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The map label for this gene is pyrD

Identifier: 15897526

GI number: 15897526

Start: 531861

End: 532733

Strand: Reverse

Name: pyrD

Synonym: SSO0610

Alternate gene names: 15897526

Gene position: 532733-531861 (Counterclockwise)

Preceding gene: 15897527

Following gene: 15897525

Centisome position: 17.8

GC content: 36.88

Gene sequence:

>873_bases
ATGATTACGATAAAAAATATCACACTAAACGACCCTTTAATAATAGCCTCTGGAATCATACCAGATGTTCCAAATTATGT
GGAGACAATTTGCGAAAAATATAAACCCTCTGCAATTACCACGAAGACAGTAACACTTAACCCCTTAGAACCTCATAAGC
CTCCTACAGTCATCAAACTTCACGATGGTATCTATATGAACGCTATAGGTTTAGGAAATCCCGGTGCTAAGGCAATAAAT
GAAATTGGCGTTTTATGTCCCCTTATAGTAAGCGTTGGTGGTTCCTCCATAAACGAGATAAAAGAAGTGGTTGAAGTTGT
TCAGAGTAAGGCGAAGATAATAGAAATAAACGTGAGTAGTCCTAACAGAAAGGGTTACGGGGAATCATTATCTAAGTTAA
TTGGGGATATAATTGAAAGTGTCAAAAGTGTGACTAAATTACCAGTATTTGTTAAATTAGGTCCTTGGGATAACGTTATT
GAGCTTGCAGGGAAAGCTTTAGAGAAAGGTGCTGATGGACTTACCCTTATAAATACTATAAAGGGACTAATTATTGATGT
AGAGACTTTCAAGCCAATTCTCTATTATGGTACAGGAGGCGTTTCTGGCAGATGCCTTTATCCTATTGCTCTTAGGATAA
TTAAAGATGTTTACGAAGAGTATGGAGTTGACATTATAGGAGTTGGGGGTGTGTATGATTGGACTGATGTAATTGGTATG
TTGGCAGCTGGTGCTAAATTGGTAGGCCTGGGTACTGTATTAATCGAGAAAGGATTTAGTGTAATTGAGGAAATTCGGAA
GGGTTTGCAGTCCTATTTACTTGAAAAGGGTTTAAAATTTGAAGATATTATAGGTATTTCAGTGAGAAAATAA

Upstream 100 bases:

>100_bases
TAAGAGCTTCGATTTACATGACTATCATTCAAGGTAAGGTAGGTAGTTTGGAGGGAGAGGTATTTCCAGTGAAGGGAATA
AATCCGTTTGGTGAGAATAA

Downstream 100 bases:

>100_bases
AATGGTTAGGCCAGTAATGAAAGGAAGAGATTTAGAAACATTAGTATTCCTAGGGCGATTAAAGGAGGTAAAAGTAGAGT
ATTGTGACGAAGAAAAGAAG

Product: dihydroorotate dehydrogenase (dihydroorotate oxidase) (DHOdehase) (pyrD)

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MITIKNITLNDPLIIASGIIPDVPNYVETICEKYKPSAITTKTVTLNPLEPHKPPTVIKLHDGIYMNAIGLGNPGAKAIN
EIGVLCPLIVSVGGSSINEIKEVVEVVQSKAKIIEINVSSPNRKGYGESLSKLIGDIIESVKSVTKLPVFVKLGPWDNVI
ELAGKALEKGADGLTLINTIKGLIIDVETFKPILYYGTGGVSGRCLYPIALRIIKDVYEEYGVDIIGVGGVYDWTDVIGM
LAAGAKLVGLGTVLIEKGFSVIEEIRKGLQSYLLEKGLKFEDIIGISVRK

Sequences:

>Translated_290_residues
MITIKNITLNDPLIIASGIIPDVPNYVETICEKYKPSAITTKTVTLNPLEPHKPPTVIKLHDGIYMNAIGLGNPGAKAIN
EIGVLCPLIVSVGGSSINEIKEVVEVVQSKAKIIEINVSSPNRKGYGESLSKLIGDIIESVKSVTKLPVFVKLGPWDNVI
ELAGKALEKGADGLTLINTIKGLIIDVETFKPILYYGTGGVSGRCLYPIALRIIKDVYEEYGVDIIGVGGVYDWTDVIGM
LAAGAKLVGLGTVLIEKGFSVIEEIRKGLQSYLLEKGLKFEDIIGISVRK
>Mature_290_residues
MITIKNITLNDPLIIASGIIPDVPNYVETICEKYKPSAITTKTVTLNPLEPHKPPTVIKLHDGIYMNAIGLGNPGAKAIN
EIGVLCPLIVSVGGSSINEIKEVVEVVQSKAKIIEINVSSPNRKGYGESLSKLIGDIIESVKSVTKLPVFVKLGPWDNVI
ELAGKALEKGADGLTLINTIKGLIIDVETFKPILYYGTGGVSGRCLYPIALRIIKDVYEEYGVDIIGVGGVYDWTDVIGM
LAAGAKLVGLGTVLIEKGFSVIEEIRKGLQSYLLEKGLKFEDIIGISVRK

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI119943098, Length=185, Percent_Identity=29.1891891891892, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI45006951, Length=282, Percent_Identity=28.0141843971631, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87082059, Length=217, Percent_Identity=29.0322580645161, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71984108, Length=187, Percent_Identity=27.807486631016, Blast_Score=68, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322633, Length=295, Percent_Identity=28.4745762711864, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24640763, Length=188, Percent_Identity=30.3191489361702, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI18858217, Length=188, Percent_Identity=30.3191489361702, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_SULSO (Q9UX04)

Other databases:

- EMBL:   Y18930
- EMBL:   AE006641
- PIR:   B90208
- RefSeq:   NP_342131.1
- ProteinModelPortal:   Q9UX04
- SMR:   Q9UX04
- GeneID:   1454888
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0610
- NMPDR:   fig|273057.1.peg.554
- HOGENOM:   HBG472415
- OMA:   VTKSIGP
- PhylomeDB:   Q9UX04
- ProtClustDB:   CLSK802790
- BioCyc:   SSOL273057:SSO0610-MONOMER
- BRENDA:   1.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00224_A
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01037

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.3.1

Molecular weight: Translated: 31154; Mature: 31154

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITIKNITLNDPLIIASGIIPDVPNYVETICEKYKPSAITTKTVTLNPLEPHKPPTVIKL
CEEEEEEECCCCEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCEEEE
HDGIYMNAIGLGNPGAKAINEIGVLCPLIVSVGGSSINEIKEVVEVVQSKAKIIEINVSS
ECCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEECCC
PNRKGYGESLSKLIGDIIESVKSVTKLPVFVKLGPWDNVIELAGKALEKGADGLTLINTI
CCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHH
KGLIIDVETFKPILYYGTGGVSGRCLYPIALRIIKDVYEEYGVDIIGVGGVYDWTDVIGM
HHHEEEHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHH
LAAGAKLVGLGTVLIEKGFSVIEEIRKGLQSYLLEKGLKFEDIIGISVRK
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECEEECC
>Mature Secondary Structure
MITIKNITLNDPLIIASGIIPDVPNYVETICEKYKPSAITTKTVTLNPLEPHKPPTVIKL
CEEEEEEECCCCEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCEEEE
HDGIYMNAIGLGNPGAKAINEIGVLCPLIVSVGGSSINEIKEVVEVVQSKAKIIEINVSS
ECCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEECCC
PNRKGYGESLSKLIGDIIESVKSVTKLPVFVKLGPWDNVIELAGKALEKGADGLTLINTI
CCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHH
KGLIIDVETFKPILYYGTGGVSGRCLYPIALRIIKDVYEEYGVDIIGVGGVYDWTDVIGM
HHHEEEHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHH
LAAGAKLVGLGTVLIEKGFSVIEEIRKGLQSYLLEKGLKFEDIIGISVRK
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726