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The map label for this gene is tyrA [H]

Identifier: 15897245

GI number: 15897245

Start: 257014

End: 258054

Strand: Direct

Name: tyrA [H]

Synonym: SSO0302

Alternate gene names: 15897245

Gene position: 257014-258054 (Clockwise)

Preceding gene: 15897244

Following gene: 15897246

Centisome position: 8.59

GC content: 31.22

Gene sequence:

>1041_bases
ATGACTGAAGAAATAACACGGCTGAGGGAAGAAATAGATAAGGTAGACGAGCAGTTAGTAAAGTTACTCTCATATAGATT
AGAATTATCTAGAAAAATAGGGAAAGCTAAGTCGAATTCTAATATAAGTGTTACTGACGAGAATAGGGAAATGAAAGTTA
GAGAAAAATGGATTGCTAACGCAAAAAAGTATAATATTCCAAATAGTCTGGTTGAATCTATATTGCCTTTGATTTTTTCT
TATTCTAAACTAGTTCAGATTAACCCAGGAGAGAAAGAAAGAGTAGTAATATATGGATATGGCGGAATGGCTAAATCGAT
CGTTTCTATTCTTTCATTAGCTGGGCATGAAGTATCGATTACTGGAAGAGATTTAAGTAAAGCGGAGATGTTAGCTAATC
AATTTAAATGTGTAAGTATGTCCTTATTAAAAGCAATAGATTGGGGGGATATAATTATATTTGCAATACCTCCTAGTGCA
ATATTAAATAATTCCGATGAATTATTTTCAAAGGCACTTAAAGATAAGATTGTTATGGATATTAGTTCTTCTAAATTTAA
AATATTTGGCTTCCTAGAAGAATTATCTAGGAAACTAGAGTTTAGGTATATTTCTACACATCCACTTTTCGGTCCTATTG
AATACCCTATTGGAGAGAGAGTTGTAATTATACCTTCCAAAACTAGTTCTAATGATGATGTCATGAAGGTGGAGAATTTC
TGGAGGAAAAGTGGTTTAGTACCCGTCATAACTGATGTTGAAACTCATGAAAAAGCAATGGCTATTGTTCAAGTTCTAAC
GCATTATTATCTTCTGGGTTTATCAAACGCAATTGATACTTTATCGTTAGAGTTAGGTGTAGATTACAGTAATTTCCATA
CTACAAACTTTAGAGAATTAAACAAGATTTTAAAGCGGGTTAAAGATCTAAAAAATGTAATTACTGAAATACAAAATCAA
AACCCTTATTCTTATAAAGTTAGAAATATAGGTTTAGAGGAGCTTAAAAAAATTAAAGAAGAATTAGAAGGAGGTAAATA
G

Upstream 100 bases:

>100_bases
GACTTTTGGAAGATCTGCTAGAAGCCAAAGGGATCTACTAGATTACTATAATATAAACTATAAAACAATTATAAGGGAGG
CAATTGATTTATTGAAGTAG

Downstream 100 bases:

>100_bases
AATGATCTTATATGTCCTTAAGGATAGAGCTGATTACTCTATACTAATAGAAAAGCTAAATGAAAACTCAGCATCTTTCA
AGATATTAAACCTATATGGT

Product: chorismate mutase/prephenate dehydratase, putative (tyrA)

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MTEEITRLREEIDKVDEQLVKLLSYRLELSRKIGKAKSNSNISVTDENREMKVREKWIANAKKYNIPNSLVESILPLIFS
YSKLVQINPGEKERVVIYGYGGMAKSIVSILSLAGHEVSITGRDLSKAEMLANQFKCVSMSLLKAIDWGDIIIFAIPPSA
ILNNSDELFSKALKDKIVMDISSSKFKIFGFLEELSRKLEFRYISTHPLFGPIEYPIGERVVIIPSKTSSNDDVMKVENF
WRKSGLVPVITDVETHEKAMAIVQVLTHYYLLGLSNAIDTLSLELGVDYSNFHTTNFRELNKILKRVKDLKNVITEIQNQ
NPYSYKVRNIGLEELKKIKEELEGGK

Sequences:

>Translated_346_residues
MTEEITRLREEIDKVDEQLVKLLSYRLELSRKIGKAKSNSNISVTDENREMKVREKWIANAKKYNIPNSLVESILPLIFS
YSKLVQINPGEKERVVIYGYGGMAKSIVSILSLAGHEVSITGRDLSKAEMLANQFKCVSMSLLKAIDWGDIIIFAIPPSA
ILNNSDELFSKALKDKIVMDISSSKFKIFGFLEELSRKLEFRYISTHPLFGPIEYPIGERVVIIPSKTSSNDDVMKVENF
WRKSGLVPVITDVETHEKAMAIVQVLTHYYLLGLSNAIDTLSLELGVDYSNFHTTNFRELNKILKRVKDLKNVITEIQNQ
NPYSYKVRNIGLEELKKIKEELEGGK
>Mature_345_residues
TEEITRLREEIDKVDEQLVKLLSYRLELSRKIGKAKSNSNISVTDENREMKVREKWIANAKKYNIPNSLVESILPLIFSY
SKLVQINPGEKERVVIYGYGGMAKSIVSILSLAGHEVSITGRDLSKAEMLANQFKCVSMSLLKAIDWGDIIIFAIPPSAI
LNNSDELFSKALKDKIVMDISSSKFKIFGFLEELSRKLEFRYISTHPLFGPIEYPIGERVVIIPSKTSSNDDVMKVENFW
RKSGLVPVITDVETHEKAMAIVQVLTHYYLLGLSNAIDTLSLELGVDYSNFHTTNFRELNKILKRVKDLKNVITEIQNQN
PYSYKVRNIGLEELKKIKEELEGGK

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=294, Percent_Identity=26.530612244898, Blast_Score=82, Evalue=6e-17,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099 [H]

Pfam domain/function: PF01817 CM_2; PF02153 PDH [H]

EC number: =5.4.99.5; =1.3.1.12 [H]

Molecular weight: Translated: 39380; Mature: 39249

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEEITRLREEIDKVDEQLVKLLSYRLELSRKIGKAKSNSNISVTDENREMKVREKWIAN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHCC
AKKYNIPNSLVESILPLIFSYSKLVQINPGEKERVVIYGYGGMAKSIVSILSLAGHEVSI
CCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEE
TGRDLSKAEMLANQFKCVSMSLLKAIDWGDIIIFAIPPSAILNNSDELFSKALKDKIVMD
ECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHCCCHHHHHHHHHHHEEEE
ISSSKFKIFGFLEELSRKLEFRYISTHPLFGPIEYPIGERVVIIPSKTSSNDDVMKVENF
CCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHH
WRKSGLVPVITDVETHEKAMAIVQVLTHYYLLGLSNAIDTLSLELGVDYSNFHTTNFREL
HHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCHHHH
NKILKRVKDLKNVITEIQNQNPYSYKVRNIGLEELKKIKEELEGGK
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TEEITRLREEIDKVDEQLVKLLSYRLELSRKIGKAKSNSNISVTDENREMKVREKWIAN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHCC
AKKYNIPNSLVESILPLIFSYSKLVQINPGEKERVVIYGYGGMAKSIVSILSLAGHEVSI
CCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEE
TGRDLSKAEMLANQFKCVSMSLLKAIDWGDIIIFAIPPSAILNNSDELFSKALKDKIVMD
ECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHCCCHHHHHHHHHHHEEEE
ISSSKFKIFGFLEELSRKLEFRYISTHPLFGPIEYPIGERVVIIPSKTSSNDDVMKVENF
CCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHH
WRKSGLVPVITDVETHEKAMAIVQVLTHYYLLGLSNAIDTLSLELGVDYSNFHTTNFREL
HHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCHHHH
NKILKRVKDLKNVITEIQNQNPYSYKVRNIGLEELKKIKEELEGGK
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6396419; 9205837; 9278503 [H]