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The map label for this gene is serB [H]

Identifier: 21673014

GI number: 21673014

Start: 180464

End: 181687

Strand: Reverse

Name: serB [H]

Synonym: CT0173

Alternate gene names: 21673014

Gene position: 181687-180464 (Counterclockwise)

Preceding gene: 21673016

Following gene: 21673013

Centisome position: 8.43

GC content: 60.7

Gene sequence:

>1224_bases
ATGCACGAACTGCTGCTCATCAACATTTCCGGGCCGGACAAGCCGGGCCTGACCTCCAAAATTACCGAAGTGCTTGCACG
ATACAACGTGCCGGTGCTCGACATCGGCCAGTCGGTCATTCACAACCACCTCTCGCTCGGGATGCTCATCGAGGTGCCGA
AAGCCTCCGCCTCCGCGCCGATCCTGAAAGACCTGCTCTTCACGGCGCACACGCTCAAGCTGGAGATCGAGTTTTCACCC
ATCTCCACGCGCGACTACCACAAATGGGTTGGCGAACAGGGCAAGCCGCGCTACCTGCTCTCGCTGCTCGGCAGAAAAAT
CACGTCGGAACATCTCGAACGGGTCACCACGCTGGTCGCCAGCCACGGCTTCAACATCGACACGATCAACCGCCTCTCGG
GCCGTCTGCCGCTCAAGGACGAGGGCGATTCCGGCAAAACAAAAGCCTGCATCGAGTTTTCGCTGAGGGGTGCACCCGCA
AACGAAGAACAGTTCAGAACTGAAATGCTGGCCATCACCGACAGCCTCGGCATCGACATCGCCTTCCAGGAGGACAACAT
CTTCCGGCGGACGCGACGGCTCGTGGTGTTCGACATGGACTCAACGCTGATTACGTCAGAGGTGATCGACGAACTGGCCA
AAGAGGCCGGATCAGGCGAGCTGGTGGCGGCGATCACCGAGCAGGCGATGCGCGGCGAACTCGACTTCACCGAGAGCCTG
AAAAAGCGCGTCGGCACGCTGGCGGGGCTGGAAGAATCGACGCTGCAGAAGGTGGCCGAGCGGCTGCAACTGACCGAAGG
CGCCGAGCACCTCTTCTACAACCTGCATCGCCTCGGCTTCAAAACCGCCATCCTCTCCGGCGGCTTCACCTACTTCGGGC
GCTACTTGCAGAAAAAGCTCAACATCGACTACGTCTTCGCCAACGAGCTTGAAATCGTGGACGGCAAGATGACCGGCAAC
GTCATCGGTCAGGTGGTCGATGGCAAGCGCAAGGCGGAGCTGCTCGAGCAGATCGCCGCCACGGAAAACATCCGCCTCGA
ACAGACCGTTGCGGTCGGCGATGGCGCCAACGACCTGCCAATGCTCGGCAAAGCCGGACTCGGCATCGCCTTCCGCGCCA
AGCCAATCGTACGCGAAACCGCAAAACAGGCGATCTCAACGCTCGGCCTCGACGCCATTCTCTATCTGATGGGATTCCGC
GACCGCGACGCGCTGGCGGTGTAG

Upstream 100 bases:

>100_bases
CCATGCTTTGTCCGCAAACTGGGCGGAATCATAAATCATTACAAGGCAACGCCTTGCCTCTTCCCCTCCACCGACGAGGA
CTAACCGAGAATTTCAGCAC

Downstream 100 bases:

>100_bases
AGAATCCAGCATTCCCGGCGTACGGAAATCATGAGGCCTGTCAGCCCCCTCCTCATGTTCCCGAAGAACAGTTCTTTTAT
GATATATTGTTCATGAAACC

Product: phosphoserine phosphatase

Products: NA

Alternate protein names: PSP; PSPase; O-phosphoserine phosphohydrolase [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MHELLLINISGPDKPGLTSKITEVLARYNVPVLDIGQSVIHNHLSLGMLIEVPKASASAPILKDLLFTAHTLKLEIEFSP
ISTRDYHKWVGEQGKPRYLLSLLGRKITSEHLERVTTLVASHGFNIDTINRLSGRLPLKDEGDSGKTKACIEFSLRGAPA
NEEQFRTEMLAITDSLGIDIAFQEDNIFRRTRRLVVFDMDSTLITSEVIDELAKEAGSGELVAAITEQAMRGELDFTESL
KKRVGTLAGLEESTLQKVAERLQLTEGAEHLFYNLHRLGFKTAILSGGFTYFGRYLQKKLNIDYVFANELEIVDGKMTGN
VIGQVVDGKRKAELLEQIAATENIRLEQTVAVGDGANDLPMLGKAGLGIAFRAKPIVRETAKQAISTLGLDAILYLMGFR
DRDALAV

Sequences:

>Translated_407_residues
MHELLLINISGPDKPGLTSKITEVLARYNVPVLDIGQSVIHNHLSLGMLIEVPKASASAPILKDLLFTAHTLKLEIEFSP
ISTRDYHKWVGEQGKPRYLLSLLGRKITSEHLERVTTLVASHGFNIDTINRLSGRLPLKDEGDSGKTKACIEFSLRGAPA
NEEQFRTEMLAITDSLGIDIAFQEDNIFRRTRRLVVFDMDSTLITSEVIDELAKEAGSGELVAAITEQAMRGELDFTESL
KKRVGTLAGLEESTLQKVAERLQLTEGAEHLFYNLHRLGFKTAILSGGFTYFGRYLQKKLNIDYVFANELEIVDGKMTGN
VIGQVVDGKRKAELLEQIAATENIRLEQTVAVGDGANDLPMLGKAGLGIAFRAKPIVRETAKQAISTLGLDAILYLMGFR
DRDALAV
>Mature_407_residues
MHELLLINISGPDKPGLTSKITEVLARYNVPVLDIGQSVIHNHLSLGMLIEVPKASASAPILKDLLFTAHTLKLEIEFSP
ISTRDYHKWVGEQGKPRYLLSLLGRKITSEHLERVTTLVASHGFNIDTINRLSGRLPLKDEGDSGKTKACIEFSLRGAPA
NEEQFRTEMLAITDSLGIDIAFQEDNIFRRTRRLVVFDMDSTLITSEVIDELAKEAGSGELVAAITEQAMRGELDFTESL
KKRVGTLAGLEESTLQKVAERLQLTEGAEHLFYNLHRLGFKTAILSGGFTYFGRYLQKKLNIDYVFANELEIVDGKMTGN
VIGQVVDGKRKAELLEQIAATENIRLEQTVAVGDGANDLPMLGKAGLGIAFRAKPIVRETAKQAISTLGLDAILYLMGFR
DRDALAV

Specific function: Unknown

COG id: COG0560

COG function: function code E; Phosphoserine phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serB family [H]

Homologues:

Organism=Homo sapiens, GI46249388, Length=200, Percent_Identity=30.5, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1790849, Length=196, Percent_Identity=58.1632653061224, Blast_Score=218, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI115534454, Length=223, Percent_Identity=31.390134529148, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI115534456, Length=223, Percent_Identity=31.390134529148, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321647, Length=243, Percent_Identity=41.9753086419753, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24661601, Length=199, Percent_Identity=30.1507537688442, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006383
- InterPro:   IPR023190
- InterPro:   IPR004469 [H]

Pfam domain/function: PF01842 ACT; PF00702 Hydrolase [H]

EC number: =3.1.3.3 [H]

Molecular weight: Translated: 44859; Mature: 44859

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHELLLINISGPDKPGLTSKITEVLARYNVPVLDIGQSVIHNHLSLGMLIEVPKASASAP
CCCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHCCHHHHHHHHCCCEEEEECCCCCCCH
ILKDLLFTAHTLKLEIEFSPISTRDYHKWVGEQGKPRYLLSLLGRKITSEHLERVTTLVA
HHHHHHHHHEEEEEEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SHGFNIDTINRLSGRLPLKDEGDSGKTKACIEFSLRGAPANEEQFRTEMLAITDSLGIDI
HCCCCCCHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEE
AFQEDNIFRRTRRLVVFDMDSTLITSEVIDELAKEAGSGELVAAITEQAMRGELDFTESL
EECCCHHHHHCCEEEEEECCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCHHHHH
KKRVGTLAGLEESTLQKVAERLQLTEGAEHLFYNLHRLGFKTAILSGGFTYFGRYLQKKL
HHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
NIDYVFANELEIVDGKMTGNVIGQVVDGKRKAELLEQIAATENIRLEQTVAVGDGANDLP
CEEEEEECCEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCC
MLGKAGLGIAFRAKPIVRETAKQAISTLGLDAILYLMGFRDRDALAV
CCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MHELLLINISGPDKPGLTSKITEVLARYNVPVLDIGQSVIHNHLSLGMLIEVPKASASAP
CCCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHCCHHHHHHHHCCCEEEEECCCCCCCH
ILKDLLFTAHTLKLEIEFSPISTRDYHKWVGEQGKPRYLLSLLGRKITSEHLERVTTLVA
HHHHHHHHHEEEEEEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SHGFNIDTINRLSGRLPLKDEGDSGKTKACIEFSLRGAPANEEQFRTEMLAITDSLGIDI
HCCCCCCHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEE
AFQEDNIFRRTRRLVVFDMDSTLITSEVIDELAKEAGSGELVAAITEQAMRGELDFTESL
EECCCHHHHHCCEEEEEECCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCHHHHH
KKRVGTLAGLEESTLQKVAERLQLTEGAEHLFYNLHRLGFKTAILSGGFTYFGRYLQKKL
HHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
NIDYVFANELEIVDGKMTGNVIGQVVDGKRKAELLEQIAATENIRLEQTVAVGDGANDLP
CEEEEEECCEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCC
MLGKAGLGIAFRAKPIVRETAKQAISTLGLDAILYLMGFRDRDALAV
CCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA