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The map label for this gene is pyrC

Identifier: 15897527

GI number: 15897527

Start: 532730

End: 533902

Strand: Reverse

Name: pyrC

Synonym: SSO0611

Alternate gene names: 15897527

Gene position: 533902-532730 (Counterclockwise)

Preceding gene: 15897528

Following gene: 15897526

Centisome position: 17.84

GC content: 35.12

Gene sequence:

>1173_bases
TTGATGATCTTGTGGATTATGGGAAAGGCGTACTTAAGTAAGGAGATTAGGGATGTTTGTATAAATTTCGATAGGAGAAT
AAAGGAAATTAAATCAATTTGTAAACCAGATATTGCATTACCAAAAGGTACATTAATATTGCCTGGGGCAATAGATCTTC
ACACTCACATAAGAGGATTGAAATTGGCTTATAAGGAAGATGTAGTATCAGGTACCAGTGAAGCCTCTTACGGTGGGATT
ACATTAATAGGAGATATGCCAAATAGTGTGCCTTTCGTAAACACGATGGAGACAATAACTGCCAAGTTAAGAGAGTTTGA
ATATTACTCTAGGGTTGACTATTTCGTGTACTCTGGTGTTACTAAGGATTTAAAGAAAGTTGATAAATTCCCTATAGCTG
GTTATAAGATATTCCCAGAAGATTTAGAGAAAGAAGAGACGTTAGAGGTTTTAAAATCTATGAAACTGAAAATCCTTCAC
CCTGAAGTTCCGTTAGCATTAAGGGGTAATAGAAAGTTAAGATTGAATATATGGTATGAGATAGGAGCATTATATTATGT
AAAAGGGTATCAAAATGTTCACATAACGCATGCAACTAATATACGTACTGTAAGATTAGCTAAGGAGCTGGGTTTTACTG
TAGATATAACGCCACATCACTTGTTAGTAGATAGAGAAAAGGAATGTCTAACCAAAGTGAATCCACCAATAAGAGATACA
AATGAAAGGCTTTGGCTATTGCAAGCTATAAATGAAGTAGATACAGTTGTAAGCGATCATGCTCCTCATGCGAGTTTTGA
AAAACAGCAACCTTACGAGATATGTCCACCTGGCATAGCTGCTCTTTCATTTACAGTTCCTTTTATATTAACGTTAGTTA
GCAAAGGTATAATTAGTATTGATAGAGCAGTAGAACTCATTTCTACAAATCCAGCTAGGATATTAAATATCCCCTACGGC
GAGATTAAGGAGAATAACTATGCTAATTTTACTATTATTCAATTTAAAGATTGGAGATATTCGACTAAATATTCTAAGGT
TATTGAAACTCCTCTAGATGGATTTCCGCTAAGAGCTTCGATTTACATGACTATCATTCAAGGTAAGGTAGGTAGTTTGG
AGGGAGAGGTATTTCCAGTGAAGGGAATAAATCCGTTTGGTGAGAATAAATGA

Upstream 100 bases:

>100_bases
GTCTATAATAGATGGGTTAAAATGAATTGTAATCTAGGAGTGTGTGGGTTATGTGAAGTTAAAGGTAAATTAACTTGTAT
AGATGGTCCTTTCATGAGGT

Downstream 100 bases:

>100_bases
TTACGATAAAAAATATCACACTAAACGACCCTTTAATAATAGCCTCTGGAATCATACCAGATGTTCCAAATTATGTGGAG
ACAATTTGCGAAAAATATAA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MMILWIMGKAYLSKEIRDVCINFDRRIKEIKSICKPDIALPKGTLILPGAIDLHTHIRGLKLAYKEDVVSGTSEASYGGI
TLIGDMPNSVPFVNTMETITAKLREFEYYSRVDYFVYSGVTKDLKKVDKFPIAGYKIFPEDLEKEETLEVLKSMKLKILH
PEVPLALRGNRKLRLNIWYEIGALYYVKGYQNVHITHATNIRTVRLAKELGFTVDITPHHLLVDREKECLTKVNPPIRDT
NERLWLLQAINEVDTVVSDHAPHASFEKQQPYEICPPGIAALSFTVPFILTLVSKGIISIDRAVELISTNPARILNIPYG
EIKENNYANFTIIQFKDWRYSTKYSKVIETPLDGFPLRASIYMTIIQGKVGSLEGEVFPVKGINPFGENK

Sequences:

>Translated_390_residues
MMILWIMGKAYLSKEIRDVCINFDRRIKEIKSICKPDIALPKGTLILPGAIDLHTHIRGLKLAYKEDVVSGTSEASYGGI
TLIGDMPNSVPFVNTMETITAKLREFEYYSRVDYFVYSGVTKDLKKVDKFPIAGYKIFPEDLEKEETLEVLKSMKLKILH
PEVPLALRGNRKLRLNIWYEIGALYYVKGYQNVHITHATNIRTVRLAKELGFTVDITPHHLLVDREKECLTKVNPPIRDT
NERLWLLQAINEVDTVVSDHAPHASFEKQQPYEICPPGIAALSFTVPFILTLVSKGIISIDRAVELISTNPARILNIPYG
EIKENNYANFTIIQFKDWRYSTKYSKVIETPLDGFPLRASIYMTIIQGKVGSLEGEVFPVKGINPFGENK
>Mature_390_residues
MMILWIMGKAYLSKEIRDVCINFDRRIKEIKSICKPDIALPKGTLILPGAIDLHTHIRGLKLAYKEDVVSGTSEASYGGI
TLIGDMPNSVPFVNTMETITAKLREFEYYSRVDYFVYSGVTKDLKKVDKFPIAGYKIFPEDLEKEETLEVLKSMKLKILH
PEVPLALRGNRKLRLNIWYEIGALYYVKGYQNVHITHATNIRTVRLAKELGFTVDITPHHLLVDREKECLTKVNPPIRDT
NERLWLLQAINEVDTVVSDHAPHASFEKQQPYEICPPGIAALSFTVPFILTLVSKGIISIDRAVELISTNPARILNIPYG
EIKENNYANFTIIQFKDWRYSTKYSKVIETPLDGFPLRASIYMTIIQGKVGSLEGEVFPVKGINPFGENK

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=356, Percent_Identity=27.8089887640449, Blast_Score=117, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI193204318, Length=368, Percent_Identity=27.445652173913, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24642586, Length=363, Percent_Identity=27.8236914600551, Blast_Score=125, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_SULSO (Q9UX05)

Other databases:

- EMBL:   Y18930
- EMBL:   AE006641
- PIR:   C90208
- RefSeq:   NP_342132.1
- ProteinModelPortal:   Q9UX05
- GeneID:   1454889
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0611
- NMPDR:   fig|273057.1.peg.555
- HOGENOM:   HBG724623
- OMA:   LLAHCEH
- ProtClustDB:   PRK00369
- BioCyc:   SSOL273057:SSO0611-MONOMER
- BRENDA:   3.5.2.3
- HAMAP:   MF_00220_A
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195

Pfam domain/function: PF01979 Amidohydro_1

EC number: =3.5.2.3

Molecular weight: Translated: 44333; Mature: 44333

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMILWIMGKAYLSKEIRDVCINFDRRIKEIKSICKPDIALPKGTLILPGAIDLHTHIRGL
CEEEEEECHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCEEECCCEEHHHHHHHH
KLAYKEDVVSGTSEASYGGITLIGDMPNSVPFVNTMETITAKLREFEYYSRVDYFVYSGV
EEEHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCC
TKDLKKVDKFPIAGYKIFPEDLEKEETLEVLKSMKLKILHPEVPLALRGNRKLRLNIWYE
HHHHHHHHCCCCCCEEECHHHCCHHHHHHHHHHCCEEEECCCCCEEEECCCEEEEEEEEE
IGALYYVKGYQNVHITHATNIRTVRLAKELGFTVDITPHHLLVDREKECLTKVNPPIRDT
ECEEEEEECCCEEEEEECCCEEEEEEHHHCCCEEECCCCEEEECCCHHHHHHCCCCCCCC
NERLWLLQAINEVDTVVSDHAPHASFEKQQPYEICPPGIAALSFTVPFILTLVSKGIISI
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHH
DRAVELISTNPARILNIPYGEIKENNYANFTIIQFKDWRYSTKYSKVIETPLDGFPLRAS
HHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHCCCCCCCCCCE
IYMTIIQGKVGSLEGEVFPVKGINPFGENK
EEEEEEECCCCCCCCCEEEECCCCCCCCCC
>Mature Secondary Structure
MMILWIMGKAYLSKEIRDVCINFDRRIKEIKSICKPDIALPKGTLILPGAIDLHTHIRGL
CEEEEEECHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCEEECCCEEHHHHHHHH
KLAYKEDVVSGTSEASYGGITLIGDMPNSVPFVNTMETITAKLREFEYYSRVDYFVYSGV
EEEHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCC
TKDLKKVDKFPIAGYKIFPEDLEKEETLEVLKSMKLKILHPEVPLALRGNRKLRLNIWYE
HHHHHHHHCCCCCCEEECHHHCCHHHHHHHHHHCCEEEECCCCCEEEECCCEEEEEEEEE
IGALYYVKGYQNVHITHATNIRTVRLAKELGFTVDITPHHLLVDREKECLTKVNPPIRDT
ECEEEEEECCCEEEEEECCCEEEEEEHHHCCCEEECCCCEEEECCCHHHHHHCCCCCCCC
NERLWLLQAINEVDTVVSDHAPHASFEKQQPYEICPPGIAALSFTVPFILTLVSKGIISI
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHH
DRAVELISTNPARILNIPYGEIKENNYANFTIIQFKDWRYSTKYSKVIETPLDGFPLRAS
HHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHCCCCCCCCCCE
IYMTIIQGKVGSLEGEVFPVKGINPFGENK
EEEEEEECCCCCCCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726