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The map label for this gene is purM [H]

Identifier: 21672935

GI number: 21672935

Start: 88645

End: 89634

Strand: Reverse

Name: purM [H]

Synonym: CT0094

Alternate gene names: 21672935

Gene position: 89634-88645 (Counterclockwise)

Preceding gene: 21672936

Following gene: 21672934

Centisome position: 4.16

GC content: 60.4

Gene sequence:

>990_bases
ATGGATTACAAGAAAGCCGGAGTCGATATTTCCGCAGGTGAAGAGTTCGTCCGCCTCATCAAACCCCATGTCCGCCAGAC
CTTCACTCCGCAGGTGATGACCGACATCGGCGCGTTCGGCGGATTCTTTCAGCCCGATTTCGCGAAGTATGAGAAGCCGG
TGCTGGTCAGCAGCATCGACGGCGTGGGCACCAAGCTCAAGATCGCCATCGAGCTCGGCAAGTACGACACGGTCGGCTCC
TGCCTGGTCAACCACTGCGTGAACGACATTCTGGTCTGCGGCGCCCGCCCGCTCTTTTTCCTCGACTACTATGCCTGCGG
CAAGCTCAAGCCTGAGATTGCCGCGTCCGTGGTGACCGGCATGGTGAAGGCGTGCCGCGAGAACGGCGCGGCGCTCATCG
GTGGCGAAACCGCCGAGATGCCGGGCGTGTACGACGTGGAGGATTTCGATCTCGCTGGTACGATTGTCGGCATGGTCGAT
CAGCCGCACATCATCAACGGCTCGAAGATCGAGGCGGGCGACGTGATGATAGGCCTGCCTTCGACCGGCCTGCACACCAA
CGGCTATTCGCTAGCCCGCAAGGTGTTCGAGGGGCGGATGAACGAGACGTTTGCCGAGCTTGACGGTACGGTCGGCGAGG
AGCTCTTGAAGGTGCACCGCTCCTACCTGCCGGTCATCGAACCGCTGCTTGGCACTGGCGACCTGCGCGGCATGTCGCAT
ATCACCGGCGGTGGTCTCATGGGGAACACCATGCGCATCGTGCCGGAAGGCCTCGCCCTTTCGGTGGACTGGAATTCATG
GCCGGAACCGCTGATTTTCGACCTGATCCGCAAGGAGGGCTCGGTGCCCGAAGAGGATATGCGCCGCACCTTCAACCTGG
GCCTCGGTCTGGTGATGATTGTCGCGAAAGATCGCGTCGATCACATCATGGGCTACTTGAAGTCGAAGGATGAAAATGCC
TACATTGTTGGAGAGGTCGTCAAGGCCTGA

Upstream 100 bases:

>100_bases
CTTTGCGGAATCGCAGTGCGACGCGATTTTCGAGAAACCGGCGGGCAGCTAAGACCGCAAACGCAAAAAAAAATTAAAAG
GATAATCACGAACAAGAGCT

Downstream 100 bases:

>100_bases
CCATTCGATTATGTGTTTGTCTGTCATTTAATCGAGACTGATATGCTGACATTTCTTGCCATCATCGTCGTCGCGTACCT
GATTGGCTCCATTCCGACCA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MDYKKAGVDISAGEEFVRLIKPHVRQTFTPQVMTDIGAFGGFFQPDFAKYEKPVLVSSIDGVGTKLKIAIELGKYDTVGS
CLVNHCVNDILVCGARPLFFLDYYACGKLKPEIAASVVTGMVKACRENGAALIGGETAEMPGVYDVEDFDLAGTIVGMVD
QPHIINGSKIEAGDVMIGLPSTGLHTNGYSLARKVFEGRMNETFAELDGTVGEELLKVHRSYLPVIEPLLGTGDLRGMSH
ITGGGLMGNTMRIVPEGLALSVDWNSWPEPLIFDLIRKEGSVPEEDMRRTFNLGLGLVMIVAKDRVDHIMGYLKSKDENA
YIVGEVVKA

Sequences:

>Translated_329_residues
MDYKKAGVDISAGEEFVRLIKPHVRQTFTPQVMTDIGAFGGFFQPDFAKYEKPVLVSSIDGVGTKLKIAIELGKYDTVGS
CLVNHCVNDILVCGARPLFFLDYYACGKLKPEIAASVVTGMVKACRENGAALIGGETAEMPGVYDVEDFDLAGTIVGMVD
QPHIINGSKIEAGDVMIGLPSTGLHTNGYSLARKVFEGRMNETFAELDGTVGEELLKVHRSYLPVIEPLLGTGDLRGMSH
ITGGGLMGNTMRIVPEGLALSVDWNSWPEPLIFDLIRKEGSVPEEDMRRTFNLGLGLVMIVAKDRVDHIMGYLKSKDENA
YIVGEVVKA
>Mature_329_residues
MDYKKAGVDISAGEEFVRLIKPHVRQTFTPQVMTDIGAFGGFFQPDFAKYEKPVLVSSIDGVGTKLKIAIELGKYDTVGS
CLVNHCVNDILVCGARPLFFLDYYACGKLKPEIAASVVTGMVKACRENGAALIGGETAEMPGVYDVEDFDLAGTIVGMVD
QPHIINGSKIEAGDVMIGLPSTGLHTNGYSLARKVFEGRMNETFAELDGTVGEELLKVHRSYLPVIEPLLGTGDLRGMSH
ITGGGLMGNTMRIVPEGLALSVDWNSWPEPLIFDLIRKEGSVPEEDMRRTFNLGLGLVMIVAKDRVDHIMGYLKSKDENA
YIVGEVVKA

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=336, Percent_Identity=43.1547619047619, Blast_Score=280, Evalue=1e-75,
Organism=Homo sapiens, GI209869995, Length=336, Percent_Identity=43.1547619047619, Blast_Score=280, Evalue=1e-75,
Organism=Homo sapiens, GI209869993, Length=336, Percent_Identity=43.1547619047619, Blast_Score=280, Evalue=1e-75,
Organism=Escherichia coli, GI1788845, Length=332, Percent_Identity=44.2771084337349, Blast_Score=279, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17567511, Length=335, Percent_Identity=40, Blast_Score=233, Evalue=7e-62,
Organism=Saccharomyces cerevisiae, GI6321203, Length=332, Percent_Identity=40.6626506024096, Blast_Score=239, Evalue=5e-64,
Organism=Drosophila melanogaster, GI24582400, Length=284, Percent_Identity=37.3239436619718, Blast_Score=192, Evalue=2e-49,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 35691; Mature: 35691

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKKAGVDISAGEEFVRLIKPHVRQTFTPQVMTDIGAFGGFFQPDFAKYEKPVLVSSID
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHCCCCEEEEECC
GVGTKLKIAIELGKYDTVGSCLVNHCVNDILVCGARPLFFLDYYACGKLKPEIAASVVTG
CCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHH
MVKACRENGAALIGGETAEMPGVYDVEDFDLAGTIVGMVDQPHIINGSKIEAGDVMIGLP
HHHHHHHCCCEEECCCCCCCCCCCCCCCCCCHHHEEECCCCCEEECCCEEECCCEEEECC
STGLHTNGYSLARKVFEGRMNETFAELDGTVGEELLKVHRSYLPVIEPLLGTGDLRGMSH
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
ITGGGLMGNTMRIVPEGLALSVDWNSWPEPLIFDLIRKEGSVPEEDMRRTFNLGLGLVMI
CCCCCCCCCCEEEEECCEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEE
VAKDRVDHIMGYLKSKDENAYIVGEVVKA
EHHHHHHHHHHHHHCCCCCEEEEEEECCC
>Mature Secondary Structure
MDYKKAGVDISAGEEFVRLIKPHVRQTFTPQVMTDIGAFGGFFQPDFAKYEKPVLVSSID
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHCCCCEEEEECC
GVGTKLKIAIELGKYDTVGSCLVNHCVNDILVCGARPLFFLDYYACGKLKPEIAASVVTG
CCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHH
MVKACRENGAALIGGETAEMPGVYDVEDFDLAGTIVGMVDQPHIINGSKIEAGDVMIGLP
HHHHHHHCCCEEECCCCCCCCCCCCCCCCCCHHHEEECCCCCEEECCCEEECCCEEEECC
STGLHTNGYSLARKVFEGRMNETFAELDGTVGEELLKVHRSYLPVIEPLLGTGDLRGMSH
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
ITGGGLMGNTMRIVPEGLALSVDWNSWPEPLIFDLIRKEGSVPEEDMRRTFNLGLGLVMI
CCCCCCCCCCEEEEECCEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEE
VAKDRVDHIMGYLKSKDENAYIVGEVVKA
EHHHHHHHHHHHHHCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA