Click here to switch to the map view.

The map label for this gene is argH [H]

Identifier: 15897552

GI number: 15897552

Start: 553506

End: 554885

Strand: Direct

Name: argH [H]

Synonym: SSO0639

Alternate gene names: 15897552

Gene position: 553506-554885 (Clockwise)

Preceding gene: 15897551

Following gene: 15897553

Centisome position: 18.5

GC content: 33.91

Gene sequence:

>1380_bases
TTGGGGAATGCACTCACTAATAGCGAGAAGAGTAAGGGGACTTTGATGTTATATAGAAAATGGGGATCTGAAAAAGACGA
AGTAGTTAACTATACCTCATCCGTGGATAGCGATAGAGAGATTATTGAAGAAGTGAAATTAACTATGAAGGCACACGTAA
TTAGTCTTTATTTGACTGGATACCTTGGGAAGGAAACCGCTAGAAAGATCCTTGTTGCATTAAACGAGTTTAAAGAAATT
GGCCAAGGATATGAGGATATTCATGAAGCATTAGAGGATTTCTTAATAAAGAAAGTAGGGGAGGATGCCGGATGGATAGG
GTTAGGTAGGAGTAGAAATGATCACGTTGCCACAGCTTTAAGACTGAGATTAAGAAATAAGCTAATAGAACTTTTAACTG
ACATTAATAGCTTGAGAAAAATACTATTGGATAAAGCAAAAGAGCATATAACAACAATATTTCCCTCATATACACATTTA
CAATTAGCACAACCCACAACATTTGCCCACTACCTAACTTACATTGAAGAGGAGTTAGCTTCGAGGTGGGAAATAATATT
TTCCACGTTAAAACAAGTTAATAAATCGCCATTAGGCTCTGGAGCAATAGTAGGGACAAACGTTAAGATTGATAGAGAAA
AAGAAGCCGAACTATTAGGATTTGACAGTATAATATACAATACATTATCAGCTACTTCATCGAGAGCGGATATTCTCAGC
ACGATCTCGGAATTAACTGTATTAATGGTAGTACTAAGCAGAATAGCTGAGGATTTAATTTTCTTTTCGTCAAATAAATT
AATTAAATTACCAGACTCTCATGTTAGCACTAGCAGTTTGATGCCCCAAAAGAGAAATCCAGTTACAATGGAGATACTAC
GAGCAAAGGCAGCGGAGTCTATAGGTATGCTAACTAGTTTGCTTTCCATTTACAAAGGTTTACCTACTGGATACAATCTT
GATTTACAAGAGATGAATAAATATTATTGGCTTGTAATAAACTATACTAAATCTTCAATAGGAGTTTTAAGCTCACTCTT
TAGTCAAATACAAGTAAATAAAATAAACATTGATGAATCTAGTTTGGCCACTGATGACGCTGAATTACTTTCCATAAGTA
AGAAAGTACCTTATAGATCGACCTACTTTGAGATAGCTAAAAAAGTTAGGGAAGGTTCTTATAAGTCAACTTTAAAAATA
GAGGATTCTATTAATATGAAGGCAGTAATCGGGTCTCCTAATTTTGATTTAATGGCTAATTTGATAAAAATTAGAGAAAC
TAAATTGAAAGAAGATGAAAAGGAAATCGAGGAGTATAAGTTAAAAATAATCTCCAAATTAGGAGAATTACAAGTGATCG
AAAATGAAATTGGAGAATAA

Upstream 100 bases:

>100_bases
TAGGTAGAGAATCAGAATATTCTCCATATTCTGAAAAAATTGCTAGTTATAACAAAGGATGGTATCCAAGCGACGAAATG
GCTAGGGGATTTATAGAGAT

Downstream 100 bases:

>100_bases
GAAGGGTTATTTATATCTAGAGGACGGAACGTTTATTGAAGGATATAGTTTTGGAGCTAAAGGAATCAAGGTAGGAGAGG
TAGTGTTTACAACTTCTATG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MGNALTNSEKSKGTLMLYRKWGSEKDEVVNYTSSVDSDREIIEEVKLTMKAHVISLYLTGYLGKETARKILVALNEFKEI
GQGYEDIHEALEDFLIKKVGEDAGWIGLGRSRNDHVATALRLRLRNKLIELLTDINSLRKILLDKAKEHITTIFPSYTHL
QLAQPTTFAHYLTYIEEELASRWEIIFSTLKQVNKSPLGSGAIVGTNVKIDREKEAELLGFDSIIYNTLSATSSRADILS
TISELTVLMVVLSRIAEDLIFFSSNKLIKLPDSHVSTSSLMPQKRNPVTMEILRAKAAESIGMLTSLLSIYKGLPTGYNL
DLQEMNKYYWLVINYTKSSIGVLSSLFSQIQVNKINIDESSLATDDAELLSISKKVPYRSTYFEIAKKVREGSYKSTLKI
EDSINMKAVIGSPNFDLMANLIKIRETKLKEDEKEIEEYKLKIISKLGELQVIENEIGE

Sequences:

>Translated_459_residues
MGNALTNSEKSKGTLMLYRKWGSEKDEVVNYTSSVDSDREIIEEVKLTMKAHVISLYLTGYLGKETARKILVALNEFKEI
GQGYEDIHEALEDFLIKKVGEDAGWIGLGRSRNDHVATALRLRLRNKLIELLTDINSLRKILLDKAKEHITTIFPSYTHL
QLAQPTTFAHYLTYIEEELASRWEIIFSTLKQVNKSPLGSGAIVGTNVKIDREKEAELLGFDSIIYNTLSATSSRADILS
TISELTVLMVVLSRIAEDLIFFSSNKLIKLPDSHVSTSSLMPQKRNPVTMEILRAKAAESIGMLTSLLSIYKGLPTGYNL
DLQEMNKYYWLVINYTKSSIGVLSSLFSQIQVNKINIDESSLATDDAELLSISKKVPYRSTYFEIAKKVREGSYKSTLKI
EDSINMKAVIGSPNFDLMANLIKIRETKLKEDEKEIEEYKLKIISKLGELQVIENEIGE
>Mature_458_residues
GNALTNSEKSKGTLMLYRKWGSEKDEVVNYTSSVDSDREIIEEVKLTMKAHVISLYLTGYLGKETARKILVALNEFKEIG
QGYEDIHEALEDFLIKKVGEDAGWIGLGRSRNDHVATALRLRLRNKLIELLTDINSLRKILLDKAKEHITTIFPSYTHLQ
LAQPTTFAHYLTYIEEELASRWEIIFSTLKQVNKSPLGSGAIVGTNVKIDREKEAELLGFDSIIYNTLSATSSRADILST
ISELTVLMVVLSRIAEDLIFFSSNKLIKLPDSHVSTSSLMPQKRNPVTMEILRAKAAESIGMLTSLLSIYKGLPTGYNLD
LQEMNKYYWLVINYTKSSIGVLSSLFSQIQVNKINIDESSLATDDAELLSISKKVPYRSTYFEIAKKVREGSYKSTLKIE
DSINMKAVIGSPNFDLMANLIKIRETKLKEDEKEIEEYKLKIISKLGELQVIENEIGE

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=373, Percent_Identity=34.5844504021448, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI68303542, Length=373, Percent_Identity=34.5844504021448, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI68303549, Length=373, Percent_Identity=32.7077747989276, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI68303547, Length=373, Percent_Identity=31.6353887399464, Blast_Score=162, Evalue=7e-40,
Organism=Escherichia coli, GI1790398, Length=314, Percent_Identity=38.8535031847134, Blast_Score=209, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6321806, Length=306, Percent_Identity=37.5816993464052, Blast_Score=189, Evalue=7e-49,
Organism=Drosophila melanogaster, GI221473854, Length=394, Percent_Identity=30.9644670050761, Blast_Score=175, Evalue=6e-44,
Organism=Drosophila melanogaster, GI78706858, Length=394, Percent_Identity=30.9644670050761, Blast_Score=175, Evalue=6e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51796; Mature: 51665

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNALTNSEKSKGTLMLYRKWGSEKDEVVNYTSSVDSDREIIEEVKLTMKAHVISLYLTG
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
YLGKETARKILVALNEFKEIGQGYEDIHEALEDFLIKKVGEDAGWIGLGRSRNDHVATAL
HHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHH
RLRLRNKLIELLTDINSLRKILLDKAKEHITTIFPSYTHLQLAQPTTFAHYLTYIEEELA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHH
SRWEIIFSTLKQVNKSPLGSGAIVGTNVKIDREKEAELLGFDSIIYNTLSATSSRADILS
HHHHHHHHHHHHHCCCCCCCCCEEECCEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
TISELTVLMVVLSRIAEDLIFFSSNKLIKLPDSHVSTSSLMPQKRNPVTMEILRAKAAES
HHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHCCCCCCCCHHHHHHHHHHHHH
IGMLTSLLSIYKGLPTGYNLDLQEMNKYYWLVINYTKSSIGVLSSLFSQIQVNKINIDES
HHHHHHHHHHHCCCCCCCCCCHHHCCCEEEEEEEECCHHHHHHHHHHHHHEEEEECCCHH
SLATDDAELLSISKKVPYRSTYFEIAKKVREGSYKSTLKIEDSINMKAVIGSPNFDLMAN
HCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCCHHHHHH
LIKIRETKLKEDEKEIEEYKLKIISKLGELQVIENEIGE
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GNALTNSEKSKGTLMLYRKWGSEKDEVVNYTSSVDSDREIIEEVKLTMKAHVISLYLTG
CCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
YLGKETARKILVALNEFKEIGQGYEDIHEALEDFLIKKVGEDAGWIGLGRSRNDHVATAL
HHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHH
RLRLRNKLIELLTDINSLRKILLDKAKEHITTIFPSYTHLQLAQPTTFAHYLTYIEEELA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHH
SRWEIIFSTLKQVNKSPLGSGAIVGTNVKIDREKEAELLGFDSIIYNTLSATSSRADILS
HHHHHHHHHHHHHCCCCCCCCCEEECCEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
TISELTVLMVVLSRIAEDLIFFSSNKLIKLPDSHVSTSSLMPQKRNPVTMEILRAKAAES
HHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHCCCCCCCCHHHHHHHHHHHHH
IGMLTSLLSIYKGLPTGYNLDLQEMNKYYWLVINYTKSSIGVLSSLFSQIQVNKINIDES
HHHHHHHHHHHCCCCCCCCCCHHHCCCEEEEEEEECCHHHHHHHHHHHHHEEEEECCCHH
SLATDDAELLSISKKVPYRSTYFEIAKKVREGSYKSTLKIEDSINMKAVIGSPNFDLMAN
HCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCCHHHHHH
LIKIRETKLKEDEKEIEEYKLKIISKLGELQVIENEIGE
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726 [H]