Click here to switch to the map view.

The map label for this gene is lpxB [H]

Identifier: 21673119

GI number: 21673119

Start: 291176

End: 292324

Strand: Direct

Name: lpxB [H]

Synonym: CT0280

Alternate gene names: 21673119

Gene position: 291176-292324 (Clockwise)

Preceding gene: 21673113

Following gene: 21673120

Centisome position: 13.51

GC content: 60.84

Gene sequence:

>1149_bases
ATGACGTGCCGAAGGAAGCTTTTCGTTCTGGCCGGTGAGGTCTCTGGCGACCTTCATGCGGCAGGCCCCGTGCGCGAGCT
GCTCGCGGCCCGGCCCGATACGAAAGTGTTCGGCGTCGGCGGACGCAAGCTGGCCGAACTTGGTGCGGAACTGCTTTACA
CCACCGACCAGATGAGCATCATGGGTTTTGTGGAGGTGCTCAAACACGCGGCGTTCCTGCGCAAGGCGATCCGCGAACTC
AAGGCGGCCATCGTGCGTGAAAAGCCCGATGCGGCGCTCCTCATCGACTATCCCGGCATGAACCTGCATCTGGCGGCTTT
TCTGAAGAAACAGGGGGTTCCGGTGATCTACTACATCTCCCCGCAGGTGTGGGCGTGGAAGGAGCGGCGGGTCGAGAAGA
TTCGCGCCTGCGTTGACCGGTTGCTGGTGATTTTCGACTTCGAGGTGGAGTTTTACCGTCGCCATGGCATCGATGCGGAG
TTCGTCGGCAATCCGGTTGTCGAGGAGCTGGCGGAGCTGAAGTTCGCGCCCAAGCCTGAGTTCCTCGCGCGGATGGGCAT
CGATTCCGACGCCCGCATCGTCGGACTGCTGCCAGGCAGCCGCAAGCAGGAAATCGAGAAGATTTTCCCCGAAATGCTCG
GCGCGGCAAAACACATCGGCGAGCAGGGCAAAACCGTCTTCCTGCTCGGCAGGTCGCCGCACATCGATCCAGCGCTCTAC
GATCGGTACCTCCGAGAGGCGGGCATCGAGCCGCTCGACTGCACGTCGTACGAAGTAATGCGGTACAGTGATCTGGAGCT
GGTCACCTCCGGTACGGCGACGCTCGAATCGCTTTGCTTCGCCGTGCCGATGGTGGTGCTCTACAAGACCTCGCCGCTGA
ACTATTTCATCGGCAAGCGGCTGGTGAAGCTCCACAACATCGCGCTGGCCAACATCGTTGCCTGCGGATTGCTGTCGGAA
AAACAGGCCGTGCCAGAGCTGATCCAGCACGAGGCGAACGCCGGAAACATCAGCAGGAAGGTGCTGGAAATTCTTTGTAA
TGACGCCGTATCGTCGTCGATGCGGCGCGAACTCAGGGAGGCGCGGGGGCGGCTTTCCTCGGATTCGCCCTCACGCCATG
TGGCCGCCGTGCTGTTTGAATATTTATGA

Upstream 100 bases:

>100_bases
TTGATATAATGGTGTTGACTGGCCAAGGCCTTTTCCGGTATCCGGAAGCGCAAACGTGACACAAAATACGGTTTTCTGTT
CGATGATGCAATCAACGCAG

Downstream 100 bases:

>100_bases
CCTGCCAACCATGACTACGATTATCAACTACCTGACCGCTCATCCGGTGGTGCTTGGCATCGCGGTGATCTTTTCGCTTT
TGATTGTGCTTTCGTTTGCA

Product: lipid-A-disaccharide synthase, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MTCRRKLFVLAGEVSGDLHAAGPVRELLAARPDTKVFGVGGRKLAELGAELLYTTDQMSIMGFVEVLKHAAFLRKAIREL
KAAIVREKPDAALLIDYPGMNLHLAAFLKKQGVPVIYYISPQVWAWKERRVEKIRACVDRLLVIFDFEVEFYRRHGIDAE
FVGNPVVEELAELKFAPKPEFLARMGIDSDARIVGLLPGSRKQEIEKIFPEMLGAAKHIGEQGKTVFLLGRSPHIDPALY
DRYLREAGIEPLDCTSYEVMRYSDLELVTSGTATLESLCFAVPMVVLYKTSPLNYFIGKRLVKLHNIALANIVACGLLSE
KQAVPELIQHEANAGNISRKVLEILCNDAVSSSMRRELREARGRLSSDSPSRHVAAVLFEYL

Sequences:

>Translated_382_residues
MTCRRKLFVLAGEVSGDLHAAGPVRELLAARPDTKVFGVGGRKLAELGAELLYTTDQMSIMGFVEVLKHAAFLRKAIREL
KAAIVREKPDAALLIDYPGMNLHLAAFLKKQGVPVIYYISPQVWAWKERRVEKIRACVDRLLVIFDFEVEFYRRHGIDAE
FVGNPVVEELAELKFAPKPEFLARMGIDSDARIVGLLPGSRKQEIEKIFPEMLGAAKHIGEQGKTVFLLGRSPHIDPALY
DRYLREAGIEPLDCTSYEVMRYSDLELVTSGTATLESLCFAVPMVVLYKTSPLNYFIGKRLVKLHNIALANIVACGLLSE
KQAVPELIQHEANAGNISRKVLEILCNDAVSSSMRRELREARGRLSSDSPSRHVAAVLFEYL
>Mature_381_residues
TCRRKLFVLAGEVSGDLHAAGPVRELLAARPDTKVFGVGGRKLAELGAELLYTTDQMSIMGFVEVLKHAAFLRKAIRELK
AAIVREKPDAALLIDYPGMNLHLAAFLKKQGVPVIYYISPQVWAWKERRVEKIRACVDRLLVIFDFEVEFYRRHGIDAEF
VGNPVVEELAELKFAPKPEFLARMGIDSDARIVGLLPGSRKQEIEKIFPEMLGAAKHIGEQGKTVFLLGRSPHIDPALYD
RYLREAGIEPLDCTSYEVMRYSDLELVTSGTATLESLCFAVPMVVLYKTSPLNYFIGKRLVKLHNIALANIVACGLLSEK
QAVPELIQHEANAGNISRKVLEILCNDAVSSSMRRELREARGRLSSDSPSRHVAAVLFEYL

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=389, Percent_Identity=32.3907455012853, Blast_Score=180, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42662; Mature: 42531

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTCRRKLFVLAGEVSGDLHAAGPVRELLAARPDTKVFGVGGRKLAELGAELLYTTDQMSI
CCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCHHHH
MGFVEVLKHAAFLRKAIRELKAAIVREKPDAALLIDYPGMNLHLAAFLKKQGVPVIYYIS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEC
PQVWAWKERRVEKIRACVDRLLVIFDFEVEFYRRHGIDAEFVGNPVVEELAELKFAPKPE
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHCCCHHHHHHHHCCCCCCHH
FLARMGIDSDARIVGLLPGSRKQEIEKIFPEMLGAAKHIGEQGKTVFLLGRSPHIDPALY
HHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHH
DRYLREAGIEPLDCTSYEVMRYSDLELVTSGTATLESLCFAVPMVVLYKTSPLNYFIGKR
HHHHHHCCCCCCCCCCHHHHEECCCCEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LVKLHNIALANIVACGLLSEKQAVPELIQHEANAGNISRKVLEILCNDAVSSSMRRELRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ARGRLSSDSPSRHVAAVLFEYL
HHCCCCCCCCHHHHHHHHHHHC
>Mature Secondary Structure 
TCRRKLFVLAGEVSGDLHAAGPVRELLAARPDTKVFGVGGRKLAELGAELLYTTDQMSI
CCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCHHHH
MGFVEVLKHAAFLRKAIRELKAAIVREKPDAALLIDYPGMNLHLAAFLKKQGVPVIYYIS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEC
PQVWAWKERRVEKIRACVDRLLVIFDFEVEFYRRHGIDAEFVGNPVVEELAELKFAPKPE
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHCCCHHHHHHHHCCCCCCHH
FLARMGIDSDARIVGLLPGSRKQEIEKIFPEMLGAAKHIGEQGKTVFLLGRSPHIDPALY
HHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHH
DRYLREAGIEPLDCTSYEVMRYSDLELVTSGTATLESLCFAVPMVVLYKTSPLNYFIGKR
HHHHHHCCCCCCCCCCHHHHEECCCCEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LVKLHNIALANIVACGLLSEKQAVPELIQHEANAGNISRKVLEILCNDAVSSSMRRELRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ARGRLSSDSPSRHVAAVLFEYL
HHCCCCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA