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The map label for this gene is kdsA [H]

Identifier: 21672929

GI number: 21672929

Start: 82845

End: 83687

Strand: Reverse

Name: kdsA [H]

Synonym: CT0088

Alternate gene names: 21672929

Gene position: 83687-82845 (Counterclockwise)

Preceding gene: 21672933

Following gene: 21672928

Centisome position: 3.88

GC content: 60.14

Gene sequence:

>843_bases
ATGCAAAAGTTCTCGGTTGGCACTGTATCGCTGCCAGGGCCGAAGGGCCTGTTTCTCATCGCGGGGCCTTGCCTTATCGA
AAACCGGCGGATGGCGATGGATGTGGCCGCCGAACTCGACCGCATCCGCAAAAAGGAAGATGTGCGCGTCATCTTCAAAG
GTTCTTACCGCAAGGCGAATCGCTCGTCGGCCTCTTCATACACTGGCATTGGGGACCGCCAGGCACTTGAAATCCTGCGC
GAGATCAGAGACTATTTCGGGATGCCGGTGCTAACCGATGTTCACGAAACCTCCGAGGTCGAACTCGCGGCATCCTATGT
CGATGTGCTCCAGATTCCCGCGTTCCTCTGCCGCCAGACTGACCTGATCGTGGCCGCAGCATCGACGGGGCTTGCCGTCA
ACATCAAGAAAGGGCAGTTTCTCGCGCCGGAAGACATGGCTCTTGCCGCGGCCAAAGCCGCCGCAACGGGAAACAAAAAG
ATTATGCTTACCGAACGGGGCACCACCTTTGGCTACCACAATCTCGTGGTCGATTACCGGGGGCTGCCAATCATGGCCGA
ATCCGGCTGGCCGGTCATTCTCGATGTCACCCACAGCGTCCAGTTGCCGGGTGCCGGAGCAGGCGTTTCCGGAGGCGACC
GCCGGTTCCTCATGCCGCTTGCCCGCGCCGCCGTTGCCGCGGGAGTTGATGGCCTCTTTTTCGAGGTGCATCCCGATCCG
GCGACCGCCATGTCCGACGCTTCGACCCAGGCTCCGCTCGCCGGATTCGGCGAAATGGTGCGGGAGCTGATGCAGCTTCA
GCGCTGCATGCAGTCGATCCGGGAAGAATTTCATTCACGTTAA

Upstream 100 bases:

>100_bases
AGAGAAATTATTGATTAAATTTACAGCCTAATTTATCAAGTCAAAACAAACCGGCTTCGCTTGTTACTGGCGTTAACTCT
TTAATCAAACAGGACAACGG

Downstream 100 bases:

>100_bases
CCAGATACACTCTTGAGCTCTTTCCAGTTTTTCGGTATGCAGCCCTACCAGGCTGATCCCTCTTCGCAGATCAACGCCGC
CCTCGATAGCATCAAGGCGC

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MQKFSVGTVSLPGPKGLFLIAGPCLIENRRMAMDVAAELDRIRKKEDVRVIFKGSYRKANRSSASSYTGIGDRQALEILR
EIRDYFGMPVLTDVHETSEVELAASYVDVLQIPAFLCRQTDLIVAAASTGLAVNIKKGQFLAPEDMALAAAKAAATGNKK
IMLTERGTTFGYHNLVVDYRGLPIMAESGWPVILDVTHSVQLPGAGAGVSGGDRRFLMPLARAAVAAGVDGLFFEVHPDP
ATAMSDASTQAPLAGFGEMVRELMQLQRCMQSIREEFHSR

Sequences:

>Translated_280_residues
MQKFSVGTVSLPGPKGLFLIAGPCLIENRRMAMDVAAELDRIRKKEDVRVIFKGSYRKANRSSASSYTGIGDRQALEILR
EIRDYFGMPVLTDVHETSEVELAASYVDVLQIPAFLCRQTDLIVAAASTGLAVNIKKGQFLAPEDMALAAAKAAATGNKK
IMLTERGTTFGYHNLVVDYRGLPIMAESGWPVILDVTHSVQLPGAGAGVSGGDRRFLMPLARAAVAAGVDGLFFEVHPDP
ATAMSDASTQAPLAGFGEMVRELMQLQRCMQSIREEFHSR
>Mature_280_residues
MQKFSVGTVSLPGPKGLFLIAGPCLIENRRMAMDVAAELDRIRKKEDVRVIFKGSYRKANRSSASSYTGIGDRQALEILR
EIRDYFGMPVLTDVHETSEVELAASYVDVLQIPAFLCRQTDLIVAAASTGLAVNIKKGQFLAPEDMALAAAKAAATGNKK
IMLTERGTTFGYHNLVVDYRGLPIMAESGWPVILDVTHSVQLPGAGAGVSGGDRRFLMPLARAAVAAGVDGLFFEVHPDP
ATAMSDASTQAPLAGFGEMVRELMQLQRCMQSIREEFHSR

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=273, Percent_Identity=39.1941391941392, Blast_Score=206, Evalue=2e-54,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 30318; Mature: 30318

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKFSVGTVSLPGPKGLFLIAGPCLIENRRMAMDVAAELDRIRKKEDVRVIFKGSYRKAN
CCCCCCCEEECCCCCCEEEEECCEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCC
RSSASSYTGIGDRQALEILREIRDYFGMPVLTDVHETSEVELAASYVDVLQIPAFLCRQT
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC
DLIVAAASTGLAVNIKKGQFLAPEDMALAAAKAAATGNKKIMLTERGTTFGYHNLVVDYR
CEEEEEECCCEEEEECCCCEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEEEEC
GLPIMAESGWPVILDVTHSVQLPGAGAGVSGGDRRFLMPLARAAVAAGVDGLFFEVHPDP
CCEEEECCCCEEEEEEECEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCC
ATAMSDASTQAPLAGFGEMVRELMQLQRCMQSIREEFHSR
CHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQKFSVGTVSLPGPKGLFLIAGPCLIENRRMAMDVAAELDRIRKKEDVRVIFKGSYRKAN
CCCCCCCEEECCCCCCEEEEECCEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCC
RSSASSYTGIGDRQALEILREIRDYFGMPVLTDVHETSEVELAASYVDVLQIPAFLCRQT
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC
DLIVAAASTGLAVNIKKGQFLAPEDMALAAAKAAATGNKKIMLTERGTTFGYHNLVVDYR
CEEEEEECCCEEEEECCCCEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEEEEC
GLPIMAESGWPVILDVTHSVQLPGAGAGVSGGDRRFLMPLARAAVAAGVDGLFFEVHPDP
CCEEEECCCCEEEEEEECEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCC
ATAMSDASTQAPLAGFGEMVRELMQLQRCMQSIREEFHSR
CHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA