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The map label for this gene is cysH [H]

Identifier: 15899624

GI number: 15899624

Start: 2661826

End: 2662545

Strand: Reverse

Name: cysH [H]

Synonym: SSO2911

Alternate gene names: 15899624

Gene position: 2662545-2661826 (Counterclockwise)

Preceding gene: 15899628

Following gene: 15899623

Centisome position: 88.98

GC content: 36.94

Gene sequence:

>720_bases
ATGCTTAGCAAAGATGAGTTAGACTCCCTAAATAAATTGTTCGAAGATAAGGAACCCCTAGAAGTGCTGAAATGGGGAAT
AGAGAAATTTTACCCTAAAATCGCCTTAGCTTGTAGTCTTCAGGCTGAAGATTTGGTAATACTAGATATGTTAAGTAAGG
TTACTGAAAAACCAAGAGTCTTTATAATAGATACTGGTAGACTCCACCAAGAAAGTTATGACTTAATAGAGGAAATAGTG
AAAAAGTATAACATAGACTTAAGGATATATTTTCCAGACTATAAAGAGGTAGAAGATCTAGTTAATAAGTATGGAATCAA
CTTATTTTACAAAAGTGTTGAACTTAGAAAGGCGTGCTGTGAAGTGAGGAAAGTTAGACCCCTAAAGAGAGCGTTGGATG
GAATGGAAGCTTGGATAACTGGGCTAAGGAGAGAACAAAATTTCACTAGAGGGAGGATAAGGAAAATAGAAATAGACGAA
GTCAATGGAGGGATTATTAAGTTAAATCCGTTGGCTGACTGGACATGGGAACAGGTATGGGAATATATAAATAAAAATAA
TGTTCCTTATAATAAGCTCTACGATAAAGGGTATAAGAGTATAGGATGTGTACCATGTACTAGACCAGTTAAACCTTGGG
AGCATCCAAGAGCTGGTAGATGGTGGTGGGAGCAGAATAGTGACAAGGAATGTGGGCTTCATTATAGAGAGGTGAAGTGA

Upstream 100 bases:

>100_bases
AGTCTTAATCTTGTCAAGGGTAAGCTTATATATTTAGCTATTTGTGCAAATTTTGCACATATCGAAACACTAAAGTATTA
ATCCTTACTCAATTATTCTG

Downstream 100 bases:

>100_bases
AGATTCCCATAGAGCCCAATTTTAGAACAGATCCTAAAGATTACAGTGAGGAAGAGAGAGCAAAGCTGAAAACTAAAGGA
TTAACTGAGGATACAATAGG

Product: phosphoadenosine phosphosulfate reductase

Products: NA

Alternate protein names: 3'-phosphoadenylylsulfate reductase; PAPS reductase, thioredoxin dependent; PAPS sulfotransferase; PAdoPS reductase [H]

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MLSKDELDSLNKLFEDKEPLEVLKWGIEKFYPKIALACSLQAEDLVILDMLSKVTEKPRVFIIDTGRLHQESYDLIEEIV
KKYNIDLRIYFPDYKEVEDLVNKYGINLFYKSVELRKACCEVRKVRPLKRALDGMEAWITGLRREQNFTRGRIRKIEIDE
VNGGIIKLNPLADWTWEQVWEYINKNNVPYNKLYDKGYKSIGCVPCTRPVKPWEHPRAGRWWWEQNSDKECGLHYREVK

Sequences:

>Translated_239_residues
MLSKDELDSLNKLFEDKEPLEVLKWGIEKFYPKIALACSLQAEDLVILDMLSKVTEKPRVFIIDTGRLHQESYDLIEEIV
KKYNIDLRIYFPDYKEVEDLVNKYGINLFYKSVELRKACCEVRKVRPLKRALDGMEAWITGLRREQNFTRGRIRKIEIDE
VNGGIIKLNPLADWTWEQVWEYINKNNVPYNKLYDKGYKSIGCVPCTRPVKPWEHPRAGRWWWEQNSDKECGLHYREVK
>Mature_239_residues
MLSKDELDSLNKLFEDKEPLEVLKWGIEKFYPKIALACSLQAEDLVILDMLSKVTEKPRVFIIDTGRLHQESYDLIEEIV
KKYNIDLRIYFPDYKEVEDLVNKYGINLFYKSVELRKACCEVRKVRPLKRALDGMEAWITGLRREQNFTRGRIRKIEIDE
VNGGIIKLNPLADWTWEQVWEYINKNNVPYNKLYDKGYKSIGCVPCTRPVKPWEHPRAGRWWWEQNSDKECGLHYREVK

Specific function: Reduction of activated sulfate into sulfite [H]

COG id: COG0175

COG function: function code EH; 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAPS reductase family. CysH subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789121, Length=253, Percent_Identity=28.4584980237154, Blast_Score=97, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6325425, Length=245, Percent_Identity=40, Blast_Score=146, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011798
- InterPro:   IPR004511
- InterPro:   IPR002500
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01507 PAPS_reduct [H]

EC number: =1.8.4.8 [H]

Molecular weight: Translated: 28461; Mature: 28461

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSKDELDSLNKLFEDKEPLEVLKWGIEKFYPKIALACSLQAEDLVILDMLSKVTEKPRV
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHCCCCEE
FIIDTGRLHQESYDLIEEIVKKYNIDLRIYFPDYKEVEDLVNKYGINLFYKSVELRKACC
EEEECCCCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHCHHHHHHHHHHHHHHH
EVRKVRPLKRALDGMEAWITGLRREQNFTRGRIRKIEIDEVNGGIIKLNPLADWTWEQVW
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEECCCCCCCHHHHH
EYINKNNVPYNKLYDKGYKSIGCVPCTRPVKPWEHPRAGRWWWEQNSDKECGLHYREVK
HHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCC
>Mature Secondary Structure
MLSKDELDSLNKLFEDKEPLEVLKWGIEKFYPKIALACSLQAEDLVILDMLSKVTEKPRV
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHCCCCEE
FIIDTGRLHQESYDLIEEIVKKYNIDLRIYFPDYKEVEDLVNKYGINLFYKSVELRKACC
EEEECCCCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHCHHHHHHHHHHHHHHH
EVRKVRPLKRALDGMEAWITGLRREQNFTRGRIRKIEIDEVNGGIIKLNPLADWTWEQVW
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEECCCCCCCHHHHH
EYINKNNVPYNKLYDKGYKSIGCVPCTRPVKPWEHPRAGRWWWEQNSDKECGLHYREVK
HHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA