Score=188, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6321449, Length=326, Percent_Identity=33.4355828220859, Blast_Score=125, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24643623, Length=306, Percent_Identity=39.5424836601307, Blast_Score=191, Evalue=6e-49,
Organism=Drosophila melanogaster, GI20129101, Length=306, Percent_Identity=39.5424836601307, Blast_Score=191, Evalue=6e-49,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32632; Mature: 32501

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIANITNTIGRTPLVRLNKLAKGLDADILLKLEYFNPLGSVKDRIGRAMIEAAEAEGK
CCCHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCC
IDARTLIVEPTSGNTGIALAFVCAQRGYRLLLTMPETMSIERRKLLRYLGAELVLTPGAQ
CCEEEEEEECCCCCCCHHHHEEHHHCCCEEEEECCCCCCHHHHHHHHHCCCCEEECCCCC
GMKGAIEEAARIVEAEKNSFNPGQFRNPANPLIHQATTGPEIWNDTEGRVDMLVSGVGTG
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCEEEEEECCCCC
GTITGTSRFIKALKPNFKSIAVEPKDSAVLSGGQPGPHKIQGIGAGFVPDVLDVSLLDEV
CEECHHHHHHHHHCCCCCEEEECCCCCEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHH
VTVSNDDAISTARALASQEGILCGISSGAAVHAAIEVAKRSSSAGKTIVAIIPSTGERYL
HHCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHH
STALFEDIEA
HHHHHHHHCC
>Mature Secondary Structure 
ATIANITNTIGRTPLVRLNKLAKGLDADILLKLEYFNPLGSVKDRIGRAMIEAAEAEGK
CCHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCC
IDARTLIVEPTSGNTGIALAFVCAQRGYRLLLTMPETMSIERRKLLRYLGAELVLTPGAQ
CCEEEEEEECCCCCCCHHHHEEHHHCCCEEEEECCCCCCHHHHHHHHHCCCCEEECCCCC
GMKGAIEEAARIVEAEKNSFNPGQFRNPANPLIHQATTGPEIWNDTEGRVDMLVSGVGTG
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCEEEEEECCCCC
GTITGTSRFIKALKPNFKSIAVEPKDSAVLSGGQPGPHKIQGIGAGFVPDVLDVSLLDEV
CEECHHHHHHHHHCCCCCEEEECCCCCEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHH
VTVSNDDAISTARALASQEGILCGISSGAAVHAAIEVAKRSSSAGKTIVAIIPSTGERYL
HHCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHH
STALFEDIEA
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]