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The map label for this gene is dys [H]

Identifier: 15897846

GI number: 15897846

Start: 825625

End: 826563

Strand: Direct

Name: dys [H]

Synonym: SSO0967

Alternate gene names: 15897846

Gene position: 825625-826563 (Clockwise)

Preceding gene: 15897845

Following gene: 15897847

Centisome position: 27.59

GC content: 33.65

Gene sequence:

>939_bases
ATGATAAATAGAGAGGACTTGTTAAAAAACCCAGTTGAAGATATAACATTGAGTGACCTAAAGAAGTATAACGATATAGT
TAGTGTATTCGATAAGATATACGGTTTTAGCAGTGAGGGTATAGTGAATGGTTCTAAAATACTAAAAGAAATGATAAAAA
ACGCAGATTTAAGGTTTCTATCGTTCACTGCAAATTTAGTTTCTACGGGATTAAGGGGTTTGTTTGCAGATCTTATCAAA
AAGGGATATTTTAACATAGTAGTAACCACTGGGGGCACAATAGACCATGATTTGGCTAGAAGCTTTGGTGGGGTCTATTA
CAAAGGTTCTTTCGATATTGATGATACAATGTTAAAAGATTTGGAGATTCACAGATTAGGAAATGTTTTAGTTCCCTTTG
AATCCTACGGTAAAGTAATAGAAGATGTTGTAAGGAAATTTTTGCCAGAAATAACTAAGGACAGAAAGGAAATATCAGCA
TATGAATTGTTATGGGAATTTGGAAAGAGAATAACTGATTCTAATTCGATTCTCAGAGCAGCTTATGACAAAAATGTTCC
AATAATAGTACCTGGAATATTAGATGGCAGTTTTGGGACAAATCTTTTTATACAATCTCAGTTTTTGAACTTTAGGATTA
ATCTATTTGAGGATATGCGACTAATTAAAGACTTGATCTTTTCTTCTAAAAAGAGTGGTGCATTAATAATAGGAGGGGGT
ATAAGTAAACACCATACAATATGGTGGAATCAATTCAAAGACGGTTTAAATTACGCTATATATATTACTACTGCCCAAGA
ATATGACGGTAGTTTAAGTGGAGCAAAGCCTAGGGAAGCAATCTCATGGAACAAGATTAGACCAGATGCTAAACATGTAA
CCATCTATGGAGATGCGACAATAATAGTTCCTATTTTGGCCGCGTCTTTATTAAGCTAA

Upstream 100 bases:

>100_bases
CGGGAGCCTACAAAGATGTTGATAGGGTAGCTAAAGTTGCTCATGAAGTTAAAATTGCTAAATTAGTTATGCGATTAAGA
CCCATAGGGGTTACCAAAGG

Downstream 100 bases:

>100_bases
ATATTGTAATATATAGGGTGTAACATTCATGTCTGCTAAAGAAAAGTTTGCAAGCTTATCCCCAGCAGAATTCTTTAAAA
GGAATCCGGAGCTTGCCGGA

Product: putative deoxyhypusine synthase

Products: NA

Alternate protein names: DHS [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MINREDLLKNPVEDITLSDLKKYNDIVSVFDKIYGFSSEGIVNGSKILKEMIKNADLRFLSFTANLVSTGLRGLFADLIK
KGYFNIVVTTGGTIDHDLARSFGGVYYKGSFDIDDTMLKDLEIHRLGNVLVPFESYGKVIEDVVRKFLPEITKDRKEISA
YELLWEFGKRITDSNSILRAAYDKNVPIIVPGILDGSFGTNLFIQSQFLNFRINLFEDMRLIKDLIFSSKKSGALIIGGG
ISKHHTIWWNQFKDGLNYAIYITTAQEYDGSLSGAKPREAISWNKIRPDAKHVTIYGDATIIVPILAASLLS

Sequences:

>Translated_312_residues
MINREDLLKNPVEDITLSDLKKYNDIVSVFDKIYGFSSEGIVNGSKILKEMIKNADLRFLSFTANLVSTGLRGLFADLIK
KGYFNIVVTTGGTIDHDLARSFGGVYYKGSFDIDDTMLKDLEIHRLGNVLVPFESYGKVIEDVVRKFLPEITKDRKEISA
YELLWEFGKRITDSNSILRAAYDKNVPIIVPGILDGSFGTNLFIQSQFLNFRINLFEDMRLIKDLIFSSKKSGALIIGGG
ISKHHTIWWNQFKDGLNYAIYITTAQEYDGSLSGAKPREAISWNKIRPDAKHVTIYGDATIIVPILAASLLS
>Mature_312_residues
MINREDLLKNPVEDITLSDLKKYNDIVSVFDKIYGFSSEGIVNGSKILKEMIKNADLRFLSFTANLVSTGLRGLFADLIK
KGYFNIVVTTGGTIDHDLARSFGGVYYKGSFDIDDTMLKDLEIHRLGNVLVPFESYGKVIEDVVRKFLPEITKDRKEISA
YELLWEFGKRITDSNSILRAAYDKNVPIIVPGILDGSFGTNLFIQSQFLNFRINLFEDMRLIKDLIFSSKKSGALIIGGG
ISKHHTIWWNQFKDGLNYAIYITTAQEYDGSLSGAKPREAISWNKIRPDAKHVTIYGDATIIVPILAASLLS

Specific function: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine

COG id: COG1899

COG function: function code O; Deoxyhypusine synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deoxyhypusine synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503325, Length=259, Percent_Identity=35.5212355212355, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI7108338, Length=258, Percent_Identity=29.0697674418605, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI7108340, Length=258, Percent_Identity=25.5813953488372, Blast_Score=102, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17536927, Length=256, Percent_Identity=35.546875, Blast_Score=175, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6321859, Length=276, Percent_Identity=33.3333333333333, Blast_Score=166, Evalue=4e-42,
Organism=Drosophila melanogaster, GI45550569, Length=259, Percent_Identity=34.3629343629344, Blast_Score=169, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002773
- InterPro:   IPR022899 [H]

Pfam domain/function: PF01916 DS [H]

EC number: =2.5.1.46 [H]

Molecular weight: Translated: 35051; Mature: 35051

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINREDLLKNPVEDITLSDLKKYNDIVSVFDKIYGFSSEGIVNGSKILKEMIKNADLRFL
CCCHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEE
SFTANLVSTGLRGLFADLIKKGYFNIVVTTGGTIDHDLARSFGGVYYKGSFDIDDTMLKD
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCEEEECCCCCCHHHHHH
LEIHRLGNVLVPFESYGKVIEDVVRKFLPEITKDRKEISAYELLWEFGKRITDSNSILRA
HHHHHHCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
AYDKNVPIIVPGILDGSFGTNLFIQSQFLNFRINLFEDMRLIKDLIFSSKKSGALIIGGG
HHCCCCCEEEECCCCCCCCCCEEEEEEHHHEEHHHHHHHHHHHHHHHCCCCCCEEEEECC
ISKHHTIWWNQFKDGLNYAIYITTAQEYDGSLSGAKPREAISWNKIRPDAKHVTIYGDAT
CCCCCEEEHHHHHCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHH
IIVPILAASLLS
HHHHHHHHHHCC
>Mature Secondary Structure
MINREDLLKNPVEDITLSDLKKYNDIVSVFDKIYGFSSEGIVNGSKILKEMIKNADLRFL
CCCHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEE
SFTANLVSTGLRGLFADLIKKGYFNIVVTTGGTIDHDLARSFGGVYYKGSFDIDDTMLKD
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCEEEECCCCCCHHHHHH
LEIHRLGNVLVPFESYGKVIEDVVRKFLPEITKDRKEISAYELLWEFGKRITDSNSILRA
HHHHHHCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
AYDKNVPIIVPGILDGSFGTNLFIQSQFLNFRINLFEDMRLIKDLIFSSKKSGALIIGGG
HHCCCCCEEEECCCCCCCCCCEEEEEEHHHEEHHHHHHHHHHHHHHHCCCCCCEEEEECC
ISKHHTIWWNQFKDGLNYAIYITTAQEYDGSLSGAKPREAISWNKIRPDAKHVTIYGDAT
CCCCCEEEHHHHHCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHH
IIVPILAASLLS
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA