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The map label for this gene is purE [H]

Identifier: 21673210

GI number: 21673210

Start: 382223

End: 382750

Strand: Reverse

Name: purE [H]

Synonym: CT0371

Alternate gene names: 21673210

Gene position: 382750-382223 (Counterclockwise)

Preceding gene: 21673214

Following gene: 21673209

Centisome position: 17.76

GC content: 62.69

Gene sequence:

>528_bases
ATGACACAAGTTTCCTTTGACGCACAGGCGCCGCTGGTCGGCATCCTGATGGGTTCCGATTCCGATTTCGACATCATGAA
AGAGGCCGCCACGGTGCTCAACGAGTTCGGCATTCCGTTTGAAATATCGGTCATCTCGGCGCACCGAACGCCGGGCGATC
TCGAAGCCTACGCCTCCTCGGCAGAGGAGCGCGGCCTGAAAGCGATCATCGCCGGAGCTGGCGGTGCGGCACATCTGCCG
GGCGTCACGGCGGCCATGACTCCCCTGCCGGTCATCGGCGTGCCGATCTACAGCAAAAAGCTCAGCGGCCAGGATTCGCT
CTACGCCATCGTGCAGATGCCCGCCGGAATTCCCGTAGCCACCGTCGGCATCGACAACGCCCGCAACGCCGCGCTGCTCG
CCGTGCAGATGCTCGCCCTGTGCGACGCCAGTCTGATGCAGAAGCTCAGGGAGTTCCGACAGAAGCTTGCCGAAGCCTCG
CGCCAGAAGACCGCCAAAATCCGGGAAAAACTGCGTGCGAACGGCTGA

Upstream 100 bases:

>100_bases
TTTTTTGTTAGACTGATGAAAATACAAAAACTCCGCGAATTTTTTAGCCCTCAAACTGCAACGGCGTTAACCTTCACAAG
AACGGAGAACTTCTTTTTCC

Downstream 100 bases:

>100_bases
GTTCTGGATCGGGCGCCTCGGCCTCGAACGCCATCCGGAAGGGGGCTGGTATCGCGAAACCTACCGCAGCGAAGGCTCGT
ACGGTTTCAACGGCAACAGC

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 175; Mature: 174

Protein sequence:

>175_residues
MTQVSFDAQAPLVGILMGSDSDFDIMKEAATVLNEFGIPFEISVISAHRTPGDLEAYASSAEERGLKAIIAGAGGAAHLP
GVTAAMTPLPVIGVPIYSKKLSGQDSLYAIVQMPAGIPVATVGIDNARNAALLAVQMLALCDASLMQKLREFRQKLAEAS
RQKTAKIREKLRANG

Sequences:

>Translated_175_residues
MTQVSFDAQAPLVGILMGSDSDFDIMKEAATVLNEFGIPFEISVISAHRTPGDLEAYASSAEERGLKAIIAGAGGAAHLP
GVTAAMTPLPVIGVPIYSKKLSGQDSLYAIVQMPAGIPVATVGIDNARNAALLAVQMLALCDASLMQKLREFRQKLAEAS
RQKTAKIREKLRANG
>Mature_174_residues
TQVSFDAQAPLVGILMGSDSDFDIMKEAATVLNEFGIPFEISVISAHRTPGDLEAYASSAEERGLKAIIAGAGGAAHLPG
VTAAMTPLPVIGVPIYSKKLSGQDSLYAIVQMPAGIPVATVGIDNARNAALLAVQMLALCDASLMQKLREFRQKLAEASR
QKTAKIREKLRANG

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=144, Percent_Identity=50.6944444444444, Blast_Score=131, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324702, Length=158, Percent_Identity=58.8607594936709, Blast_Score=191, Evalue=4e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 18408; Mature: 18276

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQVSFDAQAPLVGILMGSDSDFDIMKEAATVLNEFGIPFEISVISAHRTPGDLEAYASS
CCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHH
AEERGLKAIIAGAGGAAHLPGVTAAMTPLPVIGVPIYSKKLSGQDSLYAIVQMPAGIPVA
HHHCCCEEEEECCCCCCCCCCCHHHHCCCCEECCCHHHHCCCCCCCEEEEEECCCCCEEE
TVGIDNARNAALLAVQMLALCDASLMQKLREFRQKLAEASRQKTAKIREKLRANG
EECCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQVSFDAQAPLVGILMGSDSDFDIMKEAATVLNEFGIPFEISVISAHRTPGDLEAYASS
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHH
AEERGLKAIIAGAGGAAHLPGVTAAMTPLPVIGVPIYSKKLSGQDSLYAIVQMPAGIPVA
HHHCCCEEEEECCCCCCCCCCCHHHHCCCCEECCCHHHHCCCCCCCEEEEEECCCCCEEE
TVGIDNARNAALLAVQMLALCDASLMQKLREFRQKLAEASRQKTAKIREKLRANG
EECCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]