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The map label for this gene is aroB

Identifier: 15897247

GI number: 15897247

Start: 259048

End: 260112

Strand: Direct

Name: aroB

Synonym: SSO0305

Alternate gene names: 15897247

Gene position: 259048-260112 (Clockwise)

Preceding gene: 15897246

Following gene: 15897248

Centisome position: 8.66

GC content: 32.58

Gene sequence:

>1065_bases
ATGAGGGAAATCTTAGAAGATATTTGTTGCTCTGAAGTAAGAGTAGTAGTAGGAGAGGGATCACTTTCAAAATTATCTAA
GATTAAAGACAATAACGCTGCAGTTATCTATTCAAGAAAAATTAGTATAGCAGATAAAATTAATAAATATTTACCAAATG
CATACTTCATCCCAATTAATGATGGTGAAAGTACTAAAGAATTATCTAGTGTAATATCTTTAGTAGAAAAGCTATTTGAA
AAGAATTTCGATAGGGGGGATTATATTATAGGTGTTGGTGGTGGAACGGTAACTGATGTAGCTGGTTTCTTAGCATCTAT
ATATTTAAGAGGATTAAATCTGATAAACGTACCAACGACCTTCTTAGGCATGGTCGATGCAGCAATAGGGGGTAAGAATG
GAGTAAATTTCAATAATATAAAGAACTTAATTGGAACATTCTATCAACCAAGTATGATAATTTCCGATTTAGAATTTTTG
GAAACTCTACCAATAGAAGAACTAAAGAAGGGATTAGCTGAAGTAATTAAATATGGCTTAACTTTAGATAAAGAATTATA
TGATTACTTGTCTTTAAATAAGGAGAAGATACTAAATAAAGATAAACAAGCATTAGAAGATATAATCTTTAGATCTACAC
TTGATAAACTAAGTATTGTAAAAGAAGATGAGAGAGAGACTAAAGGAATACGAATAGTTCTAAATTTCGGCCATACGATA
GGTCATGCTATAGAAGCTGGATCCTCTTTTAATGTTCCACATGGCTACGCTATCTCTGTAGGAATGGTTTGTGAGGCTAA
GATGGCGGAAGAGTTAGGTTATGCAGAGGAAGGAGTAGTAGAAGATGTGTTATGGCTATTACAGATTTATGGTTTACCTT
ACGATATATCTCAAATAGATGCCCCAGTAGATCTTAAACTAGCATTAAATGCTATTAATATGGATAAAAAACATAGGAAA
GATGTAATTTTGATACCGTTTCCTACTAGAATAGGTAGCTGGAAAAAAGTTGAAGTTCCTCTAGATACCGTAAAGGGGTT
TGCCGAACAATGCTTGAAGAAATAA

Upstream 100 bases:

>100_bases
AAAAGGCATTAAGTGATTCAGAGCAACAACTTACACCGGAATCATTCGAAGTTCTAATGAATCGAATTAGAACGCTAGCT
AGAGCTTTAGGGAGAGATGC

Downstream 100 bases:

>100_bases
ATTATGATACTAAGTTATTCGGTCTAATAGGTAAAAACATAAAGTACACGCTATCCCCTTATATTCATAATTTCTCATTT
AGAACACTAGGAATAAATGC

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MREILEDICCSEVRVVVGEGSLSKLSKIKDNNAAVIYSRKISIADKINKYLPNAYFIPINDGESTKELSSVISLVEKLFE
KNFDRGDYIIGVGGGTVTDVAGFLASIYLRGLNLINVPTTFLGMVDAAIGGKNGVNFNNIKNLIGTFYQPSMIISDLEFL
ETLPIEELKKGLAEVIKYGLTLDKELYDYLSLNKEKILNKDKQALEDIIFRSTLDKLSIVKEDERETKGIRIVLNFGHTI
GHAIEAGSSFNVPHGYAISVGMVCEAKMAEELGYAEEGVVEDVLWLLQIYGLPYDISQIDAPVDLKLALNAINMDKKHRK
DVILIPFPTRIGSWKKVEVPLDTVKGFAEQCLKK

Sequences:

>Translated_354_residues
MREILEDICCSEVRVVVGEGSLSKLSKIKDNNAAVIYSRKISIADKINKYLPNAYFIPINDGESTKELSSVISLVEKLFE
KNFDRGDYIIGVGGGTVTDVAGFLASIYLRGLNLINVPTTFLGMVDAAIGGKNGVNFNNIKNLIGTFYQPSMIISDLEFL
ETLPIEELKKGLAEVIKYGLTLDKELYDYLSLNKEKILNKDKQALEDIIFRSTLDKLSIVKEDERETKGIRIVLNFGHTI
GHAIEAGSSFNVPHGYAISVGMVCEAKMAEELGYAEEGVVEDVLWLLQIYGLPYDISQIDAPVDLKLALNAINMDKKHRK
DVILIPFPTRIGSWKKVEVPLDTVKGFAEQCLKK
>Mature_354_residues
MREILEDICCSEVRVVVGEGSLSKLSKIKDNNAAVIYSRKISIADKINKYLPNAYFIPINDGESTKELSSVISLVEKLFE
KNFDRGDYIIGVGGGTVTDVAGFLASIYLRGLNLINVPTTFLGMVDAAIGGKNGVNFNNIKNLIGTFYQPSMIISDLEFL
ETLPIEELKKGLAEVIKYGLTLDKELYDYLSLNKEKILNKDKQALEDIIFRSTLDKLSIVKEDERETKGIRIVLNFGHTI
GHAIEAGSSFNVPHGYAISVGMVCEAKMAEELGYAEEGVVEDVLWLLQIYGLPYDISQIDAPVDLKLALNAINMDKKHRK
DVILIPFPTRIGSWKKVEVPLDTVKGFAEQCLKK

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=238, Percent_Identity=42.8571428571429, Blast_Score=177, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6320332, Length=304, Percent_Identity=30.9210526315789, Blast_Score=149, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_SULSO (Q980I9)

Other databases:

- EMBL:   AE006641
- PIR:   C90173
- RefSeq:   NP_341852.1
- ProteinModelPortal:   Q980I9
- SMR:   Q980I9
- GeneID:   1455452
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0305
- NMPDR:   fig|273057.1.peg.275
- HOGENOM:   HBG632303
- OMA:   TERMISD
- ProtClustDB:   PRK00002
- BioCyc:   SSOL273057:SSO0305-MONOMER
- BRENDA:   4.2.3.4
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 39300; Mature: 39300

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREILEDICCSEVRVVVGEGSLSKLSKIKDNNAAVIYSRKISIADKINKYLPNAYFIPIN
CHHHHHHHHHHHEEEEECCCCHHHHHHHCCCCEEEEEEECCHHHHHHHHHCCCCEEEECC
DGESTKELSSVISLVEKLFEKNFDRGDYIIGVGGGTVTDVAGFLASIYLRGLNLINVPTT
CCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCEECCHHH
FLGMVDAAIGGKNGVNFNNIKNLIGTFYQPSMIISDLEFLETLPIEELKKGLAEVIKYGL
HHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
TLDKELYDYLSLNKEKILNKDKQALEDIIFRSTLDKLSIVKEDERETKGIRIVLNFGHTI
CCCHHHHHHHCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHH
GHAIEAGSSFNVPHGYAISVGMVCEAKMAEELGYAEEGVVEDVLWLLQIYGLPYDISQID
HHHHHCCCCCCCCCCCEEEECHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHCC
APVDLKLALNAINMDKKHRKDVILIPFPTRIGSWKKVEVPLDTVKGFAEQCLKK
CCCCCEEEHHHHCCCHHHCCCEEEEECCCCCCCCEEEECCHHHHHHHHHHHHCC
>Mature Secondary Structure
MREILEDICCSEVRVVVGEGSLSKLSKIKDNNAAVIYSRKISIADKINKYLPNAYFIPIN
CHHHHHHHHHHHEEEEECCCCHHHHHHHCCCCEEEEEEECCHHHHHHHHHCCCCEEEECC
DGESTKELSSVISLVEKLFEKNFDRGDYIIGVGGGTVTDVAGFLASIYLRGLNLINVPTT
CCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCEECCHHH
FLGMVDAAIGGKNGVNFNNIKNLIGTFYQPSMIISDLEFLETLPIEELKKGLAEVIKYGL
HHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
TLDKELYDYLSLNKEKILNKDKQALEDIIFRSTLDKLSIVKEDERETKGIRIVLNFGHTI
CCCHHHHHHHCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHH
GHAIEAGSSFNVPHGYAISVGMVCEAKMAEELGYAEEGVVEDVLWLLQIYGLPYDISQID
HHHHHCCCCCCCCCCCEEEECHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHCC
APVDLKLALNAINMDKKHRKDVILIPFPTRIGSWKKVEVPLDTVKGFAEQCLKK
CCCCCEEEHHHHCCCHHHCCCEEEEECCCCCCCCEEEECCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726