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The map label for this gene is NuoH [H]

Identifier: 15897265

GI number: 15897265

Start: 277514

End: 278572

Strand: Direct

Name: NuoH [H]

Synonym: SSO0325

Alternate gene names: 15897265

Gene position: 277514-278572 (Clockwise)

Preceding gene: 15897264

Following gene: 15897266

Centisome position: 9.27

GC content: 33.81

Gene sequence:

>1059_bases
ATGAGCGTTCTCTCAGCTTTGCAATATTATTTCTTTTATCCTTCATTTTTCTTAACAGTAATTTTCCCTGGTCTAATATT
CACTCTAATTTTTCTTTTAGTTACTATATGGTTTGAAAGAAAAGCAGCAGCTATAGTTCAACTTAGATACGGTCCTTACT
ATGCATCTAAACGATTAGGAGGTATACTTCAGTTATTTGCTGACGCTATAAAATTTGTATTCTCGGAGATAATAATTCCT
AATGGAGTAAATCAAACACTTTATGCAATATCTCCAGTTCTAGTATTAATATTTGCGTTTTTACCTATGGCTCTTATACC
AATATCTACTATACCAACACAAGGATCTATATTGTCAGTTTATCATGGCATATTTTATGACACCCAAATTCATCAAGGTA
TTTTAGTTCCATATTTCATAGAGTACAATTTAATAGGAATAATCGCACTGGAATCTCTATATCCAATACTTGTCATATTC
TTGGCATGGAATACAAACAATAGATTCGCTATAGTAGGTTCTATAAGGGAGGCTTATTTGTCAGTATCTTATGATGTATT
AATCATAATTTCGACACTTGCATTAGGATTAGAATATCACACACTTGATGTTGCTAAGATAGTGACTTCTGGAATACCGG
GATTTATAGCTAATCCTATTGCGGCATTTGTATTCTTAGTTGCAATGTTAATAGGTTCTTCGAGGTTTCCATTTGAAATA
GTAGAAGCTGAAACAGAGTTAGTTATAGGTCCTTATACTGAATATAGCGGTTTTCTATTTGTATTAACCATGGCGGGTTC
CTATGTGGCAAATTTGGTATATGCAATTCTCTTTGTGGACTTATTCTTGGGTGGTTGGCTTCCATTTACGGGATTTGTAG
GTGCAATATTTACCGTTTTCAAGGCAGCAATAGTGGTATTTTTTGCTGTATTTCTTAGAGCGGTTTATGGAAGATACAGA
ATAGATCAAGCTTTAAGGGGAAGTTGGAAATATTTCTTTCCCTTAGCTTTAGCTTCCTTATTATTAGGTGTGGTGGTGGG
TTATTTATGGATAAGGTGA

Upstream 100 bases:

>100_bases
TAATATATGTTTTTAAAGAGTTATGTAAAGGTTCACGATATGCTGATTTGGTTTCGATTTATGGTAGTCTAGATTATTTC
CCTCCGGAGGCGGATAGGTA

Downstream 100 bases:

>100_bases
AAGAATATAAAAAAGAAAATATAGCGAGTTTATTTGCAGAACATATACAGTCCATAGTTACGGGTATAAAATATTTTGTA
AAGCCTCAGAGAATCACACT

Product: NADH dehydrogenase subunit H

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I subunit 1; NDH-1 subunit 1; NDH-A [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MSVLSALQYYFFYPSFFLTVIFPGLIFTLIFLLVTIWFERKAAAIVQLRYGPYYASKRLGGILQLFADAIKFVFSEIIIP
NGVNQTLYAISPVLVLIFAFLPMALIPISTIPTQGSILSVYHGIFYDTQIHQGILVPYFIEYNLIGIIALESLYPILVIF
LAWNTNNRFAIVGSIREAYLSVSYDVLIIISTLALGLEYHTLDVAKIVTSGIPGFIANPIAAFVFLVAMLIGSSRFPFEI
VEAETELVIGPYTEYSGFLFVLTMAGSYVANLVYAILFVDLFLGGWLPFTGFVGAIFTVFKAAIVVFFAVFLRAVYGRYR
IDQALRGSWKYFFPLALASLLLGVVVGYLWIR

Sequences:

>Translated_352_residues
MSVLSALQYYFFYPSFFLTVIFPGLIFTLIFLLVTIWFERKAAAIVQLRYGPYYASKRLGGILQLFADAIKFVFSEIIIP
NGVNQTLYAISPVLVLIFAFLPMALIPISTIPTQGSILSVYHGIFYDTQIHQGILVPYFIEYNLIGIIALESLYPILVIF
LAWNTNNRFAIVGSIREAYLSVSYDVLIIISTLALGLEYHTLDVAKIVTSGIPGFIANPIAAFVFLVAMLIGSSRFPFEI
VEAETELVIGPYTEYSGFLFVLTMAGSYVANLVYAILFVDLFLGGWLPFTGFVGAIFTVFKAAIVVFFAVFLRAVYGRYR
IDQALRGSWKYFFPLALASLLLGVVVGYLWIR
>Mature_351_residues
SVLSALQYYFFYPSFFLTVIFPGLIFTLIFLLVTIWFERKAAAIVQLRYGPYYASKRLGGILQLFADAIKFVFSEIIIPN
GVNQTLYAISPVLVLIFAFLPMALIPISTIPTQGSILSVYHGIFYDTQIHQGILVPYFIEYNLIGIIALESLYPILVIFL
AWNTNNRFAIVGSIREAYLSVSYDVLIIISTLALGLEYHTLDVAKIVTSGIPGFIANPIAAFVFLVAMLIGSSRFPFEIV
EAETELVIGPYTEYSGFLFVLTMAGSYVANLVYAILFVDLFLGGWLPFTGFVGAIFTVFKAAIVVFFAVFLRAVYGRYRI
DQALRGSWKYFFPLALASLLLGVVVGYLWIR

Specific function: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=318, Percent_Identity=26.1006289308176, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI1788618, Length=317, Percent_Identity=29.3375394321767, Blast_Score=118, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: 1.6.5.3

Molecular weight: Translated: 39369; Mature: 39238

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLSALQYYFFYPSFFLTVIFPGLIFTLIFLLVTIWFERKAAAIVQLRYGPYYASKRLG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHH
GILQLFADAIKFVFSEIIIPNGVNQTLYAISPVLVLIFAFLPMALIPISTIPTQGSILSV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
YHGIFYDTQIHQGILVPYFIEYNLIGIIALESLYPILVIFLAWNTNNRFAIVGSIREAYL
HHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEHHHHHHH
SVSYDVLIIISTLALGLEYHTLDVAKIVTSGIPGFIANPIAAFVFLVAMLIGSSRFPFEI
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEE
VEAETELVIGPYTEYSGFLFVLTMAGSYVANLVYAILFVDLFLGGWLPFTGFVGAIFTVF
EECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
KAAIVVFFAVFLRAVYGRYRIDQALRGSWKYFFPLALASLLLGVVVGYLWIR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVLSALQYYFFYPSFFLTVIFPGLIFTLIFLLVTIWFERKAAAIVQLRYGPYYASKRLG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHH
GILQLFADAIKFVFSEIIIPNGVNQTLYAISPVLVLIFAFLPMALIPISTIPTQGSILSV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
YHGIFYDTQIHQGILVPYFIEYNLIGIIALESLYPILVIFLAWNTNNRFAIVGSIREAYL
HHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEHHHHHHH
SVSYDVLIIISTLALGLEYHTLDVAKIVTSGIPGFIANPIAAFVFLVAMLIGSSRFPFEI
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEE
VEAETELVIGPYTEYSGFLFVLTMAGSYVANLVYAILFVDLFLGGWLPFTGFVGAIFTVF
EECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
KAAIVVFFAVFLRAVYGRYRIDQALRGSWKYFFPLALASLLLGVVVGYLWIR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1463844; 8590279; 8905231 [H]