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The map label for this gene is qacA [H]

Identifier: 15899421

GI number: 15899421

Start: 2456673

End: 2458376

Strand: Direct

Name: qacA [H]

Synonym: SSO2704

Alternate gene names: 15899421

Gene position: 2456673-2458376 (Clockwise)

Preceding gene: 15899420

Following gene: 15899422

Centisome position: 82.1

GC content: 36.38

Gene sequence:

>1704_bases
ATGGTTCAGTACAAGTGGATTGCATTGTCCAATACAAGTCTCGGTGCATTCATGGGATTTATGAACGCTAATGTAGTATT
AATAGCATTACCAGCAATATTTAGAGGAATTAATATTAATCCGTTTAACTCTTTCCAATACTTATTATGGATCTTATTTG
GTTATAGTATAGTATCAGCAATCTTAGTAGTGAATGTAGGTAGGATCTCAGATATCTTCGGAAGGGTGAGAATGTACAAT
TTAGGATTCCTAATTTTTACAATTGCATCTATACTATTATATTTAACCCCTGGCAAAGGAGATATAGCCGCAATTCAATT
AATAATTTACAGGATACTTCAAGGTATAGGAGGATCATTCTTAATGGCTAATAGCGCTGCAATTTTATCTGAGGCATTTC
CACCAAATGAGAGGGGATTTGCATTAGGATTAAATGGCGTAATAGGAATATTCGGTGGAGTAGCTGGAATAATCATCGGT
GGAATTCTTGCTTCAATATACTGGCGTGACGTATTTTTAGTGAGCGTTCCTATAGGTATTTTAGGAACTATTTGGTCATA
TAAATCCTTAAGGCAATTAAATAAGCCTAATAGAAATCAAAGTATCGATATAGTTGGAAATATCCTTTATGCCGTTTCCC
TTATATCAATACTGCTTGGGATAACGTATGGTATTTTACCATATGGTAATCAAGTTACTGGTTGGACAAATCCATTTGTG
ATATCGGGTATTGTAGCAGGTGTAGGAATGTTCATCGGATTCTTGTTCGTTGAGAGTAGAGTTAAAGACCCCATGTTTAG
AATAGAACTATTTAAAATAAGGGCATTTACATCTTCAGCAGTATCAATAATCTTAGCACAGCTAGCATTTGGAGGTCTTC
AATTGATGCTAGTATTATTACTTCAAGCCATATGGCTACCTTTACACGGTTATAGTTATGAAGTAACACCTTTCTGGGCC
GGAGTATATCTTCTTCCACTATTAGCTGGATTTGGAATAATGGGGTCAATAGCGGGTAGACTAGCAGATCGTTATGGAGC
GCGAAGCTTAGCCACTATTGGACTTTTAATCATGGGAATAGGAGTTTTGACACTAACAACATTGCCATATAATTTCAACT
ATATAGAATTTGCTGTGATAATATTTTTCATAGGTGTTGGAAATGGACTATTTGTATCGCCTAATATGACAGCCTTAATG
AATGCCTCACCACCACAGCATAGAGGATCTGCTTCTGGAATAAGAGCTATGTTAACTAATACCGGTAGTACATTAAGTAT
TGGGATATTCTTTACTATAGTAATTGACACCTTATACATTTCATTACCTCCAGTATTAACTAATGCATTAACTGCTGCTG
GAGCTCCTCAACTAGCCCCAATATTAAGTAAAATACCTCCAACTGCTGCGATATTTGCGAGTTTTCTAGGCTATAATCCT
GTTTCGACGATACTTTCGCAACTACCGACCTCATTAGTTAACGCAATTCCTGCCTCTACAATAGCTACCATAACCGGTAC
ATATTGGTTCCCTAACGTGATAGCATCACCCTTCATGGAAGCTCTAAGAATTGCATTTTACGTTTCAGCATCAATGGCAT
TTTTAGCTACTATAGCTTCAGCTTTAAGAGGAAAAACGGTGATTTATGAAAGAGATTTAATGAGACCTATGGCTGTAAAC
TCCTCAGATGATAAAAAGGATTAA

Upstream 100 bases:

>100_bases
GCAAACGGTAGGTAAATCATTATAAATTTATGATTTTTTAAAAAAGTATGATCGTTATTGGGCAAAAGTTTTAATAAATT
AAAGTTAAGTCTTTAACTAT

Downstream 100 bases:

>100_bases
AAGCTAATTATACTAAAATACTAAGGCATGGAGCCGAATTTAATTACCTTAAGTAATTACAAGGCGACTTTAGGAGAGGG
CCCCGTTTACGATAAGGAGT

Product: permease, multidrug efflux

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 567; Mature: 567

Protein sequence:

>567_residues
MVQYKWIALSNTSLGAFMGFMNANVVLIALPAIFRGININPFNSFQYLLWILFGYSIVSAILVVNVGRISDIFGRVRMYN
LGFLIFTIASILLYLTPGKGDIAAIQLIIYRILQGIGGSFLMANSAAILSEAFPPNERGFALGLNGVIGIFGGVAGIIIG
GILASIYWRDVFLVSVPIGILGTIWSYKSLRQLNKPNRNQSIDIVGNILYAVSLISILLGITYGILPYGNQVTGWTNPFV
ISGIVAGVGMFIGFLFVESRVKDPMFRIELFKIRAFTSSAVSIILAQLAFGGLQLMLVLLLQAIWLPLHGYSYEVTPFWA
GVYLLPLLAGFGIMGSIAGRLADRYGARSLATIGLLIMGIGVLTLTTLPYNFNYIEFAVIIFFIGVGNGLFVSPNMTALM
NASPPQHRGSASGIRAMLTNTGSTLSIGIFFTIVIDTLYISLPPVLTNALTAAGAPQLAPILSKIPPTAAIFASFLGYNP
VSTILSQLPTSLVNAIPASTIATITGTYWFPNVIASPFMEALRIAFYVSASMAFLATIASALRGKTVIYERDLMRPMAVN
SSDDKKD

Sequences:

>Translated_567_residues
MVQYKWIALSNTSLGAFMGFMNANVVLIALPAIFRGININPFNSFQYLLWILFGYSIVSAILVVNVGRISDIFGRVRMYN
LGFLIFTIASILLYLTPGKGDIAAIQLIIYRILQGIGGSFLMANSAAILSEAFPPNERGFALGLNGVIGIFGGVAGIIIG
GILASIYWRDVFLVSVPIGILGTIWSYKSLRQLNKPNRNQSIDIVGNILYAVSLISILLGITYGILPYGNQVTGWTNPFV
ISGIVAGVGMFIGFLFVESRVKDPMFRIELFKIRAFTSSAVSIILAQLAFGGLQLMLVLLLQAIWLPLHGYSYEVTPFWA
GVYLLPLLAGFGIMGSIAGRLADRYGARSLATIGLLIMGIGVLTLTTLPYNFNYIEFAVIIFFIGVGNGLFVSPNMTALM
NASPPQHRGSASGIRAMLTNTGSTLSIGIFFTIVIDTLYISLPPVLTNALTAAGAPQLAPILSKIPPTAAIFASFLGYNP
VSTILSQLPTSLVNAIPASTIATITGTYWFPNVIASPFMEALRIAFYVSASMAFLATIASALRGKTVIYERDLMRPMAVN
SSDDKKD
>Mature_567_residues
MVQYKWIALSNTSLGAFMGFMNANVVLIALPAIFRGININPFNSFQYLLWILFGYSIVSAILVVNVGRISDIFGRVRMYN
LGFLIFTIASILLYLTPGKGDIAAIQLIIYRILQGIGGSFLMANSAAILSEAFPPNERGFALGLNGVIGIFGGVAGIIIG
GILASIYWRDVFLVSVPIGILGTIWSYKSLRQLNKPNRNQSIDIVGNILYAVSLISILLGITYGILPYGNQVTGWTNPFV
ISGIVAGVGMFIGFLFVESRVKDPMFRIELFKIRAFTSSAVSIILAQLAFGGLQLMLVLLLQAIWLPLHGYSYEVTPFWA
GVYLLPLLAGFGIMGSIAGRLADRYGARSLATIGLLIMGIGVLTLTTLPYNFNYIEFAVIIFFIGVGNGLFVSPNMTALM
NASPPQHRGSASGIRAMLTNTGSTLSIGIFFTIVIDTLYISLPPVLTNALTAAGAPQLAPILSKIPPTAAIFASFLGYNP
VSTILSQLPTSLVNAIPASTIATITGTYWFPNVIASPFMEALRIAFYVSASMAFLATIASALRGKTVIYERDLMRPMAVN
SSDDKKD

Specific function: Confers export-mediated resistance against antiseptic and disinfectant compounds such as intercalating dyes, quaternary ammonium salts and diamidines [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=351, Percent_Identity=27.9202279202279, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI87081983, Length=410, Percent_Identity=25.8536585365854, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1789042, Length=447, Percent_Identity=25.7270693512304, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788710, Length=441, Percent_Identity=25.6235827664399, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788392, Length=424, Percent_Identity=23.3490566037736, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324954, Length=402, Percent_Identity=22.636815920398, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 61050; Mature: 61050

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQYKWIALSNTSLGAFMGFMNANVVLIALPAIFRGININPFNSFQYLLWILFGYSIVSA
CCEEEEEEECCCCHHHHHHHHCCCEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
ILVVNVGRISDIFGRVRMYNLGFLIFTIASILLYLTPGKGDIAAIQLIIYRILQGIGGSF
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCCE
LMANSAAILSEAFPPNERGFALGLNGVIGIFGGVAGIIIGGILASIYWRDVFLVSVPIGI
EEECCHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LGTIWSYKSLRQLNKPNRNQSIDIVGNILYAVSLISILLGITYGILPYGNQVTGWTNPFV
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
ISGIVAGVGMFIGFLFVESRVKDPMFRIELFKIRAFTSSAVSIILAQLAFGGLQLMLVLL
HHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQAIWLPLHGYSYEVTPFWAGVYLLPLLAGFGIMGSIAGRLADRYGARSLATIGLLIMGI
HHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
GVLTLTTLPYNFNYIEFAVIIFFIGVGNGLFVSPNMTALMNASPPQHRGSASGIRAMLTN
HHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEECCCCCEEECCCCCCCCCCHHHHHHHHCC
TGSTLSIGIFFTIVIDTLYISLPPVLTNALTAAGAPQLAPILSKIPPTAAIFASFLGYNP
CCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHCCCH
VSTILSQLPTSLVNAIPASTIATITGTYWFPNVIASPFMEALRIAFYVSASMAFLATIAS
HHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALRGKTVIYERDLMRPMAVNSSDDKKD
HHCCCEEEEHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVQYKWIALSNTSLGAFMGFMNANVVLIALPAIFRGININPFNSFQYLLWILFGYSIVSA
CCEEEEEEECCCCHHHHHHHHCCCEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
ILVVNVGRISDIFGRVRMYNLGFLIFTIASILLYLTPGKGDIAAIQLIIYRILQGIGGSF
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCCE
LMANSAAILSEAFPPNERGFALGLNGVIGIFGGVAGIIIGGILASIYWRDVFLVSVPIGI
EEECCHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LGTIWSYKSLRQLNKPNRNQSIDIVGNILYAVSLISILLGITYGILPYGNQVTGWTNPFV
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
ISGIVAGVGMFIGFLFVESRVKDPMFRIELFKIRAFTSSAVSIILAQLAFGGLQLMLVLL
HHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQAIWLPLHGYSYEVTPFWAGVYLLPLLAGFGIMGSIAGRLADRYGARSLATIGLLIMGI
HHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
GVLTLTTLPYNFNYIEFAVIIFFIGVGNGLFVSPNMTALMNASPPQHRGSASGIRAMLTN
HHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEECCCCCEEECCCCCCCCCCHHHHHHHHCC
TGSTLSIGIFFTIVIDTLYISLPPVLTNALTAAGAPQLAPILSKIPPTAAIFASFLGYNP
CCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHCCCH
VSTILSQLPTSLVNAIPASTIATITGTYWFPNVIASPFMEALRIAFYVSASMAFLATIAS
HHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALRGKTVIYERDLMRPMAVNSSDDKKD
HHCCCEEEEHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]