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The map label for this gene is argG [H]

Identifier: 15897551

GI number: 15897551

Start: 552331

End: 553551

Strand: Direct

Name: argG [H]

Synonym: SSO0638

Alternate gene names: 15897551

Gene position: 552331-553551 (Clockwise)

Preceding gene: 15897550

Following gene: 15897552

Centisome position: 18.46

GC content: 35.87

Gene sequence:

>1221_bases
ATGATATCAATTGTTTTTAAGCTTCTTCTTTACCCTTTTTGTGAAATGAAAATAGTCCTTGCATACTCTGGTGGACTTGA
TACTACAGTATCGATTAGATGGCTAAAGGAAACCTTTAAGGCTGAGATTATAACAGTTACTGTAGATGTTGGTCAAAAGG
ACGATTTTAAGAAAATAGAAGAAAGAGCGTATATAGCCGGCGCCTCAAAGCATTATACAATAGACGCTGTTAGGCAATTT
GCCAACAATTACATAGCATATGCGATAAAATTAAATGGATTATATGAAGGAGTCTATCCGTTGTCAACGGCATTGGCAAG
ACCATTAATAGCAGAAAAAGTAGTTGAAGTTGCAAAAAAGGAAGGAGCTGAAGCCGTAGCTCACGGTTCTACATCTAAGG
GAAATGATCAAGTGAGATTTGACCTTGCAGTTAAGGCATTATACCCTGACGTTAAGATAATAGCACCAGCTAGAATATGG
AATATGACTAGAGAAGACGAAATAAAATACGCTAAAGAGAAAGGAATACCTATCAAGGTTGAAAGTGACAAATACAGCAT
AGATGAGAATCTTTGGGGAAGAAGTATAGAAGGAGACATAATCTCTGATCCTTCTCTTGAAGTCCCAGAAGATGCCTTTG
AATGGACTAAACAGATCTACAATAAAAAGGAAATAGTCTCTATAGAATTTAGTAATGGAGTTCCTACAGCTGTGAACGGA
GAAAAAATGGAATTAAATAAGTTAGTAGATTTTCTAAATTTAAAATTCGGAAGCCATGGATTTGGAAGGGTAGAACATAT
AGAAAATAGAGTTGTTGGATTTAAGTCTAGAGAGGTATATGAAGTACCAGCTGCTCTAGGTCTAATTTACGCTCATATTG
ACTTAGAAAAAACTATCTATACTCCAATGGAATTAAGATTCAAAAGACACATAGATCAGTTATGGTCTGATCTAGTATAT
CAAGGATTATGGTTTGAGCCACTAAGAGAGACATTACATAAAGTTGCTGATGAAATGAATAAATGGATTAGCGGAGAAGC
GAAGGTTGAAGTTAGTAATGGTTCGTTCAGAATAGTAGGTAGAGAATCAGAATATTCTCCATATTCTGAAAAAATTGCTA
GTTATAACAAAGGATGGTATCCAAGCGACGAAATGGCTAGGGGATTTATAGAGATTTGGGGAATGCACTCACTAATAGCG
AGAAGAGTAAGGGGACTTTGA

Upstream 100 bases:

>100_bases
AGTAGAACTGAGTTCATAAAACAAGCAATAGAATTCTATATAAAGAATAAGGGCTAAAGGAAACCTTTAACATGCTATTT
ATCAAGAATCCCTTGTTTTC

Downstream 100 bases:

>100_bases
TGTTATATAGAAAATGGGGATCTGAAAAAGACGAAGTAGTTAACTATACCTCATCCGTGGATAGCGATAGAGAGATTATT
GAAGAAGTGAAATTAACTAT

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MISIVFKLLLYPFCEMKIVLAYSGGLDTTVSIRWLKETFKAEIITVTVDVGQKDDFKKIEERAYIAGASKHYTIDAVRQF
ANNYIAYAIKLNGLYEGVYPLSTALARPLIAEKVVEVAKKEGAEAVAHGSTSKGNDQVRFDLAVKALYPDVKIIAPARIW
NMTREDEIKYAKEKGIPIKVESDKYSIDENLWGRSIEGDIISDPSLEVPEDAFEWTKQIYNKKEIVSIEFSNGVPTAVNG
EKMELNKLVDFLNLKFGSHGFGRVEHIENRVVGFKSREVYEVPAALGLIYAHIDLEKTIYTPMELRFKRHIDQLWSDLVY
QGLWFEPLRETLHKVADEMNKWISGEAKVEVSNGSFRIVGRESEYSPYSEKIASYNKGWYPSDEMARGFIEIWGMHSLIA
RRVRGL

Sequences:

>Translated_406_residues
MISIVFKLLLYPFCEMKIVLAYSGGLDTTVSIRWLKETFKAEIITVTVDVGQKDDFKKIEERAYIAGASKHYTIDAVRQF
ANNYIAYAIKLNGLYEGVYPLSTALARPLIAEKVVEVAKKEGAEAVAHGSTSKGNDQVRFDLAVKALYPDVKIIAPARIW
NMTREDEIKYAKEKGIPIKVESDKYSIDENLWGRSIEGDIISDPSLEVPEDAFEWTKQIYNKKEIVSIEFSNGVPTAVNG
EKMELNKLVDFLNLKFGSHGFGRVEHIENRVVGFKSREVYEVPAALGLIYAHIDLEKTIYTPMELRFKRHIDQLWSDLVY
QGLWFEPLRETLHKVADEMNKWISGEAKVEVSNGSFRIVGRESEYSPYSEKIASYNKGWYPSDEMARGFIEIWGMHSLIA
RRVRGL
>Mature_406_residues
MISIVFKLLLYPFCEMKIVLAYSGGLDTTVSIRWLKETFKAEIITVTVDVGQKDDFKKIEERAYIAGASKHYTIDAVRQF
ANNYIAYAIKLNGLYEGVYPLSTALARPLIAEKVVEVAKKEGAEAVAHGSTSKGNDQVRFDLAVKALYPDVKIIAPARIW
NMTREDEIKYAKEKGIPIKVESDKYSIDENLWGRSIEGDIISDPSLEVPEDAFEWTKQIYNKKEIVSIEFSNGVPTAVNG
EKMELNKLVDFLNLKFGSHGFGRVEHIENRVVGFKSREVYEVPAALGLIYAHIDLEKTIYTPMELRFKRHIDQLWSDLVY
QGLWFEPLRETLHKVADEMNKWISGEAKVEVSNGSFRIVGRESEYSPYSEKIASYNKGWYPSDEMARGFIEIWGMHSLIA
RRVRGL

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=391, Percent_Identity=39.6419437340153, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI16950633, Length=391, Percent_Identity=39.6419437340153, Blast_Score=246, Evalue=3e-65,
Organism=Escherichia coli, GI1789563, Length=401, Percent_Identity=27.6807980049875, Blast_Score=109, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6324514, Length=414, Percent_Identity=33.3333333333333, Blast_Score=206, Evalue=5e-54,
Organism=Drosophila melanogaster, GI21358151, Length=395, Percent_Identity=38.2278481012658, Blast_Score=238, Evalue=4e-63,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 46286; Mature: 46286

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1 ; PS00565 ARGININOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISIVFKLLLYPFCEMKIVLAYSGGLDTTVSIRWLKETFKAEIITVTVDVGQKDDFKKIE
CHHHHHHHHHHCCCCEEEEEEECCCCCCEEEHHHHHHHHCEEEEEEEEECCCCCHHHHHH
ERAYIAGASKHYTIDAVRQFANNYIAYAIKLNGLYEGVYPLSTALARPLIAEKVVEVAKK
HHHHEECCCCCEEHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EGAEAVAHGSTSKGNDQVRFDLAVKALYPDVKIIAPARIWNMTREDEIKYAKEKGIPIKV
CCCHHHHCCCCCCCCCEEEEEEEEEECCCCCEEEECHHHHCCCCHHHHHHHHHCCCEEEE
ESDKYSIDENLWGRSIEGDIISDPSLEVPEDAFEWTKQIYNKKEIVSIEFSNGVPTAVNG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCC
EKMELNKLVDFLNLKFGSHGFGRVEHIENRVVGFKSREVYEVPAALGLIYAHIDLEKTIY
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCEEHHHHHHHHHEEEEHHHHHC
TPMELRFKRHIDQLWSDLVYQGLWFEPLRETLHKVADEMNKWISGEAKVEVSNGSFRIVG
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEE
RESEYSPYSEKIASYNKGWYPSDEMARGFIEIWGMHSLIARRVRGL
CCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MISIVFKLLLYPFCEMKIVLAYSGGLDTTVSIRWLKETFKAEIITVTVDVGQKDDFKKIE
CHHHHHHHHHHCCCCEEEEEEECCCCCCEEEHHHHHHHHCEEEEEEEEECCCCCHHHHHH
ERAYIAGASKHYTIDAVRQFANNYIAYAIKLNGLYEGVYPLSTALARPLIAEKVVEVAKK
HHHHEECCCCCEEHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EGAEAVAHGSTSKGNDQVRFDLAVKALYPDVKIIAPARIWNMTREDEIKYAKEKGIPIKV
CCCHHHHCCCCCCCCCEEEEEEEEEECCCCCEEEECHHHHCCCCHHHHHHHHHCCCEEEE
ESDKYSIDENLWGRSIEGDIISDPSLEVPEDAFEWTKQIYNKKEIVSIEFSNGVPTAVNG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCC
EKMELNKLVDFLNLKFGSHGFGRVEHIENRVVGFKSREVYEVPAALGLIYAHIDLEKTIY
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCEEHHHHHHHHHEEEEHHHHHC
TPMELRFKRHIDQLWSDLVYQGLWFEPLRETLHKVADEMNKWISGEAKVEVSNGSFRIVG
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEE
RESEYSPYSEKIASYNKGWYPSDEMARGFIEIWGMHSLIARRVRGL
CCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726 [H]