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The map label for this gene is huyA-2

Identifier: 15898801

GI number: 15898801

Start: 1823352

End: 1825286

Strand: Direct

Name: huyA-2

Synonym: SSO2008

Alternate gene names: NA

Gene position: 1823352-1825286 (Clockwise)

Preceding gene: 15898800

Following gene: 15898802

Centisome position: 60.94

GC content: 38.86

Gene sequence:

>1935_bases
GTGAAGTGTAAGGTTGCAATCGATATTGGAGGAACTTTTACTGATTTCATAATACTCTCCGAGGTAGGTGAAGTTAGTAC
GATAAAATTTTTAACTAATCCCAGAAATCCTGGTGAGGTAATACAAAATGTAATAAAAGGCTTAAACTGCGAGGTAGAGG
AGGTAGTGCATGCCACGACATTAGCTACAAACGCTTTATTAGGGCAGGAGAATCTTAACATTCCCAGAACTGCTCTTCTT
ACTACTAAAGGTTTTAGAGATGTAATAGAAATAGGGAGACAAAATAGGCCTAGATTGTATGATCTGTATTTCGAAAAACC
TAAACAAATAGTCCCCAGAGAGTTAAGAATAGAGGTAGATGAGAGAGTTAATGCAGATGGTGAAATTTTAAAAGAGGTAG
ATGAGATAGAGGTAGAGGAAAAGGTAAGCAAGATAAAAGCCGAAGCCGTAGCAGTGAGTTATTTACACTCTTATATTAAT
CCACATAATGAATTAAAGACTAAGGAGGTCTTAAAGAAATATTTTAAGTATATCTCAATATCCTCAGAAGTAGCTCCAGA
ACCACGAGAGTACGAAAGAACTTCTACCACGGTAATTAATGCAGCTTTAATGCCAATAGTCTCCTCTTATCTTGAAAATA
TCCAGTCTTCTTTACCGACTGATAATTTTTATATAATGTCAAGCTCTGGAGGGCTAGTAGATATTAATGAGGCTTTAAAT
AAGTCCGTCCAATTAATAGAATCTGGTCCTGCAGCTGGAGTGATAGCGTCAGCCAGTTTCCTTCCCGAGGAGAACTTAAT
AAGTTTTGATATGGGAGGGACTACAGCAAAAGCGGGAGTCGTAATAAACGGCAAATTCGAGATAACTTCTGAGTATGAAG
TAGGAGGAGAGGTTCATCACGGTAGAGTGGTTAAGGGTAGCGGGTACCCGATAAGGTTTCCCTTTGTGGACTTAGCAGAA
GTTTCAGCTGGAGGAGGTACGATTATATGGAGAGATGAGGCTAACGCTTTAAGGGTGGGACCGATAAGTGCTGGTGCAGA
TCCCGGACCGATATGTTATAACAAAGGGGGAAATAAACCAACGATAACTGATGCTAATTTAGTCTTAGGTAGACTTGGAG
AGGAATTATTAGGAGGAAACATGAAACTTTATAAAGAGAAGGCCTTAGAGGGCTTATCTAGACTAGGTGATCCATATGAG
GTAAGTAAAGTCGCGTTAGATTTAGTCAATTTAGAAATGGCTAGGGCTATAAGGTTAGTTACTGTTGAGAGGGGCTTAGA
TCCGTCAAATTTCTCTCTTATAGCTTTTGGAGGGGCTGGTCCTCAACATGCGTTATATTTAGCCGATGAGATAGGTATAA
AAAGGGTAATAATTCCACCTTATCCTGGACTGTTTAGTGCATTAGGACTTTTACTTGCTGACTGGCGTTTTGAGGCTAGG
AAATCTTACCCTAAAGACTTAGAGAGGGACTTCAAGGAGTTAGAAAATAAATTAATTGAAAGGCTCAAAAAGGTTGATTA
CTTCATTAGATATGCCGATGTTAGATATAAGGGGCAGGGATGGGAACTGACAATTCAGGTTCCAGAAAACGTTAATGAAA
TTAGAAAGGTGTTCGAGGATAAACATTTAGCTACATATGGTTTCGTTATGAGTGATAGGGAAATAGAGATAGTTACTATA
AGGGTGTTCGCAATTAGAAGGAGAGTTACGCCAAAAATATCACCTACATTTGGGAACGAAAACAAACCTAAGGAAATTAG
AAAGGTTCTAATAGAAGATGATTGGGTTAATACAGAGGTCTACGTTAGGGAGAAGTTACCTAAGGGATTTGAAATAAGGG
GTCCGGCAATTATTGAGGAGTATAGCTCTACTATCGTGGTCAAGCCAGGTTGGAAGGCTTTAGTAGATGATTCAATTATA
ATGGTGAGAGAATGA

Upstream 100 bases:

>100_bases
ATAAAATTGAGGTCTAAAGACTTTCCGGCGTTCTATATAGGAAATACTAGTGATGTAAGTTCCCCGAAAAACATTAATAC
TAATATCGTGAGTATGAAGT

Downstream 100 bases:

>100_bases
CGAGTTGGGAAATAATTCATAAGGCTTTTGAATTTATTGCAGAAGAAATGGGAGTTATGTTAAAGAGATCGGCGATGTCA
CCTAATATTAGGGAGAGAAT

Product: N-methyl hydantoinase A (huyA-2)

Products: ADP; phosphate; N-carbamoylsarcosine

Alternate protein names: NA

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MKCKVAIDIGGTFTDFIILSEVGEVSTIKFLTNPRNPGEVIQNVIKGLNCEVEEVVHATTLATNALLGQENLNIPRTALL
TTKGFRDVIEIGRQNRPRLYDLYFEKPKQIVPRELRIEVDERVNADGEILKEVDEIEVEEKVSKIKAEAVAVSYLHSYIN
PHNELKTKEVLKKYFKYISISSEVAPEPREYERTSTTVINAALMPIVSSYLENIQSSLPTDNFYIMSSSGGLVDINEALN
KSVQLIESGPAAGVIASASFLPEENLISFDMGGTTAKAGVVINGKFEITSEYEVGGEVHHGRVVKGSGYPIRFPFVDLAE
VSAGGGTIIWRDEANALRVGPISAGADPGPICYNKGGNKPTITDANLVLGRLGEELLGGNMKLYKEKALEGLSRLGDPYE
VSKVALDLVNLEMARAIRLVTVERGLDPSNFSLIAFGGAGPQHALYLADEIGIKRVIIPPYPGLFSALGLLLADWRFEAR
KSYPKDLERDFKELENKLIERLKKVDYFIRYADVRYKGQGWELTIQVPENVNEIRKVFEDKHLATYGFVMSDREIEIVTI
RVFAIRRRVTPKISPTFGNENKPKEIRKVLIEDDWVNTEVYVREKLPKGFEIRGPAIIEEYSSTIVVKPGWKALVDDSII
MVRE

Sequences:

>Translated_644_residues
MKCKVAIDIGGTFTDFIILSEVGEVSTIKFLTNPRNPGEVIQNVIKGLNCEVEEVVHATTLATNALLGQENLNIPRTALL
TTKGFRDVIEIGRQNRPRLYDLYFEKPKQIVPRELRIEVDERVNADGEILKEVDEIEVEEKVSKIKAEAVAVSYLHSYIN
PHNELKTKEVLKKYFKYISISSEVAPEPREYERTSTTVINAALMPIVSSYLENIQSSLPTDNFYIMSSSGGLVDINEALN
KSVQLIESGPAAGVIASASFLPEENLISFDMGGTTAKAGVVINGKFEITSEYEVGGEVHHGRVVKGSGYPIRFPFVDLAE
VSAGGGTIIWRDEANALRVGPISAGADPGPICYNKGGNKPTITDANLVLGRLGEELLGGNMKLYKEKALEGLSRLGDPYE
VSKVALDLVNLEMARAIRLVTVERGLDPSNFSLIAFGGAGPQHALYLADEIGIKRVIIPPYPGLFSALGLLLADWRFEAR
KSYPKDLERDFKELENKLIERLKKVDYFIRYADVRYKGQGWELTIQVPENVNEIRKVFEDKHLATYGFVMSDREIEIVTI
RVFAIRRRVTPKISPTFGNENKPKEIRKVLIEDDWVNTEVYVREKLPKGFEIRGPAIIEEYSSTIVVKPGWKALVDDSII
MVRE
>Mature_644_residues
MKCKVAIDIGGTFTDFIILSEVGEVSTIKFLTNPRNPGEVIQNVIKGLNCEVEEVVHATTLATNALLGQENLNIPRTALL
TTKGFRDVIEIGRQNRPRLYDLYFEKPKQIVPRELRIEVDERVNADGEILKEVDEIEVEEKVSKIKAEAVAVSYLHSYIN
PHNELKTKEVLKKYFKYISISSEVAPEPREYERTSTTVINAALMPIVSSYLENIQSSLPTDNFYIMSSSGGLVDINEALN
KSVQLIESGPAAGVIASASFLPEENLISFDMGGTTAKAGVVINGKFEITSEYEVGGEVHHGRVVKGSGYPIRFPFVDLAE
VSAGGGTIIWRDEANALRVGPISAGADPGPICYNKGGNKPTITDANLVLGRLGEELLGGNMKLYKEKALEGLSRLGDPYE
VSKVALDLVNLEMARAIRLVTVERGLDPSNFSLIAFGGAGPQHALYLADEIGIKRVIIPPYPGLFSALGLLLADWRFEAR
KSYPKDLERDFKELENKLIERLKKVDYFIRYADVRYKGQGWELTIQVPENVNEIRKVFEDKHLATYGFVMSDREIEIVTI
RVFAIRRRVTPKISPTFGNENKPKEIRKVLIEDDWVNTEVYVREKLPKGFEIRGPAIIEEYSSTIVVKPGWKALVDDSII
MVRE

Specific function: Unknown

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=724, Percent_Identity=30.939226519337, Blast_Score=220, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI133901900, Length=705, Percent_Identity=30.7801418439716, Blast_Score=230, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6322634, Length=746, Percent_Identity=31.0991957104558, Blast_Score=239, Evalue=8e-64,
Organism=Drosophila melanogaster, GI45550492, Length=720, Percent_Identity=29.5833333333333, Blast_Score=235, Evalue=7e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: 3.5.2.14

Molecular weight: Translated: 71777; Mature: 71777

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCKVAIDIGGTFTDFIILSEVGEVSTIKFLTNPRNPGEVIQNVIKGLNCEVEEVVHATT
CCEEEEEEECCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHH
LATNALLGQENLNIPRTALLTTKGFRDVIEIGRQNRPRLYDLYFEKPKQIVPRELRIEVD
HHHHHHCCCCCCCCCCEEEEECCCHHHHHHHCCCCCCEEEEEEECCCHHHCCHHEEEEEH
ERVNADGEILKEVDEIEVEEKVSKIKAEAVAVSYLHSYINPHNELKTKEVLKKYFKYISI
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEC
SSEVAPEPREYERTSTTVINAALMPIVSSYLENIQSSLPTDNFYIMSSSGGLVDINEALN
CHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEHHHHHC
KSVQLIESGPAAGVIASASFLPEENLISFDMGGTTAKAGVVINGKFEITSEYEVGGEVHH
HHHHHHHCCCCCCEEEHHCCCCCCCEEEEECCCCCEECCEEEECEEEEEECCCCCCEEEC
GRVVKGSGYPIRFPFVDLAEVSAGGGTIIWRDEANALRVGPISAGADPGPICYNKGGNKP
CEEEECCCCEEECCCCCHHHCCCCCCEEEEECCCCEEEECCCCCCCCCCCEEECCCCCCC
TITDANLVLGRLGEELLGGNMKLYKEKALEGLSRLGDPYEVSKVALDLVNLEMARAIRLV
CEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEE
TVERGLDPSNFSLIAFGGAGPQHALYLADEIGIKRVIIPPYPGLFSALGLLLADWRFEAR
EEECCCCCCCEEEEEECCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
KSYPKDLERDFKELENKLIERLKKVDYFIRYADVRYKGQGWELTIQVPENVNEIRKVFED
HCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEEECCCCHHHHHHHHCC
KHLATYGFVMSDREIEIVTIRVFAIRRRVTPKISPTFGNENKPKEIRKVLIEDDWVNTEV
CCEEEEEEEECCCEEEEEEEEEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEE
YVREKLPKGFEIRGPAIIEEYSSTIVVKPGWKALVDDSIIMVRE
EEEECCCCCCCCCCCHHHHCCCCEEEECCCCHHHCCCCEEEEEC
>Mature Secondary Structure
MKCKVAIDIGGTFTDFIILSEVGEVSTIKFLTNPRNPGEVIQNVIKGLNCEVEEVVHATT
CCEEEEEEECCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHH
LATNALLGQENLNIPRTALLTTKGFRDVIEIGRQNRPRLYDLYFEKPKQIVPRELRIEVD
HHHHHHCCCCCCCCCCEEEEECCCHHHHHHHCCCCCCEEEEEEECCCHHHCCHHEEEEEH
ERVNADGEILKEVDEIEVEEKVSKIKAEAVAVSYLHSYINPHNELKTKEVLKKYFKYISI
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEC
SSEVAPEPREYERTSTTVINAALMPIVSSYLENIQSSLPTDNFYIMSSSGGLVDINEALN
CHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEHHHHHC
KSVQLIESGPAAGVIASASFLPEENLISFDMGGTTAKAGVVINGKFEITSEYEVGGEVHH
HHHHHHHCCCCCCEEEHHCCCCCCCEEEEECCCCCEECCEEEECEEEEEECCCCCCEEEC
GRVVKGSGYPIRFPFVDLAEVSAGGGTIIWRDEANALRVGPISAGADPGPICYNKGGNKP
CEEEECCCCEEECCCCCHHHCCCCCCEEEEECCCCEEEECCCCCCCCCCCEEECCCCCCC
TITDANLVLGRLGEELLGGNMKLYKEKALEGLSRLGDPYEVSKVALDLVNLEMARAIRLV
CEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEE
TVERGLDPSNFSLIAFGGAGPQHALYLADEIGIKRVIIPPYPGLFSALGLLLADWRFEAR
EEECCCCCCCEEEEEECCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
KSYPKDLERDFKELENKLIERLKKVDYFIRYADVRYKGQGWELTIQVPENVNEIRKVFED
HCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEEECCCCHHHHHHHHCC
KHLATYGFVMSDREIEIVTIRVFAIRRRVTPKISPTFGNENKPKEIRKVLIEDDWVNTEV
CCEEEEEEEECCCEEEEEEEEEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEE
YVREKLPKGFEIRGPAIIEEYSSTIVVKPGWKALVDDSIIMVRE
EEEECCCCCCCCCCCHHHHCCCCEEEECCCCHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O

Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]