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The map label for this gene is gmk

Identifier: 21673086

GI number: 21673086

Start: 258269

End: 258856

Strand: Direct

Name: gmk

Synonym: CT0247

Alternate gene names: 21673086

Gene position: 258269-258856 (Clockwise)

Preceding gene: 21673085

Following gene: 21673087

Centisome position: 11.98

GC content: 55.78

Gene sequence:

>588_bases
ATGAGCGCAGAACAGGTTTTGGACCAGGGCAGGCTGATCGTCTTTTCCGCGCCTTCCGGCACCGGGAAATCGACGGTTGC
AAAACTCGTGATGGAGCGTCTCGGCTCTCTCGAATTTTCTGTTTCGGCTACCACGCGCCAGATGAGAGCTGGCGAGCGCG
ATGGCGTCGATTACCACTTTCTCTCCCGCGAAGAGTTTGAGAAAAAGATCGCTGAAAATGGCTTCATCGAACACGAGTTC
TTTTTCGGTAACTTCTATGGGACGCTCCTCGACAAGACCATCGATGCGATCAAAGCGGGCCACAATCTGCTTTTCGATCT
CGATGTGAAGGGTGCGCTGAACCTCAAGAGAATTTTTGGAGACCAGGCGCTGCTCGTTTTCCTCAAACCCCCAAGCATGG
AGGAGCTTGCCCGCCGCCTGCAGGCGCGCGATAGCGAGAGTGCCGAAGCGCTGAAAAGCCGTCTCGAACGAGCGGAGATG
GAGCTTTCCCATGCCGGAGAGTTCGATTTTGTCGTGGTCAACGACGATCTCGGGCGCACCGTCGATGCGGTTGCGACGCG
GATCGCCGAGTTTCTTCCACAACCATAA

Upstream 100 bases:

>100_bases
GCGTCCAAGTCGCAGAATGCCGATATTTCGCAGAAAGTGGTGCATATCAAGGAGGAGCTCGAAAAGGTCAGGGAGCAGTT
GCAAAACATCGAATGAGTCT

Downstream 100 bases:

>100_bases
CGCACTATTGCCATGTCGGTCAAACCTGTCGATTTGAACAAGCTGAGAAGTACGCATGAAAATCTCTACGAAACCGTTGT
AGCCATTTCAAAGAAAGCGA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MSAEQVLDQGRLIVFSAPSGTGKSTVAKLVMERLGSLEFSVSATTRQMRAGERDGVDYHFLSREEFEKKIAENGFIEHEF
FFGNFYGTLLDKTIDAIKAGHNLLFDLDVKGALNLKRIFGDQALLVFLKPPSMEELARRLQARDSESAEALKSRLERAEM
ELSHAGEFDFVVVNDDLGRTVDAVATRIAEFLPQP

Sequences:

>Translated_195_residues
MSAEQVLDQGRLIVFSAPSGTGKSTVAKLVMERLGSLEFSVSATTRQMRAGERDGVDYHFLSREEFEKKIAENGFIEHEF
FFGNFYGTLLDKTIDAIKAGHNLLFDLDVKGALNLKRIFGDQALLVFLKPPSMEELARRLQARDSESAEALKSRLERAEM
ELSHAGEFDFVVVNDDLGRTVDAVATRIAEFLPQP
>Mature_194_residues
SAEQVLDQGRLIVFSAPSGTGKSTVAKLVMERLGSLEFSVSATTRQMRAGERDGVDYHFLSREEFEKKIAENGFIEHEFF
FGNFYGTLLDKTIDAIKAGHNLLFDLDVKGALNLKRIFGDQALLVFLKPPSMEELARRLQARDSESAEALKSRLERAEME
LSHAGEFDFVVVNDDLGRTVDAVATRIAEFLPQP

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=172, Percent_Identity=41.8604651162791, Blast_Score=120, Evalue=8e-28,
Organism=Homo sapiens, GI4504221, Length=172, Percent_Identity=41.8604651162791, Blast_Score=120, Evalue=8e-28,
Organism=Homo sapiens, GI226874831, Length=172, Percent_Identity=41.8604651162791, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI38570142, Length=198, Percent_Identity=32.3232323232323, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI111154074, Length=163, Percent_Identity=30.6748466257669, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI21361598, Length=199, Percent_Identity=26.6331658291457, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI14780902, Length=189, Percent_Identity=28.042328042328, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI261862237, Length=156, Percent_Identity=32.0512820512821, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI119943106, Length=139, Percent_Identity=35.2517985611511, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI119943108, Length=156, Percent_Identity=32.0512820512821, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI52630447, Length=194, Percent_Identity=24.2268041237113, Blast_Score=64, Evalue=6e-11,
Organism=Homo sapiens, GI262118263, Length=172, Percent_Identity=27.3255813953488, Blast_Score=64, Evalue=8e-11,
Organism=Homo sapiens, GI262118259, Length=172, Percent_Identity=27.3255813953488, Blast_Score=64, Evalue=9e-11,
Organism=Homo sapiens, GI262118255, Length=172, Percent_Identity=27.3255813953488, Blast_Score=64, Evalue=9e-11,
Organism=Homo sapiens, GI4505237, Length=172, Percent_Identity=27.3255813953488, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1790080, Length=182, Percent_Identity=38.4615384615385, Blast_Score=128, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17508835, Length=174, Percent_Identity=39.6551724137931, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI193203132, Length=174, Percent_Identity=39.6551724137931, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320662, Length=172, Percent_Identity=44.7674418604651, Blast_Score=141, Evalue=5e-35,
Organism=Drosophila melanogaster, GI21356141, Length=171, Percent_Identity=40.3508771929825, Blast_Score=114, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24640542, Length=172, Percent_Identity=30.8139534883721, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI161077626, Length=188, Percent_Identity=29.2553191489362, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI116007136, Length=172, Percent_Identity=30.8139534883721, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45554489, Length=172, Percent_Identity=30.8139534883721, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI85724806, Length=172, Percent_Identity=30.8139534883721, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45554481, Length=172, Percent_Identity=30.8139534883721, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_CHLTE (Q8KFS5)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_661151.1
- ProteinModelPortal:   Q8KFS5
- GeneID:   1007740
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0247
- NMPDR:   fig|194439.1.peg.245
- TIGR:   CT0247
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- ProtClustDB:   PRK00300
- BioCyc:   CTEP194439:CT_0247-MONOMER
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 21773; Mature: 21642

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAEQVLDQGRLIVFSAPSGTGKSTVAKLVMERLGSLEFSVSATTRQMRAGERDGVDYHF
CCHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCEEE
LSREEFEKKIAENGFIEHEFFFGNFYGTLLDKTIDAIKAGHNLLFDLDVKGALNLKRIFG
CCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHC
DQALLVFLKPPSMEELARRLQARDSESAEALKSRLERAEMELSHAGEFDFVVVNDDLGRT
CCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHH
VDAVATRIAEFLPQP
HHHHHHHHHHHCCCC
>Mature Secondary Structure 
SAEQVLDQGRLIVFSAPSGTGKSTVAKLVMERLGSLEFSVSATTRQMRAGERDGVDYHF
CHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCEEE
LSREEFEKKIAENGFIEHEFFFGNFYGTLLDKTIDAIKAGHNLLFDLDVKGALNLKRIFG
CCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHC
DQALLVFLKPPSMEELARRLQARDSESAEALKSRLERAEMELSHAGEFDFVVVNDDLGRT
CCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHH
VDAVATRIAEFLPQP
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901