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The map label for this gene is mscM [H]

Identifier: 21673491

GI number: 21673491

Start: 657457

End: 658704

Strand: Direct

Name: mscM [H]

Synonym: CT0659

Alternate gene names: 21673491

Gene position: 657457-658704 (Clockwise)

Preceding gene: 21673490

Following gene: 21673493

Centisome position: 30.51

GC content: 55.77

Gene sequence:

>1248_bases
ATGCTCGACTCTCTTTTGCTCTATATAGAATCCTTCAACGTTGACCGGTCGATCGCCGTACCTGTGGCCACGCTGCTTGC
CGTTCTTGTGGCCATGCTGCTTATCGCCATTGTCGAGCTTGTCACGAAAAAAATTCTCCTGCGATCCATCGATCACTTTG
TTGCCAAAACAGCAAGCAACCTGGACGATCTGCTGGTCAGATATGGCGTGTTCAACTGGATCGCCCACCTGGTGCCGCCT
CTGCTCGCATACCGGATGGCCGGTACTGTTCTGCAGTTCTATCCCGCTGCGGTGCCGCAGGTAACGGATGGGCTGGTCAT
CTATTTTGCCGTGGTCGTTATTCTGCTGCTGCTCGCCGTGCTCGATGTCGTTTACGAATTCTACTCGGGGCACCCGATTG
GCATGAAGCTGCCGATCAAAAGCATCGTGCAGGTAATCAAGACGGTTGTCGTTTCGATTGGCGTGGTGATTGTCATCTCC
CGCCTGCTCGGCCAGTCTCCCGTGGTTTTCATCAGCGGTATCGGCGCGTTCACGGCGGTGCTGCTGCTCATTTTCAAGGA
TTCGATTCTCGGTCTCGTGGCGGGTGTGCAGCTTTCGACCAACGACCTGGTGCGCATCGGCGACTGGATCACGATGCCCA
AATACGGCGCTGATGGAGAGGTGATCGACATTTCGCTCGTGACCGTGTCGGTGCAGAACTTCGACAAGACCATCGTGGTG
CTTCCGGCCTATACGCTCATTTCCGAGGGGTTCAAGAACTGGCGGGGGATGCAGGAGTCGGACGGGCGGCGGATCAAGCG
CTCCTTCAATATCGACATGCAGAGTATCCGTTTTCTCGACGGCGAACTCATGAAAAAAATCGAGGCGGTCCAGCTGCTGA
AGCCTTACCTGCAGGAACGTTTTCAGGAGATCACCAGCCACAACCGGGCGGTGGGCGCTGATGAAGACTCGCCGGTCAAT
GGCCGCCGACTTACCAATCTCGGTACTTTCCGCGCCTATCTCCAGGCTTATGTGCACAGCCAGTCCAGAATCAACACCGA
CATGATGATCATGATCCGGTACCTGCAACCGGATGCCTTCGGATTACCGTGCGAGATCTACTGCTTCACCAGAACGAAAG
AGTGGGCGGAATACGAAGGGGTACAGGCGGATATTTTCGATCATATTTTCGCTGTGCTGCCCTGGTTCGATCTCAAGGCC
TATCAGCTCCAGGGCGCAGCGGTTCCTCCGCCAGCCGTCACAGCGTGA

Upstream 100 bases:

>100_bases
GCTATTTTTTCGGTTAATCGCCATTTTTTTTTGTCACATAACCCTACAGGCTATGAAAAAACGCTGATCCTCTTGAACCC
CGCAATAGTTCAATTCCGCT

Downstream 100 bases:

>100_bases
GCGACAGGTCGCGCTCCGGCCAGCGGCTCTCTGCGATGATCTGGCGATGCAGCGGAATCCTTACTGGCGGCATGTTGTCG
GGCCGGTAGAAGCCCGCCTC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MLDSLLLYIESFNVDRSIAVPVATLLAVLVAMLLIAIVELVTKKILLRSIDHFVAKTASNLDDLLVRYGVFNWIAHLVPP
LLAYRMAGTVLQFYPAAVPQVTDGLVIYFAVVVILLLLAVLDVVYEFYSGHPIGMKLPIKSIVQVIKTVVVSIGVVIVIS
RLLGQSPVVFISGIGAFTAVLLLIFKDSILGLVAGVQLSTNDLVRIGDWITMPKYGADGEVIDISLVTVSVQNFDKTIVV
LPAYTLISEGFKNWRGMQESDGRRIKRSFNIDMQSIRFLDGELMKKIEAVQLLKPYLQERFQEITSHNRAVGADEDSPVN
GRRLTNLGTFRAYLQAYVHSQSRINTDMMIMIRYLQPDAFGLPCEIYCFTRTKEWAEYEGVQADIFDHIFAVLPWFDLKA
YQLQGAAVPPPAVTA

Sequences:

>Translated_415_residues
MLDSLLLYIESFNVDRSIAVPVATLLAVLVAMLLIAIVELVTKKILLRSIDHFVAKTASNLDDLLVRYGVFNWIAHLVPP
LLAYRMAGTVLQFYPAAVPQVTDGLVIYFAVVVILLLLAVLDVVYEFYSGHPIGMKLPIKSIVQVIKTVVVSIGVVIVIS
RLLGQSPVVFISGIGAFTAVLLLIFKDSILGLVAGVQLSTNDLVRIGDWITMPKYGADGEVIDISLVTVSVQNFDKTIVV
LPAYTLISEGFKNWRGMQESDGRRIKRSFNIDMQSIRFLDGELMKKIEAVQLLKPYLQERFQEITSHNRAVGADEDSPVN
GRRLTNLGTFRAYLQAYVHSQSRINTDMMIMIRYLQPDAFGLPCEIYCFTRTKEWAEYEGVQADIFDHIFAVLPWFDLKA
YQLQGAAVPPPAVTA
>Mature_415_residues
MLDSLLLYIESFNVDRSIAVPVATLLAVLVAMLLIAIVELVTKKILLRSIDHFVAKTASNLDDLLVRYGVFNWIAHLVPP
LLAYRMAGTVLQFYPAAVPQVTDGLVIYFAVVVILLLLAVLDVVYEFYSGHPIGMKLPIKSIVQVIKTVVVSIGVVIVIS
RLLGQSPVVFISGIGAFTAVLLLIFKDSILGLVAGVQLSTNDLVRIGDWITMPKYGADGEVIDISLVTVSVQNFDKTIVV
LPAYTLISEGFKNWRGMQESDGRRIKRSFNIDMQSIRFLDGELMKKIEAVQLLKPYLQERFQEITSHNRAVGADEDSPVN
GRRLTNLGTFRAYLQAYVHSQSRINTDMMIMIRYLQPDAFGLPCEIYCFTRTKEWAEYEGVQADIFDHIFAVLPWFDLKA
YQLQGAAVPPPAVTA

Specific function: Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1786791, Length=366, Percent_Identity=44.8087431693989, Blast_Score=325, Evalue=3e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685 [H]

Pfam domain/function: PF00924 MS_channel [H]

EC number: NA

Molecular weight: Translated: 46214; Mature: 46214

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSLLLYIESFNVDRSIAVPVATLLAVLVAMLLIAIVELVTKKILLRSIDHFVAKTASN
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LDDLLVRYGVFNWIAHLVPPLLAYRMAGTVLQFYPAAVPQVTDGLVIYFAVVVILLLLAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCHHHHHHHHHHHHHHHHH
LDVVYEFYSGHPIGMKLPIKSIVQVIKTVVVSIGVVIVISRLLGQSPVVFISGIGAFTAV
HHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHH
LLLIFKDSILGLVAGVQLSTNDLVRIGDWITMPKYGADGEVIDISLVTVSVQNFDKTIVV
HHHHHHHHHHHHHHCCEECCCCCEEECCEEECCCCCCCCCEEEEEEEEEEECCCCCEEEE
LPAYTLISEGFKNWRGMQESDGRRIKRSFNIDMQSIRFLDGELMKKIEAVQLLKPYLQER
EHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FQEITSHNRAVGADEDSPVNGRRLTNLGTFRAYLQAYVHSQSRINTDMMIMIRYLQPDAF
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCC
GLPCEIYCFTRTKEWAEYEGVQADIFDHIFAVLPWFDLKAYQLQGAAVPPPAVTA
CCCEEEEEEECCCHHHHHCCCHHHHHHHHHHHHCCCCCCHHEECCCCCCCCCCCC
>Mature Secondary Structure
MLDSLLLYIESFNVDRSIAVPVATLLAVLVAMLLIAIVELVTKKILLRSIDHFVAKTASN
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LDDLLVRYGVFNWIAHLVPPLLAYRMAGTVLQFYPAAVPQVTDGLVIYFAVVVILLLLAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCHHHHHHHHHHHHHHHHH
LDVVYEFYSGHPIGMKLPIKSIVQVIKTVVVSIGVVIVISRLLGQSPVVFISGIGAFTAV
HHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHH
LLLIFKDSILGLVAGVQLSTNDLVRIGDWITMPKYGADGEVIDISLVTVSVQNFDKTIVV
HHHHHHHHHHHHHHCCEECCCCCEEECCEEECCCCCCCCCEEEEEEEEEEECCCCCEEEE
LPAYTLISEGFKNWRGMQESDGRRIKRSFNIDMQSIRFLDGELMKKIEAVQLLKPYLQER
EHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FQEITSHNRAVGADEDSPVNGRRLTNLGTFRAYLQAYVHSQSRINTDMMIMIRYLQPDAF
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCC
GLPCEIYCFTRTKEWAEYEGVQADIFDHIFAVLPWFDLKAYQLQGAAVPPPAVTA
CCCEEEEEEECCCHHHHHCCCHHHHHHHHHHHHCCCCCCHHEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 7813889 [H]