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The map label for this gene is proC [H]

Identifier: 15897420

GI number: 15897420

Start: 426293

End: 427126

Strand: Direct

Name: proC [H]

Synonym: SSO0495

Alternate gene names: 15897420

Gene position: 426293-427126 (Clockwise)

Preceding gene: 15897419

Following gene: 15897421

Centisome position: 14.25

GC content: 36.09

Gene sequence:

>834_bases
TTGAAAATTATGGAAGATTTAACTATTGGAATATTAGGAGCTGGTAAAATAGGTTCTGCAATAGTAAGGGCAATAAGGCT
AAAGTATCCTAGCATCCACGTAATTGCTACTGCGAGAAAAGATGAGACTTTAAGAAATGTAAAAGATCTAGAGGTAGAGA
CTACTAAGGATAATAATTATGCAGTTAATAAATCAGATGTAATTATCTTAAGCGTTAAGCCTCAGCATTTTCCTACTGTT
CTAAGGCAAGTTGGCATAGAGTCATGGAGAGATAAGGTAGTAATTTCAATAATGGCAGGAGTTAAGTTATCTACATTATC
TACCCTACTTAATAATGCTGAGGTTTATAGAGCCATGCCAAACATTAATGCAATAGTATATAAGTCTACTACTACAATTG
CTGAGAATAACGGGAAAAGTAGAGAATTAGTGGAGAACATATTTAAGACACTAGGTAACGTATACTGGCTTCCAGAAGAA
TACTTGGATATTTGGACTGCACTAGTAGGCAGTGGTCCAGCTTTTATATCTGAAATTATAGATGCGTTAAGTTTAGGTGC
AGTTGCTTGTGGAATGCAAAGAGAGATAGCCTACAATGCGGTTTTGGATATGATAAGTGGAACTATAATTATGCTTAAGG
AGGGTAAAATAGATCATCCTATGCTATTACGTGATCAAGTGACTACGCCAGTCGGTACCACAATAAGGGGACTCATGGTT
ATGGAAGCTAAGAGCGTTAAGTCAGCGTTAATTGAGACAATAGAGGCATCATATAAGAGGGCAGTTGAAATAGGCAATGA
GATTGACAAGAGTATTAGGAATAATAGCAAATAA

Upstream 100 bases:

>100_bases
TAAAATTTTAACTGAGAAATCTTAAAGTGTGTGATGATAAGGGACCACATGGAGTGGTGAAGATAACTTACCCGTCTGAA
TATTTAAGTTCCAGAGCATT

Downstream 100 bases:

>100_bases
GGAGGTGATGATTAAGCTTAATAATAACATGCGAAAATAATTATTGCGCTCAATATGGATAAGCGTATAGCGACAATCAT
ATTGAGTATAGTAAATATTA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MKIMEDLTIGILGAGKIGSAIVRAIRLKYPSIHVIATARKDETLRNVKDLEVETTKDNNYAVNKSDVIILSVKPQHFPTV
LRQVGIESWRDKVVISIMAGVKLSTLSTLLNNAEVYRAMPNINAIVYKSTTTIAENNGKSRELVENIFKTLGNVYWLPEE
YLDIWTALVGSGPAFISEIIDALSLGAVACGMQREIAYNAVLDMISGTIIMLKEGKIDHPMLLRDQVTTPVGTTIRGLMV
MEAKSVKSALIETIEASYKRAVEIGNEIDKSIRNNSK

Sequences:

>Translated_277_residues
MKIMEDLTIGILGAGKIGSAIVRAIRLKYPSIHVIATARKDETLRNVKDLEVETTKDNNYAVNKSDVIILSVKPQHFPTV
LRQVGIESWRDKVVISIMAGVKLSTLSTLLNNAEVYRAMPNINAIVYKSTTTIAENNGKSRELVENIFKTLGNVYWLPEE
YLDIWTALVGSGPAFISEIIDALSLGAVACGMQREIAYNAVLDMISGTIIMLKEGKIDHPMLLRDQVTTPVGTTIRGLMV
MEAKSVKSALIETIEASYKRAVEIGNEIDKSIRNNSK
>Mature_277_residues
MKIMEDLTIGILGAGKIGSAIVRAIRLKYPSIHVIATARKDETLRNVKDLEVETTKDNNYAVNKSDVIILSVKPQHFPTV
LRQVGIESWRDKVVISIMAGVKLSTLSTLLNNAEVYRAMPNINAIVYKSTTTIAENNGKSRELVENIFKTLGNVYWLPEE
YLDIWTALVGSGPAFISEIIDALSLGAVACGMQREIAYNAVLDMISGTIIMLKEGKIDHPMLLRDQVTTPVGTTIRGLMV
MEAKSVKSALIETIEASYKRAVEIGNEIDKSIRNNSK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=263, Percent_Identity=34.6007604562738, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI24797097, Length=275, Percent_Identity=30.9090909090909, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI24797095, Length=275, Percent_Identity=30.9090909090909, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI21361454, Length=275, Percent_Identity=30.1818181818182, Blast_Score=120, Evalue=1e-27,
Organism=Escherichia coli, GI1786585, Length=260, Percent_Identity=28.8461538461538, Blast_Score=102, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17569021, Length=278, Percent_Identity=30.5755395683453, Blast_Score=137, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17540664, Length=290, Percent_Identity=26.551724137931, Blast_Score=88, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320861, Length=287, Percent_Identity=31.3588850174216, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21358587, Length=267, Percent_Identity=31.8352059925094, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24648116, Length=280, Percent_Identity=32.5, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24647700, Length=172, Percent_Identity=31.3953488372093, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 30519; Mature: 30519

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIMEDLTIGILGAGKIGSAIVRAIRLKYPSIHVIATARKDETLRNVKDLEVETTKDNNY
CCCHHCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHCHHHCEEEEECCCCE
AVNKSDVIILSVKPQHFPTVLRQVGIESWRDKVVISIMAGVKLSTLSTLLNNAEVYRAMP
EECCCCEEEEEECCCHHHHHHHHHCHHHHHHHEEHHHHHCCHHHHHHHHHCCHHHHHHCC
NINAIVYKSTTTIAENNGKSRELVENIFKTLGNVYWLPEEYLDIWTALVGSGPAFISEII
CCCEEEEECEEEEECCCCCHHHHHHHHHHHHCCEEECCHHHHHHHHHHHCCCHHHHHHHH
DALSLGAVACGMQREIAYNAVLDMISGTIIMLKEGKIDHPMLLRDQVTTPVGTTIRGLMV
HHHHHHHHHHCHHHHHHHHHHHHHHCCEEEEEECCCCCCCEEEHHCCCCCCCHHHHHHHH
MEAKSVKSALIETIEASYKRAVEIGNEIDKSIRNNSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKIMEDLTIGILGAGKIGSAIVRAIRLKYPSIHVIATARKDETLRNVKDLEVETTKDNNY
CCCHHCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHCHHHCEEEEECCCCE
AVNKSDVIILSVKPQHFPTVLRQVGIESWRDKVVISIMAGVKLSTLSTLLNNAEVYRAMP
EECCCCEEEEEECCCHHHHHHHHHCHHHHHHHEEHHHHHCCHHHHHHHHHCCHHHHHHCC
NINAIVYKSTTTIAENNGKSRELVENIFKTLGNVYWLPEEYLDIWTALVGSGPAFISEII
CCCEEEEECEEEEECCCCCHHHHHHHHHHHHCCEEECCHHHHHHHHHHHCCCHHHHHHHH
DALSLGAVACGMQREIAYNAVLDMISGTIIMLKEGKIDHPMLLRDQVTTPVGTTIRGLMV
HHHHHHHHHHCHHHHHHHHHHHHHHCCEEEEEECCCCCCCEEEHHCCCCCCCHHHHHHHH
MEAKSVKSALIETIEASYKRAVEIGNEIDKSIRNNSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11844777; 11932238 [H]