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The map label for this gene is ubiA [H]

Identifier: 15897566

GI number: 15897566

Start: 566686

End: 567546

Strand: Reverse

Name: ubiA [H]

Synonym: SSO0656

Alternate gene names: 15897566

Gene position: 567546-566686 (Counterclockwise)

Preceding gene: 15897567

Following gene: 15897564

Centisome position: 18.97

GC content: 34.03

Gene sequence:

>861_bases
TTGATGAGCTTACAGCAGAAAATAAAGGCTTATTTAAAATTAGGTAAACTTGGTGTGGTAAGTCTTCTTGATTTGGCAGC
AATTGCTGGGGCTTTTCTGGCGTACAAACACGGCATTTCACTTTTACCAATCATTCCTATGCTTATTGGAGGTACATTAG
CGTCAATGGGTGCAATGATAATTAATAGTGGAATAGAAATAAATAGAGACAAAGTAATGTCTAGAACATCAAATAGACCT
ACAGTAGTTGGCTATGTCAGTAGGAAAGAAGTTATAGTAGTGGGCTCACTTCTAGCAGTTTTAGGTACAGCATTAGGTTT
TATAGATAACGCTTTAACTGCTTTCTTTATAGCACTAGGGGTAATAATATATGTATTCGTATATACGATCCTATTGAAAC
CTAGGACATGGCTAAACATAGTAATAGGTGGATTTGCTGGTAGTGCTGCAGCTTGGGCTGGTTATACGTCTTTAACTAAT
TCTTTAACTTTAGAAGCATTTCTTTTAGGTTTTCTAATATTTATGTGGACTCCAGGCCATTTCTGGTCGTTGGCACTAAA
ATATAGAGAGGATTACATTAACGCTCATTATCCAATGTTACCTGCTGTGGTCGGTATAACTACTTCTGCAAGGGCAATAG
CAACTTCTAATGCCTTAATGATTCCTATTGTACTTTTGATGGGATACTACATTAGCCTTATAGCGCTTATAGTGTTTTCT
GTTTTAAGTGCATTATTATTGTTTCTTTCTTATAGGTTAATACTTAATCCAACCAAGGAAGAAGCAATGAAATCCTTCAT
ATTTTCAAATATTTACCTAATGTTAATACTTTTAAGTATAATAATAATTAAATTAATATGA

Upstream 100 bases:

>100_bases
CAGGTCCGATAAATGCTGCATACGGTGCCCTTTCAGATTTAGTGTTATTATTGGAAGGATGTTTATGACAATTTTTTTAT
TCTTATAATACAATTGTAAC

Downstream 100 bases:

>100_bases
GATATCTATTACCATATCAGCTATTTTCTTAGAGGAGATTATAATTCTAATATCTATATCTCCGCATTTTCTTCTTATTA
CTAACTTATCCTCATTTTGA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MMSLQQKIKAYLKLGKLGVVSLLDLAAIAGAFLAYKHGISLLPIIPMLIGGTLASMGAMIINSGIEINRDKVMSRTSNRP
TVVGYVSRKEVIVVGSLLAVLGTALGFIDNALTAFFIALGVIIYVFVYTILLKPRTWLNIVIGGFAGSAAAWAGYTSLTN
SLTLEAFLLGFLIFMWTPGHFWSLALKYREDYINAHYPMLPAVVGITTSARAIATSNALMIPIVLLMGYYISLIALIVFS
VLSALLLFLSYRLILNPTKEEAMKSFIFSNIYLMLILLSIIIIKLI

Sequences:

>Translated_286_residues
MMSLQQKIKAYLKLGKLGVVSLLDLAAIAGAFLAYKHGISLLPIIPMLIGGTLASMGAMIINSGIEINRDKVMSRTSNRP
TVVGYVSRKEVIVVGSLLAVLGTALGFIDNALTAFFIALGVIIYVFVYTILLKPRTWLNIVIGGFAGSAAAWAGYTSLTN
SLTLEAFLLGFLIFMWTPGHFWSLALKYREDYINAHYPMLPAVVGITTSARAIATSNALMIPIVLLMGYYISLIALIVFS
VLSALLLFLSYRLILNPTKEEAMKSFIFSNIYLMLILLSIIIIKLI
>Mature_286_residues
MMSLQQKIKAYLKLGKLGVVSLLDLAAIAGAFLAYKHGISLLPIIPMLIGGTLASMGAMIINSGIEINRDKVMSRTSNRP
TVVGYVSRKEVIVVGSLLAVLGTALGFIDNALTAFFIALGVIIYVFVYTILLKPRTWLNIVIGGFAGSAAAWAGYTSLTN
SLTLEAFLLGFLIFMWTPGHFWSLALKYREDYINAHYPMLPAVVGITTSARAIATSNALMIPIVLLMGYYISLIALIVFS
VLSALLLFLSYRLILNPTKEEAMKSFIFSNIYLMLILLSIIIIKLI

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=234, Percent_Identity=28.2051282051282, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786631, Length=206, Percent_Identity=30.0970873786408, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6325085, Length=260, Percent_Identity=28.4615384615385, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19921064, Length=288, Percent_Identity=26.3888888888889, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 31192; Mature: 31192

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSLQQKIKAYLKLGKLGVVSLLDLAAIAGAFLAYKHGISLLPIIPMLIGGTLASMGAMI
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
INSGIEINRDKVMSRTSNRPTVVGYVSRKEVIVVGSLLAVLGTALGFIDNALTAFFIALG
HHCCCCCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIIYVFVYTILLKPRTWLNIVIGGFAGSAAAWAGYTSLTNSLTLEAFLLGFLIFMWTPGH
HHHHHHHHHHHHCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
FWSLALKYREDYINAHYPMLPAVVGITTSARAIATSNALMIPIVLLMGYYISLIALIVFS
HHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
VLSALLLFLSYRLILNPTKEEAMKSFIFSNIYLMLILLSIIIIKLI
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMSLQQKIKAYLKLGKLGVVSLLDLAAIAGAFLAYKHGISLLPIIPMLIGGTLASMGAMI
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
INSGIEINRDKVMSRTSNRPTVVGYVSRKEVIVVGSLLAVLGTALGFIDNALTAFFIALG
HHCCCCCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIIYVFVYTILLKPRTWLNIVIGGFAGSAAAWAGYTSLTNSLTLEAFLLGFLIFMWTPGH
HHHHHHHHHHHHCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
FWSLALKYREDYINAHYPMLPAVVGITTSARAIATSNALMIPIVLLMGYYISLIALIVFS
HHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
VLSALLLFLSYRLILNPTKEEAMKSFIFSNIYLMLILLSIIIIKLI
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA