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The map label for this gene is gpsA

Identifier: 21672933

GI number: 21672933

Start: 86889

End: 87890

Strand: Reverse

Name: gpsA

Synonym: CT0092

Alternate gene names: 21672933

Gene position: 87890-86889 (Counterclockwise)

Preceding gene: 21672934

Following gene: 21672929

Centisome position: 4.08

GC content: 62.38

Gene sequence:

>1002_bases
ATGAAGATCACTGTTCTCGGCGCAGGAAGTTGGGGAACCACGCTTGCCATGCTGCTGGCCAATAAAGGCCACGAAGTACG
GCTGTGGGCGCACCGCCCGGAGTTCGCCCGCGCGCTTGAGGCCGACCGCGAAAACAAGCGCTACCTCAAAGGGGTTCTTT
TTCCCGACAACCTGCGTGTGGTCGAAAATCTTCACGACGCCGTCGAAACAGCGGAGATGATCGTGACAGCAGTGCCGTCG
CATGCGCTGCGGGAGACGGCGGCGGCGTTTGCGCACCTGCCTCTCGACGGCAAAATCATCGTCAACGTCGCCAAGGGGAT
CGAGCAGCACACCGGAAAGCGCATGTCCGAGGTGTTACTCGAAGCGCTGCCCCGCATCGCGCCGGAGCAGATCGCCGTGC
TCTACGGCCCAAGCCATGCCGAGGAGGTCGCCCGCCAGCAGCCGACCACCGTTGTCGCCTGCTCTGTTTCGGAAGCGACC
GCCCGCCGGGTTCAGGAGGCGTTTCACACCAGCAGCTTCCGCGTCTATGTCAACACCGACCTCATCGGCGTCGAGATCGC
CGGATCAGTCAAGAACGTCATCGCCATCGCCGCCGGAATTTCCGACGGACTCGGCTTCGGCGACAACGCCAAGGCGGCGA
TCATCACGCGCGGCCTGGCTGAAATCTCGCGCCTCAGCTCGAAGCTTGGCGCCGACCCGCTGACCCTATCGGGTCTGTCC
GGCATCGGCGACCTGGTCGTAACCTGCCTGAGCCAGCACAGCCGCAACCGCTACGTCGGCGAGCAGATTGGCAAGGGCCG
CAAGCTCGACGAAGTGATCGGAGAGATGAGCATGGTAGCCGAAGGGGTGCTCACCTCCAAAGCCGTAGTCAAGCTCGCCG
AACGCCTCGGCGTCGAAATGCCCATCTCGCAAGCCGTCTATGAAATGCTCTACGAAAACAAACCCGCCCCGCAAGCCATT
CTGGAGCTGATGGAAAGGGATCCCAAGCCGGAGCATTATTGA

Upstream 100 bases:

>100_bases
GTGGCGATCATCTACACGCACCGTGCCAACATCAAGCGCCTCTTTTCTGGAACCGAAAACCGCCTGAGCTTCGGGCGGAA
AAACTGAGCGGCTGTTTACA

Downstream 100 bases:

>100_bases
AGTTTAAGCGTATAGGTCGTGTAGGACTTATAAGACCTATATGACCTATAAGCTCTCAAGAGCGCACATAATGCGCCCCT
GCGGTTGGCCAGCCCTCACT

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MKITVLGAGSWGTTLAMLLANKGHEVRLWAHRPEFARALEADRENKRYLKGVLFPDNLRVVENLHDAVETAEMIVTAVPS
HALRETAAAFAHLPLDGKIIVNVAKGIEQHTGKRMSEVLLEALPRIAPEQIAVLYGPSHAEEVARQQPTTVVACSVSEAT
ARRVQEAFHTSSFRVYVNTDLIGVEIAGSVKNVIAIAAGISDGLGFGDNAKAAIITRGLAEISRLSSKLGADPLTLSGLS
GIGDLVVTCLSQHSRNRYVGEQIGKGRKLDEVIGEMSMVAEGVLTSKAVVKLAERLGVEMPISQAVYEMLYENKPAPQAI
LELMERDPKPEHY

Sequences:

>Translated_333_residues
MKITVLGAGSWGTTLAMLLANKGHEVRLWAHRPEFARALEADRENKRYLKGVLFPDNLRVVENLHDAVETAEMIVTAVPS
HALRETAAAFAHLPLDGKIIVNVAKGIEQHTGKRMSEVLLEALPRIAPEQIAVLYGPSHAEEVARQQPTTVVACSVSEAT
ARRVQEAFHTSSFRVYVNTDLIGVEIAGSVKNVIAIAAGISDGLGFGDNAKAAIITRGLAEISRLSSKLGADPLTLSGLS
GIGDLVVTCLSQHSRNRYVGEQIGKGRKLDEVIGEMSMVAEGVLTSKAVVKLAERLGVEMPISQAVYEMLYENKPAPQAI
LELMERDPKPEHY
>Mature_333_residues
MKITVLGAGSWGTTLAMLLANKGHEVRLWAHRPEFARALEADRENKRYLKGVLFPDNLRVVENLHDAVETAEMIVTAVPS
HALRETAAAFAHLPLDGKIIVNVAKGIEQHTGKRMSEVLLEALPRIAPEQIAVLYGPSHAEEVARQQPTTVVACSVSEAT
ARRVQEAFHTSSFRVYVNTDLIGVEIAGSVKNVIAIAAGISDGLGFGDNAKAAIITRGLAEISRLSSKLGADPLTLSGLS
GIGDLVVTCLSQHSRNRYVGEQIGKGRKLDEVIGEMSMVAEGVLTSKAVVKLAERLGVEMPISQAVYEMLYENKPAPQAI
LELMERDPKPEHY

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI24307999, Length=354, Percent_Identity=28.2485875706215, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI33695088, Length=355, Percent_Identity=28.7323943661972, Blast_Score=132, Evalue=3e-31,
Organism=Escherichia coli, GI1790037, Length=330, Percent_Identity=45.4545454545455, Blast_Score=275, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI32564399, Length=339, Percent_Identity=30.3834808259587, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI32564403, Length=346, Percent_Identity=29.7687861271676, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI193210136, Length=346, Percent_Identity=29.7687861271676, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17507425, Length=334, Percent_Identity=27.5449101796407, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI193210134, Length=337, Percent_Identity=27.299703264095, Blast_Score=110, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6320181, Length=357, Percent_Identity=29.6918767507003, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324513, Length=361, Percent_Identity=27.4238227146814, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17136202, Length=352, Percent_Identity=25.8522727272727, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17136200, Length=352, Percent_Identity=25.8522727272727, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17136204, Length=352, Percent_Identity=25.8522727272727, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI22026922, Length=350, Percent_Identity=24.8571428571429, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI45551945, Length=236, Percent_Identity=25, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI281362270, Length=236, Percent_Identity=25, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24648969, Length=182, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_CHLTE (Q8KG76)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_660998.1
- ProteinModelPortal:   Q8KG76
- SMR:   Q8KG76
- GeneID:   1006513
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0092
- NMPDR:   fig|194439.1.peg.92
- TIGR:   CT0092
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- ProtClustDB:   PRK00094
- BioCyc:   CTEP194439:CT_0092-MONOMER
- BRENDA:   1.1.1.94
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 35982; Mature: 35982

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 191-191 BINDING 105-105 BINDING 105-105 BINDING 140-140 BINDING 255-255 BINDING 281-281

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITVLGAGSWGTTLAMLLANKGHEVRLWAHRPEFARALEADRENKRYLKGVLFPDNLRV
CEEEEEECCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCCHHHHHHCCCCCHHHH
VENLHDAVETAEMIVTAVPSHALRETAAAFAHLPLDGKIIVNVAKGIEQHTGKRMSEVLL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHH
EALPRIAPEQIAVLYGPSHAEEVARQQPTTVVACSVSEATARRVQEAFHTSSFRVYVNTD
HHHCCCCCHHEEEEECCCHHHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCEEEEEECC
LIGVEIAGSVKNVIAIAAGISDGLGFGDNAKAAIITRGLAEISRLSSKLGADPLTLSGLS
EEEEEECCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEECCCC
GIGDLVVTCLSQHSRNRYVGEQIGKGRKLDEVIGEMSMVAEGVLTSKAVVKLAERLGVEM
HHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PISQAVYEMLYENKPAPQAILELMERDPKPEHY
CHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKITVLGAGSWGTTLAMLLANKGHEVRLWAHRPEFARALEADRENKRYLKGVLFPDNLRV
CEEEEEECCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCCHHHHHHCCCCCHHHH
VENLHDAVETAEMIVTAVPSHALRETAAAFAHLPLDGKIIVNVAKGIEQHTGKRMSEVLL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHH
EALPRIAPEQIAVLYGPSHAEEVARQQPTTVVACSVSEATARRVQEAFHTSSFRVYVNTD
HHHCCCCCHHEEEEECCCHHHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCEEEEEECC
LIGVEIAGSVKNVIAIAAGISDGLGFGDNAKAAIITRGLAEISRLSSKLGADPLTLSGLS
EEEEEECCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEECCCC
GIGDLVVTCLSQHSRNRYVGEQIGKGRKLDEVIGEMSMVAEGVLTSKAVVKLAERLGVEM
HHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PISQAVYEMLYENKPAPQAILELMERDPKPEHY
CHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901