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The map label for this gene is gyrA [H]

Identifier: 21672982

GI number: 21672982

Start: 134602

End: 137082

Strand: Direct

Name: gyrA [H]

Synonym: CT0141

Alternate gene names: 21672982

Gene position: 134602-137082 (Clockwise)

Preceding gene: 21672981

Following gene: 21672983

Centisome position: 6.25

GC content: 58.28

Gene sequence:

>2481_bases
ATGCAGCGCGAGAAAATATTGCCGATCAGTATTGAAGAGGAAATGCGGGATTCTTATCTCGACTATTCAATGTCGGTTAT
TGTCAGTCGAGCGCTTCCCGATGTCCGGGACGGTCTGAAGCCGGTGCATCGCCGCGTGCTTTACGGCATGCACGAGCTGG
GTCTGCAGGCGGGCAAGCCGTACAAGAAATCGGCTCGTGTCGTCGGTGAAGTGCTCGGTAAGTATCACCCGCATGGCGAC
TCCGCTGTTTACGACAGTCTTGTGCGCATGGTGCAGGATTTTTCGCTGCGTTATCCGCTGATCGACGGCCAGGGCAACTT
CGGCTCGGTCGATGGCGACTCCCCTGCGGCCATGCGTTACACCGAGGTGCGCATGAAGGCCATCGCTGGCGAGATGCTCA
AGGACCTCGACAAGGAGACGGTTGATTTCTCGCTCAACTTCGACGATTCGCTCGAAGAGCCAACGGTGCTTCCGGCGGCG
ATTCCGAACCTGCTGGTCAATGGCGCTTCGGGTATCGCGGTTGGTATGGCGACTAACATTCCGCCGCACAACATGCGCGA
GGTGGTCAGTGGCCTGATCGCGCTCATCGAGAATCCCGAGATCGAGATTGGCGACCTGATGAAGCACGTCACTGCGCCAG
ACTTTCCCACCGGCGGCATTATCTACGGCTACGAAGGTGTTCGTCAGGCCTACCTGACCGGTCGCGGCAAGGTGGTGATC
CGGGCCAGAGCCGTCGTAGAGGTGACGCAGAAAAACGGTCGCGAGTCGATCATCGTTACCGAACTTCCCTATCAGGTCAA
CAAGGTCAGGCTCATCGAGAAGATCGTCGAGCTGGTGCACGACAAGAAGGTTGAGGGCATTGCCGATATCCGTGACGAAT
CCGACCGCGAAGGTATGCGCCTGGTGATCGAGCTGAAACGCGACGCCGTGGCCAAGGTGGTGCTGAACAATCTTTACAAG
CACACCCCGATGCAGGATACTTTCGGGGTGATTATGCTAGCGCTTGTCGATGGTGTGCCGCGCGTTTTGAACCTCAAGGA
GATGATGCAGTACTATATCCGGCATCGCAACGAGATTGTACTGCGTCGCACGCAGTATGACCTCAACGCTGCCGAAAAGC
GCGCGCACATCCTCGAAGGTCTCAAAATCTGCCTCGACAATCTCGACGAGGTGATCTCGACAATCCGCCAGTCTCCCGAT
ACTCCGGCTGCTCAGAGCCGCCTTATGGACCGCTTTGGCCTGACCGAGGCGCAGTCGAAGGCAATCCTCGAAATGCGCTT
GCAGCGTCTGACTGGCATGGAACGCCAGAAGATCGACGACGAGTACCGCGAAACCCTCGCACTCATCGAAGAGCTGAAAT
CGATTCTCGAAAGTCCGGCCAAGCAGATGGAGATCATCAAAGCCGAGCTGCTCAAGGTCAGCGACGTTTATGGCGATGAA
CGCCGCACCGAGCTTCGTCCGCAGGAGGGCGACTTTTCGATTGAGGATATGATCGCCCAGGAGGATGTGGTCATCACCAT
TACCCACGAGGGCTTCATCAAGCGCTTCCCCGTTTCTGGCTATCGTCGCCAGCACCGCGGTGGAAGAGGCGTGGCCGGAG
CGCAGGCGAAGAACGAGGATTTCATCGAGCATATGTTCATCGCCTCCACGCATAACTATATCCTCTTTTTCACCACTGCC
GGACGCTGTTACTGGCTCAAAGTGTATGAAATCCCGGAGGCCGGACGGGCCGCTCGAGGTCGCTCGCTGGCCAACATCAT
GGAGCTTCCGCCCGGCGAGAAAATCAGAACCTATATCAATGTCCGGAACTTCGACGATCCGCACTTCATCATCATGGCCA
CGGCCAAAGGTATCGTCAAGAAGACCAGCCTCGAGGAGTACTCGCATCCGCGCCGCACCGGCATCAACGCCATTACCATC
GATGAGGGCGACGAGCTGATCGAGGCGCGCCTTACCGATGGCGATCACCAGATCATTCTGGCTAAAAGCTCCGGTTACGC
CGTCCGGTTTCCGGAATCGGAGGTTCGCTCGATGGGCCGCACCGCGATGGGCGTCAAGGGAATCACGCTCGACGAAGATG
AGCGCTGCATCTCGATGGTTACCACCAAGCGCAACGACACCTCGTTGCTCGCCGTTACGGACAATGGCTACGGCAAGCGC
AGCAAGGTCGAGGATTACCGCATGACCAAGCGCGGCGCGCGGGGCGTCATCACGATCAAGGCGCACGAGAAAATCGGCAA
CCTGGTCGGTCTGCTCGACGTCAACGACGAGGACGACCTGATCATCATCACGACCAACGGCATCGTCATCCGCCAGCACG
TTTCGGACATCCGGGTGCTTGGTCGGAACACCTCGGGAGTCAGGCTCATCAGGCTTGATGCCGGCGACAGGATTTCTGCC
ACGGCGCGCGTGCCCAAGAGCGACGACGACTCGGCGACCGAGCCGCTTGGCGACGAGGGGCAGATCGACCTGGAGTTCTG
A

Upstream 100 bases:

>100_bases
GGGCCACCTGCCGGGAACGCTCCGGAGCTTTACGTTTTTCAAGCTATTTTATACATTACGCCATTGTTTTTCAGGGTAAA
TCAAAGTCAGGGCATCGATT

Downstream 100 bases:

>100_bases
GCATGGATTGTTTGTGATCCAAACCGGCTGACGAAAGAGGTATTGATCGGAGAGCCGGGCGTTCTCCGGAAATGAATTCG
ACTGTTATCACTTAATTATT

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 826; Mature: 826

Protein sequence:

>826_residues
MQREKILPISIEEEMRDSYLDYSMSVIVSRALPDVRDGLKPVHRRVLYGMHELGLQAGKPYKKSARVVGEVLGKYHPHGD
SAVYDSLVRMVQDFSLRYPLIDGQGNFGSVDGDSPAAMRYTEVRMKAIAGEMLKDLDKETVDFSLNFDDSLEEPTVLPAA
IPNLLVNGASGIAVGMATNIPPHNMREVVSGLIALIENPEIEIGDLMKHVTAPDFPTGGIIYGYEGVRQAYLTGRGKVVI
RARAVVEVTQKNGRESIIVTELPYQVNKVRLIEKIVELVHDKKVEGIADIRDESDREGMRLVIELKRDAVAKVVLNNLYK
HTPMQDTFGVIMLALVDGVPRVLNLKEMMQYYIRHRNEIVLRRTQYDLNAAEKRAHILEGLKICLDNLDEVISTIRQSPD
TPAAQSRLMDRFGLTEAQSKAILEMRLQRLTGMERQKIDDEYRETLALIEELKSILESPAKQMEIIKAELLKVSDVYGDE
RRTELRPQEGDFSIEDMIAQEDVVITITHEGFIKRFPVSGYRRQHRGGRGVAGAQAKNEDFIEHMFIASTHNYILFFTTA
GRCYWLKVYEIPEAGRAARGRSLANIMELPPGEKIRTYINVRNFDDPHFIIMATAKGIVKKTSLEEYSHPRRTGINAITI
DEGDELIEARLTDGDHQIILAKSSGYAVRFPESEVRSMGRTAMGVKGITLDEDERCISMVTTKRNDTSLLAVTDNGYGKR
SKVEDYRMTKRGARGVITIKAHEKIGNLVGLLDVNDEDDLIIITTNGIVIRQHVSDIRVLGRNTSGVRLIRLDAGDRISA
TARVPKSDDDSATEPLGDEGQIDLEF

Sequences:

>Translated_826_residues
MQREKILPISIEEEMRDSYLDYSMSVIVSRALPDVRDGLKPVHRRVLYGMHELGLQAGKPYKKSARVVGEVLGKYHPHGD
SAVYDSLVRMVQDFSLRYPLIDGQGNFGSVDGDSPAAMRYTEVRMKAIAGEMLKDLDKETVDFSLNFDDSLEEPTVLPAA
IPNLLVNGASGIAVGMATNIPPHNMREVVSGLIALIENPEIEIGDLMKHVTAPDFPTGGIIYGYEGVRQAYLTGRGKVVI
RARAVVEVTQKNGRESIIVTELPYQVNKVRLIEKIVELVHDKKVEGIADIRDESDREGMRLVIELKRDAVAKVVLNNLYK
HTPMQDTFGVIMLALVDGVPRVLNLKEMMQYYIRHRNEIVLRRTQYDLNAAEKRAHILEGLKICLDNLDEVISTIRQSPD
TPAAQSRLMDRFGLTEAQSKAILEMRLQRLTGMERQKIDDEYRETLALIEELKSILESPAKQMEIIKAELLKVSDVYGDE
RRTELRPQEGDFSIEDMIAQEDVVITITHEGFIKRFPVSGYRRQHRGGRGVAGAQAKNEDFIEHMFIASTHNYILFFTTA
GRCYWLKVYEIPEAGRAARGRSLANIMELPPGEKIRTYINVRNFDDPHFIIMATAKGIVKKTSLEEYSHPRRTGINAITI
DEGDELIEARLTDGDHQIILAKSSGYAVRFPESEVRSMGRTAMGVKGITLDEDERCISMVTTKRNDTSLLAVTDNGYGKR
SKVEDYRMTKRGARGVITIKAHEKIGNLVGLLDVNDEDDLIIITTNGIVIRQHVSDIRVLGRNTSGVRLIRLDAGDRISA
TARVPKSDDDSATEPLGDEGQIDLEF
>Mature_826_residues
MQREKILPISIEEEMRDSYLDYSMSVIVSRALPDVRDGLKPVHRRVLYGMHELGLQAGKPYKKSARVVGEVLGKYHPHGD
SAVYDSLVRMVQDFSLRYPLIDGQGNFGSVDGDSPAAMRYTEVRMKAIAGEMLKDLDKETVDFSLNFDDSLEEPTVLPAA
IPNLLVNGASGIAVGMATNIPPHNMREVVSGLIALIENPEIEIGDLMKHVTAPDFPTGGIIYGYEGVRQAYLTGRGKVVI
RARAVVEVTQKNGRESIIVTELPYQVNKVRLIEKIVELVHDKKVEGIADIRDESDREGMRLVIELKRDAVAKVVLNNLYK
HTPMQDTFGVIMLALVDGVPRVLNLKEMMQYYIRHRNEIVLRRTQYDLNAAEKRAHILEGLKICLDNLDEVISTIRQSPD
TPAAQSRLMDRFGLTEAQSKAILEMRLQRLTGMERQKIDDEYRETLALIEELKSILESPAKQMEIIKAELLKVSDVYGDE
RRTELRPQEGDFSIEDMIAQEDVVITITHEGFIKRFPVSGYRRQHRGGRGVAGAQAKNEDFIEHMFIASTHNYILFFTTA
GRCYWLKVYEIPEAGRAARGRSLANIMELPPGEKIRTYINVRNFDDPHFIIMATAKGIVKKTSLEEYSHPRRTGINAITI
DEGDELIEARLTDGDHQIILAKSSGYAVRFPESEVRSMGRTAMGVKGITLDEDERCISMVTTKRNDTSLLAVTDNGYGKR
SKVEDYRMTKRGARGVITIKAHEKIGNLVGLLDVNDEDDLIIITTNGIVIRQHVSDIRVLGRNTSGVRLIRLDAGDRISA
TARVPKSDDDSATEPLGDEGQIDLEF

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=318, Percent_Identity=25.4716981132075, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI19913406, Length=321, Percent_Identity=24.9221183800623, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1788562, Length=840, Percent_Identity=51.547619047619, Blast_Score=855, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=684, Percent_Identity=37.719298245614, Blast_Score=420, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17535065, Length=368, Percent_Identity=26.0869565217391, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI212645657, Length=367, Percent_Identity=24.7956403269755, Blast_Score=76, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI212645845, Length=187, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=177, Percent_Identity=30.5084745762712, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI17136538, Length=177, Percent_Identity=30.5084745762712, Blast_Score=74, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 92695; Mature: 92695

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQREKILPISIEEEMRDSYLDYSMSVIVSRALPDVRDGLKPVHRRVLYGMHELGLQAGKP
CCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
YKKSARVVGEVLGKYHPHGDSAVYDSLVRMVQDFSLRYPLIDGQGNFGSVDGDSPAAMRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCHHHH
TEVRMKAIAGEMLKDLDKETVDFSLNFDDSLEEPTVLPAAIPNLLVNGASGIAVGMATNI
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCC
PPHNMREVVSGLIALIENPEIEIGDLMKHVTAPDFPTGGIIYGYEGVRQAYLTGRGKVVI
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCHHHHHHHHCCCCEEEE
RARAVVEVTQKNGRESIIVTELPYQVNKVRLIEKIVELVHDKKVEGIADIRDESDREGMR
EEEEEEHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCE
LVIELKRDAVAKVVLNNLYKHTPMQDTFGVIMLALVDGVPRVLNLKEMMQYYIRHRNEIV
EEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHCCCEEE
LRRTQYDLNAAEKRAHILEGLKICLDNLDEVISTIRQSPDTPAAQSRLMDRFGLTEAQSK
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHH
AILEMRLQRLTGMERQKIDDEYRETLALIEELKSILESPAKQMEIIKAELLKVSDVYGDE
HHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCC
RRTELRPQEGDFSIEDMIAQEDVVITITHEGFIKRFPVSGYRRQHRGGRGVAGAQAKNED
HHHCCCCCCCCCCHHHHHCCCCEEEEEECCCHHCCCCCCCHHHHCCCCCCCCCCCCCCHH
FIEHMFIASTHNYILFFTTAGRCYWLKVYEIPEAGRAARGRSLANIMELPPGEKIRTYIN
HHHHHHHEECCCEEEEEEECCCEEEEEEEECCCCCCHHCCCHHHHHHHCCCCCCEEEEEE
VRNFDDPHFIIMATAKGIVKKTSLEEYSHPRRTGINAITIDEGDELIEARLTDGDHQIIL
EECCCCCCEEEEEECCCHHHHCCHHHHCCCHHCCCCEEEECCCCHHHHEEECCCCCEEEE
AKSSGYAVRFPESEVRSMGRTAMGVKGITLDEDERCISMVTTKRNDTSLLAVTDNGYGKR
EECCCCEEECCHHHHHHCCCHHCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCC
SKVEDYRMTKRGARGVITIKAHEKIGNLVGLLDVNDEDDLIIITTNGIVIRQHVSDIRVL
CCCHHHHHHHCCCCEEEEEEEHHHHCCEEEEEECCCCCCEEEEEECCEEEEEHHHHHHEE
GRNTSGVRLIRLDAGDRISATARVPKSDDDSATEPLGDEGQIDLEF
CCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCEEECC
>Mature Secondary Structure
MQREKILPISIEEEMRDSYLDYSMSVIVSRALPDVRDGLKPVHRRVLYGMHELGLQAGKP
CCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
YKKSARVVGEVLGKYHPHGDSAVYDSLVRMVQDFSLRYPLIDGQGNFGSVDGDSPAAMRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCHHHH
TEVRMKAIAGEMLKDLDKETVDFSLNFDDSLEEPTVLPAAIPNLLVNGASGIAVGMATNI
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCC
PPHNMREVVSGLIALIENPEIEIGDLMKHVTAPDFPTGGIIYGYEGVRQAYLTGRGKVVI
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCHHHHHHHHCCCCEEEE
RARAVVEVTQKNGRESIIVTELPYQVNKVRLIEKIVELVHDKKVEGIADIRDESDREGMR
EEEEEEHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCE
LVIELKRDAVAKVVLNNLYKHTPMQDTFGVIMLALVDGVPRVLNLKEMMQYYIRHRNEIV
EEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHCCCEEE
LRRTQYDLNAAEKRAHILEGLKICLDNLDEVISTIRQSPDTPAAQSRLMDRFGLTEAQSK
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHH
AILEMRLQRLTGMERQKIDDEYRETLALIEELKSILESPAKQMEIIKAELLKVSDVYGDE
HHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCC
RRTELRPQEGDFSIEDMIAQEDVVITITHEGFIKRFPVSGYRRQHRGGRGVAGAQAKNED
HHHCCCCCCCCCCHHHHHCCCCEEEEEECCCHHCCCCCCCHHHHCCCCCCCCCCCCCCHH
FIEHMFIASTHNYILFFTTAGRCYWLKVYEIPEAGRAARGRSLANIMELPPGEKIRTYIN
HHHHHHHEECCCEEEEEEECCCEEEEEEEECCCCCCHHCCCHHHHHHHCCCCCCEEEEEE
VRNFDDPHFIIMATAKGIVKKTSLEEYSHPRRTGINAITIDEGDELIEARLTDGDHQIIL
EECCCCCCEEEEEECCCHHHHCCHHHHCCCHHCCCCEEEECCCCHHHHEEECCCCCEEEE
AKSSGYAVRFPESEVRSMGRTAMGVKGITLDEDERCISMVTTKRNDTSLLAVTDNGYGKR
EECCCCEEECCHHHHHHCCCHHCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCC
SKVEDYRMTKRGARGVITIKAHEKIGNLVGLLDVNDEDDLIIITTNGIVIRQHVSDIRVL
CCCHHHHHHHCCCCEEEEEEEHHHHCCEEEEEECCCCCCEEEEEECCEEEEEHHHHHHEE
GRNTSGVRLIRLDAGDRISATARVPKSDDDSATEPLGDEGQIDLEF
CCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]