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The map label for this gene is hisB [H]

Identifier: 15897512

GI number: 15897512

Start: 522187

End: 522768

Strand: Direct

Name: hisB [H]

Synonym: SSO0596

Alternate gene names: 15897512

Gene position: 522187-522768 (Clockwise)

Preceding gene: 15897511

Following gene: 15897513

Centisome position: 17.45

GC content: 35.74

Gene sequence:

>582_bases
TTGTCTAGAAGCGCAAATATAACTAGAGAAACAAAGGAGACTAAAATAGAGGTACTCTTAGACATAGATAGAAAAGGCGA
AGTTAAGGTTTCCACTCCAATTCCATTTTTTAACCACATGCTTATAACATTACTAACCTACATGAACTCTACTGCAATAG
TGTCTGCTACAGATAAACTACCCTATGACGATCATCATATTGTGGAAGATGTCGCAATAACGCTTGGTTTGGCAATAAAG
ACCGCACTAGGCGATAAGAGAGGAATAAAAAGATTCTCCCACCAAATTATACCAATGGATGATGCTTTGGTTTTAGTTTC
ACTAGATATTTCAAATAGAGGAATGGCCTTCGTTAATCTTAATTTGAAAAGAAGTGAAATTGGTGGATTAGCTACGGAAA
ATGTTCCACATTTCTTCCAATCCTTTGCTTACAATAGTGGAATCACTTTACATATTTCTCAATTGAGTGGATATAATACA
CACCATATCATAGAGGCTAGTTTTAAGGCCTTAGGATTAGCACTATACGAAGCAACGAGAATAGTAGACAATGAAATAAG
AAGCACGAAGGGGATAATATGA

Upstream 100 bases:

>100_bases
GTTTCAAGTGATTCAGATATTACGTTTTTAAAAAACGTTGGATTTGATTACATAATAGTTGGAATGGCTTTTTACCTAAA
TAAAATAAGGGGGACTAACG

Downstream 100 bases:

>100_bases
CAACGAAAAGAATAATAGCTTGCCTCGATGTAAAGGACGGTAACGTAGTTAAAGGAGTAAATTTCCTTAATCTCCAATTG
AAAGGAGATCCGGTTAGCCT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MSRSANITRETKETKIEVLLDIDRKGEVKVSTPIPFFNHMLITLLTYMNSTAIVSATDKLPYDDHHIVEDVAITLGLAIK
TALGDKRGIKRFSHQIIPMDDALVLVSLDISNRGMAFVNLNLKRSEIGGLATENVPHFFQSFAYNSGITLHISQLSGYNT
HHIIEASFKALGLALYEATRIVDNEIRSTKGII

Sequences:

>Translated_193_residues
MSRSANITRETKETKIEVLLDIDRKGEVKVSTPIPFFNHMLITLLTYMNSTAIVSATDKLPYDDHHIVEDVAITLGLAIK
TALGDKRGIKRFSHQIIPMDDALVLVSLDISNRGMAFVNLNLKRSEIGGLATENVPHFFQSFAYNSGITLHISQLSGYNT
HHIIEASFKALGLALYEATRIVDNEIRSTKGII
>Mature_192_residues
SRSANITRETKETKIEVLLDIDRKGEVKVSTPIPFFNHMLITLLTYMNSTAIVSATDKLPYDDHHIVEDVAITLGLAIKT
ALGDKRGIKRFSHQIIPMDDALVLVSLDISNRGMAFVNLNLKRSEIGGLATENVPHFFQSFAYNSGITLHISQLSGYNTH
HIIEASFKALGLALYEATRIVDNEIRSTKGII

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=192, Percent_Identity=41.1458333333333, Blast_Score=154, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6324776, Length=167, Percent_Identity=44.9101796407186, Blast_Score=144, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21437; Mature: 21306

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRSANITRETKETKIEVLLDIDRKGEVKVSTPIPFFNHMLITLLTYMNSTAIVSATDKL
CCCCCCCCCCCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCC
PYDDHHIVEDVAITLGLAIKTALGDKRGIKRFSHQIIPMDDALVLVSLDISNRGMAFVNL
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCEECCCCCEEEEEEEEECCCCEEEEEE
NLKRSEIGGLATENVPHFFQSFAYNSGITLHISQLSGYNTHHIIEASFKALGLALYEATR
EEEHHHCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHH
IVDNEIRSTKGII
HHHHHHHHHCCCC
>Mature Secondary Structure 
SRSANITRETKETKIEVLLDIDRKGEVKVSTPIPFFNHMLITLLTYMNSTAIVSATDKL
CCCCCCCCCCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCC
PYDDHHIVEDVAITLGLAIKTALGDKRGIKRFSHQIIPMDDALVLVSLDISNRGMAFVNL
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCEECCCCCEEEEEEEEECCCCEEEEEE
NLKRSEIGGLATENVPHFFQSFAYNSGITLHISQLSGYNTHHIIEASFKALGLALYEATR
EEEHHHCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHH
IVDNEIRSTKGII
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA