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The map label for this gene is acaB-1

Identifier: 15897458

GI number: 15897458

Start: 462588

End: 463667

Strand: Reverse

Name: acaB-1

Synonym: SSO0534

Alternate gene names: NA

Gene position: 463667-462588 (Counterclockwise)

Preceding gene: 15897459

Following gene: 15897457

Centisome position: 15.5

GC content: 36.2

Gene sequence:

>1080_bases
ATGGTAGAGGTTTACTTAAATTCTTCATCAATGATTCCAATAGATAGATATTACGAGTATGATATTTATGATTTGGTAAT
AGAGGCCTATAAGAACTTTGAAGGAGAATACGATGTAAATAGTATTGACCTAATTGTTGTTGCGAATGCCTATTCCCAAA
AACTGAATAACGCGTCTTTAATTGCACCAAAGATTGCTGAAAAGATAGGGAAACCTAACGTACCTTCTATTAAAGTGGAT
AACGCTGACGCCAGTGGAGGTGCTGCTTTACTTACAGCTTATTCACTGATTAAGAGTAATATGGTAAATTCGGTTTTAAT
AGTAGGAGTTGAGAAGCAGTCGGATTATCCTTCTAAGTATCTTTATGATGCCATATCCACCAATTTAGATGATTACATGT
TTTATAATGGCATCTCTTCTCATTCAGTAGCTGCACTATTAATGAGACAGTATATGAAAAGGTATGGCGTTGATAGAAAT
TATTTTGCGAATTGGGCTATCAAAATGCACAAGAACGCCACGGAAAATCCTTTTGCGTATTTAAGGTTTCAGGTTGACTT
AAATACCGTAATTAATTCGCAGATTATCTCAGATCCTGTAAGATTATTTGACGTCGGTGCGAGAGCTGACGGGGCTGCAA
TACTCTTACTTTCAAATAATAAGACTGAGTCAGCGGTAAAGATTAATAAAATCCTTTCCGCACAAGCCAGATATGACTTT
TCTCCATCTTTACCTTCTGTAAGAATGTTAAGGGATAAGTTAGAATTGAAATTCAGTGAAAGAACCGGGATTGATATTCA
CGACTCCTATAGTATTATGGCTGCTTTAATGTTAGAAGAAGCGGGAATATTTGAAAGCGGTAAATCCTTGCATAATTTAG
ATAGTGTGAATGTAAATTTAGGCGGAGGATTAAAAGCCCGAGGACATGTAGGTGGGGCTTCCGCCATATACCAATTAGCT
GAGGCTCACATGCAATTAATTGGTTCGTTTAAAGGCAAAAAGGCTAGTGTTGATAATTATATAGTAATTTCCTCAGATGA
TTTAGGTATGGTGAGTTATGGTATTAATTTATCGAGGTGA

Upstream 100 bases:

>100_bases
AAAAATTGGCTAAAACCGTAGAATATTATATAAATAATAAAAAACTCGTATCTTATGCTGAATATGCTAAATATACTAAT
AAGATAAAGGTGTATGAGTA

Downstream 100 bases:

>100_bases
TCTAGATGAAAATAGCTCCTCCTCAAGTTTGGAGAAATAAAAGATTCATGTATAAGTTAACAGCGAGTAGGTGTGAACGT
TGCGGACATATAAGCTTTCC

Product: Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-1)

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MVEVYLNSSSMIPIDRYYEYDIYDLVIEAYKNFEGEYDVNSIDLIVVANAYSQKLNNASLIAPKIAEKIGKPNVPSIKVD
NADASGGAALLTAYSLIKSNMVNSVLIVGVEKQSDYPSKYLYDAISTNLDDYMFYNGISSHSVAALLMRQYMKRYGVDRN
YFANWAIKMHKNATENPFAYLRFQVDLNTVINSQIISDPVRLFDVGARADGAAILLLSNNKTESAVKINKILSAQARYDF
SPSLPSVRMLRDKLELKFSERTGIDIHDSYSIMAALMLEEAGIFESGKSLHNLDSVNVNLGGGLKARGHVGGASAIYQLA
EAHMQLIGSFKGKKASVDNYIVISSDDLGMVSYGINLSR

Sequences:

>Translated_359_residues
MVEVYLNSSSMIPIDRYYEYDIYDLVIEAYKNFEGEYDVNSIDLIVVANAYSQKLNNASLIAPKIAEKIGKPNVPSIKVD
NADASGGAALLTAYSLIKSNMVNSVLIVGVEKQSDYPSKYLYDAISTNLDDYMFYNGISSHSVAALLMRQYMKRYGVDRN
YFANWAIKMHKNATENPFAYLRFQVDLNTVINSQIISDPVRLFDVGARADGAAILLLSNNKTESAVKINKILSAQARYDF
SPSLPSVRMLRDKLELKFSERTGIDIHDSYSIMAALMLEEAGIFESGKSLHNLDSVNVNLGGGLKARGHVGGASAIYQLA
EAHMQLIGSFKGKKASVDNYIVISSDDLGMVSYGINLSR
>Mature_359_residues
MVEVYLNSSSMIPIDRYYEYDIYDLVIEAYKNFEGEYDVNSIDLIVVANAYSQKLNNASLIAPKIAEKIGKPNVPSIKVD
NADASGGAALLTAYSLIKSNMVNSVLIVGVEKQSDYPSKYLYDAISTNLDDYMFYNGISSHSVAALLMRQYMKRYGVDRN
YFANWAIKMHKNATENPFAYLRFQVDLNTVINSQIISDPVRLFDVGARADGAAILLLSNNKTESAVKINKILSAQARYDF
SPSLPSVRMLRDKLELKFSERTGIDIHDSYSIMAALMLEEAGIFESGKSLHNLDSVNVNLGGGLKARGHVGGASAIYQLA
EAHMQLIGSFKGKKASVDNYIVISSDDLGMVSYGINLSR

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=299, Percent_Identity=26.4214046822742, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI302344760, Length=299, Percent_Identity=26.4214046822742, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI302344767, Length=291, Percent_Identity=26.4604810996564, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI302344762, Length=306, Percent_Identity=24.8366013071895, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17537653, Length=365, Percent_Identity=23.8356164383562, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921506, Length=320, Percent_Identity=23.4375, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 39649; Mature: 39649

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEVYLNSSSMIPIDRYYEYDIYDLVIEAYKNFEGEYDVNSIDLIVVANAYSQKLNNASL
CEEEEECCCCCCCHHHCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEECHHHHCCCCCEE
IAPKIAEKIGKPNVPSIKVDNADASGGAALLTAYSLIKSNMVNSVLIVGVEKQSDYPSKY
ECHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHH
LYDAISTNLDDYMFYNGISSHSVAALLMRQYMKRYGVDRNYFANWAIKMHKNATENPFAY
HHHHHHCCCCHHEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCEEE
LRFQVDLNTVINSQIISDPVRLFDVGARADGAAILLLSNNKTESAVKINKILSAQARYDF
EEEEEEHHHHHHHHHHHCCHHEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCC
SPSLPSVRMLRDKLELKFSERTGIDIHDSYSIMAALMLEEAGIFESGKSLHNLDSVNVNL
CCCCCHHHHHHHHHHEEECCCCCCEECCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEE
GGGLKARGHVGGASAIYQLAEAHMQLIGSFKGKKASVDNYIVISSDDLGMVSYGINLSR
CCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEECCEECC
>Mature Secondary Structure
MVEVYLNSSSMIPIDRYYEYDIYDLVIEAYKNFEGEYDVNSIDLIVVANAYSQKLNNASL
CEEEEECCCCCCCHHHCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEECHHHHCCCCCEE
IAPKIAEKIGKPNVPSIKVDNADASGGAALLTAYSLIKSNMVNSVLIVGVEKQSDYPSKY
ECHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHH
LYDAISTNLDDYMFYNGISSHSVAALLMRQYMKRYGVDRNYFANWAIKMHKNATENPFAY
HHHHHHCCCCHHEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCEEE
LRFQVDLNTVINSQIISDPVRLFDVGARADGAAILLLSNNKTESAVKINKILSAQARYDF
EEEEEEHHHHHHHHHHHCCHHEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCC
SPSLPSVRMLRDKLELKFSERTGIDIHDSYSIMAALMLEEAGIFESGKSLHNLDSVNVNL
CCCCCHHHHHHHHHHEEECCCCCCEECCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEE
GGGLKARGHVGGASAIYQLAEAHMQLIGSFKGKKASVDNYIVISSDDLGMVSYGINLSR
CCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEECCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]