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The map label for this gene is ygcA [C]

Identifier: 21672850

GI number: 21672850

Start: 7593

End: 9044

Strand: Direct

Name: ygcA [C]

Synonym: CT0009

Alternate gene names: 21672850

Gene position: 7593-9044 (Clockwise)

Preceding gene: 21672849

Following gene: 21672853

Centisome position: 0.35

GC content: 60.19

Gene sequence:

>1452_bases
TTGCACACTCCATTGGAACAACAGGAAATCCGCTACAGAAAAGGCGACATCATCGAACTCACCATCACTGACCACGCCGA
GAAAGACAAATGCTTCGGCAAAACCACCGAGGGCATGGGGGTGATGGTCTCCGGCATTCTCGCCCCCGGTGACCGCGTTT
CGGCGCAAATTTACAAGGTCAAGTCGCGCTACCTCGAAGCACGGGCCATCGAGGTGCTCGAAGCGTCGCCGGATCGCGTT
GAGCCAGTCTGCCCGGTCTTCGGCTCCTGCGGCGGATGCAAGTGGATGCACGTCAGCTATGAGGCGCAGCTTCGCTACAA
GCACAAAAAGGTGACGGACTCGCTGGAGCACATCGGCGGTTTTGAGAGTCCCGACGTCCGTCCGGTGCTTGCCGCGCCAG
ACGCGCTGCACTACCGCAACAAGGTGGAGTTCTCCTGCTCCAACATGCGCTACCTGCTCCAGTCGGAGATCGACAGTGAT
CAGCTTGCCAAGCCGAAAACCTTCGCCCTCGGCTTCCACGCGCCGGGCAACTTCGAGAAGGTGCTCGACCTCGACACCTG
CTACCTCGCCAAGGAGTGTATGAACCGGGTGCTGAACGTCTTGCGTGACTTCGCCATCGAACGCGGTCTCGAGCCCTACG
CCGCCAAGGCGCACGAAGGCTACCTGCGTAACCTTATGCTCCGCTACAGCGAACGCCATGAGCAGTTGATGGTCAACATC
GTCACCTCATGGTACGACAAGGCGCTGATGCAGGCGCTCAAAGAGCGGCTCGAAGCGGCCATGCCGGAACAGCAGATGAC
GCTGCTCAACAACGTCACCACGCGCAAGAACACCGTCGCCACCGGCGAGCAAGAGTACGTCATCAGCGGCGACGGCTACG
TCACCGAACGGCTCGGCGACCTCGACTTCCGGATTTCGGCCAACTCCTTTTTCCAGACCAACACCCGCCAGGCCGAAACG
CTCTACGACCAGATCATCGCTGTCGGCGGCATCACTCCGGAGGATACGGTCTATGACCTCTACTGCGGCACTGGCACCAT
CACGCTCTACCTCGCCCGCCACTGTAAGCAGGCGATCGGCATCGAGGTGGTCGAAAGTGCCGTCAAGGATGCCGAGATGA
ACGCCGAACTCAACGGCCTCTCGAACACCGTCTTCTTCCAAGCCGACCTCAAGAATTTCCACGCCATGCAGGAGGCGCTC
GAACCCTACGCCAAACCGCGCATTATTGTTACCGACCCTCCGCGCGCCGGAATGCACCCCAAAGCACTCGACACCATGCT
CAAGCTCCAGCCCGAACGCATTGTTTACGTCAGCTGCAACCCCGACAACCTCGCCCGCGACGGCAAAGAGATCGCGGCGA
GAGGCTACCGCATGACGTCCGCCCAACCGGTGGACATGTTTCCGCAGACGAACCACATCGAGACCGTGGCCTGTTTCGAG
CGGGCAGAATAA

Upstream 100 bases:

>100_bases
TGCTTGGCGACAGCGCGGGCGTGTTCGGCGCAGCACTGCTCTCGGGGCCGCCACTCATTGCACAGTATTGATTCACCGCG
ACTCCCCTGCGGAGCGCTTA

Downstream 100 bases:

>100_bases
ATCCGGGCAGGACGCGTCCCGAAAGCTTTGGGCGGAGCTTATTGTCTTGTCAACTGCCAGAATTTCAACAAAAAAGCCGG
ACATGCTCACATGTCCGGCT

Product: RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MHTPLEQQEIRYRKGDIIELTITDHAEKDKCFGKTTEGMGVMVSGILAPGDRVSAQIYKVKSRYLEARAIEVLEASPDRV
EPVCPVFGSCGGCKWMHVSYEAQLRYKHKKVTDSLEHIGGFESPDVRPVLAAPDALHYRNKVEFSCSNMRYLLQSEIDSD
QLAKPKTFALGFHAPGNFEKVLDLDTCYLAKECMNRVLNVLRDFAIERGLEPYAAKAHEGYLRNLMLRYSERHEQLMVNI
VTSWYDKALMQALKERLEAAMPEQQMTLLNNVTTRKNTVATGEQEYVISGDGYVTERLGDLDFRISANSFFQTNTRQAET
LYDQIIAVGGITPEDTVYDLYCGTGTITLYLARHCKQAIGIEVVESAVKDAEMNAELNGLSNTVFFQADLKNFHAMQEAL
EPYAKPRIIVTDPPRAGMHPKALDTMLKLQPERIVYVSCNPDNLARDGKEIAARGYRMTSAQPVDMFPQTNHIETVACFE
RAE

Sequences:

>Translated_483_residues
MHTPLEQQEIRYRKGDIIELTITDHAEKDKCFGKTTEGMGVMVSGILAPGDRVSAQIYKVKSRYLEARAIEVLEASPDRV
EPVCPVFGSCGGCKWMHVSYEAQLRYKHKKVTDSLEHIGGFESPDVRPVLAAPDALHYRNKVEFSCSNMRYLLQSEIDSD
QLAKPKTFALGFHAPGNFEKVLDLDTCYLAKECMNRVLNVLRDFAIERGLEPYAAKAHEGYLRNLMLRYSERHEQLMVNI
VTSWYDKALMQALKERLEAAMPEQQMTLLNNVTTRKNTVATGEQEYVISGDGYVTERLGDLDFRISANSFFQTNTRQAET
LYDQIIAVGGITPEDTVYDLYCGTGTITLYLARHCKQAIGIEVVESAVKDAEMNAELNGLSNTVFFQADLKNFHAMQEAL
EPYAKPRIIVTDPPRAGMHPKALDTMLKLQPERIVYVSCNPDNLARDGKEIAARGYRMTSAQPVDMFPQTNHIETVACFE
RAE
>Mature_483_residues
MHTPLEQQEIRYRKGDIIELTITDHAEKDKCFGKTTEGMGVMVSGILAPGDRVSAQIYKVKSRYLEARAIEVLEASPDRV
EPVCPVFGSCGGCKWMHVSYEAQLRYKHKKVTDSLEHIGGFESPDVRPVLAAPDALHYRNKVEFSCSNMRYLLQSEIDSD
QLAKPKTFALGFHAPGNFEKVLDLDTCYLAKECMNRVLNVLRDFAIERGLEPYAAKAHEGYLRNLMLRYSERHEQLMVNI
VTSWYDKALMQALKERLEAAMPEQQMTLLNNVTTRKNTVATGEQEYVISGDGYVTERLGDLDFRISANSFFQTNTRQAET
LYDQIIAVGGITPEDTVYDLYCGTGTITLYLARHCKQAIGIEVVESAVKDAEMNAELNGLSNTVFFQADLKNFHAMQEAL
EPYAKPRIIVTDPPRAGMHPKALDTMLKLQPERIVYVSCNPDNLARDGKEIAARGYRMTSAQPVDMFPQTNHIETVACFE
RAE

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain

Homologues:

Organism=Homo sapiens, GI34222389, Length=403, Percent_Identity=30.5210918114144, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI51173878, Length=403, Percent_Identity=30.5210918114144, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI269784680, Length=431, Percent_Identity=27.1461716937355, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI269784676, Length=431, Percent_Identity=27.1461716937355, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI20149688, Length=431, Percent_Identity=27.1461716937355, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI269784678, Length=373, Percent_Identity=27.6139410187668, Blast_Score=119, Evalue=8e-27,
Organism=Escherichia coli, GI1789148, Length=473, Percent_Identity=27.2727272727273, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1787083, Length=392, Percent_Identity=27.2959183673469, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1790403, Length=261, Percent_Identity=24.1379310344828, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71997438, Length=172, Percent_Identity=34.8837209302326, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322909, Length=407, Percent_Identity=24.8157248157248, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24666579, Length=429, Percent_Identity=31.9347319347319, Blast_Score=174, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y009_CHLTE (Q8KGF9)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_660915.1
- ProteinModelPortal:   Q8KGF9
- GeneID:   1006160
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0009
- NMPDR:   fig|194439.1.peg.9
- TIGR:   CT0009
- HOGENOM:   HBG690163
- OMA:   RKGCDEA
- ProtClustDB:   CLSK637102
- BioCyc:   CTEP194439:CT_0009-MONOMER
- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280
- TIGRFAMs:   TIGR00479

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 54476; Mature: 54476

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS50926 TRAM; PS01230 TRMA_1; PS01231 TRMA_2

Important sites: ACT_SITE 439-439 BINDING 312-312 BINDING 341-341 BINDING 362-362 BINDING 412-412

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTPLEQQEIRYRKGDIIELTITDHAEKDKCFGKTTEGMGVMVSGILAPGDRVSAQIYKV
CCCCCCHHHHHHCCCCEEEEEECCCCCCHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHH
KSRYLEARAIEVLEASPDRVEPVCPVFGSCGGCKWMHVSYEAQLRYKHKKVTDSLEHIGG
HHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHCCC
FESPDVRPVLAAPDALHYRNKVEFSCSNMRYLLQSEIDSDQLAKPKTFALGFHAPGNFEK
CCCCCCCEEEECCCHHHHCCCCEEEHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHH
VLDLDTCYLAKECMNRVLNVLRDFAIERGLEPYAAKAHEGYLRNLMLRYSERHEQLMVNI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTSWYDKALMQALKERLEAAMPEQQMTLLNNVTTRKNTVATGEQEYVISGDGYVTERLGD
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEECCCCEEEECCCCEEEHHCCC
LDFRISANSFFQTNTRQAETLYDQIIAVGGITPEDTVYDLYCGTGTITLYLARHCKQAIG
EEEEEECCCEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
IEVVESAVKDAEMNAELNGLSNTVFFQADLKNFHAMQEALEPYAKPRIIVTDPPRAGMHP
HHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCH
KALDTMLKLQPERIVYVSCNPDNLARDGKEIAARGYRMTSAQPVDMFPQTNHIETVACFE
HHHHHHHHCCCCEEEEEEECCHHHHHCCHHHHHCCCEECCCCCCCCCCCCCCCHHHHHHH
RAE
CCC
>Mature Secondary Structure
MHTPLEQQEIRYRKGDIIELTITDHAEKDKCFGKTTEGMGVMVSGILAPGDRVSAQIYKV
CCCCCCHHHHHHCCCCEEEEEECCCCCCHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHH
KSRYLEARAIEVLEASPDRVEPVCPVFGSCGGCKWMHVSYEAQLRYKHKKVTDSLEHIGG
HHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHCCC
FESPDVRPVLAAPDALHYRNKVEFSCSNMRYLLQSEIDSDQLAKPKTFALGFHAPGNFEK
CCCCCCCEEEECCCHHHHCCCCEEEHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHH
VLDLDTCYLAKECMNRVLNVLRDFAIERGLEPYAAKAHEGYLRNLMLRYSERHEQLMVNI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTSWYDKALMQALKERLEAAMPEQQMTLLNNVTTRKNTVATGEQEYVISGDGYVTERLGD
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEECCCCEEEECCCCEEEHHCCC
LDFRISANSFFQTNTRQAETLYDQIIAVGGITPEDTVYDLYCGTGTITLYLARHCKQAIG
EEEEEECCCEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
IEVVESAVKDAEMNAELNGLSNTVFFQADLKNFHAMQEALEPYAKPRIIVTDPPRAGMHP
HHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCH
KALDTMLKLQPERIVYVSCNPDNLARDGKEIAARGYRMTSAQPVDMFPQTNHIETVACFE
HHHHHHHHCCCCEEEEEEECCHHHHHCCHHHHHCCCEECCCCCCCCCCCCCCCHHHHHHH
RAE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901