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The map label for this gene is tmK-1

Identifier: 15897682

GI number: 15897682

Start: 663613

End: 664182

Strand: Direct

Name: tmK-1

Synonym: SSO0780

Alternate gene names: 15897682

Gene position: 663613-664182 (Clockwise)

Preceding gene: 15897681

Following gene: 15897684

Centisome position: 22.18

GC content: 31.75

Gene sequence:

>570_bases
ATGCAAAAGCTAATTGCAATTGAAGGAATAGATGGGTCAGGCAAAACAACACTTGCGAATCTATTAAAGGAGCATCTAGA
ATCTAAAATGAAACTGAACGTGATTGTTACGAGAGAGCCATTTTCTGAAGATATAATAAAGTTAATAGAAAAAATTGGCT
GGAATGATCCAATCCTATTAGTATTGCTCTTTGCAGCAGACCGAGAAATACACGTTAATTGGCTATCTAAAATAAAGGAT
GCTGATCTAATAATACTTGATAGATATTATTTCTCCAGCATAGCCTATCAAGGGGCTCTAGGAGTAGATGAGCAATGGAT
AAAAATGGTGAATTCCTATTTCCCTAAACCAGATATGGTAATATTATTAGACTTACCAATTGAGGTTGCTATCAGTAGAA
TAAAAAATGATAAATTCAACTTCGAAGAAAAGATTAAAAGCCTTGCAAAAGTTAGGGAAAAATACCTAAAACTTGCAAAA
GAATATAATTTCTACGTAGTAGATGCAAGCAAGGATAAGAATGAAGTATTAGAACAAGCAATAAAAATTATTCAGAAGAA
TTTATTTTAA

Upstream 100 bases:

>100_bases
AAATAACAATACTAAGTAGAGTAAACAAGTTTACAGGGTTAGTTTTAGGGTATATTAGCTTAAATGATAAATTTGAGGAA
AGAAGAATTAGATTTAGAAA

Downstream 100 bases:

>100_bases
TCTTCCTTAATCGTTCTAATGCATCTAAATACCTTATGATCTGAATTATCCTTTCAGAATCTAATGGATCCTCCTTCATC
TTTTTTGCGCTTAAATATAG

Product: thymidylate kinase (tmK-1)

Products: NA

Alternate protein names: dTMP kinase 1

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MQKLIAIEGIDGSGKTTLANLLKEHLESKMKLNVIVTREPFSEDIIKLIEKIGWNDPILLVLLFAADREIHVNWLSKIKD
ADLIILDRYYFSSIAYQGALGVDEQWIKMVNSYFPKPDMVILLDLPIEVAISRIKNDKFNFEEKIKSLAKVREKYLKLAK
EYNFYVVDASKDKNEVLEQAIKIIQKNLF

Sequences:

>Translated_189_residues
MQKLIAIEGIDGSGKTTLANLLKEHLESKMKLNVIVTREPFSEDIIKLIEKIGWNDPILLVLLFAADREIHVNWLSKIKD
ADLIILDRYYFSSIAYQGALGVDEQWIKMVNSYFPKPDMVILLDLPIEVAISRIKNDKFNFEEKIKSLAKVREKYLKLAK
EYNFYVVDASKDKNEVLEQAIKIIQKNLF
>Mature_189_residues
MQKLIAIEGIDGSGKTTLANLLKEHLESKMKLNVIVTREPFSEDIIKLIEKIGWNDPILLVLLFAADREIHVNWLSKIKD
ADLIILDRYYFSSIAYQGALGVDEQWIKMVNSYFPKPDMVILLDLPIEVAISRIKNDKFNFEEKIKSLAKVREKYLKLAK
EYNFYVVDASKDKNEVLEQAIKIIQKNLF

Specific function: Phosphorylation Of Dtmp To Form Dtdp In Both De Novo And Salvage Pathways Of Dttp Synthesis. [C]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=201, Percent_Identity=28.3582089552239, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17535647, Length=145, Percent_Identity=35.1724137931034, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573735, Length=190, Percent_Identity=29.4736842105263, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY1_SULSO (Q9UXG7)

Other databases:

- EMBL:   Y18930
- EMBL:   AE006641
- PIR:   F90227
- RefSeq:   NP_342287.1
- ProteinModelPortal:   Q9UXG7
- SMR:   Q9UXG7
- GeneID:   1455044
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0780
- NMPDR:   fig|273057.1.peg.710
- HOGENOM:   HBG626009
- OMA:   SSLAYQW
- PhylomeDB:   Q9UXG7
- ProtClustDB:   CLSK802872
- BioCyc:   SSOL273057:SSO0780-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 21889; Mature: 21889

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLIAIEGIDGSGKTTLANLLKEHLESKMKLNVIVTREPFSEDIIKLIEKIGWNDPILL
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCCCHHHH
VLLFAADREIHVNWLSKIKDADLIILDRYYFSSIAYQGALGVDEQWIKMVNSYFPKPDMV
HHHHHCCCEEEHHHHHHCCCCCEEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEE
ILLDLPIEVAISRIKNDKFNFEEKIKSLAKVREKYLKLAKEYNFYVVDASKDKNEVLEQA
EEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHH
IKIIQKNLF
HHHHHHHCC
>Mature Secondary Structure
MQKLIAIEGIDGSGKTTLANLLKEHLESKMKLNVIVTREPFSEDIIKLIEKIGWNDPILL
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCCCHHHH
VLLFAADREIHVNWLSKIKDADLIILDRYYFSSIAYQGALGVDEQWIKMVNSYFPKPDMV
HHHHHCCCEEEHHHHHHCCCCCEEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEE
ILLDLPIEVAISRIKNDKFNFEEKIKSLAKVREKYLKLAKEYNFYVVDASKDKNEVLEQA
EEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHH
IKIIQKNLF
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726