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The map label for this gene is phoR [H]

Identifier: 21673490

GI number: 21673490

Start: 656128

End: 657327

Strand: Direct

Name: phoR [H]

Synonym: CT0658

Alternate gene names: 21673490

Gene position: 656128-657327 (Clockwise)

Preceding gene: 21673489

Following gene: 21673491

Centisome position: 30.45

GC content: 60.5

Gene sequence:

>1200_bases
ATGTTTCTTTCCCGCCCGCTCGTCAGGATTGCCAGCGCAGCCGACCGCTTCCTGCATGGCGAGACGGAGGTGAAGATTCC
CGTCAAGCATGACGACGAGATCGGGCGCCTGGCGCGGGCGTTCAACTATCTTTCCGAAGAGATCGTGCGGCTGACCCGCA
AGGAGGAGTGGCTGCGGGAGGTGCTGTCGAGTATTCGCGAGGCCATTATCGTGACCAACGCTTCGGGCGAGATCGTACTT
GCCAACCCCGCCGCATCGCGGCTGTTCATGATCGAGGCGGCCCGCAAGCGTTCGATTCCCGTGACCAACATCGAGGATGC
GGCGATGCGGGAGCTGTTCGAGCGGGTGCAGAAGCGGCAGAGTGGCATCTACAACGAGGAGCTGACGGCCATGACCTCCA
AAGGAAAGCGCACGCTCAAGGTGACAGCCGTACCGGTCATGCGGCGGGGGGCGCTGTTCGACGGCACTGTGCTGGTTATC
AACGATGTGACCCGACTGCGCAATCTGGAGCGCACCCGCCGGGACTTCGTTTCGAGCGTGTCGCACGAACTGCGCACGCC
ACTGGCGAGCATCAAGGGGTACACTGAAACCCTGCTCGAGGGGGCGATGAACGATCCGGAAAACGCCACGGCATTTCTGA
ATATCATCCATCAGGAGGCCGAGCAGCTCACGGCGCTGGTCAACGATGTGCTCGACCTGTCGCGCATCGAATCGGGCAAG
ATTGCTTACTCTTTCGAGCCGGTCGATGTCAAGCCGCAGCTCGAAAAAACGGCGGCGCTCTTTGAACCAGCCGCTGCACG
CAAGGGCGTGCGCATCGAGCTGAATGCGCCTGAAGGGCTTCCGGCGGTTCTGGCCGACCGGAGCTACTTTGACATCGTCG
TGCGCAACCTTATCGACAACGCGATCAAATATGTCGATGCAGAGAGCGGTCGGGTACGAGTCAGCGCTTACGCTACGGGC
GATAGTGTCAGCATCGAGGTGGCGGACAACGGCATCGGCATTCCGCAGGCCGATCTCGACCGTATTTTCGAACGCTTCTA
CCGCGTGGACAAGGCGCGTTCGCGCGAACTTGGTGGCACGGGGCTTGGTCTCTCCATCGTCAAGCATATCGTACTTGCAC
ATAAAGGCAAGGTCGAGGTTCGCTCCAGAATCAATCGTGGTACGACTTTCACCGTTACGCTTCCCGTCGCCGGAGCCTGA

Upstream 100 bases:

>100_bases
GCACGACATCGCTGCCGTCGAAGCGCAGATCGACAAAGGCATCGAGAGTGGCCTCTACTGGGCGCTGCTGATTTCCCTGA
CTGCTGGAGCGCTGTCGGCC

Downstream 100 bases:

>100_bases
ACGCGAGGCTGTTGAAACGGCTGGAACTGGCTATTTTTTCGGTTAATCGCCATTTTTTTTTGTCACATAACCCTACAGGC
TATGAAAAAACGCTGATCCT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MFLSRPLVRIASAADRFLHGETEVKIPVKHDDEIGRLARAFNYLSEEIVRLTRKEEWLREVLSSIREAIIVTNASGEIVL
ANPAASRLFMIEAARKRSIPVTNIEDAAMRELFERVQKRQSGIYNEELTAMTSKGKRTLKVTAVPVMRRGALFDGTVLVI
NDVTRLRNLERTRRDFVSSVSHELRTPLASIKGYTETLLEGAMNDPENATAFLNIIHQEAEQLTALVNDVLDLSRIESGK
IAYSFEPVDVKPQLEKTAALFEPAAARKGVRIELNAPEGLPAVLADRSYFDIVVRNLIDNAIKYVDAESGRVRVSAYATG
DSVSIEVADNGIGIPQADLDRIFERFYRVDKARSRELGGTGLGLSIVKHIVLAHKGKVEVRSRINRGTTFTVTLPVAGA

Sequences:

>Translated_399_residues
MFLSRPLVRIASAADRFLHGETEVKIPVKHDDEIGRLARAFNYLSEEIVRLTRKEEWLREVLSSIREAIIVTNASGEIVL
ANPAASRLFMIEAARKRSIPVTNIEDAAMRELFERVQKRQSGIYNEELTAMTSKGKRTLKVTAVPVMRRGALFDGTVLVI
NDVTRLRNLERTRRDFVSSVSHELRTPLASIKGYTETLLEGAMNDPENATAFLNIIHQEAEQLTALVNDVLDLSRIESGK
IAYSFEPVDVKPQLEKTAALFEPAAARKGVRIELNAPEGLPAVLADRSYFDIVVRNLIDNAIKYVDAESGRVRVSAYATG
DSVSIEVADNGIGIPQADLDRIFERFYRVDKARSRELGGTGLGLSIVKHIVLAHKGKVEVRSRINRGTTFTVTLPVAGA
>Mature_399_residues
MFLSRPLVRIASAADRFLHGETEVKIPVKHDDEIGRLARAFNYLSEEIVRLTRKEEWLREVLSSIREAIIVTNASGEIVL
ANPAASRLFMIEAARKRSIPVTNIEDAAMRELFERVQKRQSGIYNEELTAMTSKGKRTLKVTAVPVMRRGALFDGTVLVI
NDVTRLRNLERTRRDFVSSVSHELRTPLASIKGYTETLLEGAMNDPENATAFLNIIHQEAEQLTALVNDVLDLSRIESGK
IAYSFEPVDVKPQLEKTAALFEPAAARKGVRIELNAPEGLPAVLADRSYFDIVVRNLIDNAIKYVDAESGRVRVSAYATG
DSVSIEVADNGIGIPQADLDRIFERFYRVDKARSRELGGTGLGLSIVKHIVLAHKGKVEVRSRINRGTTFTVTLPVAGA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=228, Percent_Identity=35.0877192982456, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1786600, Length=336, Percent_Identity=29.7619047619048, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI48994928, Length=375, Percent_Identity=29.6, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1789149, Length=224, Percent_Identity=33.4821428571429, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI145693157, Length=232, Percent_Identity=31.8965517241379, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI1788713, Length=369, Percent_Identity=25.2032520325203, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1786912, Length=226, Percent_Identity=31.858407079646, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI87081816, Length=225, Percent_Identity=32.4444444444444, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=32.579185520362, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1788549, Length=377, Percent_Identity=24.9336870026525, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1790346, Length=236, Percent_Identity=30.0847457627119, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786783, Length=237, Percent_Identity=30.8016877637131, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI87082128, Length=235, Percent_Identity=31.063829787234, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790861, Length=213, Percent_Identity=32.8638497652582, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1787894, Length=225, Percent_Identity=29.7777777777778, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1790300, Length=365, Percent_Identity=27.3972602739726, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788279, Length=233, Percent_Identity=27.0386266094421, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1787374, Length=225, Percent_Identity=28.8888888888889, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789808, Length=233, Percent_Identity=28.3261802575107, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789403, Length=215, Percent_Identity=33.953488372093, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790551, Length=239, Percent_Identity=26.3598326359833, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 44274; Mature: 44274

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLSRPLVRIASAADRFLHGETEVKIPVKHDDEIGRLARAFNYLSEEIVRLTRKEEWLRE
CCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLSSIREAIIVTNASGEIVLANPAASRLFMIEAARKRSIPVTNIEDAAMRELFERVQKRQ
HHHHHHHEEEEECCCCCEEEECCCCHHEEEEEHHHHCCCCCCCCCHHHHHHHHHHHHHHH
SGIYNEELTAMTSKGKRTLKVTAVPVMRRGALFDGTVLVINDVTRLRNLERTRRDFVSSV
CCCCCHHHHHHHHCCCEEEEEEEEHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHH
SHELRTPLASIKGYTETLLEGAMNDPENATAFLNIIHQEAEQLTALVNDVLDLSRIESGK
HHHHHCHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
IAYSFEPVDVKPQLEKTAALFEPAAARKGVRIELNAPEGLPAVLADRSYFDIVVRNLIDN
EEEEECCCCCCCHHHHHHHHHCCHHHCCCEEEEEECCCCCCHHHCCCHHHHHHHHHHHHH
AIKYVDAESGRVRVSAYATGDSVSIEVADNGIGIPQADLDRIFERFYRVDKARSRELGGT
HHHHHCCCCCEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
GLGLSIVKHIVLAHKGKVEVRSRINRGTTFTVTLPVAGA
CHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEEECCCC
>Mature Secondary Structure
MFLSRPLVRIASAADRFLHGETEVKIPVKHDDEIGRLARAFNYLSEEIVRLTRKEEWLRE
CCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLSSIREAIIVTNASGEIVLANPAASRLFMIEAARKRSIPVTNIEDAAMRELFERVQKRQ
HHHHHHHEEEEECCCCCEEEECCCCHHEEEEEHHHHCCCCCCCCCHHHHHHHHHHHHHHH
SGIYNEELTAMTSKGKRTLKVTAVPVMRRGALFDGTVLVINDVTRLRNLERTRRDFVSSV
CCCCCHHHHHHHHCCCEEEEEEEEHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHH
SHELRTPLASIKGYTETLLEGAMNDPENATAFLNIIHQEAEQLTALVNDVLDLSRIESGK
HHHHHCHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
IAYSFEPVDVKPQLEKTAALFEPAAARKGVRIELNAPEGLPAVLADRSYFDIVVRNLIDN
EEEEECCCCCCCHHHHHHHHHCCHHHCCCEEEEEECCCCCCHHHCCCHHHHHHHHHHHHH
AIKYVDAESGRVRVSAYATGDSVSIEVADNGIGIPQADLDRIFERFYRVDKARSRELGGT
HHHHHCCCCCEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
GLGLSIVKHIVLAHKGKVEVRSRINRGTTFTVTLPVAGA
CHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]