Click here to switch to the map view.

The map label for this gene is murA

Identifier: 21673390

GI number: 21673390

Start: 563665

End: 564939

Strand: Reverse

Name: murA

Synonym: CT0555

Alternate gene names: 21673390

Gene position: 564939-563665 (Counterclockwise)

Preceding gene: 21673391

Following gene: 21673385

Centisome position: 26.22

GC content: 60.47

Gene sequence:

>1275_bases
ATGGACAAGCTTGTCATCCGGGGCGGAAAACAGATTTGCGGCACCATCCCCGCCTCAGGATCGAAAAATTCCGCGCTGCC
AATCATCGCAGCAACACTGTTGACACCTGATGGCACCTTCGCCATTGATCGCACCCCGGATCTCAAGGATGTCCGGACCT
TCATCCAGCTGCTCAACTATCTCGGTGCGGAAACGTCATTCGAAAATAACCTGCTGAAGGTCTCGACCGGTCAGCTGAAG
AGCATCGAGGCTCCGTACGAGCTGGTCAAGAAGATGCGCGCCTCGATCTACGTGCTTGGCCCGCTGCTCGCCCGGTTCGG
CCACACGAGGGTCTCCTTGCCCGGCGGATGTGCTTTCGGCCCGCGTCCGGTCGATCTGCACATCATGGTAATGGAAAAGC
TCGGCGCGACCGTCACCATCGAAAAGGGCTTCATCAACGCCCGCGTCAACGGCTCACGCCTGCGCGGCACGCACATCGAC
TTTCCGATCTCGTCAGTCGGCGCAACCGGCAACGCCTTGATGGCCTCAGTCATGGCCAAAGGCACCACCATTCTCGACAA
CGCCGCCCTCGAACCGGAGATCGAATGCCTGTGCAACTTCCTCGTGAAAATGGGCGCCAAGATCGACGGTATCGGCACCA
CAACGCTCGTCATTGACGGAGTCGATCAGCTCAAGGCGGTTGAGTTCGAAAACATCTTCGACCGCATCGAAGCGGGCACG
CTCCTCTGCGCCGCCGCGATCACCGGCGGCAGCGTCACCGTTACGAGCGTCGCGCCGGAACAGCTCGCCTCAGTGCTCGA
CGCATTCCGCCAGTCCGGCTGCACGGTCACGACGAACGGAAATTCGGTGACGCTCACCGCACCCGCCGAACTCAATCCGG
TCGATATTACCGCGCGTCCCTATCCCGAGTTTCCGACCGACATGCAGGCGCAGTGGATGGCGCTCATGACGCAGGCCCGC
GGCGACAGCACCATCATCGACCGCATCTACCTCGAACGCTTCAACCACATTCCGGAGTTGAACCGGCTCGGAGCGCACAT
CGAAATCAGGGACAACTGGGCGCTCGTCCACGGCCCGCAGGAGCTGACCGGCACCAAAGTGATGTCCACCGACCTTCGCG
CTTCGGCCTGCCTCGTGCTTGCCGGACTGGTTGCCAAAGACACCACAGAGGTGCTCCGCGTCTATCATCTCGACCGCGGC
TACGAAGCCATCGAGAAGAAACTCACAGCACTCGGAGCCGACATCAGGAGAGAGAAGTACCAGGAATTTTCCTGA

Upstream 100 bases:

>100_bases
CAGTTTGCAGGTTCAGATAAAAAGTGGCTTTAAAATAAAATTTGTTTTTCTGAGCCTGAAATAATTAAATAGGCCTTTTT
GCATGTAACCCTTGAATCGA

Downstream 100 bases:

>100_bases
AAAAAGAGTCAAATATCGTTTGCAATTTTAATCACATACCTTATATTAGACCACTCTGAAGCAAAAACAGGCTTGCGAGG
GCCCTTAGCTCAGTTGGTCA

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase; UDP-N-acetylglucosamine enolpyruvyl transferase; EPT

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MDKLVIRGGKQICGTIPASGSKNSALPIIAATLLTPDGTFAIDRTPDLKDVRTFIQLLNYLGAETSFENNLLKVSTGQLK
SIEAPYELVKKMRASIYVLGPLLARFGHTRVSLPGGCAFGPRPVDLHIMVMEKLGATVTIEKGFINARVNGSRLRGTHID
FPISSVGATGNALMASVMAKGTTILDNAALEPEIECLCNFLVKMGAKIDGIGTTTLVIDGVDQLKAVEFENIFDRIEAGT
LLCAAAITGGSVTVTSVAPEQLASVLDAFRQSGCTVTTNGNSVTLTAPAELNPVDITARPYPEFPTDMQAQWMALMTQAR
GDSTIIDRIYLERFNHIPELNRLGAHIEIRDNWALVHGPQELTGTKVMSTDLRASACLVLAGLVAKDTTEVLRVYHLDRG
YEAIEKKLTALGADIRREKYQEFS

Sequences:

>Translated_424_residues
MDKLVIRGGKQICGTIPASGSKNSALPIIAATLLTPDGTFAIDRTPDLKDVRTFIQLLNYLGAETSFENNLLKVSTGQLK
SIEAPYELVKKMRASIYVLGPLLARFGHTRVSLPGGCAFGPRPVDLHIMVMEKLGATVTIEKGFINARVNGSRLRGTHID
FPISSVGATGNALMASVMAKGTTILDNAALEPEIECLCNFLVKMGAKIDGIGTTTLVIDGVDQLKAVEFENIFDRIEAGT
LLCAAAITGGSVTVTSVAPEQLASVLDAFRQSGCTVTTNGNSVTLTAPAELNPVDITARPYPEFPTDMQAQWMALMTQAR
GDSTIIDRIYLERFNHIPELNRLGAHIEIRDNWALVHGPQELTGTKVMSTDLRASACLVLAGLVAKDTTEVLRVYHLDRG
YEAIEKKLTALGADIRREKYQEFS
>Mature_424_residues
MDKLVIRGGKQICGTIPASGSKNSALPIIAATLLTPDGTFAIDRTPDLKDVRTFIQLLNYLGAETSFENNLLKVSTGQLK
SIEAPYELVKKMRASIYVLGPLLARFGHTRVSLPGGCAFGPRPVDLHIMVMEKLGATVTIEKGFINARVNGSRLRGTHID
FPISSVGATGNALMASVMAKGTTILDNAALEPEIECLCNFLVKMGAKIDGIGTTTLVIDGVDQLKAVEFENIFDRIEAGT
LLCAAAITGGSVTVTSVAPEQLASVLDAFRQSGCTVTTNGNSVTLTAPAELNPVDITARPYPEFPTDMQAQWMALMTQAR
GDSTIIDRIYLERFNHIPELNRLGAHIEIRDNWALVHGPQELTGTKVMSTDLRASACLVLAGLVAKDTTEVLRVYHLDRG
YEAIEKKLTALGADIRREKYQEFS

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=420, Percent_Identity=47.3809523809524, Blast_Score=371, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA_CHLTE (Q8KEX7)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_661455.1
- ProteinModelPortal:   Q8KEX7
- SMR:   Q8KEX7
- GeneID:   1006343
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0555
- NMPDR:   fig|194439.1.peg.549
- TIGR:   CT0555
- HOGENOM:   HBG482701
- OMA:   MVKTMRA
- ProtClustDB:   PRK09369
- BioCyc:   CTEP194439:CT_0555-MONOMER
- BRENDA:   2.5.1.7
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 45760; Mature: 45760

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: ACT_SITE 117-117

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKLVIRGGKQICGTIPASGSKNSALPIIAATLLTPDGTFAIDRTPDLKDVRTFIQLLNY
CCCEEEECCCCEEEECCCCCCCCCCCCEEEEEEECCCCCEEECCCCCHHHHHHHHHHHHH
LGAETSFENNLLKVSTGQLKSIEAPYELVKKMRASIYVLGPLLARFGHTRVSLPGGCAFG
HCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHEEHHHHHHHHCCCCEEECCCCCCCC
PRPVDLHIMVMEKLGATVTIEKGFINARVNGSRLRGTHIDFPISSVGATGNALMASVMAK
CCCCEEEEEEEHHHCCEEEEECCEEEEEECCCEECCCCCCCCHHHCCCCCHHHHHHHHHC
GTTILDNAALEPEIECLCNFLVKMGAKIDGIGTTTLVIDGVDQLKAVEFENIFDRIEAGT
CCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHCC
LLCAAAITGGSVTVTSVAPEQLASVLDAFRQSGCTVTTNGNSVTLTAPAELNPVDITARP
EEEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCEEEECCCEEEEECCCCCCCEEEECCC
YPEFPTDMQAQWMALMTQARGDSTIIDRIYLERFNHIPELNRLGAHIEIRDNWALVHGPQ
CCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHCCCEEEEECCEEEEECCH
ELTGTKVMSTDLRASACLVLAGLVAKDTTEVLRVYHLDRGYEAIEKKLTALGADIRREKY
HHCCCEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
QEFS
HCCC
>Mature Secondary Structure
MDKLVIRGGKQICGTIPASGSKNSALPIIAATLLTPDGTFAIDRTPDLKDVRTFIQLLNY
CCCEEEECCCCEEEECCCCCCCCCCCCEEEEEEECCCCCEEECCCCCHHHHHHHHHHHHH
LGAETSFENNLLKVSTGQLKSIEAPYELVKKMRASIYVLGPLLARFGHTRVSLPGGCAFG
HCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHEEHHHHHHHHCCCCEEECCCCCCCC
PRPVDLHIMVMEKLGATVTIEKGFINARVNGSRLRGTHIDFPISSVGATGNALMASVMAK
CCCCEEEEEEEHHHCCEEEEECCEEEEEECCCEECCCCCCCCHHHCCCCCHHHHHHHHHC
GTTILDNAALEPEIECLCNFLVKMGAKIDGIGTTTLVIDGVDQLKAVEFENIFDRIEAGT
CCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHCC
LLCAAAITGGSVTVTSVAPEQLASVLDAFRQSGCTVTTNGNSVTLTAPAELNPVDITARP
EEEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCEEEECCCEEEEECCCCCCCEEEECCC
YPEFPTDMQAQWMALMTQARGDSTIIDRIYLERFNHIPELNRLGAHIEIRDNWALVHGPQ
CCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHCCCEEEEECCEEEEECCH
ELTGTKVMSTDLRASACLVLAGLVAKDTTEVLRVYHLDRGYEAIEKKLTALGADIRREKY
HHCCCEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
QEFS
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901