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The map label for this gene is ilvC-3

Identifier: 15898741

GI number: 15898741

Start: 1760648

End: 1761646

Strand: Direct

Name: ilvC-3

Synonym: SSO1942

Alternate gene names: 15898741

Gene position: 1760648-1761646 (Clockwise)

Preceding gene: 15898740

Following gene: 15898742

Centisome position: 58.84

GC content: 39.14

Gene sequence:

>999_bases
ATGGATAAAACAGTTTTAGACGCGAGTTTAGAACCTTTAAAGGGAAAGACAATAGCCGTAATTGGTTACGGTAACCAAGG
GAGAGTTCAAGCTAATATTATGAGGGAAAATGGTCTGAACGTTATTATAGGAAACGTTAAGGATAGGTATTACGATTTGG
CTATAAAGGAAGGGTTTGAAGTTTACGATATAGGTGAAGCAGTGAAGAAAGCTGATGTTGCCTTTCTCCTAATTCCAGAT
GAAATAATGAAGGAAATTTATGAAAAGAAGATTGCCCCAATTTTAGAAGGCAAGAAAGAGTTCGTATTGGACTTCGCCAG
TGGATATAATGTGGCCTTTGGACTTATTAGACCACCTAAAAACGTTGATACTGTTATGGTTGCTCCCAGAATGGTTGGGG
AAGGGATTATGGATTTGCATAAACAAGGGAAAGGTTATCCCGTATTATTGGGAGTTAAACAAGATGCATCTGGAAAGGCA
TGGGATTACGCTAAGGCAATAGCCAAGGGTATAGGTGCAATTCCAGGAGGGATTGCAGTTATTTCATCATTTGAGGAGGA
AGCGTTATTAGATTTAATGAGCGAACACACTTGGGTGCCAATATTGTTTGGGGCAATAAAGGCTTGTTTTGACGTTGCTG
TAAAGGAATATGGGGTATCTCCAGAAGCGGCGTTGTTGGAGTTTTATGCCTCTGGGGAATTGGTTGAGATTGCTAGACTA
ATTGCTGAAGAGGGTATATTTAATCAAATGGTTCACCACAGTACTACTAGTCAATACGGTACTTTAACGAGAATGTTCAA
ATATTATGACTTAGTCAAGGAAATTGTTAAAGATGAGGCAAAGTACATATGGGATGGTAGTTTCGCTAAGGAGTGGACAT
TAGAACAACAAGCTGGATACCCCGTATTTTATAGATTGTGGGAATTGGCTGTACAGAGCGAAATGGCTAAGGCTGAAAAG
GAGTTGTATAAAATTCTAAGAAGAAAGGTAAGCGATTAA

Upstream 100 bases:

>100_bases
TCCAATGATGTGGGCTATGGATCAAGTTAGGAAGATAGGTTCTTCATCATCCCTATAAGTACGGATTCGTATTTTTATTT
TCAAACAACAACACTTTTTT

Downstream 100 bases:

>100_bases
AAATTACGCTAAGACATTACAGCGTTTACCCGTTGCGTAACTTATCCTTACTTTTAATTCCGTCACGGGCACCCTATATA
GGTTGAAAGGACCCACGTGG

Product: ketol-acid reductoisomerase (ilvC-3)

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase 3; Alpha-keto-beta-hydroxylacil reductoisomerase 3

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MDKTVLDASLEPLKGKTIAVIGYGNQGRVQANIMRENGLNVIIGNVKDRYYDLAIKEGFEVYDIGEAVKKADVAFLLIPD
EIMKEIYEKKIAPILEGKKEFVLDFASGYNVAFGLIRPPKNVDTVMVAPRMVGEGIMDLHKQGKGYPVLLGVKQDASGKA
WDYAKAIAKGIGAIPGGIAVISSFEEEALLDLMSEHTWVPILFGAIKACFDVAVKEYGVSPEAALLEFYASGELVEIARL
IAEEGIFNQMVHHSTTSQYGTLTRMFKYYDLVKEIVKDEAKYIWDGSFAKEWTLEQQAGYPVFYRLWELAVQSEMAKAEK
ELYKILRRKVSD

Sequences:

>Translated_332_residues
MDKTVLDASLEPLKGKTIAVIGYGNQGRVQANIMRENGLNVIIGNVKDRYYDLAIKEGFEVYDIGEAVKKADVAFLLIPD
EIMKEIYEKKIAPILEGKKEFVLDFASGYNVAFGLIRPPKNVDTVMVAPRMVGEGIMDLHKQGKGYPVLLGVKQDASGKA
WDYAKAIAKGIGAIPGGIAVISSFEEEALLDLMSEHTWVPILFGAIKACFDVAVKEYGVSPEAALLEFYASGELVEIARL
IAEEGIFNQMVHHSTTSQYGTLTRMFKYYDLVKEIVKDEAKYIWDGSFAKEWTLEQQAGYPVFYRLWELAVQSEMAKAEK
ELYKILRRKVSD
>Mature_332_residues
MDKTVLDASLEPLKGKTIAVIGYGNQGRVQANIMRENGLNVIIGNVKDRYYDLAIKEGFEVYDIGEAVKKADVAFLLIPD
EIMKEIYEKKIAPILEGKKEFVLDFASGYNVAFGLIRPPKNVDTVMVAPRMVGEGIMDLHKQGKGYPVLLGVKQDASGKA
WDYAKAIAKGIGAIPGGIAVISSFEEEALLDLMSEHTWVPILFGAIKACFDVAVKEYGVSPEAALLEFYASGELVEIARL
IAEEGIFNQMVHHSTTSQYGTLTRMFKYYDLVKEIVKDEAKYIWDGSFAKEWTLEQQAGYPVFYRLWELAVQSEMAKAEK
ELYKILRRKVSD

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=230, Percent_Identity=31.304347826087, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323387, Length=286, Percent_Identity=32.1678321678322, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC3_SULSO (Q97X13)

Other databases:

- EMBL:   AE006641
- PIR:   A90360
- RefSeq:   NP_343346.1
- ProteinModelPortal:   Q97X13
- SMR:   Q97X13
- GeneID:   1453463
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO1942
- NMPDR:   fig|273057.1.peg.1769
- HOGENOM:   HBG286525
- OMA:   KEWALEQ
- ProtClustDB:   CLSK339264
- BioCyc:   SSOL273057:SSO1942-MONOMER
- BRENDA:   1.1.1.86
- GO:   GO:0005488
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013116
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 37071; Mature: 37071

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKTVLDASLEPLKGKTIAVIGYGNQGRVQANIMRENGLNVIIGNVKDRYYDLAIKEGFE
CCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHCCCC
VYDIGEAVKKADVAFLLIPDEIMKEIYEKKIAPILEGKKEFVLDFASGYNVAFGLIRPPK
EEEHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHCCCHHHEEECCCCCCEEEEEECCCC
NVDTVMVAPRMVGEGIMDLHKQGKGYPVLLGVKQDASGKAWDYAKAIAKGIGAIPGGIAV
CCCEEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHH
ISSFEEEALLDLMSEHTWVPILFGAIKACFDVAVKEYGVSPEAALLEFYASGELVEIARL
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHH
IAEEGIFNQMVHHSTTSQYGTLTRMFKYYDLVKEIVKDEAKYIWDGSFAKEWTLEQQAGY
HHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHCCCHHHCCC
PVFYRLWELAVQSEMAKAEKELYKILRRKVSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDKTVLDASLEPLKGKTIAVIGYGNQGRVQANIMRENGLNVIIGNVKDRYYDLAIKEGFE
CCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHCCCC
VYDIGEAVKKADVAFLLIPDEIMKEIYEKKIAPILEGKKEFVLDFASGYNVAFGLIRPPK
EEEHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHCCCHHHEEECCCCCCEEEEEECCCC
NVDTVMVAPRMVGEGIMDLHKQGKGYPVLLGVKQDASGKAWDYAKAIAKGIGAIPGGIAV
CCCEEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHH
ISSFEEEALLDLMSEHTWVPILFGAIKACFDVAVKEYGVSPEAALLEFYASGELVEIARL
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHH
IAEEGIFNQMVHHSTTSQYGTLTRMFKYYDLVKEIVKDEAKYIWDGSFAKEWTLEQQAGY
HHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHCCCHHHCCC
PVFYRLWELAVQSEMAKAEKELYKILRRKVSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726