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The map label for this gene is pyrG [H]

Identifier: 21672983

GI number: 21672983

Start: 137194

End: 138891

Strand: Direct

Name: pyrG [H]

Synonym: CT0142

Alternate gene names: 21672983

Gene position: 137194-138891 (Clockwise)

Preceding gene: 21672982

Following gene: 21672986

Centisome position: 6.37

GC content: 54.36

Gene sequence:

>1698_bases
ATGGCGCGCCCGAAGAATGTAAAGCATATTTTTGTAACCGGCGGGGTGATCTCCTCTCTTGGAAAGGGCATCCTTTCTGC
TTCGCTTGGCCTTTTGCTCAAGTCCCGCGGATTGCGCGTGGCGATCCAGAAATACGATCCCTACATCAACGTCGATCCCG
GTACGATGTCGCCCTACCAGCATGGCGAGGTTTACGTGACCGACGACGGCGCTGAGACTGATCTCGATCTTGGCCACTAC
GAGCGCTTCCTCGACGAACCGACCTCGCAGGCCTGCAACCTGACGATGGGCCGCGTCTACAAGTCGGTCATCGACAAGGA
GCGGCGCGGCGAATATCTCGGCGGTACGGTGCAGGTCGTGCCCCACGTGATCGACGAGATCAAGGAGAAGATGGGCGATC
TGGCCAAAAATGGTAGCATCGATGTGCTGATCACCGAAATTGGCGGTACCATCGGCGATATCGAGTCGCTTCCCTTCCTC
GAAGCGATGCGCCAGCTCAAGCTCGAACTTGGCGAGCACAATCTGCTCAACATCCACCTTACCTTCGTGCCGTACATCAA
GGCGGCTAGCGAGCTGAAGACCAAGCCGACGCAGCACAGTGTCAAGATGCTGCTCGAAACCGGTATTCAGCCCGACATTC
TGGTCTGCCGGAGCGAGAAGCCGCTGTCGAGGGAGATCAAGAACAAGGTTGGTCACTTCTGCAACGTTCATGACCTGGAC
GTTATCGGCCTCAACGACTGTGATACGATCTACGAAGTGCCGCTCATGCTGCTCAAGGAGCAGCTCGATCTGCGCGTCAT
GAAAAAGCTGGGGTTGAAGAAGTTCCGCGAACCCAATCTGGAGTACTGGAAGAACTTCTGCGAAAAGGTGAAGCATCCGA
AGGATGGCGAGATCACCATTGGCATATGCGGCAAGTACACTGAGTATCCCGACGCCTACAAATCGATTATCGAATCGTTC
ATTCATGCCGGCGCTAGCAATGACGTCAGGGTGTTGGTCAAGATGCTCAGGGCTGAAGATGCCGAAGATCCGAAGTTCGA
TATTTCGAGCGCCTTCAAGGGGATCAGTGGCCTGCTTGTCGCGCCTGGTTTTGGCGACCGTGGCATCGAGGGCAAAGTGC
GTTTCGTTCAGTATGCACGAGAGAACAACATTCCGTTCTTTGGTATCTGCCTCGGCATGCAGTGCGCCACCATCGAATTC
GCCCGCAACATCTGTGACCTGCCCGACGCCAACTCGACCGAGTTCAACAAGCGAACACGTTTTCCGGTCATCGACCTCAT
GGAGCACCAGAAAAAGGTCAAGGAGAAAGGGGGAACGATGCGTCTCGGCAGCTATCCTTGTATTCTGAAGGAGGGTTCGA
AAGCTCATGAGCTCTATGGCAAATTCCTTATCAATGAGCGTCATCGCCACCGGTACGAATTCAACAACCAGTTCCGCAAG
CTTTTCGAAGAGAAAGGAATGATTTTTTCAGGCACCTCGCCGAACGGTGATCTGGTAGAGATCGTTGAACTGAAGAATCA
TCGCTGGTTCGTAGCTGTGCAGTTCCATCCCGAGCTGAAATCGCGAGTGCAGAAAGTGCATCCGCTTTTTGACGGCTTCG
TTCATGCTGCCAAGGAGTTTGCACAAGGCAAGCGCCAGCTCTCTCTTGAGGTCGAAATGCCGAGGCTCAGTTCTACGGAG
ATGGAGAACGCAGGCTGA

Upstream 100 bases:

>100_bases
TTGTGATCCAAACCGGCTGACGAAAGAGGTATTGATCGGAGAGCCGGGCGTTCTCCGGAAATGAATTCGACTGTTATCAC
TTAATTATTGTTAGAAAGGT

Downstream 100 bases:

>100_bases
GTATCTCGCCGTCGCTGATTTTTCTATTATGAGTGGATATTGCTGGTGGAAAAAACCGCGGGCAATGTCCATTTTCTTTT
TTGTGGCAGCCGGATGCAGC

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MARPKNVKHIFVTGGVISSLGKGILSASLGLLLKSRGLRVAIQKYDPYINVDPGTMSPYQHGEVYVTDDGAETDLDLGHY
ERFLDEPTSQACNLTMGRVYKSVIDKERRGEYLGGTVQVVPHVIDEIKEKMGDLAKNGSIDVLITEIGGTIGDIESLPFL
EAMRQLKLELGEHNLLNIHLTFVPYIKAASELKTKPTQHSVKMLLETGIQPDILVCRSEKPLSREIKNKVGHFCNVHDLD
VIGLNDCDTIYEVPLMLLKEQLDLRVMKKLGLKKFREPNLEYWKNFCEKVKHPKDGEITIGICGKYTEYPDAYKSIIESF
IHAGASNDVRVLVKMLRAEDAEDPKFDISSAFKGISGLLVAPGFGDRGIEGKVRFVQYARENNIPFFGICLGMQCATIEF
ARNICDLPDANSTEFNKRTRFPVIDLMEHQKKVKEKGGTMRLGSYPCILKEGSKAHELYGKFLINERHRHRYEFNNQFRK
LFEEKGMIFSGTSPNGDLVEIVELKNHRWFVAVQFHPELKSRVQKVHPLFDGFVHAAKEFAQGKRQLSLEVEMPRLSSTE
MENAG

Sequences:

>Translated_565_residues
MARPKNVKHIFVTGGVISSLGKGILSASLGLLLKSRGLRVAIQKYDPYINVDPGTMSPYQHGEVYVTDDGAETDLDLGHY
ERFLDEPTSQACNLTMGRVYKSVIDKERRGEYLGGTVQVVPHVIDEIKEKMGDLAKNGSIDVLITEIGGTIGDIESLPFL
EAMRQLKLELGEHNLLNIHLTFVPYIKAASELKTKPTQHSVKMLLETGIQPDILVCRSEKPLSREIKNKVGHFCNVHDLD
VIGLNDCDTIYEVPLMLLKEQLDLRVMKKLGLKKFREPNLEYWKNFCEKVKHPKDGEITIGICGKYTEYPDAYKSIIESF
IHAGASNDVRVLVKMLRAEDAEDPKFDISSAFKGISGLLVAPGFGDRGIEGKVRFVQYARENNIPFFGICLGMQCATIEF
ARNICDLPDANSTEFNKRTRFPVIDLMEHQKKVKEKGGTMRLGSYPCILKEGSKAHELYGKFLINERHRHRYEFNNQFRK
LFEEKGMIFSGTSPNGDLVEIVELKNHRWFVAVQFHPELKSRVQKVHPLFDGFVHAAKEFAQGKRQLSLEVEMPRLSSTE
MENAG
>Mature_564_residues
ARPKNVKHIFVTGGVISSLGKGILSASLGLLLKSRGLRVAIQKYDPYINVDPGTMSPYQHGEVYVTDDGAETDLDLGHYE
RFLDEPTSQACNLTMGRVYKSVIDKERRGEYLGGTVQVVPHVIDEIKEKMGDLAKNGSIDVLITEIGGTIGDIESLPFLE
AMRQLKLELGEHNLLNIHLTFVPYIKAASELKTKPTQHSVKMLLETGIQPDILVCRSEKPLSREIKNKVGHFCNVHDLDV
IGLNDCDTIYEVPLMLLKEQLDLRVMKKLGLKKFREPNLEYWKNFCEKVKHPKDGEITIGICGKYTEYPDAYKSIIESFI
HAGASNDVRVLVKMLRAEDAEDPKFDISSAFKGISGLLVAPGFGDRGIEGKVRFVQYARENNIPFFGICLGMQCATIEFA
RNICDLPDANSTEFNKRTRFPVIDLMEHQKKVKEKGGTMRLGSYPCILKEGSKAHELYGKFLINERHRHRYEFNNQFRKL
FEEKGMIFSGTSPNGDLVEIVELKNHRWFVAVQFHPELKSRVQKVHPLFDGFVHAAKEFAQGKRQLSLEVEMPRLSSTEM
ENAG

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=550, Percent_Identity=43.2727272727273, Blast_Score=440, Evalue=1e-123,
Organism=Homo sapiens, GI28559085, Length=551, Percent_Identity=44.2831215970962, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI28559083, Length=551, Percent_Identity=44.2831215970962, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI221316689, Length=551, Percent_Identity=44.2831215970962, Blast_Score=438, Evalue=1e-123,
Organism=Escherichia coli, GI1789142, Length=551, Percent_Identity=51.3611615245009, Blast_Score=540, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI25148299, Length=626, Percent_Identity=36.741214057508, Blast_Score=391, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6322563, Length=563, Percent_Identity=41.3854351687389, Blast_Score=412, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6319432, Length=573, Percent_Identity=39.9650959860384, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24664469, Length=551, Percent_Identity=45.3720508166969, Blast_Score=453, Evalue=1e-127,
Organism=Drosophila melanogaster, GI21357815, Length=495, Percent_Identity=43.4343434343434, Blast_Score=380, Evalue=1e-105,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 63832; Mature: 63700

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARPKNVKHIFVTGGVISSLGKGILSASLGLLLKSRGLRVAIQKYDPYINVDPGTMSPYQ
CCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCC
HGEVYVTDDGAETDLDLGHYERFLDEPTSQACNLTMGRVYKSVIDKERRGEYLGGTVQVV
CCEEEEECCCCCCCCCHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHH
PHVIDEIKEKMGDLAKNGSIDVLITEIGGTIGDIESLPFLEAMRQLKLELGEHNLLNIHL
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEE
TFVPYIKAASELKTKPTQHSVKMLLETGIQPDILVCRSEKPLSREIKNKVGHFCNVHDLD
EEHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCEE
VIGLNDCDTIYEVPLMLLKEQLDLRVMKKLGLKKFREPNLEYWKNFCEKVKHPKDGEITI
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHCCCCCCCEEE
GICGKYTEYPDAYKSIIESFIHAGASNDVRVLVKMLRAEDAEDPKFDISSAFKGISGLLV
EECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCEEE
APGFGDRGIEGKVRFVQYARENNIPFFGICLGMQCATIEFARNICDLPDANSTEFNKRTR
ECCCCCCCCCCCCHHEEEHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
FPVIDLMEHQKKVKEKGGTMRLGSYPCILKEGSKAHELYGKFLINERHRHRYEFNNQFRK
CCHHHHHHHHHHHHHCCCCEEECCCCEEECCCCHHHHHHHHHHHCHHHHHHHHHHHHHHH
LFEEKGMIFSGTSPNGDLVEIVELKNHRWFVAVQFHPELKSRVQKVHPLFDGFVHAAKEF
HHHHCCCEEECCCCCCCEEEEEEECCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
AQGKRQLSLEVEMPRLSSTEMENAG
HCCHHEEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
ARPKNVKHIFVTGGVISSLGKGILSASLGLLLKSRGLRVAIQKYDPYINVDPGTMSPYQ
CCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCC
HGEVYVTDDGAETDLDLGHYERFLDEPTSQACNLTMGRVYKSVIDKERRGEYLGGTVQVV
CCEEEEECCCCCCCCCHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHH
PHVIDEIKEKMGDLAKNGSIDVLITEIGGTIGDIESLPFLEAMRQLKLELGEHNLLNIHL
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEE
TFVPYIKAASELKTKPTQHSVKMLLETGIQPDILVCRSEKPLSREIKNKVGHFCNVHDLD
EEHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCEE
VIGLNDCDTIYEVPLMLLKEQLDLRVMKKLGLKKFREPNLEYWKNFCEKVKHPKDGEITI
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHCCCCCCCEEE
GICGKYTEYPDAYKSIIESFIHAGASNDVRVLVKMLRAEDAEDPKFDISSAFKGISGLLV
EECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCEEE
APGFGDRGIEGKVRFVQYARENNIPFFGICLGMQCATIEFARNICDLPDANSTEFNKRTR
ECCCCCCCCCCCCHHEEEHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
FPVIDLMEHQKKVKEKGGTMRLGSYPCILKEGSKAHELYGKFLINERHRHRYEFNNQFRK
CCHHHHHHHHHHHHHCCCCEEECCCCEEECCCCHHHHHHHHHHHCHHHHHHHHHHHHHHH
LFEEKGMIFSGTSPNGDLVEIVELKNHRWFVAVQFHPELKSRVQKVHPLFDGFVHAAKEF
HHHHCCCEEECCCCCCCEEEEEEECCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
AQGKRQLSLEVEMPRLSSTEMENAG
HCCHHEEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA