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The map label for this gene is hisA

Identifier: 15897511

GI number: 15897511

Start: 521496

End: 522194

Strand: Direct

Name: hisA

Synonym: SSO0594

Alternate gene names: 15897511

Gene position: 521496-522194 (Clockwise)

Preceding gene: 15897510

Following gene: 15897512

Centisome position: 17.43

GC content: 32.33

Gene sequence:

>699_bases
TTGAATGAAATAATTCCAAGTATTGATATAAGCTTTGGAAAAGCGGTAAAACGAATTAGAGGAGTTAGGGGAACTGGTCT
AGTTTTAGGTAATCCAATAGAACTAGCAAATAAACTCTATAATGAAGGATACTCAAGAATACACGTAGTTGATTTAGATG
CTGCAGAAGGGGTTGGTAACAACGAGATGTACATCAAAGAAATATGTAAAATAGGATTTGATTGGATTCAAGTAGGCGGG
GGTATAAGGGACGTTGAAAAAGCTAAAAGATTAATCTCATTAGATGTTAATGCCCTAATTTTCTCCACAATAGTATTTAC
TAATTTCAATCTATTTTACAATATTGTAAGAGAAATCGGAAATAATAGAGTAATAGTATCTATAGATTATGACGATACGA
AAAGAGTTCTAATAAGCGGATGGAAAGAGAGATCAATGGAAATAATAGATGGTATTAAGAAGGTAAATGAACTTGAATTA
TTAGGGATTATACTAACCTATGTCACCAATGAAGGTACCGTTAAAGGAATCGATTATAGTGTGAAAGATTATGCAAAACT
AATACGAGGGGTAAAAGAATATGCTGGCGGTGTTTCAAGTGATTCAGATATTACGTTTTTAAAAAACGTTGGATTTGATT
ACATAATAGTTGGAATGGCTTTTTACCTAAATAAAATAAGGGGGACTAACGTTGTCTAG

Upstream 100 bases:

>100_bases
GTAGCAGAGGAGGATATACTACCAGAAGTTATAGCCAAAGTGAAAGCTGCTGGAGCTAGGGATATCGTTGTAATTGATAT
AGAGAAAGTGGTGAAATAGA

Downstream 100 bases:

>100_bases
AAGCGCAAATATAACTAGAGAAACAAAGGAGACTAAAATAGAGGTACTCTTAGACATAGATAGAAAAGGCGAAGTTAAGG
TTTCCACTCCAATTCCATTT

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MNEIIPSIDISFGKAVKRIRGVRGTGLVLGNPIELANKLYNEGYSRIHVVDLDAAEGVGNNEMYIKEICKIGFDWIQVGG
GIRDVEKAKRLISLDVNALIFSTIVFTNFNLFYNIVREIGNNRVIVSIDYDDTKRVLISGWKERSMEIIDGIKKVNELEL
LGIILTYVTNEGTVKGIDYSVKDYAKLIRGVKEYAGGVSSDSDITFLKNVGFDYIIVGMAFYLNKIRGTNVV

Sequences:

>Translated_232_residues
MNEIIPSIDISFGKAVKRIRGVRGTGLVLGNPIELANKLYNEGYSRIHVVDLDAAEGVGNNEMYIKEICKIGFDWIQVGG
GIRDVEKAKRLISLDVNALIFSTIVFTNFNLFYNIVREIGNNRVIVSIDYDDTKRVLISGWKERSMEIIDGIKKVNELEL
LGIILTYVTNEGTVKGIDYSVKDYAKLIRGVKEYAGGVSSDSDITFLKNVGFDYIIVGMAFYLNKIRGTNVV
>Mature_232_residues
MNEIIPSIDISFGKAVKRIRGVRGTGLVLGNPIELANKLYNEGYSRIHVVDLDAAEGVGNNEMYIKEICKIGFDWIQVGG
GIRDVEKAKRLISLDVNALIFSTIVFTNFNLFYNIVREIGNNRVIVSIDYDDTKRVLISGWKERSMEIIDGIKKVNELEL
LGIILTYVTNEGTVKGIDYSVKDYAKLIRGVKEYAGGVSSDSDITFLKNVGFDYIIVGMAFYLNKIRGTNVV

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=231, Percent_Identity=23.8095238095238, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_SULSO (O33772)

Other databases:

- EMBL:   U82227
- EMBL:   Y18930
- EMBL:   AE006641
- PIR:   C90206
- RefSeq:   NP_342116.1
- ProteinModelPortal:   O33772
- SMR:   O33772
- GeneID:   1454873
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0594
- NMPDR:   fig|273057.1.peg.539
- HOGENOM:   HBG541613
- OMA:   GRCQLGG
- ProtClustDB:   PRK13586
- BioCyc:   SSOL273057:SSO0594-MONOMER
- BRENDA:   5.3.1.16
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 25899; Mature: 25899

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: NA

Important sites: ACT_SITE 9-9 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEIIPSIDISFGKAVKRIRGVRGTGLVLGNPIELANKLYNEGYSRIHVVDLDAAEGVGN
CCCCCCCCCCHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHCCCCEEEEEECCHHCCCCC
NEMYIKEICKIGFDWIQVGGGIRDVEKAKRLISLDVNALIFSTIVFTNFNLFYNIVREIG
CCHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHC
NNRVIVSIDYDDTKRVLISGWKERSMEIIDGIKKVNELELLGIILTYVTNEGTVKGIDYS
CCEEEEEECCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCC
VKDYAKLIRGVKEYAGGVSSDSDITFLKNVGFDYIIVGMAFYLNKIRGTNVV
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNEIIPSIDISFGKAVKRIRGVRGTGLVLGNPIELANKLYNEGYSRIHVVDLDAAEGVGN
CCCCCCCCCCHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHCCCCEEEEEECCHHCCCCC
NEMYIKEICKIGFDWIQVGGGIRDVEKAKRLISLDVNALIFSTIVFTNFNLFYNIVREIG
CCHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHC
NNRVIVSIDYDDTKRVLISGWKERSMEIIDGIKKVNELELLGIILTYVTNEGTVKGIDYS
CCEEEEEECCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCC
VKDYAKLIRGVKEYAGGVSSDSDITFLKNVGFDYIIVGMAFYLNKIRGTNVV
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9209067; 10701121; 11427726