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The map label for this gene is adh-4 [H]

Identifier: 15898142

GI number: 15898142

Start: 1129863

End: 1130912

Strand: Reverse

Name: adh-4 [H]

Synonym: SSO1300

Alternate gene names: 15898142

Gene position: 1130912-1129863 (Counterclockwise)

Preceding gene: 15898143

Following gene: 15898141

Centisome position: 37.79

GC content: 39.9

Gene sequence:

>1050_bases
ATGGAAAATGTAAATATGGTTAAATCAAAAGCAGCCCTTCTAAAGAAGTTCTCTGAACCATTATCAATAGAAGACGTTAA
CATTCCAGAACCCCAAGGGGAAGAGGTGTTAATAAGGATAGGAGGAGCTGGAGTCTGTAGAACAGATTTAAGAGTATGGA
AGGGAGTTGAAGCGAAGCAAGGCTTTAGATTACCAATAATACTAGGTCACGAAAACGCTGGGACAATAGTGGAAGTCGGA
GAGTTAGCAAAGGTAAAGAAGGGAGACAACGTAGTAGTTTACGCAACATGGGGTGACCTAACTTGCAGATATTGCAGAGA
GGGGAAGTTCAACATTTGTAAAAATCAAATAATCCCCGGGCAAACAACAAATGGTGGTTTCTCAGAGTACATGTTGGTTA
AAAGCTCCAGATGGCTGGTAAAATTAAACAGCCTAAGCCCAGTTGAAGCAGCACCCTTAGCGGATGCCGGTACGACCTCT
ATGGGGGCTATAAGGCAAGCCTTGCCGTTCATAAGTAAATTCGCTGAACCAGTTGTTATAGTTAACGGTATTGGAGGGTT
AGCCGTTTACACTATCCAAATATTAAAAGCGTTAATGAAGAATATAACTATAGTTGGAATTTCTAGGAGTAAGAAGCATA
GGGATTTCGCGTTAGAGTTAGGAGCAGACTATGTGTCGGAAATGAAAGACGCTGAGAGTCTAATAAACAAACTCACAGAT
GGTTTAGGTGCTAGTATTGCAATAGATCTGGTGGGGACTGAGGAAACTACTTATAATTTAGGAAAATTATTAGCACAAGA
AGGTGCAATAATACTGGTAGGAATGGAGGGGAAGAGAGTAAGTTTAGAAGCCTTTGATACTGCGGTGTGGAATAAGAAGC
TTCTGGGTTCAAATTACGGTTCGCTAAACGATTTAGAAGATGTAGTAAGGCTTAGTGAAAGTGGAAAAATTAAGCCATAT
ATTATTAAGGTACCTTTAGATGATATTAACAAAGCATTCACTAACTTGGATGAGGGAAGAGTAGACGGAAGACAAGTAAT
AACACCATAA

Upstream 100 bases:

>100_bases
TTTAGAAATGTTGTTGCCCTTCAGACTATAAGCAAGTATAATTAACTTTAGTGATGAATACCAATCCTAACATGTTTGGA
ATCACCTTTTATTCAGCTTT

Downstream 100 bases:

>100_bases
TTTAACCTTGATGGGGATTAAGGAGGCGAAAGTCCCCTTCCGTGACGGTAGACCCAAAATCGCCCACTTGAAAATAAATC
TATAGTATCATTAAGCGTTT

Product: zinc-containing alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MENVNMVKSKAALLKKFSEPLSIEDVNIPEPQGEEVLIRIGGAGVCRTDLRVWKGVEAKQGFRLPIILGHENAGTIVEVG
ELAKVKKGDNVVVYATWGDLTCRYCREGKFNICKNQIIPGQTTNGGFSEYMLVKSSRWLVKLNSLSPVEAAPLADAGTTS
MGAIRQALPFISKFAEPVVIVNGIGGLAVYTIQILKALMKNITIVGISRSKKHRDFALELGADYVSEMKDAESLINKLTD
GLGASIAIDLVGTEETTYNLGKLLAQEGAIILVGMEGKRVSLEAFDTAVWNKKLLGSNYGSLNDLEDVVRLSESGKIKPY
IIKVPLDDINKAFTNLDEGRVDGRQVITP

Sequences:

>Translated_349_residues
MENVNMVKSKAALLKKFSEPLSIEDVNIPEPQGEEVLIRIGGAGVCRTDLRVWKGVEAKQGFRLPIILGHENAGTIVEVG
ELAKVKKGDNVVVYATWGDLTCRYCREGKFNICKNQIIPGQTTNGGFSEYMLVKSSRWLVKLNSLSPVEAAPLADAGTTS
MGAIRQALPFISKFAEPVVIVNGIGGLAVYTIQILKALMKNITIVGISRSKKHRDFALELGADYVSEMKDAESLINKLTD
GLGASIAIDLVGTEETTYNLGKLLAQEGAIILVGMEGKRVSLEAFDTAVWNKKLLGSNYGSLNDLEDVVRLSESGKIKPY
IIKVPLDDINKAFTNLDEGRVDGRQVITP
>Mature_349_residues
MENVNMVKSKAALLKKFSEPLSIEDVNIPEPQGEEVLIRIGGAGVCRTDLRVWKGVEAKQGFRLPIILGHENAGTIVEVG
ELAKVKKGDNVVVYATWGDLTCRYCREGKFNICKNQIIPGQTTNGGFSEYMLVKSSRWLVKLNSLSPVEAAPLADAGTTS
MGAIRQALPFISKFAEPVVIVNGIGGLAVYTIQILKALMKNITIVGISRSKKHRDFALELGADYVSEMKDAESLINKLTD
GLGASIAIDLVGTEETTYNLGKLLAQEGAIILVGMEGKRVSLEAFDTAVWNKKLLGSNYGSLNDLEDVVRLSESGKIKPY
IIKVPLDDINKAFTNLDEGRVDGRQVITP

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=374, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI71743840, Length=375, Percent_Identity=26.1333333333333, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI262073058, Length=374, Percent_Identity=26.2032085561497, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI34577061, Length=373, Percent_Identity=27.3458445040214, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI4501929, Length=374, Percent_Identity=27.2727272727273, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI71565154, Length=374, Percent_Identity=26.7379679144385, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI4501939, Length=370, Percent_Identity=25.6756756756757, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI156523966, Length=371, Percent_Identity=25.6064690026954, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI71565152, Length=375, Percent_Identity=25.0666666666667, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI156627571, Length=328, Percent_Identity=22.8658536585366, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI87081918, Length=318, Percent_Identity=25.7861635220126, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI226510992, Length=299, Percent_Identity=30.1003344481605, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788075, Length=315, Percent_Identity=26.6666666666667, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786552, Length=373, Percent_Identity=27.6139410187668, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786518, Length=359, Percent_Identity=26.1838440111421, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1788073, Length=282, Percent_Identity=29.4326241134752, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790045, Length=337, Percent_Identity=22.8486646884273, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787863, Length=316, Percent_Identity=25, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87082125, Length=352, Percent_Identity=25, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI87082401, Length=352, Percent_Identity=25.5681818181818, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788407, Length=188, Percent_Identity=30.8510638297872, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562584, Length=354, Percent_Identity=26.5536723163842, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71988145, Length=343, Percent_Identity=24.7813411078717, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17562582, Length=348, Percent_Identity=25.8620689655172, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI25146526, Length=378, Percent_Identity=27.5132275132275, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=380, Percent_Identity=27.3684210526316, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=326, Percent_Identity=23.0061349693252, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17544682, Length=356, Percent_Identity=24.438202247191, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319621, Length=346, Percent_Identity=28.3236994219653, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6323961, Length=345, Percent_Identity=27.536231884058, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324486, Length=343, Percent_Identity=26.530612244898, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6323729, Length=332, Percent_Identity=25.6024096385542, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320033, Length=373, Percent_Identity=27.6139410187668, Blast_Score=99, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6319257, Length=329, Percent_Identity=27.0516717325228, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322619, Length=340, Percent_Identity=25, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319258, Length=328, Percent_Identity=26.219512195122, Blast_Score=69, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6319955, Length=340, Percent_Identity=25, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6319949, Length=335, Percent_Identity=23.2835820895522, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI17737895, Length=375, Percent_Identity=28.5333333333333, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37879; Mature: 37879

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENVNMVKSKAALLKKFSEPLSIEDVNIPEPQGEEVLIRIGGAGVCRTDLRVWKGVEAKQ
CCCCHHHHHHHHHHHHHCCCCCEECCCCCCCCCCEEEEEECCCCEEHHHHHHHCCCCCCC
GFRLPIILGHENAGTIVEVGELAKVKKGDNVVVYATWGDLTCRYCREGKFNICKNQIIPG
CCEEEEEEECCCCCCEEEECHHHHHCCCCCEEEEEECCCCCHHHHCCCCCCHHHCCCCCC
QTTNGGFSEYMLVKSSRWLVKLNSLSPVEAAPLADAGTTSMGAIRQALPFISKFAEPVVI
CCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
VNGIGGLAVYTIQILKALMKNITIVGISRSKKHRDFALELGADYVSEMKDAESLINKLTD
EECCCHHHHHHHHHHHHHHHCEEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHC
GLGASIAIDLVGTEETTYNLGKLLAQEGAIILVGMEGKRVSLEAFDTAVWNKKLLGSNYG
CCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCEEEHHHHHHHHHHHHHHCCCCC
SLNDLEDVVRLSESGKIKPYIIKVPLDDINKAFTNLDEGRVDGRQVITP
CHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHCCCCCCCCCEEECCC
>Mature Secondary Structure
MENVNMVKSKAALLKKFSEPLSIEDVNIPEPQGEEVLIRIGGAGVCRTDLRVWKGVEAKQ
CCCCHHHHHHHHHHHHHCCCCCEECCCCCCCCCCEEEEEECCCCEEHHHHHHHCCCCCCC
GFRLPIILGHENAGTIVEVGELAKVKKGDNVVVYATWGDLTCRYCREGKFNICKNQIIPG
CCEEEEEEECCCCCCEEEECHHHHHCCCCCEEEEEECCCCCHHHHCCCCCCHHHCCCCCC
QTTNGGFSEYMLVKSSRWLVKLNSLSPVEAAPLADAGTTSMGAIRQALPFISKFAEPVVI
CCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
VNGIGGLAVYTIQILKALMKNITIVGISRSKKHRDFALELGADYVSEMKDAESLINKLTD
EECCCHHHHHHHHHHHHHHHCEEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHC
GLGASIAIDLVGTEETTYNLGKLLAQEGAIILVGMEGKRVSLEAFDTAVWNKKLLGSNYG
CCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCEEEHHHHHHHHHHHHHHCCCCC
SLNDLEDVVRLSESGKIKPYIIKVPLDDINKAFTNLDEGRVDGRQVITP
CHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHCCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA