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The map label for this gene is menG

Identifier: 21673298

GI number: 21673298

Start: 481152

End: 481880

Strand: Reverse

Name: menG

Synonym: CT0462

Alternate gene names: 21673298

Gene position: 481880-481152 (Counterclockwise)

Preceding gene: 21673299

Following gene: 21673289

Centisome position: 22.36

GC content: 55.97

Gene sequence:

>729_bases
TTGATGAGTAGTTCCAAAGAGACCGCAAAGTCCCTCATACAAACCAAGTCACGCTCCTCGATCCGCAACATGTTCGACGA
GGTCGCGCCGACCTATGACTTCCTCAACCACCTGCTGAGCCTCGGCATCGACAACTACTGGCGTGTCGTAGCCGCCAAAA
AGGCCCGCAAGCAGCTGGAAGGCGAACGCGAGCCGAAAATTCTCGACGTGGCCACCGGCACGGGCGACCTGGCCGCATCA
ATGGCAAAGATCCCCGGTGCAAAGGTGACCGGCTACGACCTCTCTCCCGAGATGCTCGCCATCGCGCGCAAGAAGTACCC
GAACATCGAGTTCCTGGAAGGCTTCGCTGAAAAGATGCCTTTTGACGACCGGAGCTTCCACGTCGTCAGCGCAGGCTTCG
GCGTCCGGAACTTCGAAGACCTCGCGCAGGGTATGAAAGAGTTCCACCGCGTGCTCAAGCCCGGCGGCTGCGCTTACATC
ATCGAGCCGATGATTCCGCGCAACGCGGTGATGAAAAAGCTCTACCTGATCTACTTCAAGAACGTCCTACCGAAAATCGC
CGGAATGTTCAGCAAATCGACCTTTGCTTACGACTACCTCCCCAATTCGGTGGAACAGTTCCCCCAAGCCGAAGCGTTCA
CGAAAATTCTGAAAAACGCGGGATTCAAAAAGGCCGAGTACTTCCCGATGACCTTCGAGACCTCTATTTTGTACGTGGCC
ATGAAGTGA

Upstream 100 bases:

>100_bases
CTCCTGCTTCTACCGGAGAACGGTGGACGGCGAGTCGATGGAGATCTGCGACACGCTGATGTTCGATCCCGAAGAGGTTT
ACGGCAAACAAAGCTGACCC

Downstream 100 bases:

>100_bases
GGCAAGAGTTTGATATGACGTCAAAGCAAAAAGGTGAAGCATAAAAACTTCACCTTTTTCATTTTACCGGAACAGGACCT
CCGGAAATTTTATTGTGACC

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MMSSSKETAKSLIQTKSRSSIRNMFDEVAPTYDFLNHLLSLGIDNYWRVVAAKKARKQLEGEREPKILDVATGTGDLAAS
MAKIPGAKVTGYDLSPEMLAIARKKYPNIEFLEGFAEKMPFDDRSFHVVSAGFGVRNFEDLAQGMKEFHRVLKPGGCAYI
IEPMIPRNAVMKKLYLIYFKNVLPKIAGMFSKSTFAYDYLPNSVEQFPQAEAFTKILKNAGFKKAEYFPMTFETSILYVA
MK

Sequences:

>Translated_242_residues
MMSSSKETAKSLIQTKSRSSIRNMFDEVAPTYDFLNHLLSLGIDNYWRVVAAKKARKQLEGEREPKILDVATGTGDLAAS
MAKIPGAKVTGYDLSPEMLAIARKKYPNIEFLEGFAEKMPFDDRSFHVVSAGFGVRNFEDLAQGMKEFHRVLKPGGCAYI
IEPMIPRNAVMKKLYLIYFKNVLPKIAGMFSKSTFAYDYLPNSVEQFPQAEAFTKILKNAGFKKAEYFPMTFETSILYVA
MK
>Mature_242_residues
MMSSSKETAKSLIQTKSRSSIRNMFDEVAPTYDFLNHLLSLGIDNYWRVVAAKKARKQLEGEREPKILDVATGTGDLAAS
MAKIPGAKVTGYDLSPEMLAIARKKYPNIEFLEGFAEKMPFDDRSFHVVSAGFGVRNFEDLAQGMKEFHRVLKPGGCAYI
IEPMIPRNAVMKKLYLIYFKNVLPKIAGMFSKSTFAYDYLPNSVEQFPQAEAFTKILKNAGFKKAEYFPMTFETSILYVA
MK

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2)

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family

Homologues:

Organism=Homo sapiens, GI116063536, Length=252, Percent_Identity=29.7619047619048, Blast_Score=119, Evalue=3e-27,
Organism=Escherichia coli, GI48994983, Length=244, Percent_Identity=31.5573770491803, Blast_Score=132, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17557039, Length=238, Percent_Identity=29.4117647058824, Blast_Score=116, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6323526, Length=253, Percent_Identity=30.8300395256917, Blast_Score=121, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24641702, Length=254, Percent_Identity=26.7716535433071, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIE_CHLTE (Q8KF69)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_661363.1
- ProteinModelPortal:   Q8KF69
- SMR:   Q8KF69
- GeneID:   1008195
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0462
- NMPDR:   fig|194439.1.peg.457
- TIGR:   CT0462
- HOGENOM:   HBG559580
- OMA:   GGAISKN
- ProtClustDB:   CLSK637337
- BioCyc:   CTEP194439:CT_0462-MONOMER
- HAMAP:   MF_01813
- InterPro:   IPR004033
- PANTHER:   PTHR10108:SF24
- TIGRFAMs:   TIGR01934

Pfam domain/function: PF01209 Ubie_methyltran

EC number: 2.1.1.-

Molecular weight: Translated: 27307; Mature: 27307

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS01183 UBIE_1; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSSSKETAKSLIQTKSRSSIRNMFDEVAPTYDFLNHLLSLGIDNYWRVVAAKKARKQLE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
GEREPKILDVATGTGDLAASMAKIPGAKVTGYDLSPEMLAIARKKYPNIEFLEGFAEKMP
CCCCCCEEEEECCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHCC
FDDRSFHVVSAGFGVRNFEDLAQGMKEFHRVLKPGGCAYIIEPMIPRNAVMKKLYLIYFK
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHH
NVLPKIAGMFSKSTFAYDYLPNSVEQFPQAEAFTKILKNAGFKKAEYFPMTFETSILYVA
HHHHHHHHHHHCCCEEHHHCCHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEECEEEEEE
MK
EC
>Mature Secondary Structure
MMSSSKETAKSLIQTKSRSSIRNMFDEVAPTYDFLNHLLSLGIDNYWRVVAAKKARKQLE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
GEREPKILDVATGTGDLAASMAKIPGAKVTGYDLSPEMLAIARKKYPNIEFLEGFAEKMP
CCCCCCEEEEECCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHCC
FDDRSFHVVSAGFGVRNFEDLAQGMKEFHRVLKPGGCAYIIEPMIPRNAVMKKLYLIYFK
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHH
NVLPKIAGMFSKSTFAYDYLPNSVEQFPQAEAFTKILKNAGFKKAEYFPMTFETSILYVA
HHHHHHHHHHHCCCEEHHHCCHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEECEEEEEE
MK
EC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901