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The map label for this gene is hisC

Identifier: 15897509

GI number: 15897509

Start: 519526

End: 520656

Strand: Direct

Name: hisC

Synonym: SSO0592

Alternate gene names: 15897509

Gene position: 519526-520656 (Clockwise)

Preceding gene: 15897507

Following gene: 15897510

Centisome position: 17.36

GC content: 32.89

Gene sequence:

>1131_bases
ATGAGATTTTCATTAAAGCTTATTTATTTATTTTACGTTGCTTATCTAGGGTTTTATATTGCACCAACCAAGTTAGTTAG
AAATAAGATAAAATCTTGGCTATTAAATGCAAGCGAATATGATTTTACAGATATAAAAGAAGGAATAAGATTACATCTTA
ATGAATCCCCATTTGAGCCTCCACAATTTATAATAGATGCGGTTAAGATGTATTTAAGTAAGGGAAACAGATATCAACAT
CCAGATCTTTTAGAAAAATATAGGGAATTGGCTGCTGAATATTCGAAGGTGGAACCAGAAAACATTTATCCATCTGTAGG
TGCGGATGGGTCAATCAGAGCAATATTTTATAACCTTGTAGAGCCGGGTGATACAATACTAACGAATTACCCGTCTTATA
GTATGTATTCTGTTTACTCTTCAGTAAGAGGAACTAAGGTAATTAAAGTAAATCTTAAAGAGGATAATGAATGGTGGAAA
GAAAACACTGATGATTTACTTGCTCAAGCAGAAAAAGTTGAGTTAGTCATAATTGATGATCCTAATAATCCTACAGGATC
GCCAATGCTAAATGGGAAAAAGGAACTAATAGGTCAATTAGCAGAAAACACAAAAGGGTTTGTTGTAATTGATGAGGCAT
ACTACGAATTTGGAGGATATACAGTTTCACCTTATATTTACGACTATCCTAACGTTTTGGTGGTTAGGACTCTGAGTAAG
GCATTTTCATTAGCTTCCTATAGATTAGGTTATACGATAGCTAATGAGGAGATAGTAAAGGCTCTTATGAAATCATCAAC
ACCTTTTGATATACCTTTACCTTCACTCATTGCCGGAATTACAGCATTAGAAAACCCGTCATATATAAAAGATGTCGTAA
ACATAGTTAATAGGAATAGGGAAATATTATATCAAGGGCTTAAGAATCTAAATCTGAAAGTTTACAAGTCGATAACCAAT
TTCCTTTTAATAAAAGATAACAGAAACTTGCAGGAAATGCTTATGAGACACGGGATTGCAATAAGAAAGTTATATGACAA
CTTTTATAGAATAACAATAGGGACTGAAGATCAGTGCAAGATGGTTATAGATAAACTTGGTGAGGAACTTGAAAATAGCA
ATTCCAAATAA

Upstream 100 bases:

>100_bases
TGTAATATTATAAATTAAAACAATTTTAGCGTTAATATGATACGACTGCAAAAGTATTTTTCTATTTCTCAAGGACATTA
GATAATCTAACAAATTCACG

Downstream 100 bases:

>100_bases
AGGAAGACTCCAGCAACCTACGCTACAATTTTTACAGTCAGTAGGCATAAAACCGTTGGCCAGTGACGATAGAGCGTTAA
TAGTACCGACAAGTTGGGAG

Product: histidinol-phosphate aminotransferase (hisC)

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MRFSLKLIYLFYVAYLGFYIAPTKLVRNKIKSWLLNASEYDFTDIKEGIRLHLNESPFEPPQFIIDAVKMYLSKGNRYQH
PDLLEKYRELAAEYSKVEPENIYPSVGADGSIRAIFYNLVEPGDTILTNYPSYSMYSVYSSVRGTKVIKVNLKEDNEWWK
ENTDDLLAQAEKVELVIIDDPNNPTGSPMLNGKKELIGQLAENTKGFVVIDEAYYEFGGYTVSPYIYDYPNVLVVRTLSK
AFSLASYRLGYTIANEEIVKALMKSSTPFDIPLPSLIAGITALENPSYIKDVVNIVNRNREILYQGLKNLNLKVYKSITN
FLLIKDNRNLQEMLMRHGIAIRKLYDNFYRITIGTEDQCKMVIDKLGEELENSNSK

Sequences:

>Translated_376_residues
MRFSLKLIYLFYVAYLGFYIAPTKLVRNKIKSWLLNASEYDFTDIKEGIRLHLNESPFEPPQFIIDAVKMYLSKGNRYQH
PDLLEKYRELAAEYSKVEPENIYPSVGADGSIRAIFYNLVEPGDTILTNYPSYSMYSVYSSVRGTKVIKVNLKEDNEWWK
ENTDDLLAQAEKVELVIIDDPNNPTGSPMLNGKKELIGQLAENTKGFVVIDEAYYEFGGYTVSPYIYDYPNVLVVRTLSK
AFSLASYRLGYTIANEEIVKALMKSSTPFDIPLPSLIAGITALENPSYIKDVVNIVNRNREILYQGLKNLNLKVYKSITN
FLLIKDNRNLQEMLMRHGIAIRKLYDNFYRITIGTEDQCKMVIDKLGEELENSNSK
>Mature_376_residues
MRFSLKLIYLFYVAYLGFYIAPTKLVRNKIKSWLLNASEYDFTDIKEGIRLHLNESPFEPPQFIIDAVKMYLSKGNRYQH
PDLLEKYRELAAEYSKVEPENIYPSVGADGSIRAIFYNLVEPGDTILTNYPSYSMYSVYSSVRGTKVIKVNLKEDNEWWK
ENTDDLLAQAEKVELVIIDDPNNPTGSPMLNGKKELIGQLAENTKGFVVIDEAYYEFGGYTVSPYIYDYPNVLVVRTLSK
AFSLASYRLGYTIANEEIVKALMKSSTPFDIPLPSLIAGITALENPSYIKDVVNIVNRNREILYQGLKNLNLKVYKSITN
FLLIKDNRNLQEMLMRHGIAIRKLYDNFYRITIGTEDQCKMVIDKLGEELENSNSK

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Homo sapiens, GI95147551, Length=348, Percent_Identity=21.551724137931, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI169881279, Length=348, Percent_Identity=21.551724137931, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1788332, Length=325, Percent_Identity=33.8461538461538, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1788722, Length=229, Percent_Identity=26.6375545851528, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322075, Length=365, Percent_Identity=28.7671232876712, Blast_Score=124, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_SULSO (O33770)

Other databases:

- EMBL:   U82227
- EMBL:   Y18930
- EMBL:   AE006641
- PIR:   A90206
- RefSeq:   NP_342114.1
- ProteinModelPortal:   O33770
- SMR:   O33770
- GeneID:   1454871
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0592
- NMPDR:   fig|273057.1.peg.537
- HOGENOM:   HBG646350
- OMA:   MSARYHH
- ProtClustDB:   CLSK802777
- BioCyc:   SSOL273057:SSO0592-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 43194; Mature: 43194

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFSLKLIYLFYVAYLGFYIAPTKLVRNKIKSWLLNASEYDFTDIKEGIRLHLNESPFEP
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEECCCCCCC
PQFIIDAVKMYLSKGNRYQHPDLLEKYRELAAEYSKVEPENIYPSVGADGSIRAIFYNLV
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHEEECC
EPGDTILTNYPSYSMYSVYSSVRGTKVIKVNLKEDNEWWKENTDDLLAQAEKVELVIIDD
CCCCEEEECCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHCCHHHHHHHHCEEEEEEEEC
PNNPTGSPMLNGKKELIGQLAENTKGFVVIDEAYYEFGGYTVSPYIYDYPNVLVVRTLSK
CCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEHHHHHCCCEEECCEEECCCCHHHHHHHHH
AFSLASYRLGYTIANEEIVKALMKSSTPFDIPLPSLIAGITALENPSYIKDVVNIVNRNR
HHHHHHHHHCEEECHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCH
EILYQGLKNLNLKVYKSITNFLLIKDNRNLQEMLMRHGIAIRKLYDNFYRITIGTEDQCK
HHHHHHHHCCCHHEEEHHHCEEEEECCCCHHHHHHHCCHHHHHHHCCEEEEEECCCHHHH
MVIDKLGEELENSNSK
HHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRFSLKLIYLFYVAYLGFYIAPTKLVRNKIKSWLLNASEYDFTDIKEGIRLHLNESPFEP
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEECCCCCCC
PQFIIDAVKMYLSKGNRYQHPDLLEKYRELAAEYSKVEPENIYPSVGADGSIRAIFYNLV
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHEEECC
EPGDTILTNYPSYSMYSVYSSVRGTKVIKVNLKEDNEWWKENTDDLLAQAEKVELVIIDD
CCCCEEEECCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHCCHHHHHHHHCEEEEEEEEC
PNNPTGSPMLNGKKELIGQLAENTKGFVVIDEAYYEFGGYTVSPYIYDYPNVLVVRTLSK
CCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEHHHHHCCCEEECCEEECCCCHHHHHHHHH
AFSLASYRLGYTIANEEIVKALMKSSTPFDIPLPSLIAGITALENPSYIKDVVNIVNRNR
HHHHHHHHHCEEECHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCH
EILYQGLKNLNLKVYKSITNFLLIKDNRNLQEMLMRHGIAIRKLYDNFYRITIGTEDQCK
HHHHHHHHCCCHHEEEHHHCEEEEECCCCHHHHHHHCCHHHHHHHCCEEEEEECCCHHHH
MVIDKLGEELENSNSK
HHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9209067; 10701121; 11427726