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The map label for this gene is top6A [H]

Identifier: 15897848

GI number: 15897848

Start: 828181

End: 829350

Strand: Direct

Name: top6A [H]

Synonym: SSO0969

Alternate gene names: 15897848

Gene position: 828181-829350 (Clockwise)

Preceding gene: 15897847

Following gene: 15897849

Centisome position: 27.68

GC content: 36.75

Gene sequence:

>1170_bases
ATGAGTTCTGAATTTATATCAAAGGTTGATAAAGAAGCGAGAAGGAAAGCTGCTAGTATATTGCGCGATAAGTTCCTTAA
TTTAGTTGAACAACTTAAGAAAGGCGAACCATTAGTAATGGAAATCCCAATGAGAACTTTATCTAATGCGATCTATGATG
AAAAGAGAAAGCTACTACTCTTGGGAGAAAAGAAACTTAAAAGGAATTTTCTAGATATGAACGAAGCAAAACGATTTATG
CAGACCGTATTGATGGCATCAATAATTTATGACGCGCTAGTTAGCGATGAGTACCCAACTATACGTGATCTTTACTACAG
AGGAAAGCACTCACTTTTGTTAAAGTCAATTGATGGCAATAAGATAGTGTCTGAAGAGAATACATGGGATGAACAAAAGG
AGTCAGATAGTGTTATAGTTGATATCGAAGTATTTACGTCTCTCCTTAGAGAAGAAATGCTGATTCTCAGTAAGGAAAAG
GGTAAAGTAGTAGGTAATTTAAGGATAAGGAGCGGAAATGATACAATAGATCTGAGTAAAACTGGTCATGGAGCCTACGC
GATTGAACCTACTCCCGATTTGATAGATTTCATTGATGTTGATGCAGAATTTGTACTAGTAGTGGAGAAAGATGCAGTAT
TCCAACAGTTGCATAGAGCTGGTTTTTGGAAACAGTATAAGTCCATTTTAATAACTAGTGCGGGTCAACCAGATAGGGCA
ACTAGGAGATTTGTCAGAAGACTTAATGAGGAGCTAAAATTGCCAGTTTATATCTTAACTGATGCTGATCCCTATGGATG
GTATATATTCAGCGTATTCAGAATAGGCTCAATATCTTTATCTTACGAGAGTGAGAGGCTAGCTACTCCAGACGCCAAAT
TTTTGGGCGTATCAATGAGTGATATCTTCGGTAATTCCAGAAAGAAACCCTATTTAAGTGAAGCCGAGAGAAAGAATTAT
ATAATTAAGGCCAAAGAGGCAGATATAAAGAGAGCTGAGGAAATTAAAAACTATGAGTGGTTTAAGACTAAAGCATGGGA
AGAAGAGATAAACACTTTCCTACATAGGAAAGCTAAATTGGAAATAGAAGCTATGGCAAGCAAGGGTCTTAAGTTTCTCG
CTTTCCAGTACATTCCAGAGAAGATAACTAATAAGGATTACATTGCCTAA

Upstream 100 bases:

>100_bases
ATCAAGGTGAGATTGTGGAAGGTTTATTTAAACTTATTTCTAAGAAATTAGATTTGATTAATATTGAAGAGTATAGAAAG
GTATATAAGGTGGATAGTGA

Downstream 100 bases:

>100_bases
TCAGCCGAGACAGGTTATTTCATGTGTAGTCAATTTTATGGGTTTCATCACTCCTATTCATAATAACCAAGAATCTCATT
AAAAGTATTCTTCTTACACA

Product: DNA topoisomerase VI subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MSSEFISKVDKEARRKAASILRDKFLNLVEQLKKGEPLVMEIPMRTLSNAIYDEKRKLLLLGEKKLKRNFLDMNEAKRFM
QTVLMASIIYDALVSDEYPTIRDLYYRGKHSLLLKSIDGNKIVSEENTWDEQKESDSVIVDIEVFTSLLREEMLILSKEK
GKVVGNLRIRSGNDTIDLSKTGHGAYAIEPTPDLIDFIDVDAEFVLVVEKDAVFQQLHRAGFWKQYKSILITSAGQPDRA
TRRFVRRLNEELKLPVYILTDADPYGWYIFSVFRIGSISLSYESERLATPDAKFLGVSMSDIFGNSRKKPYLSEAERKNY
IIKAKEADIKRAEEIKNYEWFKTKAWEEEINTFLHRKAKLEIEAMASKGLKFLAFQYIPEKITNKDYIA

Sequences:

>Translated_389_residues
MSSEFISKVDKEARRKAASILRDKFLNLVEQLKKGEPLVMEIPMRTLSNAIYDEKRKLLLLGEKKLKRNFLDMNEAKRFM
QTVLMASIIYDALVSDEYPTIRDLYYRGKHSLLLKSIDGNKIVSEENTWDEQKESDSVIVDIEVFTSLLREEMLILSKEK
GKVVGNLRIRSGNDTIDLSKTGHGAYAIEPTPDLIDFIDVDAEFVLVVEKDAVFQQLHRAGFWKQYKSILITSAGQPDRA
TRRFVRRLNEELKLPVYILTDADPYGWYIFSVFRIGSISLSYESERLATPDAKFLGVSMSDIFGNSRKKPYLSEAERKNY
IIKAKEADIKRAEEIKNYEWFKTKAWEEEINTFLHRKAKLEIEAMASKGLKFLAFQYIPEKITNKDYIA
>Mature_388_residues
SSEFISKVDKEARRKAASILRDKFLNLVEQLKKGEPLVMEIPMRTLSNAIYDEKRKLLLLGEKKLKRNFLDMNEAKRFMQ
TVLMASIIYDALVSDEYPTIRDLYYRGKHSLLLKSIDGNKIVSEENTWDEQKESDSVIVDIEVFTSLLREEMLILSKEKG
KVVGNLRIRSGNDTIDLSKTGHGAYAIEPTPDLIDFIDVDAEFVLVVEKDAVFQQLHRAGFWKQYKSILITSAGQPDRAT
RRFVRRLNEELKLPVYILTDADPYGWYIFSVFRIGSISLSYESERLATPDAKFLGVSMSDIFGNSRKKPYLSEAERKNYI
IKAKEADIKRAEEIKNYEWFKTKAWEEEINTFLHRKAKLEIEAMASKGLKFLAFQYIPEKITNKDYIA

Specific function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity [H]

COG id: COG1697

COG function: function code L; DNA topoisomerase VI, subunit A

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TOP6A family [H]

Homologues:

Organism=Homo sapiens, GI38201680, Length=316, Percent_Identity=29.746835443038, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI6912680, Length=310, Percent_Identity=30, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17542064, Length=328, Percent_Identity=27.4390243902439, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45552753, Length=239, Percent_Identity=34.3096234309623, Blast_Score=115, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002815
- InterPro:   IPR013049
- InterPro:   IPR004085
- InterPro:   IPR022904
- InterPro:   IPR011991 [H]

Pfam domain/function: PF04406 TP6A_N [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 45061; Mature: 44929

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSEFISKVDKEARRKAASILRDKFLNLVEQLKKGEPLVMEIPMRTLSNAIYDEKRKLLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCEEE
LGEKKLKRNFLDMNEAKRFMQTVLMASIIYDALVSDEYPTIRDLYYRGKHSLLLKSIDGN
ECHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCC
KIVSEENTWDEQKESDSVIVDIEVFTSLLREEMLILSKEKGKVVGNLRIRSGNDTIDLSK
EEECCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEEEEC
TGHGAYAIEPTPDLIDFIDVDAEFVLVVEKDAVFQQLHRAGFWKQYKSILITSAGQPDRA
CCCCEEEECCCCHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHEEECCCCCCHH
TRRFVRRLNEELKLPVYILTDADPYGWYIFSVFRIGSISLSYESERLATPDAKFLGVSMS
HHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCEEECCHH
DIFGNSRKKPYLSEAERKNYIIKAKEADIKRAEEIKNYEWFKTKAWEEEINTFLHRKAKL
HHHCCCCCCCCHHHHHCCCEEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
EIEAMASKGLKFLAFQYIPEKITNKDYIA
HHHHHHHCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SSEFISKVDKEARRKAASILRDKFLNLVEQLKKGEPLVMEIPMRTLSNAIYDEKRKLLL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCEEE
LGEKKLKRNFLDMNEAKRFMQTVLMASIIYDALVSDEYPTIRDLYYRGKHSLLLKSIDGN
ECHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCC
KIVSEENTWDEQKESDSVIVDIEVFTSLLREEMLILSKEKGKVVGNLRIRSGNDTIDLSK
EEECCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEEEEC
TGHGAYAIEPTPDLIDFIDVDAEFVLVVEKDAVFQQLHRAGFWKQYKSILITSAGQPDRA
CCCCEEEECCCCHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHEEECCCCCCHH
TRRFVRRLNEELKLPVYILTDADPYGWYIFSVFRIGSISLSYESERLATPDAKFLGVSMS
HHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCEEECCHH
DIFGNSRKKPYLSEAERKNYIIKAKEADIKRAEEIKNYEWFKTKAWEEEINTFLHRKAKL
HHHCCCCCCCCHHHHHCCCEEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
EIEAMASKGLKFLAFQYIPEKITNKDYIA
HHHHHHHCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9121560 [H]