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The map label for this gene is hdb-1 [H]

Identifier: 15897557

GI number: 15897557

Start: 560615

End: 561589

Strand: Direct

Name: hdb-1 [H]

Synonym: SSO0647

Alternate gene names: 15897557

Gene position: 560615-561589 (Clockwise)

Preceding gene: 15897555

Following gene: 15897560

Centisome position: 18.74

GC content: 36.0

Gene sequence:

>975_bases
ATGTTTATACATATGAAATCAATTAATAAGGTAGCCGTAATAGGAGCCGGGGTAATAGGCGTAGGGTGGACCACTCTTTT
ACTAGCGAAAGGTTATAAAGTAAATTTGTATACGGAAAAGAAAGAAACCTTAGAAAAAGCTTTAGCAAAAGTATCAGCTT
ATTTAGTTAATCTGAAAAATCTTGGAATGATAAATGAAGAACCAGAATCCTACATAACAAATCTAACTGGAATCACGAAA
ATTGATGACGCAATCCATAATGTGGATTTTGTAATAGAAGCTATAATTGAGGATTATACTGCTAAGAAGAATTTATTCAA
ACTACTTGATACTCAATTGCCTCAAGACATAATAATTGCGAGTAGCACTTCTGGTTTATTAATGACTGAAATCCAAAAAG
CTATGATAAGACATCCAGAAAGAGGAGTAATTGCTCATCCGTGGAATCCCCCACATCTATTGCCTTTAGTTGAAATAGTA
CCGGGCGAGAAAACGTCAAAGGAGACAGTAGATTTGACTAGAGAATTTATGGAAAAGTTAGATAGGGTAGTAGTGCTACT
GAGGAAGGAAGTCCCCGGGTTTATAGGAAATAGATTGGCCTTCGCTTTATTTAGAGAAGCGGTGAATTTAGTTGATGAAG
GAGTAGCCACAGTTGAAGATATAGATAAAGTAATGACAGCTGCCATAGGTCTAAGATGGGCATTTATGGGGCCATTCTTA
ACTTATCATTTAGGTGGAGGTGAAGGAGGAATCGAATACTTCTTTAGTAAAGGATTCGGATATGGTGCAAATGAATGGAT
GCACACTTTGGCAAAGTGGGACAAATTCCCATATACTGCGGTCAAAAAGGTATTGGAGCAAATGAAAGAATACGAATTTA
TAAAAGGAAAGAGCTTTCAAGATCTATCTAGATGGAGAGACGAGAAGCTAGTAACAATTTATAAGGCAGTATATAAGGAA
AAATGTAATTCATAA

Upstream 100 bases:

>100_bases
ATTAAGATAACCTTTAATTTTCTCAACAAGCATAGTAATTCCACTATATCCGCACTTTTAACTCTATCCATTAATAGAAA
TTTACTTATACTTCTTAAAC

Downstream 100 bases:

>100_bases
TATTACCAATTTTAACTTACTCTCTAAATTCTAAGATTCCTAAACTCTCAAGTAAACCAGAATCCGTTACATCAAATAGA
ATACAATCATCGTCTCCAGT

Product: 3-hydroxyacyl-CoA dehydrogenase (hdb-1)

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MFIHMKSINKVAVIGAGVIGVGWTTLLLAKGYKVNLYTEKKETLEKALAKVSAYLVNLKNLGMINEEPESYITNLTGITK
IDDAIHNVDFVIEAIIEDYTAKKNLFKLLDTQLPQDIIIASSTSGLLMTEIQKAMIRHPERGVIAHPWNPPHLLPLVEIV
PGEKTSKETVDLTREFMEKLDRVVVLLRKEVPGFIGNRLAFALFREAVNLVDEGVATVEDIDKVMTAAIGLRWAFMGPFL
TYHLGGGEGGIEYFFSKGFGYGANEWMHTLAKWDKFPYTAVKKVLEQMKEYEFIKGKSFQDLSRWRDEKLVTIYKAVYKE
KCNS

Sequences:

>Translated_324_residues
MFIHMKSINKVAVIGAGVIGVGWTTLLLAKGYKVNLYTEKKETLEKALAKVSAYLVNLKNLGMINEEPESYITNLTGITK
IDDAIHNVDFVIEAIIEDYTAKKNLFKLLDTQLPQDIIIASSTSGLLMTEIQKAMIRHPERGVIAHPWNPPHLLPLVEIV
PGEKTSKETVDLTREFMEKLDRVVVLLRKEVPGFIGNRLAFALFREAVNLVDEGVATVEDIDKVMTAAIGLRWAFMGPFL
TYHLGGGEGGIEYFFSKGFGYGANEWMHTLAKWDKFPYTAVKKVLEQMKEYEFIKGKSFQDLSRWRDEKLVTIYKAVYKE
KCNS
>Mature_324_residues
MFIHMKSINKVAVIGAGVIGVGWTTLLLAKGYKVNLYTEKKETLEKALAKVSAYLVNLKNLGMINEEPESYITNLTGITK
IDDAIHNVDFVIEAIIEDYTAKKNLFKLLDTQLPQDIIIASSTSGLLMTEIQKAMIRHPERGVIAHPWNPPHLLPLVEIV
PGEKTSKETVDLTREFMEKLDRVVVLLRKEVPGFIGNRLAFALFREAVNLVDEGVATVEDIDKVMTAAIGLRWAFMGPFL
TYHLGGGEGGIEYFFSKGFGYGANEWMHTLAKWDKFPYTAVKKVLEQMKEYEFIKGKSFQDLSRWRDEKLVTIYKAVYKE
KCNS

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=307, Percent_Identity=31.5960912052117, Blast_Score=175, Evalue=4e-44,
Organism=Homo sapiens, GI296179429, Length=238, Percent_Identity=32.3529411764706, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI296179427, Length=255, Percent_Identity=30.1960784313725, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI20127408, Length=212, Percent_Identity=30.6603773584906, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI261878539, Length=241, Percent_Identity=24.896265560166, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI68989263, Length=241, Percent_Identity=24.896265560166, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1787661, Length=236, Percent_Identity=33.0508474576271, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790281, Length=151, Percent_Identity=36.4238410596026, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788682, Length=159, Percent_Identity=28.3018867924528, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533614, Length=282, Percent_Identity=32.6241134751773, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI193203623, Length=285, Percent_Identity=32.9824561403509, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17553560, Length=240, Percent_Identity=28.3333333333333, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17563036, Length=239, Percent_Identity=30.9623430962343, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17508953, Length=257, Percent_Identity=30.7392996108949, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI25144276, Length=259, Percent_Identity=30.8880308880309, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17508951, Length=258, Percent_Identity=31.0077519379845, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17549919, Length=242, Percent_Identity=27.6859504132231, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17558304, Length=221, Percent_Identity=31.2217194570136, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71985923, Length=248, Percent_Identity=27.8225806451613, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71985930, Length=240, Percent_Identity=27.9166666666667, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45549573, Length=318, Percent_Identity=32.3899371069182, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI20129993, Length=252, Percent_Identity=33.3333333333333, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI19921000, Length=221, Percent_Identity=28.9592760180996, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24583077, Length=221, Percent_Identity=28.9592760180996, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24583079, Length=221, Percent_Identity=28.9592760180996, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 36626; Mature: 36626

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIHMKSINKVAVIGAGVIGVGWTTLLLAKGYKVNLYTEKKETLEKALAKVSAYLVNLKN
CEEEECCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHH
LGMINEEPESYITNLTGITKIDDAIHNVDFVIEAIIEDYTAKKNLFKLLDTQLPQDIIIA
CCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
SSTSGLLMTEIQKAMIRHPERGVIAHPWNPPHLLPLVEIVPGEKTSKETVDLTREFMEKL
CCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHH
DRVVVLLRKEVPGFIGNRLAFALFREAVNLVDEGVATVEDIDKVMTAAIGLRWAFMGPFL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
TYHLGGGEGGIEYFFSKGFGYGANEWMHTLAKWDKFPYTAVKKVLEQMKEYEFIKGKSFQ
EEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHH
DLSRWRDEKLVTIYKAVYKEKCNS
HHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFIHMKSINKVAVIGAGVIGVGWTTLLLAKGYKVNLYTEKKETLEKALAKVSAYLVNLKN
CEEEECCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHH
LGMINEEPESYITNLTGITKIDDAIHNVDFVIEAIIEDYTAKKNLFKLLDTQLPQDIIIA
CCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
SSTSGLLMTEIQKAMIRHPERGVIAHPWNPPHLLPLVEIVPGEKTSKETVDLTREFMEKL
CCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHH
DRVVVLLRKEVPGFIGNRLAFALFREAVNLVDEGVATVEDIDKVMTAAIGLRWAFMGPFL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
TYHLGGGEGGIEYFFSKGFGYGANEWMHTLAKWDKFPYTAVKKVLEQMKEYEFIKGKSFQ
EEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHH
DLSRWRDEKLVTIYKAVYKEKCNS
HHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA