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The map label for this gene is guaA

Identifier: 15899196

GI number: 15899196

Start: 2223552

End: 2224118

Strand: Direct

Name: guaA

Synonym: SSO2451

Alternate gene names: 15899196

Gene position: 2223552-2224118 (Clockwise)

Preceding gene: 15899195

Following gene: 15899198

Centisome position: 74.31

GC content: 38.8

Gene sequence:

>567_bases
GTGAAAGTAGGTTTAGTATATTATGGCGGACAATATAATCACCTAATACTTAAGAACGTAAAGTATTTGGGAGCGGACAT
TGAGGTAATTCCCCCACATAAGCCAGTGGAGGAACTTAAGAAATTCGATTGCGTTATATTTAGTGGTGGCCCCTACTCAG
TGTCAGAGGAAATTCAAAAAATGGGAAATTCTCCCCTTTATATAAAAGAACTGAAAGTCCCAATGTTAGGCATATGCCTA
GGTCATCAGCTAATTGCCTATGTATTGGGTGGGGTTGTAAGAAGAGCCCTAAATCCAGAATACGGACTCACTAGGATAAA
TATATTTGACGAAGATACTATTCTGAAAGGTTTCTCACAGCAACTTAACGTTTGGGAAAGTCACAATGATGAGGTAGTTG
AACCGCCTAGCGGATTCAGAGTGTTAGCTAGTAGCGCAAATGCAAGAGTCCAAGCAATGGCGAACTCAAGTAATTCAATA
TTTGGTGTGCAGTTTCATCCTGAAGTTAAACATACAGAAAGAGGAATAGAGATATTTAAGAACTTCTTAGGAGTATGTAG
AAAATAG

Upstream 100 bases:

>100_bases
ATCTATTATTGAAATGATGTCTGGTGACGGCTCTGAGCCAGTGATGTCGCCAAAAAGTCTGATCAATATTTTTTAAATAT
CCAAAAACTTAGATTCTAGT

Downstream 100 bases:

>100_bases
ATTCACTTCAATTCCTCCTCAGTCTTTTTGCCACTCTCAATGATCTTTCTCTTTACCTTTTCTGGCAATGTATAATCTTC
CCTTCTTTCCTCTAATCTTC

Product: GMP synthase subunit A

Products: NA

Alternate protein names: Glutamine amidotransferase

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MKVGLVYYGGQYNHLILKNVKYLGADIEVIPPHKPVEELKKFDCVIFSGGPYSVSEEIQKMGNSPLYIKELKVPMLGICL
GHQLIAYVLGGVVRRALNPEYGLTRINIFDEDTILKGFSQQLNVWESHNDEVVEPPSGFRVLASSANARVQAMANSSNSI
FGVQFHPEVKHTERGIEIFKNFLGVCRK

Sequences:

>Translated_188_residues
MKVGLVYYGGQYNHLILKNVKYLGADIEVIPPHKPVEELKKFDCVIFSGGPYSVSEEIQKMGNSPLYIKELKVPMLGICL
GHQLIAYVLGGVVRRALNPEYGLTRINIFDEDTILKGFSQQLNVWESHNDEVVEPPSGFRVLASSANARVQAMANSSNSI
FGVQFHPEVKHTERGIEIFKNFLGVCRK
>Mature_188_residues
MKVGLVYYGGQYNHLILKNVKYLGADIEVIPPHKPVEELKKFDCVIFSGGPYSVSEEIQKMGNSPLYIKELKVPMLGICL
GHQLIAYVLGGVVRRALNPEYGLTRINIFDEDTILKGFSQQLNVWESHNDEVVEPPSGFRVLASSANARVQAMANSSNSI
FGVQFHPEVKHTERGIEIFKNFLGVCRK

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0518

COG function: function code F; GMP synthase - Glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=177, Percent_Identity=35.5932203389831, Blast_Score=101, Evalue=5e-22,
Organism=Escherichia coli, GI1788854, Length=197, Percent_Identity=31.4720812182741, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1789760, Length=174, Percent_Identity=31.6091954022989, Blast_Score=74, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI133901714, Length=194, Percent_Identity=32.4742268041237, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71992717, Length=194, Percent_Identity=32.4742268041237, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71992710, Length=194, Percent_Identity=32.4742268041237, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323873, Length=177, Percent_Identity=35.0282485875706, Blast_Score=113, Evalue=1e-26,
Organism=Drosophila melanogaster, GI281365319, Length=184, Percent_Identity=33.1521739130435, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAAA_SULSO (Q97VZ9)

Other databases:

- EMBL:   AE006641
- PIR:   H90416
- RefSeq:   NP_343801.1
- ProteinModelPortal:   Q97VZ9
- SMR:   Q97VZ9
- GeneID:   1453918
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO2451
- NMPDR:   fig|273057.1.peg.2224
- HOGENOM:   HBG292341
- OMA:   GQYVHRI
- ProtClustDB:   PRK00758
- BRENDA:   6.3.5.2
- HAMAP:   MF_01510
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR004739
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase

EC number: =6.3.5.2

Molecular weight: Translated: 21036; Mature: 21036

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 79-79 ACT_SITE 166-166 ACT_SITE 168-168

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGLVYYGGQYNHLILKNVKYLGADIEVIPPHKPVEELKKFDCVIFSGGPYSVSEEIQK
CEEEEEEECCCCCEEHHHHHHHHCCCEEEECCCCCHHHHHHCCEEEECCCCCCHHHHHHH
MGNSPLYIKELKVPMLGICLGHQLIAYVLGGVVRRALNPEYGLTRINIFDEDTILKGFSQ
HCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHH
QLNVWESHNDEVVEPPSGFRVLASSANARVQAMANSSNSIFGVQFHPEVKHTERGIEIFK
HHHHHCCCCCCEECCCCCCEEEECCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHH
NFLGVCRK
HHHHHHCC
>Mature Secondary Structure
MKVGLVYYGGQYNHLILKNVKYLGADIEVIPPHKPVEELKKFDCVIFSGGPYSVSEEIQK
CEEEEEEECCCCCEEHHHHHHHHCCCEEEECCCCCHHHHHHCCEEEECCCCCCHHHHHHH
MGNSPLYIKELKVPMLGICLGHQLIAYVLGGVVRRALNPEYGLTRINIFDEDTILKGFSQ
HCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHH
QLNVWESHNDEVVEPPSGFRVLASSANARVQAMANSSNSIFGVQFHPEVKHTERGIEIFK
HHHHHCCCCCCEECCCCCCEEEECCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHH
NFLGVCRK
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726