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The map label for this gene is hisG

Identifier: 15897510

GI number: 15897510

Start: 520622

End: 521494

Strand: Direct

Name: hisG

Synonym: SSO0593

Alternate gene names: 15897510

Gene position: 520622-521494 (Clockwise)

Preceding gene: 15897509

Following gene: 15897511

Centisome position: 17.4

GC content: 38.83

Gene sequence:

>873_bases
TTGGTGAGGAACTTGAAAATAGCAATTCCAAATAAAGGAAGACTCCAGCAACCTACGCTACAATTTTTACAGTCAGTAGG
CATAAAACCGTTGGCCAGTGACGATAGAGCGTTAATAGTACCGACAAGTTGGGAGGGAGTGCAGCTAGTCATGATCAGAA
CCGAGGACATACCTAATATTGTGGAAACCGGTGCTACAGAATTAGGAATTACTGGTCATGATTATGTTATAGAAAGTAGT
GCAGATGTTGAAGAGCTAATCAAACTAGACTTTGGAAGATCAAAAATAGTTCTAGCAGTACCTCAAACTTGGAGAGAAAA
TTCTGTGGACGAATTGAAAGGAAAGGAATTTAGAGTAGCTACTAAATACTATAACATCGCAAAGGAATACGTAAGGAGAA
GAGAACTAAATGCAAAGGTAGTAAAAATAAGCGGAGCTGCTGAGGTAATGCCATCACTGGGTGCTGCTGAGGCAATAATC
GACGTAATGAGTACTGGGACTACACTAAAACTACATGGGTTAAAAGCAATAGACGTTATAATGGACTCCTATGCTGTAGT
TATAGGAAATAGAAACTGGATAAAAAACGATGAGGCTGATAGGATTAATTTACTTCTTACAATGATGAAAGGGGCAATAG
CAGCTAAGGGTAAGAAAATGATATTCATGAATGTACCCGATAATAAACTAGATGGAGTAATAAATTCGCTGCCTGCAATG
TTAGCCCCAGCAATAACTAGATTAAGCAGATCAGACATATGGGAAGTAATTACGGTAGCAGAGGAGGATATACTACCAGA
AGTTATAGCCAAAGTGAAAGCTGCTGGAGCTAGGGATATCGTTGTAATTGATATAGAGAAAGTGGTGAAATAG

Upstream 100 bases:

>100_bases
ATGCTTATGAGACACGGGATTGCAATAAGAAAGTTATATGACAACTTTTATAGAATAACAATAGGGACTGAAGATCAGTG
CAAGATGGTTATAGATAAAC

Downstream 100 bases:

>100_bases
ATTGAATGAAATAATTCCAAGTATTGATATAAGCTTTGGAAAAGCGGTAAAACGAATTAGAGGAGTTAGGGGAACTGGTC
TAGTTTTAGGTAATCCAATA

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MVRNLKIAIPNKGRLQQPTLQFLQSVGIKPLASDDRALIVPTSWEGVQLVMIRTEDIPNIVETGATELGITGHDYVIESS
ADVEELIKLDFGRSKIVLAVPQTWRENSVDELKGKEFRVATKYYNIAKEYVRRRELNAKVVKISGAAEVMPSLGAAEAII
DVMSTGTTLKLHGLKAIDVIMDSYAVVIGNRNWIKNDEADRINLLLTMMKGAIAAKGKKMIFMNVPDNKLDGVINSLPAM
LAPAITRLSRSDIWEVITVAEEDILPEVIAKVKAAGARDIVVIDIEKVVK

Sequences:

>Translated_290_residues
MVRNLKIAIPNKGRLQQPTLQFLQSVGIKPLASDDRALIVPTSWEGVQLVMIRTEDIPNIVETGATELGITGHDYVIESS
ADVEELIKLDFGRSKIVLAVPQTWRENSVDELKGKEFRVATKYYNIAKEYVRRRELNAKVVKISGAAEVMPSLGAAEAII
DVMSTGTTLKLHGLKAIDVIMDSYAVVIGNRNWIKNDEADRINLLLTMMKGAIAAKGKKMIFMNVPDNKLDGVINSLPAM
LAPAITRLSRSDIWEVITVAEEDILPEVIAKVKAAGARDIVVIDIEKVVK
>Mature_290_residues
MVRNLKIAIPNKGRLQQPTLQFLQSVGIKPLASDDRALIVPTSWEGVQLVMIRTEDIPNIVETGATELGITGHDYVIESS
ADVEELIKLDFGRSKIVLAVPQTWRENSVDELKGKEFRVATKYYNIAKEYVRRRELNAKVVKISGAAEVMPSLGAAEAII
DVMSTGTTLKLHGLKAIDVIMDSYAVVIGNRNWIKNDEADRINLLLTMMKGAIAAKGKKMIFMNVPDNKLDGVINSLPAM
LAPAITRLSRSDIWEVITVAEEDILPEVIAKVKAAGARDIVVIDIEKVVK

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=299, Percent_Identity=33.7792642140468, Blast_Score=135, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6320896, Length=290, Percent_Identity=29.3103448275862, Blast_Score=110, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_SULSO (O33771)

Other databases:

- EMBL:   U82227
- EMBL:   Y18930
- EMBL:   AE006641
- PIR:   B90206
- RefSeq:   NP_342115.1
- ProteinModelPortal:   O33771
- SMR:   O33771
- GeneID:   1454872
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0593
- NMPDR:   fig|273057.1.peg.538
- HOGENOM:   HBG391868
- OMA:   YLRPRDI
- PhylomeDB:   O33771
- ProtClustDB:   PRK00489
- BioCyc:   SSOL273057:SSO0593-MONOMER
- BRENDA:   2.4.2.17
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 31925; Mature: 31925

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRNLKIAIPNKGRLQQPTLQFLQSVGIKPLASDDRALIVPTSWEGVQLVMIRTEDIPNI
CCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCHH
VETGATELGITGHDYVIESSADVEELIKLDFGRSKIVLAVPQTWRENSVDELKGKEFRVA
HHCCCCEECCCCCCEEEECCCCHHHHHHHCCCCCEEEEECCCCCCCCCHHHHCCCEEEEH
TKYYNIAKEYVRRRELNAKVVKISGAAEVMPSLGAAEAIIDVMSTGTTLKLHGLKAIDVI
HHHHHHHHHHHHHHCCCCEEEEECCHHHHHHCCCHHHHHHHHHCCCCEEEECCCHHHHHH
MDSYAVVIGNRNWIKNDEADRINLLLTMMKGAIAAKGKKMIFMNVPDNKLDGVINSLPAM
HCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHH
LAPAITRLSRSDIWEVITVAEEDILPEVIAKVKAAGARDIVVIDIEKVVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCC
>Mature Secondary Structure
MVRNLKIAIPNKGRLQQPTLQFLQSVGIKPLASDDRALIVPTSWEGVQLVMIRTEDIPNI
CCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCHH
VETGATELGITGHDYVIESSADVEELIKLDFGRSKIVLAVPQTWRENSVDELKGKEFRVA
HHCCCCEECCCCCCEEEECCCCHHHHHHHCCCCCEEEEECCCCCCCCCHHHHCCCEEEEH
TKYYNIAKEYVRRRELNAKVVKISGAAEVMPSLGAAEAIIDVMSTGTTLKLHGLKAIDVI
HHHHHHHHHHHHHHCCCCEEEEECCHHHHHHCCCHHHHHHHHHCCCCEEEECCCHHHHHH
MDSYAVVIGNRNWIKNDEADRINLLLTMMKGAIAAKGKKMIFMNVPDNKLDGVINSLPAM
HCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHH
LAPAITRLSRSDIWEVITVAEEDILPEVIAKVKAAGARDIVVIDIEKVVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9209067; 10701121; 11427726