Click here to switch to the map view.

The map label for this gene is lysC [C]

Identifier: 21672936

GI number: 21672936

Start: 89683

End: 91095

Strand: Reverse

Name: lysC [C]

Synonym: CT0095

Alternate gene names: 21672936

Gene position: 91095-89683 (Counterclockwise)

Preceding gene: 21672937

Following gene: 21672935

Centisome position: 4.23

GC content: 59.09

Gene sequence:

>1413_bases
ATGGTAGTCATGAAATTTGGCGGCACCTCTGTTGGCTCGGCTGCGGCCATGCGGCAGGTGATCGCCAATGTCGCGGAAAA
GAAGAAATCGAGCGCGCCGCTCGTCGTTTTAAGCGCGTGCAGCGGAATAACCAACAAACTGATCCAGATCGCCGATGCGG
CCGGCTCCGGCTGTCTCGAAGAGGCCCAGCAGCTTGTTGGCGAGGTTCGCCAGTTTCACCTCGATCTGATCGGGGAGTTG
ATCGAAAGCGAGGAGCTCCAACAGGAGGTGATCGCAAAGATCGAGGTCTATCTCACCCGGCTCGAACGCCTCACCGAGGG
CATCGAGATCGTCGGTGAGCTGACCGAGCGCTCGAAAGACCGCTTCTGCTCATTCGGCGAACTGCTTTCGACCTCCGTGT
TCGCCGCCGCACTGAACGAAGCGGGCGTGAGCTGCAAGTGGATCGACGTGCGGACGGTGATGATCACCGACGACCGATTC
GGCTTTGCCCGCCCACTCGCCGAGATTTGCCAGAAAAACACCAGCGAGATCATCAAGCCACTGCTCGATGCAGGCACAGT
CGTCGTGACGCAGGGCTACATCGGCGCGACCGAGTCGGGCCGTACCACCACACTGGGACGCGGAGGCTCCGACCTGTCGG
CAGCACTTTTCGGCGCATGGCTGCATTCGGAGTCTATCGAAATCTGGACGGACGTTGATGGCGTCATGACGACTGATCCC
CGAATAGTTCCGGAGGCGAAGAGCATCAGGGTCATGACCTTTTCCGAAGCTGCCGAGCTGGCCTATCTCGGCGCGAAAGT
GCTCCATCCCGACACCATCGCCCCAGCGGTCCAAAAGAACATTCCGGTTTATGTGCTCAACACCTGGCACCCGGATTCCA
AAGGCACGCTGATCACCAACGATCCGGAGCTGCTGGCAGGAAAGAGCCACGGCGGTCTGGTCAAATCCATTGCCGTCAAG
AAAGCGCAGGCGATTCTCAATATCCGCTCGAACCGGATGTTTGGCCGCCACGGATTTATGAGCGAGCTGTTCGACGTGTT
CGAGCGCTTTGGCATTTCGGTCGAAATGATCTCGACCAGCGAAGTCTCGGTCTCCCTGACGGTTGACGATGCCGTGGTGA
GCGAGCCGCTCATCAAGGCGCTCGGCGCGCTCGGTGAGGTCGAGATTGAGCACAAGGTAGCCACGGTCAGCGTGGTTGGC
GACAATCTCCGTATGTCGAAGGGCGTTGCCGGCAGGATTTTCAACTCGCTTCGCAACGTCAACCTGCGCATGATTTCGCA
GGGCGCATCGGAGATTAACGTGGGCGTGGTGGTTGATGAAAGTGACGTGCAGGCGGCGGTTGCAAGTCTGCACTGCGAGT
TCTTTGCGGAATCGCAGTGCGACGCGATTTTCGAGAAACCGGCGGGCAGCTAA

Upstream 100 bases:

>100_bases
TGTTCCGGATTCATGAAGTGAGTCGATCATGGAAGTATAGTAAATCCGAACCGGAAAACGATCCTGAAACAATCAAAATC
CAATTCTTTCGATTGAGAGT

Downstream 100 bases:

>100_bases
GACCGCAAACGCAAAAAAAAATTAAAAGGATAATCACGAACAAGAGCTATGGATTACAAGAAAGCCGGAGTCGATATTTC
CGCAGGTGAAGAGTTCGTCC

Product: aspartate kinase III

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MVVMKFGGTSVGSAAAMRQVIANVAEKKKSSAPLVVLSACSGITNKLIQIADAAGSGCLEEAQQLVGEVRQFHLDLIGEL
IESEELQQEVIAKIEVYLTRLERLTEGIEIVGELTERSKDRFCSFGELLSTSVFAAALNEAGVSCKWIDVRTVMITDDRF
GFARPLAEICQKNTSEIIKPLLDAGTVVVTQGYIGATESGRTTTLGRGGSDLSAALFGAWLHSESIEIWTDVDGVMTTDP
RIVPEAKSIRVMTFSEAAELAYLGAKVLHPDTIAPAVQKNIPVYVLNTWHPDSKGTLITNDPELLAGKSHGGLVKSIAVK
KAQAILNIRSNRMFGRHGFMSELFDVFERFGISVEMISTSEVSVSLTVDDAVVSEPLIKALGALGEVEIEHKVATVSVVG
DNLRMSKGVAGRIFNSLRNVNLRMISQGASEINVGVVVDESDVQAAVASLHCEFFAESQCDAIFEKPAGS

Sequences:

>Translated_470_residues
MVVMKFGGTSVGSAAAMRQVIANVAEKKKSSAPLVVLSACSGITNKLIQIADAAGSGCLEEAQQLVGEVRQFHLDLIGEL
IESEELQQEVIAKIEVYLTRLERLTEGIEIVGELTERSKDRFCSFGELLSTSVFAAALNEAGVSCKWIDVRTVMITDDRF
GFARPLAEICQKNTSEIIKPLLDAGTVVVTQGYIGATESGRTTTLGRGGSDLSAALFGAWLHSESIEIWTDVDGVMTTDP
RIVPEAKSIRVMTFSEAAELAYLGAKVLHPDTIAPAVQKNIPVYVLNTWHPDSKGTLITNDPELLAGKSHGGLVKSIAVK
KAQAILNIRSNRMFGRHGFMSELFDVFERFGISVEMISTSEVSVSLTVDDAVVSEPLIKALGALGEVEIEHKVATVSVVG
DNLRMSKGVAGRIFNSLRNVNLRMISQGASEINVGVVVDESDVQAAVASLHCEFFAESQCDAIFEKPAGS
>Mature_470_residues
MVVMKFGGTSVGSAAAMRQVIANVAEKKKSSAPLVVLSACSGITNKLIQIADAAGSGCLEEAQQLVGEVRQFHLDLIGEL
IESEELQQEVIAKIEVYLTRLERLTEGIEIVGELTERSKDRFCSFGELLSTSVFAAALNEAGVSCKWIDVRTVMITDDRF
GFARPLAEICQKNTSEIIKPLLDAGTVVVTQGYIGATESGRTTTLGRGGSDLSAALFGAWLHSESIEIWTDVDGVMTTDP
RIVPEAKSIRVMTFSEAAELAYLGAKVLHPDTIAPAVQKNIPVYVLNTWHPDSKGTLITNDPELLAGKSHGGLVKSIAVK
KAQAILNIRSNRMFGRHGFMSELFDVFERFGISVEMISTSEVSVSLTVDDAVVSEPLIKALGALGEVEIEHKVATVSVVG
DNLRMSKGVAGRIFNSLRNVNLRMISQGASEINVGVVVDESDVQAAVASLHCEFFAESQCDAIFEKPAGS

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=468, Percent_Identity=38.4615384615385, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI1786183, Length=479, Percent_Identity=31.3152400835073, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1790376, Length=298, Percent_Identity=29.5302013422819, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320893, Length=493, Percent_Identity=31.237322515213, Blast_Score=228, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 50417; Mature: 50417

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVMKFGGTSVGSAAAMRQVIANVAEKKKSSAPLVVLSACSGITNKLIQIADAAGSGCLE
CEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCHHHH
EAQQLVGEVRQFHLDLIGELIESEELQQEVIAKIEVYLTRLERLTEGIEIVGELTERSKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFCSFGELLSTSVFAAALNEAGVSCKWIDVRTVMITDDRFGFARPLAEICQKNTSEIIKP
HHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCHHHHHHHHHHCCHHHHHHH
LLDAGTVVVTQGYIGATESGRTTTLGRGGSDLSAALFGAWLHSESIEIWTDVDGVMTTDP
HHCCCCEEEECCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCEEECCC
RIVPEAKSIRVMTFSEAAELAYLGAKVLHPDTIAPAVQKNIPVYVLNTWHPDSKGTLITN
CCCCCCCCEEEEEEHHHHHHHHHCHHHCCCCHHCHHHHCCCCEEEEEEECCCCCCCEEEC
DPELLAGKSHGGLVKSIAVKKAQAILNIRSNRMFGRHGFMSELFDVFERFGISVEMISTS
CHHHEECCCCCCHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHCCEEEEEECC
EVSVSLTVDDAVVSEPLIKALGALGEVEIEHKVATVSVVGDNLRMSKGVAGRIFNSLRNV
CEEEEEEECHHHHHHHHHHHHCCCCCEEEEEEEEEEEEECCCCCCCCCHHHHHHHHHHCC
NLRMISQGASEINVGVVVDESDVQAAVASLHCEFFAESQCDAIFEKPAGS
CEEEEECCCCCEEEEEEEECHHHHHHHHHHHHHHHHCCCHHHHHCCCCCC
>Mature Secondary Structure
MVVMKFGGTSVGSAAAMRQVIANVAEKKKSSAPLVVLSACSGITNKLIQIADAAGSGCLE
CEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCHHHH
EAQQLVGEVRQFHLDLIGELIESEELQQEVIAKIEVYLTRLERLTEGIEIVGELTERSKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFCSFGELLSTSVFAAALNEAGVSCKWIDVRTVMITDDRFGFARPLAEICQKNTSEIIKP
HHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCHHHHHHHHHHCCHHHHHHH
LLDAGTVVVTQGYIGATESGRTTTLGRGGSDLSAALFGAWLHSESIEIWTDVDGVMTTDP
HHCCCCEEEECCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCEEECCC
RIVPEAKSIRVMTFSEAAELAYLGAKVLHPDTIAPAVQKNIPVYVLNTWHPDSKGTLITN
CCCCCCCCEEEEEEHHHHHHHHHCHHHCCCCHHCHHHHCCCCEEEEEEECCCCCCCEEEC
DPELLAGKSHGGLVKSIAVKKAQAILNIRSNRMFGRHGFMSELFDVFERFGISVEMISTS
CHHHEECCCCCCHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHCCEEEEEECC
EVSVSLTVDDAVVSEPLIKALGALGEVEIEHKVATVSVVGDNLRMSKGVAGRIFNSLRNV
CEEEEEEECHHHHHHHHHHHHCCCCCEEEEEEEEEEEEECCCCCCCCCHHHHHHHHHHCC
NLRMISQGASEINVGVVVDESDVQAAVASLHCEFFAESQCDAIFEKPAGS
CEEEEECCCCCEEEEEEEECHHHHHHHHHHHHHHHHCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]