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The map label for this gene is hisI [H]

Identifier: 21673299

GI number: 21673299

Start: 481884

End: 482297

Strand: Reverse

Name: hisI [H]

Synonym: CT0463

Alternate gene names: 21673299

Gene position: 482297-481884 (Counterclockwise)

Preceding gene: 21673301

Following gene: 21673298

Centisome position: 22.38

GC content: 56.04

Gene sequence:

>414_bases
ATGGGCGAGAATCAAGAGACGCAGAAGAGCTTTCTCGAAACGGTCAAATTCGACAGCAACGGGCTGGTGCCCGCCATCGT
GCAGGATCACGAAACCGGCAAGGTGCTGATGATGGCCTGGATGAATCTCGAAAGCCTCAAAATGACCCTCGAAAAGAAAA
AGGCCTGCTACTGGAGCCGCAGCCGCAACAAGCTCTGGCTCAAAGGCGAATCGTCGGGAAACATGCAGGAGGTGCACGAC
ATACTCATCGACTGCGATGGCGACACGCTCTTGCTCAAGGTCTCGCAGAAAGGCGGCGCGTGCCATGTCGGCTACCACTC
CTGCTTCTACCGGAGAACGGTGGACGGCGAGTCGATGGAGATCTGCGACACGCTGATGTTCGATCCCGAAGAGGTTTACG
GCAAACAAAGCTGA

Upstream 100 bases:

>100_bases
CAAATCTTCCTGCCGGGCGTTTTCTGATGGCTCTTTCGGCTGAATTGAACGCAGGCATTAAACGCAGGCATTACGGAAAA
AATTCTAATCTACAGCTTCA

Downstream 100 bases:

>100_bases
CCCTTGATGAGTAGTTCCAAAGAGACCGCAAAGTCCCTCATACAAACCAAGTCACGCTCCTCGATCCGCAACATGTTCGA
CGAGGTCGCGCCGACCTATG

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 137; Mature: 136

Protein sequence:

>137_residues
MGENQETQKSFLETVKFDSNGLVPAIVQDHETGKVLMMAWMNLESLKMTLEKKKACYWSRSRNKLWLKGESSGNMQEVHD
ILIDCDGDTLLLKVSQKGGACHVGYHSCFYRRTVDGESMEICDTLMFDPEEVYGKQS

Sequences:

>Translated_137_residues
MGENQETQKSFLETVKFDSNGLVPAIVQDHETGKVLMMAWMNLESLKMTLEKKKACYWSRSRNKLWLKGESSGNMQEVHD
ILIDCDGDTLLLKVSQKGGACHVGYHSCFYRRTVDGESMEICDTLMFDPEEVYGKQS
>Mature_136_residues
GENQETQKSFLETVKFDSNGLVPAIVQDHETGKVLMMAWMNLESLKMTLEKKKACYWSRSRNKLWLKGESSGNMQEVHDI
LIDCDGDTLLLKVSQKGGACHVGYHSCFYRRTVDGESMEICDTLMFDPEEVYGKQS

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=91, Percent_Identity=48.3516483516484, Blast_Score=96, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319819, Length=132, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 15607; Mature: 15476

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
9.5 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
8.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGENQETQKSFLETVKFDSNGLVPAIVQDHETGKVLMMAWMNLESLKMTLEKKKACYWSR
CCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHEEC
SRNKLWLKGESSGNMQEVHDILIDCDGDTLLLKVSQKGGACHVGYHSCFYRRTVDGESME
CCCEEEEEECCCCCHHHHHEEEEECCCCEEEEEECCCCCEEEECHHHEEEEECCCCCCHH
ICDTLMFDPEEVYGKQS
HHHHHCCCHHHHCCCCC
>Mature Secondary Structure 
GENQETQKSFLETVKFDSNGLVPAIVQDHETGKVLMMAWMNLESLKMTLEKKKACYWSR
CCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHEEC
SRNKLWLKGESSGNMQEVHDILIDCDGDTLLLKVSQKGGACHVGYHSCFYRRTVDGESME
CCCEEEEEECCCCCHHHHHEEEEECCCCEEEEEECCCCCEEEECHHHEEEEECCCCCCHH
ICDTLMFDPEEVYGKQS
HHHHHCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA