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The map label for this gene is thrA/hom [H]

Identifier: 15897567

GI number: 15897567

Start: 567579

End: 568523

Strand: Reverse

Name: thrA/hom [H]

Synonym: SSO0657

Alternate gene names: 15897567

Gene position: 568523-567579 (Counterclockwise)

Preceding gene: 15897568

Following gene: 15897566

Centisome position: 19.0

GC content: 34.81

Gene sequence:

>945_bases
ATGAAGTTACTTTTAATTGGATATGGTAATGTTGGAAAGGCATTTAGAAGGCTATTACATGAAAAGAAAGATAACTATCC
AATATTGCAAGGTGTTGAGATTGCAGGAATAATAACTAGGCAAGGACTAATGGTCGGAGATAAGGAGAATTTTTCTCCAG
ATAAGCAATTGACTGTCTTAGAGGCGATTGATTATATAAACCCTGATGTAATAGTCGATATGTCAGTACCTAATTATAAA
GACGGTGAGCCATCTGTTAGTGCTTATATAAAGGCATTATCAAGAAAAATTCACGTAATAACAGTCAATAAAGCACCGCT
AGCCCTAAAGTTTAGAGAGATATTTGAAGTTGCTGAGAAAACTGGTGCCAAAATTGGATTTCAAGGAACTGTAATGAGTG
GTACTCCTTCTATTAATCTTTTTAGGATTCAACCAGTGGCTGAAGTCTCTAGGATTAGGGGAATTCTTAATGGTACTACA
AATTACATTTTAACCAGAATTTATGAAGGATTAAGTTTTAATGAAGCTTTGAAAGAGGCAAAAGAGAAAGGCTATGCAGA
GGAAGACCCAACTTTAGATCTTAATGGATTCGATGCAGCAGCAAAACTGACAATTTTATCCAACTTTATTATGAACAGAA
GTCTAAAATTAGGTGATTTCAAATTCAAGGGAATAACTGAGATTACTAATGAGGAGATTAGAAGGGCTAAAAGCGAAGGT
AAGAAAATAAAACTAATAGCCTATGCAGATAACTATGTAGTTCAAGTTTCTCCTCAAATTATAGGGCCTCAAGATCCCTT
ATACTATATAGATGGAGTTGAAAATGCACTAGAAATTCAAAATGAAATACAGAGGATTATCATTAGAGGTCCAGGTGCAG
GTCCGATAAATGCTGCATACGGTGCCCTTTCAGATTTAGTGTTATTATTGGAAGGATGTTTATGA

Upstream 100 bases:

>100_bases
ATATTGATGAAAATCTGGTCAAGTATGCAGTAGATCGTGTAGCAGATTTATTAGAAAAAGTGTGTAATGGAAAGAGAGAA
TATAATACTATGGTGATTAG

Downstream 100 bases:

>100_bases
CAATTTTTTTATTCTTATAATACAATTGTAACTTGATGAGCTTACAGCAGAAAATAAAGGCTTATTTAAAATTAGGTAAA
CTTGGTGTGGTAAGTCTTCT

Product: homoserine dehydrogenase (thrA/hom)

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MKLLLIGYGNVGKAFRRLLHEKKDNYPILQGVEIAGIITRQGLMVGDKENFSPDKQLTVLEAIDYINPDVIVDMSVPNYK
DGEPSVSAYIKALSRKIHVITVNKAPLALKFREIFEVAEKTGAKIGFQGTVMSGTPSINLFRIQPVAEVSRIRGILNGTT
NYILTRIYEGLSFNEALKEAKEKGYAEEDPTLDLNGFDAAAKLTILSNFIMNRSLKLGDFKFKGITEITNEEIRRAKSEG
KKIKLIAYADNYVVQVSPQIIGPQDPLYYIDGVENALEIQNEIQRIIIRGPGAGPINAAYGALSDLVLLLEGCL

Sequences:

>Translated_314_residues
MKLLLIGYGNVGKAFRRLLHEKKDNYPILQGVEIAGIITRQGLMVGDKENFSPDKQLTVLEAIDYINPDVIVDMSVPNYK
DGEPSVSAYIKALSRKIHVITVNKAPLALKFREIFEVAEKTGAKIGFQGTVMSGTPSINLFRIQPVAEVSRIRGILNGTT
NYILTRIYEGLSFNEALKEAKEKGYAEEDPTLDLNGFDAAAKLTILSNFIMNRSLKLGDFKFKGITEITNEEIRRAKSEG
KKIKLIAYADNYVVQVSPQIIGPQDPLYYIDGVENALEIQNEIQRIIIRGPGAGPINAAYGALSDLVLLLEGCL
>Mature_314_residues
MKLLLIGYGNVGKAFRRLLHEKKDNYPILQGVEIAGIITRQGLMVGDKENFSPDKQLTVLEAIDYINPDVIVDMSVPNYK
DGEPSVSAYIKALSRKIHVITVNKAPLALKFREIFEVAEKTGAKIGFQGTVMSGTPSINLFRIQPVAEVSRIRGILNGTT
NYILTRIYEGLSFNEALKEAKEKGYAEEDPTLDLNGFDAAAKLTILSNFIMNRSLKLGDFKFKGITEITNEEIRRAKSEG
KKIKLIAYADNYVVQVSPQIIGPQDPLYYIDGVENALEIQNEIQRIIIRGPGAGPINAAYGALSDLVLLLEGCL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=293, Percent_Identity=28.3276450511945, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790376, Length=331, Percent_Identity=25.6797583081571, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005106
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR022697
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 34691; Mature: 34691

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLLIGYGNVGKAFRRLLHEKKDNYPILQGVEIAGIITRQGLMVGDKENFSPDKQLTVL
CEEEEEECCCHHHHHHHHHHHCCCCCCCEECCEEEEEEEECCEEECCCCCCCCCHHHHHH
EAIDYINPDVIVDMSVPNYKDGEPSVSAYIKALSRKIHVITVNKAPLALKFREIFEVAEK
HHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHH
TGAKIGFQGTVMSGTPSINLFRIQPVAEVSRIRGILNGTTNYILTRIYEGLSFNEALKEA
CCCEECCCEEEECCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHH
KEKGYAEEDPTLDLNGFDAAAKLTILSNFIMNRSLKLGDFKFKGITEITNEEIRRAKSEG
HHCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCEECCEEECCHHHHHHHHHHHHHHCC
KKIKLIAYADNYVVQVSPQIIGPQDPLYYIDGVENALEIQNEIQRIIIRGPGAGPINAAY
CEEEEEEEECCEEEEECCCEECCCCCEEEECCCHHHHHHHHHHHEEEEECCCCCCCHHHH
GALSDLVLLLEGCL
HHHHHHHHHHHCCC
>Mature Secondary Structure
MKLLLIGYGNVGKAFRRLLHEKKDNYPILQGVEIAGIITRQGLMVGDKENFSPDKQLTVL
CEEEEEECCCHHHHHHHHHHHCCCCCCCEECCEEEEEEEECCEEECCCCCCCCCHHHHHH
EAIDYINPDVIVDMSVPNYKDGEPSVSAYIKALSRKIHVITVNKAPLALKFREIFEVAEK
HHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHH
TGAKIGFQGTVMSGTPSINLFRIQPVAEVSRIRGILNGTTNYILTRIYEGLSFNEALKEA
CCCEECCCEEEECCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHH
KEKGYAEEDPTLDLNGFDAAAKLTILSNFIMNRSLKLGDFKFKGITEITNEEIRRAKSEG
HHCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCEECCEEECCHHHHHHHHHHHHHHCC
KKIKLIAYADNYVVQVSPQIIGPQDPLYYIDGVENALEIQNEIQRIIIRGPGAGPINAAY
CEEEEEEEECCEEEEECCCEECCCCCEEEECCCHHHHHHHHHHHEEEEECCCCCCCHHHH
GALSDLVLLLEGCL
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]