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The map label for this gene is guaA

Identifier: 21673016

GI number: 21673016

Start: 182906

End: 184456

Strand: Reverse

Name: guaA

Synonym: CT0175

Alternate gene names: 21673016

Gene position: 184456-182906 (Counterclockwise)

Preceding gene: 21673017

Following gene: 21673014

Centisome position: 8.56

GC content: 61.7

Gene sequence:

>1551_bases
ATGGCAACATCCCTGCAATCGGTCATCGTCCTCGATTTCGGTTCACAGTACACTCAGCTCATCGCACGGCGCATCCGCGA
GATCGGCATCTACTCCGAGATTTTTCCGTACCACACAAAGGCCGAAACCATCCGGGCGCATCAGCCGAAAGCGATCATCC
TCTCCGGCGGCCCGAACAGCGTCTATGACGAAAAAGCATTCATGCCCGACCCGGAGGTGTTCAGCCTCGGCGTGCCGGTG
CTCGGCATCTGCTACGGCCTGCAGGCCATCGCCAAGCACTTCGGCGGCAACGTCGAAAGCTCCTCGAAGCAGGAGTTCGG
ACGCGCCAAGATGCTGGTGAACCACGACGAGAGCGAGAGCCTGCTCTTCCGCGACATCCCCGATTCGGACGTCTGGATGA
GCCATGGCGACAAGGTGACGCAGCTGCCGGAGGGCTTCCGCGTGACGGCGAGCACCGCGAATGCCGAGGTGTGCGCCATC
GAGAGCTTCGGCAGCAAAGCCGCGCTCAAGGTCTATGGCTTGCAGTTTCACCCCGAAGTGCAACACTCGCTCTACGGCAA
GCAGCTGCTCTCGAACTTTTTGATCGACATCGCGGGCATCACGCCGGACTGGTCGCCGAAGAGCTTCATCCAGCACCAGA
TCGAGGAGATCAAGCGGGTTGCGGGCGACTCGACCGTGGTGTGCGGCATCAGCGGCGGCGTCGATTCCACGGTGGCCGCC
GTGCTCGTCAGCAAGGCGATCGGCGACAAGCTGCACTGCGTCTTTGTTGACAACGGCCTGCTCCGCAAGGATGAAGCGGT
GAAGGTGATGGAGTTCCTCAAGCCGCTCGGTCTGAACATTTCGCTCGTCGACGCCAGCGATCTCTTTTTAGGGCGACTCA
AAGGCGTAGCCTCGCCAGAGAAGAAGCGCAAGATCATCGGGCGCACCTTCATTCAGGTGTTCGAAAAGAACATTCACGAC
GAGAAGTTCCTCGTGCAGGGCACGCTCTACCCGGACGTGATCGAGAGCGTCAGCGTGAAAGGACCGTCCGAGACGATCAA
GTCGCACCACAACGTCGGCGGCCTGCCGAAGCGCATGAAGCTCAAGCTCATCGAGCCGCTGCGCGAGCTGTTCAAGGATG
AAGTCCGCGCCGTCGGACGCGAGCTTGGCATCGCCGAGGACATCCTGATGCGCCACCCCTTCCCCGGCCCCGGCCTCGCC
GTGCGCGTGCTCGGCTCGCTCACGCGGGAGCGCCTCGACGTGCTGCGCGACGCCGACCAGATTTTCATCGACGAGCTGAA
GTCGAGCGGCCTCTACTCGAAGGTGTGGCAGGCCTTCTCGGTGCTCCTGCCGGTGCAGTCGGTCGGCGTGATGGGCGACA
AACGCACCTACGAAAACGTGCTCGCCTTGCGAGCCGTGGAATCCACCGACGGCATGACCGCCGACTGGGCGCACCTCCCC
CACGACTTCCTCGCCAAAGTCTCGAACCGCATCATCAACGAAGTGAGAGGCATCAACCGTGTGGTATACGATATTTCCTC
GAAACCGCCAGCCACGATCGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
CAGCACCGACAGCACCGACAGCACCGGCAAGCACCGACAGCACCGGCAGCCGCGCCCGCAGATAATTTTTAAACAATACT
TTACCGGTTTCACATCAACC

Downstream 100 bases:

>100_bases
GAAGGGAGAACGATTTATTGGATATGAAAAAACCCCGTCGATTTCGGCGGGGTTTTGTTGTGTTGGGGAGTAGGGAAGGA
AGGTACTCGGTCAATTACTA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MATSLQSVIVLDFGSQYTQLIARRIREIGIYSEIFPYHTKAETIRAHQPKAIILSGGPNSVYDEKAFMPDPEVFSLGVPV
LGICYGLQAIAKHFGGNVESSSKQEFGRAKMLVNHDESESLLFRDIPDSDVWMSHGDKVTQLPEGFRVTASTANAEVCAI
ESFGSKAALKVYGLQFHPEVQHSLYGKQLLSNFLIDIAGITPDWSPKSFIQHQIEEIKRVAGDSTVVCGISGGVDSTVAA
VLVSKAIGDKLHCVFVDNGLLRKDEAVKVMEFLKPLGLNISLVDASDLFLGRLKGVASPEKKRKIIGRTFIQVFEKNIHD
EKFLVQGTLYPDVIESVSVKGPSETIKSHHNVGGLPKRMKLKLIEPLRELFKDEVRAVGRELGIAEDILMRHPFPGPGLA
VRVLGSLTRERLDVLRDADQIFIDELKSSGLYSKVWQAFSVLLPVQSVGVMGDKRTYENVLALRAVESTDGMTADWAHLP
HDFLAKVSNRIINEVRGINRVVYDISSKPPATIEWE

Sequences:

>Translated_516_residues
MATSLQSVIVLDFGSQYTQLIARRIREIGIYSEIFPYHTKAETIRAHQPKAIILSGGPNSVYDEKAFMPDPEVFSLGVPV
LGICYGLQAIAKHFGGNVESSSKQEFGRAKMLVNHDESESLLFRDIPDSDVWMSHGDKVTQLPEGFRVTASTANAEVCAI
ESFGSKAALKVYGLQFHPEVQHSLYGKQLLSNFLIDIAGITPDWSPKSFIQHQIEEIKRVAGDSTVVCGISGGVDSTVAA
VLVSKAIGDKLHCVFVDNGLLRKDEAVKVMEFLKPLGLNISLVDASDLFLGRLKGVASPEKKRKIIGRTFIQVFEKNIHD
EKFLVQGTLYPDVIESVSVKGPSETIKSHHNVGGLPKRMKLKLIEPLRELFKDEVRAVGRELGIAEDILMRHPFPGPGLA
VRVLGSLTRERLDVLRDADQIFIDELKSSGLYSKVWQAFSVLLPVQSVGVMGDKRTYENVLALRAVESTDGMTADWAHLP
HDFLAKVSNRIINEVRGINRVVYDISSKPPATIEWE
>Mature_515_residues
ATSLQSVIVLDFGSQYTQLIARRIREIGIYSEIFPYHTKAETIRAHQPKAIILSGGPNSVYDEKAFMPDPEVFSLGVPVL
GICYGLQAIAKHFGGNVESSSKQEFGRAKMLVNHDESESLLFRDIPDSDVWMSHGDKVTQLPEGFRVTASTANAEVCAIE
SFGSKAALKVYGLQFHPEVQHSLYGKQLLSNFLIDIAGITPDWSPKSFIQHQIEEIKRVAGDSTVVCGISGGVDSTVAAV
LVSKAIGDKLHCVFVDNGLLRKDEAVKVMEFLKPLGLNISLVDASDLFLGRLKGVASPEKKRKIIGRTFIQVFEKNIHDE
KFLVQGTLYPDVIESVSVKGPSETIKSHHNVGGLPKRMKLKLIEPLRELFKDEVRAVGRELGIAEDILMRHPFPGPGLAV
RVLGSLTRERLDVLRDADQIFIDELKSSGLYSKVWQAFSVLLPVQSVGVMGDKRTYENVLALRAVESTDGMTADWAHLPH
DFLAKVSNRIINEVRGINRVVYDISSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=554, Percent_Identity=38.8086642599278, Blast_Score=326, Evalue=3e-89,
Organism=Escherichia coli, GI1788854, Length=523, Percent_Identity=54.4933078393882, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI1789760, Length=201, Percent_Identity=28.8557213930348, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71992717, Length=579, Percent_Identity=35.9240069084629, Blast_Score=300, Evalue=8e-82,
Organism=Caenorhabditis elegans, GI71992710, Length=579, Percent_Identity=35.9240069084629, Blast_Score=300, Evalue=9e-82,
Organism=Caenorhabditis elegans, GI133901714, Length=579, Percent_Identity=35.5785837651123, Blast_Score=300, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6323873, Length=526, Percent_Identity=53.6121673003802, Blast_Score=566, Evalue=1e-162,
Organism=Drosophila melanogaster, GI281365319, Length=553, Percent_Identity=36.3471971066908, Blast_Score=305, Evalue=4e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_CHLTE (Q8KFZ5)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_661081.1
- ProteinModelPortal:   Q8KFZ5
- SMR:   Q8KFZ5
- GeneID:   1007589
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0175
- NMPDR:   fig|194439.1.peg.175
- TIGR:   CT0175
- HOGENOM:   HBG391775
- OMA:   QDICGCE
- ProtClustDB:   PRK00074
- BioCyc:   CTEP194439:CT_0175-MONOMER
- BRENDA:   6.3.5.2
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 57025; Mature: 56894

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 84-84 ACT_SITE 177-177 ACT_SITE 179-179

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATSLQSVIVLDFGSQYTQLIARRIREIGIYSEIFPYHTKAETIRAHQPKAIILSGGPNS
CCCCCCEEEEEECCHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHCCCCCEEEEECCCCC
VYDEKAFMPDPEVFSLGVPVLGICYGLQAIAKHFGGNVESSSKQEFGRAKMLVNHDESES
CCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCHHHEEEECCCCCC
LLFRDIPDSDVWMSHGDKVTQLPEGFRVTASTANAEVCAIESFGSKAALKVYGLQFHPEV
EEEECCCCCCCHHCCCCCHHCCCCCCEEEEECCCCEEEEEECCCCCCEEEEEEEEECCHH
QHSLYGKQLLSNFLIDIAGITPDWSPKSFIQHQIEEIKRVAGDSTVVCGISGGVDSTVAA
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHH
VLVSKAIGDKLHCVFVDNGLLRKDEAVKVMEFLKPLGLNISLVDASDLFLGRLKGVASPE
HHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCCH
KKRKIIGRTFIQVFEKNIHDEKFLVQGTLYPDVIESVSVKGPSETIKSHHNVGGLPKRMK
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCCCCHHHHHHCCCCCCCCHHHH
LKLIEPLRELFKDEVRAVGRELGIAEDILMRHPFPGPGLAVRVLGSLTRERLDVLRDADQ
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IFIDELKSSGLYSKVWQAFSVLLPVQSVGVMGDKRTYENVLALRAVESTDGMTADWAHLP
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEECCCCCCCCHHHHCC
HDFLAKVSNRIINEVRGINRVVYDISSKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEECCC
>Mature Secondary Structure 
ATSLQSVIVLDFGSQYTQLIARRIREIGIYSEIFPYHTKAETIRAHQPKAIILSGGPNS
CCCCCEEEEEECCHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHCCCCCEEEEECCCCC
VYDEKAFMPDPEVFSLGVPVLGICYGLQAIAKHFGGNVESSSKQEFGRAKMLVNHDESES
CCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCHHHEEEECCCCCC
LLFRDIPDSDVWMSHGDKVTQLPEGFRVTASTANAEVCAIESFGSKAALKVYGLQFHPEV
EEEECCCCCCCHHCCCCCHHCCCCCCEEEEECCCCEEEEEECCCCCCEEEEEEEEECCHH
QHSLYGKQLLSNFLIDIAGITPDWSPKSFIQHQIEEIKRVAGDSTVVCGISGGVDSTVAA
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHH
VLVSKAIGDKLHCVFVDNGLLRKDEAVKVMEFLKPLGLNISLVDASDLFLGRLKGVASPE
HHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCCH
KKRKIIGRTFIQVFEKNIHDEKFLVQGTLYPDVIESVSVKGPSETIKSHHNVGGLPKRMK
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCCCCHHHHHHCCCCCCCCHHHH
LKLIEPLRELFKDEVRAVGRELGIAEDILMRHPFPGPGLAVRVLGSLTRERLDVLRDADQ
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IFIDELKSSGLYSKVWQAFSVLLPVQSVGVMGDKRTYENVLALRAVESTDGMTADWAHLP
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEECCCCCCCCHHHHCC
HDFLAKVSNRIINEVRGINRVVYDISSKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901